From the layer-level modeling results, this function extracts the top n significant genes. This is the workhorse function used by sig_genes_extract_all() through which we obtain the information that can then be used by functions such as layer_boxplot() for constructing informative titles.

sig_genes_extract(
  n = 10,
  modeling_results = fetch_data(type = "modeling_results"),
  model_type = names(modeling_results)[1],
  reverse = FALSE,
  sce_layer = fetch_data(type = "sce_layer")
)

Arguments

n

The number of the top ranked genes to extract.

modeling_results

Defaults to the output of fetch_data(type = 'modeling_results'). This is a list of tables with the columns f_stat_* or t_stat_* as well as p_value_* and fdr_* plus ensembl. The column name is used to extract the statistic results, the p-values, and the FDR adjusted p-values. Then the ensembl column is used for matching in some cases. See fetch_data() for more details.

model_type

A named element of the modeling_results list. By default that is either enrichment for the model that tests one human brain layer against the rest (one group vs the rest), pairwise which compares two layers (groups) denoted by layerA-layerB such that layerA is greater than layerB, and anova which determines if any layer (group) is different from the rest adjusting for the mean expression level. The statistics for enrichment and pairwise are t-statistics while the anova model ones are F-statistics.

reverse

A logical(1) indicating whether to multiply by -1 the input statistics and reverse the layerA-layerB column names (using the -) into layerB-layerA.

sce_layer

Defaults to the output of fetch_data(type = 'sce_layer'). This is a SingleCellExperiment object with the spot-level Visium data compressed via pseudo-bulking to the layer-level (group-level) resolution. See fetch_data() for more details.

Value

A data.frame() with the top n significant genes (as ordered by their statistics in decreasing order) in long format. The specific columns are described further in the vignette.

References

Adapted from https://github.com/LieberInstitute/HumanPilot/blob/master/Analysis/Layer_Guesses/layer_specificity_functions.R

See also

Other Layer modeling functions: layer_boxplot(), sig_genes_extract_all()

Examples


## Obtain the necessary data
if (!exists("modeling_results")) {
    modeling_results <- fetch_data(type = "modeling_results")
}
#> 2024-05-24 18:12:31.71533 loading file /github/home/.cache/R/BiocFileCache/2e74a1d6212_Human_DLPFC_Visium_modeling_results.Rdata%3Fdl%3D1
if (!exists("sce_layer")) sce_layer <- fetch_data(type = "sce_layer")
#> 2024-05-24 18:12:32.953542 loading file /github/home/.cache/R/BiocFileCache/2e71f430d0f_Human_DLPFC_Visium_processedData_sce_scran_sce_layer_spatialLIBD.Rdata%3Fdl%3D1

## anova top 10 genes
sig_genes_extract(
    modeling_results = modeling_results,
    sce_layer = sce_layer
)
#>    top model_type test     gene     stat         pval          fdr gene_index
#> 1    1      anova full    KRT17 142.6223 1.047345e-37 2.338827e-33      18321
#> 2    2      anova full SERPINE2 130.0159 2.154786e-36 2.405926e-32       3621
#> 3    3      anova full     GFAP 127.3117 4.267922e-36 3.176899e-32      18436
#> 4    4      anova full    CBLN4 118.0481 4.923904e-35 2.748892e-31      19844
#> 5    5      anova full   VSTM2A 111.0341 3.530274e-34 1.576691e-30       8315
#> 6    6      anova full  CAMK2N1 108.9155 6.542909e-34 2.435162e-30        308
#> 7    7      anova full   HS3ST4 104.9437 2.142606e-33 6.049917e-30      16991
#> 8    8      anova full     MYRF 104.9059 2.167361e-33 6.049917e-30      11871
#> 9    9      anova full    BCAS1 103.3046 3.537055e-33 8.776220e-30      19839
#> 10  10      anova full     MOBP 100.9366 7.389973e-33 1.650255e-29       3978
#> 11   1      anova noWM SERPINE2 209.6240 9.525498e-37 2.127139e-32       3621
#> 12   2      anova noWM  B3GALT2 181.2393 5.843659e-35 4.749316e-31       1809
#> 13   3      anova noWM    KRT17 180.6747 6.380345e-35 4.749316e-31      18321
#> 14   4      anova noWM    EFHD2 163.2460 1.099248e-33 5.247556e-30        232
#> 15   5      anova noWM  CAMK2N1 162.8576 1.174949e-33 5.247556e-30        308
#> 16   6      anova noWM     HOPX 157.1804 3.164231e-33 1.177674e-29       5291
#> 17   7      anova noWM   CLSTN2 148.4278 1.558137e-32 4.970680e-29       4638
#> 18   8      anova noWM   TUBA1B 135.6197 1.890890e-31 4.918869e-28      13893
#> 19   9      anova noWM   HS3ST2 135.3872 1.982438e-31 4.918869e-28      16964
#> 20  10      anova noWM     ETV1 130.0174 6.033934e-31 1.347438e-27       8095
#>            ensembl
#> 1  ENSG00000128422
#> 2  ENSG00000135919
#> 3  ENSG00000131095
#> 4  ENSG00000054803
#> 5  ENSG00000170419
#> 6  ENSG00000162545
#> 7  ENSG00000182601
#> 8  ENSG00000124920
#> 9  ENSG00000064787
#> 10 ENSG00000168314
#> 11 ENSG00000135919
#> 12 ENSG00000162630
#> 13 ENSG00000128422
#> 14 ENSG00000142634
#> 15 ENSG00000162545
#> 16 ENSG00000171476
#> 17 ENSG00000158258
#> 18 ENSG00000123416
#> 19 ENSG00000122254
#> 20 ENSG00000006468

## Extract all genes
sig_genes_extract(
    modeling_results = modeling_results,
    sce_layer = sce_layer,
    n = nrow(sce_layer)
)
#>         top model_type test            gene       stat         pval
#> 1         1      anova full           KRT17 142.622262 1.047345e-37
#> 2         2      anova full        SERPINE2 130.015902 2.154786e-36
#> 3         3      anova full            GFAP 127.311686 4.267922e-36
#> 4         4      anova full           CBLN4 118.048094 4.923904e-35
#> 5         5      anova full          VSTM2A 111.034071 3.530274e-34
#> 6         6      anova full         CAMK2N1 108.915472 6.542909e-34
#> 7         7      anova full          HS3ST4 104.943728 2.142606e-33
#> 8         8      anova full            MYRF 104.905907 2.167361e-33
#> 9         9      anova full           BCAS1 103.304594 3.537055e-33
#> 10       10      anova full            MOBP 100.936559 7.389973e-33
#> 11       11      anova full           EFHD2  95.119263 4.830189e-32
#> 12       12      anova full             MBP  93.310126 8.841183e-32
#> 13       13      anova full            PLP1  90.819189 2.067407e-31
#> 14       14      anova full            TLE4  89.573783 3.185778e-31
#> 15       15      anova full           SCN1B  89.299503 3.506551e-31
#> 16       16      anova full          HS3ST2  88.802684 4.174799e-31
#> 17       17      anova full          HPCAL1  87.920383 5.702797e-31
#> 18       18      anova full          FRMPD2  87.323459 7.053483e-31
#> 19       19      anova full            HOPX  87.288557 7.141974e-31
#> 20       20      anova full            CTGF  86.887308 8.245258e-31
#> 21       21      anova full          CARTPT  86.454103 9.634771e-31
#> 22       22      anova full             MAG  85.730516 1.251635e-30
#> 23       23      anova full            MT1G  85.499815 1.361082e-30
#> 24       24      anova full           LAMP5  85.498575 1.361696e-30
#> 25       25      anova full           PARM1  85.439069 1.391504e-30
#> 26       26      anova full            CNR1  82.784007 3.706832e-30
#> 27       27      anova full            SNCG  81.499616 6.013272e-30
#> 28       28      anova full          CLDND1  79.535346 1.276556e-29
#> 29       29      anova full          OPALIN  79.240219 1.431399e-29
#> 30       30      anova full          NECAB2  78.879414 1.647264e-29
#> 31       31      anova full           RGS12  78.677608 1.782330e-29
#> 32       32      anova full            RORB  77.716696 2.600133e-29
#> 33       33      anova full            CRYM  75.384631 6.612801e-29
#> 34       34      anova full              TF  74.480477 9.559810e-29
#> 35       35      anova full           SEPT4  74.280697 1.037625e-28
#> 36       36      anova full             MAL  73.881238 1.223066e-28
#> 37       37      anova full          TUBA1B  73.877595 1.224906e-28
#> 38       38      anova full           LPAR1  73.759465 1.286128e-28
#> 39       39      anova full            ERMN  73.660648 1.339754e-28
#> 40       40      anova full           EVI2A  72.843187 1.881777e-28
#> 41       41      anova full         B3GALT2  72.841104 1.883415e-28
#> 42       42      anova full           ERBB3  72.338449 2.324733e-28
#> 43       43      anova full           PVALB  72.266896 2.395696e-28
#> 44       44      anova full          SOWAHA  70.872150 4.327060e-28
#> 45       45      anova full        PPP1R14A  70.240442 5.674096e-28
#> 46       46      anova full           OLFM1  70.231543 5.695886e-28
#> 47       47      anova full          CLSTN2  70.071613 6.102471e-28
#> 48       48      anova full             SHB  69.989334 6.323153e-28
#> 49       49      anova full           SMYD2  69.816734 6.813144e-28
#> 50       50      anova full          CLDN11  69.696524 7.177327e-28
#> 51       51      anova full           CNDP1  69.232348 8.782105e-28
#> 52       52      anova full            SNCB  68.960808 9.887700e-28
#> 53       53      anova full          NAP1L5  68.857384 1.034557e-27
#> 54       54      anova full           TPPP3  68.537884 1.190263e-27
#> 55       55      anova full           PDZD2  68.338886 1.299236e-27
#> 56       56      anova full             MOG  68.069567 1.463276e-27
#> 57       57      anova full           S1PR5  67.981910 1.521144e-27
#> 58       58      anova full             CNP  67.607946 1.795712e-27
#> 59       59      anova full           STMN1  67.559103 1.835160e-27
#> 60       60      anova full          PCDH17  67.418892 1.953426e-27
#> 61       61      anova full            JAM3  67.155444 2.197292e-27
#> 62       62      anova full            SPP1  67.110367 2.242055e-27
#> 63       63      anova full            NSG2  66.843921 2.526499e-27
#> 64       64      anova full          RASSF2  66.838672 2.532462e-27
#> 65       65      anova full            AQP1  66.585709 2.837625e-27
#> 66       66      anova full            KLK6  66.376996 3.117757e-27
#> 67       67      anova full           PCDH8  66.282146 3.254313e-27
#> 68       68      anova full             CD9  66.161322 3.437214e-27
#> 69       69      anova full           HSPA2  66.016438 3.670548e-27
#> 70       70      anova full           LAMP2  65.928949 3.819274e-27
#> 71       71      anova full         ADAMTS4  65.916515 3.840907e-27
#> 72       72      anova full          NKX6-2  65.694360 4.249409e-27
#> 73       73      anova full           RXFP1  65.657475 4.321441e-27
#> 74       74      anova full           NDRG1  65.452086 4.746138e-27
#> 75       75      anova full            CUX2  65.041344 5.728994e-27
#> 76       76      anova full          HS6ST3  65.028915 5.761802e-27
#> 77       77      anova full           CRYAB  64.966071 5.930678e-27
#> 78       78      anova full           EPHA4  64.720781 6.640039e-27
#> 79       79      anova full          CAMK2D  64.590401 7.052032e-27
#> 80       80      anova full            MT2A  64.500883 7.350042e-27
#> 81       81      anova full           SATB1  64.194074 8.473373e-27
#> 82       82      anova full           CALB2  63.958061 9.456666e-27
#> 83       83      anova full            NEFL  63.952306 9.482055e-27
#> 84       84      anova full         TMEM144  63.917229 9.638339e-27
#> 85       85      anova full         SELENOP  63.787128 1.024149e-26
#> 86       86      anova full           SNRPN  63.779247 1.027925e-26
#> 87       87      anova full          RNASE1  63.492339 1.175599e-26
#> 88       88      anova full           CLIC4  63.108493 1.407984e-26
#> 89       89      anova full            NFIA  63.032333 1.459447e-26
#> 90       90      anova full            NSG1  62.723750 1.688565e-26
#> 91       91      anova full           CRLF1  62.521761 1.858283e-26
#> 92       92      anova full           FABP7  62.519048 1.860677e-26
#> 93       93      anova full            RCN1  62.032604 2.345867e-26
#> 94       94      anova full           VAMP1  61.846444 2.564412e-26
#> 95       95      anova full            HHIP  61.806289 2.614236e-26
#> 96       96      anova full             CA4  61.792508 2.631563e-26
#> 97       97      anova full           NR4A2  61.518818 3.001264e-26
#> 98       98      anova full          CARNS1  61.439000 3.118843e-26
#> 99       99      anova full             SCD  61.378123 3.211695e-26
#> 100     100      anova full           PMP22  60.923889 4.000660e-26
#> 101     101      anova full         NEUROD6  60.228791 5.613816e-26
#> 102     102      anova full         TMEM125  60.200069 5.693345e-26
#> 103     103      anova full            ASS1  59.828927 6.831717e-26
#> 104     104      anova full          FAM84A  59.680376 7.350694e-26
#> 105     105      anova full          ELOVL1  59.520451 7.954890e-26
#> 106     106      anova full         RETREG1  59.444902 8.257848e-26
#> 107     107      anova full           MEF2C  59.362161 8.603284e-26
#> 108     108      anova full           CERS2  59.280610 8.958301e-26
#> 109     109      anova full          PTP4A2  59.084779 9.873643e-26
#> 110     110      anova full            NEFM  58.862416 1.103046e-25
#> 111     111      anova full            GJC2  58.497400 1.324042e-25
#> 112     112      anova full            NEFH  58.293207 1.467049e-25
#> 113     113      anova full          HAPLN4  58.286720 1.471845e-25
#> 114     114      anova full           MTUS1  57.893109 1.795125e-25
#> 115     115      anova full           ENPP2  57.787504 1.893704e-25
#> 116     116      anova full      AC103681.2  57.354254 2.360090e-25
#> 117     117      anova full         ZFP36L1  57.304973 2.420148e-25
#> 118     118      anova full         SLC24A2  57.022317 2.796312e-25
#> 119     119      anova full            PFKP  56.954044 2.895868e-25
#> 120     120      anova full            PCP4  56.774636 3.175224e-25
#> 121     121      anova full           GPR37  56.714046 3.275707e-25
#> 122     122      anova full           PAQR6  56.650177 3.385172e-25
#> 123     123      anova full          ADGRB1  56.625683 3.428144e-25
#> 124     124      anova full            QDPR  56.414207 3.823294e-25
#> 125     125      anova full           EFHD1  56.151562 4.380079e-25
#> 126     126      anova full            ENC1  56.134416 4.419206e-25
#> 127     127      anova full            PLLP  56.123400 4.444533e-25
#> 128     128      anova full         TMEM206  55.850357 5.122381e-25
#> 129     129      anova full           PCSK1  55.180006 7.275514e-25
#> 130     130      anova full           TTYH2  55.176171 7.290203e-25
#> 131     131      anova full         CNTNAP2  55.063102 7.737368e-25
#> 132     132      anova full           AIF1L  55.059671 7.751367e-25
#> 133     133      anova full       LINC00844  54.787361 8.949995e-25
#> 134     134      anova full          SNAP25  54.738563 9.184160e-25
#> 135     135      anova full           S100B  54.731685 9.217665e-25
#> 136     136      anova full           PLPP2  54.571614 1.003403e-24
#> 137     137      anova full           TTC9B  54.493430 1.045943e-24
#> 138     138      anova full         FAM107B  54.487352 1.049326e-24
#> 139     139      anova full           ITPKA  54.378815 1.111683e-24
#> 140     140      anova full        TP53INP2  54.339292 1.135325e-24
#> 141     141      anova full         SIPA1L1  53.885748 1.446716e-24
#> 142     142      anova full             INA  53.649175 1.642759e-24
#> 143     143      anova full            SV2A  53.522601 1.758665e-24
#> 144     144      anova full         OLFML2B  53.368417 1.911294e-24
#> 145     145      anova full          TESPA1  53.115908 2.191309e-24
#> 146     146      anova full           DCLK1  53.036861 2.287377e-24
#> 147     147      anova full            MDH1  52.847217 2.535916e-24
#> 148     148      anova full          PHLDB1  52.663298 2.803517e-24
#> 149     149      anova full            RELN  52.659098 2.809957e-24
#> 150     150      anova full         TMEM63A  52.624661 2.863330e-24
#> 151     151      anova full           HIPK2  52.606057 2.892597e-24
#> 152     152      anova full            PNCK  52.579332 2.935178e-24
#> 153     153      anova full           NUAK1  52.447196 3.155382e-24
#> 154     154      anova full           FOXP2  52.212676 3.588966e-24
#> 155     155      anova full          ANP32B  51.987012 4.064111e-24
#> 156     156      anova full           SCN1A  51.935731 4.180827e-24
#> 157     157      anova full            FGF1  51.914509 4.230132e-24
#> 158     158      anova full         SLC12A5  51.689218 4.791916e-24
#> 159     159      anova full          DIRAS2  51.561052 5.145198e-24
#> 160     160      anova full            NRN1  51.298283 5.955687e-24
#> 161     161      anova full           CSRP1  51.005635 7.014430e-24
#> 162     162      anova full            TBR1  50.929882 7.318797e-24
#> 163     163      anova full            NENF  50.532032 9.155554e-24
#> 164     164      anova full           ARL4C  50.510231 9.268959e-24
#> 165     165      anova full         ZCCHC24  50.457855 9.547345e-24
#> 166     166      anova full            OXR1  50.353587 1.012743e-23
#> 167     167      anova full            AQP4  50.324273 1.029696e-23
#> 168     168      anova full           PREPL  50.322797 1.030557e-23
#> 169     169      anova full           REEP3  50.316724 1.034108e-23
#> 170     170      anova full           CMTM5  50.287563 1.051337e-23
#> 171     171      anova full            GJB1  50.068594 1.190509e-23
#> 172     172      anova full             GSN  50.021760 1.222657e-23
#> 173     173      anova full            VCAN  49.991025 1.244238e-23
#> 174     174      anova full          IPCEF1  49.952445 1.271884e-23
#> 175     175      anova full          PAIP2B  49.889068 1.318676e-23
#> 176     176      anova full          FKBP1A  49.809684 1.379794e-23
#> 177     177      anova full          TUBB2A  49.772259 1.409609e-23
#> 178     178      anova full            NCDN  49.734022 1.440758e-23
#> 179     179      anova full             BOK  49.709199 1.461355e-23
#> 180     180      anova full          TMEFF2  49.581367 1.572329e-23
#> 181     181      anova full           RAB3A  49.539237 1.610773e-23
#> 182     182      anova full          SLAIN1  49.499811 1.647623e-23
#> 183     183      anova full            ANLN  49.447874 1.697495e-23
#> 184     184      anova full           DAAM2  49.308980 1.838632e-23
#> 185     185      anova full             ID3  49.165260 1.997413e-23
#> 186     186      anova full            VWA1  49.030489 2.159121e-23
#> 187     187      anova full           GRIA4  48.973626 2.231329e-23
#> 188     188      anova full            BEX5  48.804579 2.461017e-23
#> 189     189      anova full          SEMA3E  48.579523 2.805075e-23
#> 190     190      anova full           LITAF  48.576824 2.809489e-23
#> 191     191      anova full          GABRG2  48.425845 3.068104e-23
#> 192     192      anova full             VIM  48.280348 3.340514e-23
#> 193     193      anova full          AKAP12  48.218677 3.463371e-23
#> 194     194      anova full          DIXDC1  48.210222 3.480571e-23
#> 195     195      anova full           CDK18  48.177052 3.548909e-23
#> 196     196      anova full        ATP6V1B2  48.157083 3.590713e-23
#> 197     197      anova full            GNG3  48.036490 3.854154e-23
#> 198     198      anova full        C1orf115  47.936947 4.086545e-23
#> 199     199      anova full          PCP4L1  47.931284 4.100192e-23
#> 200     200      anova full          GABRA1  47.826213 4.362054e-23
#> 201     201      anova full          MGAT5B  47.647875 4.846551e-23
#> 202     202      anova full         RASGRF2  47.560662 5.103302e-23
#> 203     203      anova full             EZR  47.557735 5.112156e-23
#> 204     204      anova full         C2orf80  47.471421 5.380522e-23
#> 205     205      anova full            BEX1  47.383870 5.667549e-23
#> 206     206      anova full             DBI  47.338124 5.823738e-23
#> 207     207      anova full            DPP6  47.323652 5.874065e-23
#> 208     208      anova full        C16orf45  47.213181 6.273271e-23
#> 209     209      anova full           ABCA8  47.177323 6.408763e-23
#> 210     210      anova full            EGR3  47.147612 6.523306e-23
#> 211     211      anova full         PIP4K2A  47.026403 7.012828e-23
#> 212     212      anova full           LZTS3  46.936892 7.398462e-23
#> 213     213      anova full             QKI  46.923607 7.457528e-23
#> 214     214      anova full           NTNG2  46.754894 8.251216e-23
#> 215     215      anova full          MALAT1  46.720492 8.423440e-23
#> 216     216      anova full             CKB  46.712016 8.466438e-23
#> 217     217      anova full           CPLX1  46.227534 1.134010e-22
#> 218     218      anova full            ENO2  46.203965 1.150317e-22
#> 219     219      anova full          NDUFA4  46.197453 1.154865e-22
#> 220     220      anova full        SERPINI1  46.147104 1.190658e-22
#> 221     221      anova full           STMN2  46.145964 1.191482e-22
#> 222     222      anova full          MAP3K9  46.094912 1.228967e-22
#> 223     223      anova full           EDIL3  45.956336 1.336950e-22
#> 224     224      anova full        ATP6V1G2  45.894949 1.387858e-22
#> 225     225      anova full          THEMIS  45.765321 1.502007e-22
#> 226     226      anova full           UCHL1  45.747191 1.518724e-22
#> 227     227      anova full           BEND5  45.633209 1.628302e-22
#> 228     228      anova full            SYT1  45.600342 1.661385e-22
#> 229     229      anova full            GLDN  45.538776 1.725227e-22
#> 230     230      anova full      AC092958.1  45.515235 1.750300e-22
#> 231     231      anova full            LMO4  45.486423 1.781497e-22
#> 232     232      anova full            SOX8  45.411680 1.865122e-22
#> 233     233      anova full         SLC35F1  45.357625 1.928106e-22
#> 234     234      anova full            RPRM  45.321602 1.971290e-22
#> 235     235      anova full            RBP4  45.235889 2.078085e-22
#> 236     236      anova full          TMSB10  45.057478 2.319875e-22
#> 237     237      anova full            RPS6  45.015360 2.381062e-22
#> 238     238      anova full            ISLR  44.975735 2.440142e-22
#> 239     239      anova full            RTN3  44.894052 2.566731e-22
#> 240     240      anova full            CALY  44.843066 2.649150e-22
#> 241     241      anova full         NEUROD1  44.823063 2.682224e-22
#> 242     242      anova full           MOAP1  44.811696 2.701207e-22
#> 243     243      anova full            FA2H  44.749458 2.807623e-22
#> 244     244      anova full            CA10  44.698750 2.897505e-22
#> 245     245      anova full           RIMS3  44.667522 2.954326e-22
#> 246     246      anova full           CNTN2  44.612188 3.057837e-22
#> 247     247      anova full           VSNL1  44.472992 3.335038e-22
#> 248     248      anova full          TMEM98  44.454678 3.373384e-22
#> 249     249      anova full            RHOU  44.385085 3.523286e-22
#> 250     250      anova full           RPS27  44.364952 3.567916e-22
#> 251     251      anova full           CPNE4  44.294426 3.728893e-22
#> 252     252      anova full             EFS  44.288640 3.742428e-22
#> 253     253      anova full            RHOG  44.257067 3.817173e-22
#> 254     254      anova full          KCNIP4  44.151052 4.079571e-22
#> 255     255      anova full         FAM19A2  43.965630 4.583977e-22
#> 256     256      anova full            CD55  43.931563 4.683410e-22
#> 257     257      anova full            PTMA  43.863461 4.888879e-22
#> 258     258      anova full          YJEFN3  43.842566 4.953763e-22
#> 259     259      anova full           PRR18  43.658781 5.564016e-22
#> 260     260      anova full           OLIG2  43.645421 5.611287e-22
#> 261     261      anova full           DOCK5  43.628878 5.670389e-22
#> 262     262      anova full            NPC1  43.507470 6.124206e-22
#> 263     263      anova full            WNK1  43.453929 6.336047e-22
#> 264     264      anova full          TSPYL1  43.421546 6.467811e-22
#> 265     265      anova full         SLC31A2  43.396973 6.569679e-22
#> 266     266      anova full            ETV1  43.395537 6.575684e-22
#> 267     267      anova full           RAMP1  43.251706 7.206513e-22
#> 268     268      anova full           GREM1  43.223634 7.336722e-22
#> 269     269      anova full           STX1B  43.191902 7.486818e-22
#> 270     270      anova full         CCDC136  43.134556 7.766131e-22
#> 271     271      anova full          TUBA1A  43.120748 7.834971e-22
#> 272     272      anova full           FOLH1  43.112905 7.874351e-22
#> 273     273      anova full           NDRG4  43.083732 8.022627e-22
#> 274     274      anova full         SELENOH  43.063232 8.128538e-22
#> 275     275      anova full            KTN1  43.037213 8.265033e-22
#> 276     276      anova full           CABP1  42.999910 8.464844e-22
#> 277     277      anova full           PREX1  42.958573 8.692071e-22
#> 278     278      anova full           RPS12  42.945062 8.767693e-22
#> 279     279      anova full            PAK6  42.826166 9.463036e-22
#> 280     280      anova full         ATP5F1B  42.771504 9.801501e-22
#> 281     281      anova full            NFIB  42.723910 1.010632e-21
#> 282     282      anova full          FAM13C  42.698612 1.027230e-21
#> 283     283      anova full            RHOA  42.617825 1.082134e-21
#> 284     284      anova full         PLEKHB1  42.587622 1.103428e-21
#> 285     285      anova full            SNCA  42.575521 1.112079e-21
#> 286     286      anova full            PIN1  42.559773 1.123443e-21
#> 287     287      anova full          LPCAT4  42.519553 1.153010e-21
#> 288     288      anova full          SREBF1  42.457996 1.199821e-21
#> 289     289      anova full            GNG2  42.388231 1.255242e-21
#> 290     290      anova full          TAGLN3  42.159594 1.456033e-21
#> 291     291      anova full            LHPP  42.154007 1.461333e-21
#> 292     292      anova full           MEIS2  42.036591 1.577435e-21
#> 293     293      anova full          SEMA3B  42.023356 1.591103e-21
#> 294     294      anova full            APOD  41.985742 1.630618e-21
#> 295     295      anova full         SLC25A4  41.970032 1.647418e-21
#> 296     296      anova full           CALM3  41.952418 1.666468e-21
#> 297     297      anova full        CDC42EP1  41.908271 1.715213e-21
#> 298     298      anova full          TCEAL6  41.781106 1.863980e-21
#> 299     299      anova full            NPC2  41.773774 1.872952e-21
#> 300     300      anova full           RAB3C  41.741601 1.912847e-21
#> 301     301      anova full         TMEM123  41.732451 1.924353e-21
#> 302     302      anova full          DBNDD1  41.669632 2.005286e-21
#> 303     303      anova full           GAP43  41.564156 2.149135e-21
#> 304     304      anova full           CDH22  41.562897 2.150914e-21
#> 305     305      anova full           HMGN2  41.555788 2.160992e-21
#> 306     306      anova full            RGS4  41.553224 2.164638e-21
#> 307     307      anova full           BASP1  41.541531 2.181347e-21
#> 308     308      anova full          ELAVL4  41.491182 2.254828e-21
#> 309     309      anova full           TMOD1  41.366208 2.448419e-21
#> 310     310      anova full        ATP6V1E1  41.321576 2.521628e-21
#> 311     311      anova full          CXCL14  41.311250 2.538883e-21
#> 312     312      anova full            UGT8  41.311116 2.539109e-21
#> 313     313      anova full           THBS2  41.239735 2.661773e-21
#> 314     314      anova full            WSB2  41.222181 2.692860e-21
#> 315     315      anova full         PRKAR1B  41.209578 2.715410e-21
#> 316     316      anova full             SNN  41.206516 2.720919e-21
#> 317     317      anova full           KITLG  41.157786 2.810135e-21
#> 318     318      anova full         SLC30A3  41.099416 2.920973e-21
#> 319     319      anova full           SOX10  40.976109 3.170137e-21
#> 320     320      anova full             NSF  40.971202 3.180492e-21
#> 321     321      anova full          HS6ST1  40.914026 3.303755e-21
#> 322     322      anova full          STXBP1  40.867341 3.408037e-21
#> 323     323      anova full             NGB  40.748656 3.688656e-21
#> 324     324      anova full          ATP1A1  40.681008 3.859126e-21
#> 325     325      anova full           KCNA2  40.666519 3.896679e-21
#> 326     326      anova full          CDKN1C  40.630755 3.990989e-21
#> 327     327      anova full           CDK14  40.623690 4.009895e-21
#> 328     328      anova full          TRIM37  40.564978 4.170615e-21
#> 329     329      anova full         ATP13A2  40.551370 4.208801e-21
#> 330     330      anova full         ARL6IP1  40.523479 4.288199e-21
#> 331     331      anova full           SPARC  40.372834 4.744452e-21
#> 332     332      anova full         RUNDC3A  40.340702 4.848064e-21
#> 333     333      anova full            RTN1  40.336052 4.863250e-21
#> 334     334      anova full         CYP46A1  40.329942 4.883277e-21
#> 335     335      anova full          PRKCSH  40.311292 4.944936e-21
#> 336     336      anova full           ACOT7  40.296731 4.993632e-21
#> 337     337      anova full           SCRT1  40.285491 5.031559e-21
#> 338     338      anova full            MT1F  40.256112 5.132093e-21
#> 339     339      anova full          ABLIM2  40.197305 5.339583e-21
#> 340     340      anova full            HPCA  40.151367 5.507655e-21
#> 341     341      anova full          CLEC2L  40.138698 5.554958e-21
#> 342     342      anova full         PIP5K1B  40.118030 5.633020e-21
#> 343     343      anova full          KCNAB1  40.068685 5.823994e-21
#> 344     344      anova full         CYP27A1  40.013979 6.043511e-21
#> 345     345      anova full            TJP1  40.008914 6.064261e-21
#> 346     346      anova full            ASPA  39.919320 6.443653e-21
#> 347     347      anova full       LINC00320  39.918813 6.445871e-21
#> 348     348      anova full        MARCKSL1  39.912195 6.474855e-21
#> 349     349      anova full            GPX3  39.890795 6.569500e-21
#> 350     350      anova full           FGF12  39.813226 6.924648e-21
#> 351     351      anova full            WIF1  39.768963 7.136091e-21
#> 352     352      anova full          TUBA4A  39.763242 7.163898e-21
#> 353     353      anova full         ALDH7A1  39.652267 7.725948e-21
#> 354     354      anova full           H3F3B  39.493688 8.608849e-21
#> 355     355      anova full            RHEB  39.370258 9.367429e-21
#> 356     356      anova full           UHMK1  39.365361 9.398903e-21
#> 357     357      anova full             VGF  39.319310 9.700279e-21
#> 358     358      anova full      AL359091.1  39.306286 9.787299e-21
#> 359     359      anova full           PTPRT  39.265758 1.006326e-20
#> 360     360      anova full            FGF9  39.256088 1.013028e-20
#> 361     361      anova full           CALM2  39.247203 1.019226e-20
#> 362     362      anova full          DDRGK1  38.960779 1.241404e-20
#> 363     363      anova full           PDE1A  38.936051 1.262784e-20
#> 364     364      anova full          MICAL2  38.913678 1.282454e-20
#> 365     365      anova full           ERBIN  38.890453 1.303206e-20
#> 366     366      anova full          EEF1A1  38.788089 1.398868e-20
#> 367     367      anova full         SLC44A1  38.776970 1.409685e-20
#> 368     368      anova full             CCK  38.700077 1.486880e-20
#> 369     369      anova full          TMBIM6  38.663638 1.524966e-20
#> 370     370      anova full         TSC22D4  38.647196 1.542478e-20
#> 371     371      anova full           CALD1  38.470163 1.744667e-20
#> 372     372      anova full           GNG13  38.424813 1.800717e-20
#> 373     373      anova full           AMER2  38.268900 2.007942e-20
#> 374     374      anova full          SYNGR1  38.248107 2.037374e-20
#> 375     375      anova full          MOSPD2  38.227440 2.067068e-20
#> 376     376      anova full             PSD  38.214913 2.085283e-20
#> 377     377      anova full          PLPPR1  38.211066 2.090908e-20
#> 378     378      anova full          CITED2  38.145538 2.189185e-20
#> 379     379      anova full            GAD2  38.136077 2.203762e-20
#> 380     380      anova full          EEF1A2  38.090301 2.275711e-20
#> 381     381      anova full           EEF1D  38.063301 2.319275e-20
#> 382     382      anova full           NPTXR  38.037653 2.361454e-20
#> 383     383      anova full         SLC12A2  38.000021 2.424771e-20
#> 384     384      anova full            CFL2  37.965561 2.484283e-20
#> 385     385      anova full           GABRD  37.950714 2.510384e-20
#> 386     386      anova full           PRKCA  37.943967 2.522338e-20
#> 387     387      anova full             FTL  37.895940 2.609140e-20
#> 388     388      anova full          RPL13A  37.883824 2.631519e-20
#> 389     389      anova full          GPRC5B  37.873582 2.650590e-20
#> 390     390      anova full        SLC22A17  37.865861 2.665060e-20
#> 391     391      anova full            SCG5  37.797912 2.795967e-20
#> 392     392      anova full         PLA2G16  37.780813 2.829940e-20
#> 393     393      anova full            DDR1  37.734665 2.923758e-20
#> 394     394      anova full            NCS1  37.729896 2.933634e-20
#> 395     395      anova full            ZEB2  37.671480 3.057423e-20
#> 396     396      anova full            DGKB  37.655495 3.092225e-20
#> 397     397      anova full           YWHAH  37.641407 3.123233e-20
#> 398     398      anova full           VAMP3  37.594351 3.229142e-20
#> 399     399      anova full         SULT4A1  37.592982 3.232278e-20
#> 400     400      anova full           SFXN5  37.505276 3.439848e-20
#> 401     401      anova full          CACNB2  37.488793 3.480363e-20
#> 402     402      anova full            PENK  37.430132 3.628570e-20
#> 403     403      anova full           PEA15  37.373841 3.776894e-20
#> 404     404      anova full           CNIH3  37.364888 3.801053e-20
#> 405     405      anova full           MYO1D  37.341268 3.865555e-20
#> 406     406      anova full          CTNNA2  37.319630 3.925630e-20
#> 407     407      anova full           SNX10  37.235244 4.169243e-20
#> 408     408      anova full            ADD3  37.215846 4.227407e-20
#> 409     409      anova full           SEPT2  37.188141 4.311929e-20
#> 410     410      anova full          NKAIN2  37.187301 4.314519e-20
#> 411     411      anova full           WIPF1  37.042309 4.786359e-20
#> 412     412      anova full          MAN1A1  36.998683 4.938469e-20
#> 413     413      anova full          PLXDC2  36.993376 4.957309e-20
#> 414     414      anova full           FXYD7  36.983896 4.991150e-20
#> 415     415      anova full           SSTR2  36.973773 5.027543e-20
#> 416     416      anova full         PHYHIPL  36.944582 5.134034e-20
#> 417     417      anova full             PGP  36.893516 5.325929e-20
#> 418     418      anova full            KLC2  36.882727 5.367406e-20
#> 419     419      anova full            CHGA  36.787025 5.750182e-20
#> 420     420      anova full           LZTS2  36.702795 6.110265e-20
#> 421     421      anova full          COL9A2  36.630344 6.438512e-20
#> 422     422      anova full       LINC01007  36.624250 6.466937e-20
#> 423     423      anova full           OGDHL  36.611344 6.527558e-20
#> 424     424      anova full         ADCYAP1  36.583624 6.659742e-20
#> 425     425      anova full            UGP2  36.506101 7.044227e-20
#> 426     426      anova full         MID1IP1  36.413994 7.530862e-20
#> 427     427      anova full      AC018647.1  36.338223 7.957029e-20
#> 428     428      anova full          IFITM3  36.320909 8.057844e-20
#> 429     429      anova full            NAPB  36.291053 8.234782e-20
#> 430     430      anova full            SUN2  36.274003 8.337611e-20
#> 431     431      anova full           LRIG1  36.267682 8.376070e-20
#> 432     432      anova full          GALNT8  36.225650 8.636474e-20
#> 433     433      anova full          DNAH17  36.224276 8.645129e-20
#> 434     434      anova full           ITPR1  36.174319 8.965818e-20
#> 435     435      anova full            KLC1  36.173079 8.973932e-20
#> 436     436      anova full           FAM3C  36.138282 9.204717e-20
#> 437     437      anova full            GAB1  36.105222 9.429642e-20
#> 438     438      anova full           SHTN1  36.080363 9.602485e-20
#> 439     439      anova full       GABARAPL1  36.058122 9.759883e-20
#> 440     440      anova full            PFKM  35.997465 1.020277e-19
#> 441     441      anova full           TXNIP  35.979900 1.033484e-19
#> 442     442      anova full       C14orf132  35.975392 1.036902e-19
#> 443     443      anova full          MLLT11  35.964973 1.044846e-19
#> 444     444      anova full            TPI1  35.947244 1.058507e-19
#> 445     445      anova full           MTCH1  35.930864 1.071292e-19
#> 446     446      anova full             RDX  35.902011 1.094200e-19
#> 447     447      anova full          MAP4K4  35.869678 1.120470e-19
#> 448     448      anova full          ARPP19  35.863202 1.125809e-19
#> 449     449      anova full          ATP8A1  35.755623 1.218429e-19
#> 450     450      anova full       LINC00052  35.719351 1.251393e-19
#> 451     451      anova full            CBR1  35.662018 1.305380e-19
#> 452     452      anova full           KCNC2  35.648714 1.318247e-19
#> 453     453      anova full          SH3GL2  35.642815 1.323994e-19
#> 454     454      anova full         ADIPOR2  35.630008 1.336558e-19
#> 455     455      anova full           APLNR  35.608102 1.358335e-19
#> 456     456      anova full           FGFR2  35.590986 1.375603e-19
#> 457     457      anova full           AHNAK  35.537657 1.430869e-19
#> 458     458      anova full           NRXN1  35.533896 1.434851e-19
#> 459     459      anova full          SFT2D2  35.527909 1.441215e-19
#> 460     460      anova full         PLEKHH1  35.367835 1.622556e-19
#> 461     461      anova full            NEK7  35.350044 1.644109e-19
#> 462     462      anova full           GPM6B  35.318176 1.683455e-19
#> 463     463      anova full             CLU  35.296665 1.710560e-19
#> 464     464      anova full           ITPKB  35.280191 1.731622e-19
#> 465     465      anova full            GLTP  35.229922 1.797550e-19
#> 466     466      anova full          CTNNA1  35.204793 1.831469e-19
#> 467     467      anova full            JPT2  35.174488 1.873252e-19
#> 468     468      anova full           ITGB8  35.071353 2.022935e-19
#> 469     469      anova full            TMC6  35.065273 2.032134e-19
#> 470     470      anova full           PTGDS  35.056458 2.045549e-19
#> 471     471      anova full           COPRS  35.053015 2.050812e-19
#> 472     472      anova full           PCSK6  35.049902 2.055584e-19
#> 473     473      anova full            PFN2  35.027227 2.090682e-19
#> 474     474      anova full        TMEM151B  35.015362 2.109294e-19
#> 475     475      anova full           KCNC1  35.002188 2.130157e-19
#> 476     476      anova full             AGT  34.987007 2.154463e-19
#> 477     477      anova full          CCDC68  34.923915 2.258571e-19
#> 478     478      anova full             PXK  34.920557 2.264255e-19
#> 479     479      anova full           C1QL2  34.918715 2.267379e-19
#> 480     480      anova full            RGS7  34.918429 2.267865e-19
#> 481     481      anova full         GUCY1B1  34.895026 2.307953e-19
#> 482     482      anova full         CCDC184  34.866318 2.358126e-19
#> 483     483      anova full        TMEM176B  34.863190 2.363660e-19
#> 484     484      anova full      AL162231.1  34.859298 2.370564e-19
#> 485     485      anova full            NREP  34.831446 2.420583e-19
#> 486     486      anova full          ICOSLG  34.819349 2.442644e-19
#> 487     487      anova full           ITGB4  34.811957 2.456226e-19
#> 488     488      anova full           MYO5A  34.785135 2.506165e-19
#> 489     489      anova full          MRPL33  34.773290 2.528550e-19
#> 490     490      anova full         FAM107A  34.763425 2.547350e-19
#> 491     491      anova full         ATP5MC3  34.726961 2.618097e-19
#> 492     492      anova full           CEND1  34.706143 2.659391e-19
#> 493     493      anova full            MCAM  34.687041 2.697868e-19
#> 494     494      anova full            OLA1  34.677367 2.717572e-19
#> 495     495      anova full          CDK5R1  34.661634 2.749935e-19
#> 496     496      anova full         SLC29A4  34.631634 2.812746e-19
#> 497     497      anova full           STAC2  34.570815 2.944649e-19
#> 498     498      anova full          RNF130  34.555648 2.978525e-19
#> 499     499      anova full           PINK1  34.550554 2.989990e-19
#> 500     500      anova full           SYNJ2  34.546358 2.999469e-19
#> 501     501      anova full          SYNGR2  34.509361 3.084399e-19
#> 502     502      anova full            LDHB  34.481309 3.150437e-19
#> 503     503      anova full          SCARB2  34.465564 3.188140e-19
#> 504     504      anova full             JUN  34.460785 3.199675e-19
#> 505     505      anova full            NRGN  34.449489 3.227109e-19
#> 506     506      anova full        C1orf198  34.445561 3.236706e-19
#> 507     507      anova full           BNIP3  34.439298 3.252068e-19
#> 508     508      anova full           GRINA  34.371720 3.422676e-19
#> 509     509      anova full       LINC00507  34.371598 3.422994e-19
#> 510     510      anova full         PLEKHG3  34.367415 3.433853e-19
#> 511     511      anova full          MEGF10  34.321182 3.556259e-19
#> 512     512      anova full          ELOVL5  34.272535 3.689906e-19
#> 513     513      anova full         ATP5IF1  34.235383 3.795443e-19
#> 514     514      anova full           RPS16  34.233609 3.800559e-19
#> 515     515      anova full            GATM  34.191390 3.924435e-19
#> 516     516      anova full             MKX  34.182437 3.951235e-19
#> 517     517      anova full           NPTX1  34.155912 4.031740e-19
#> 518     518      anova full          MVB12B  34.147866 4.056492e-19
#> 519     519      anova full          GABBR2  34.139617 4.082031e-19
#> 520     520      anova full           KCNH1  34.139442 4.082573e-19
#> 521     521      anova full           NINJ2  34.112111 4.168388e-19
#> 522     522      anova full         TAX1BP3  34.000388 4.538915e-19
#> 523     523      anova full          CDKN2D  33.952361 4.708445e-19
#> 524     524      anova full             B2M  33.909080 4.866795e-19
#> 525     525      anova full          ZNF664  33.908622 4.868502e-19
#> 526     526      anova full          OTUD7B  33.905320 4.880808e-19
#> 527     527      anova full            GNAL  33.894300 4.922115e-19
#> 528     528      anova full          TOLLIP  33.889848 4.938905e-19
#> 529     529      anova full          B3GAT2  33.885443 4.955578e-19
#> 530     530      anova full         DPY19L1  33.854408 5.074680e-19
#> 531     531      anova full           EMID1  33.827078 5.181996e-19
#> 532     532      anova full           YWHAG  33.792937 5.319348e-19
#> 533     533      anova full           VPS35  33.768485 5.420011e-19
#> 534     534      anova full           SIRT2  33.748294 5.504612e-19
#> 535     535      anova full          ZDHHC9  33.689419 5.759126e-19
#> 536     536      anova full           AKAP5  33.689267 5.759800e-19
#> 537     537      anova full           ABHD8  33.678729 5.806623e-19
#> 538     538      anova full            YBX1  33.657510 5.902091e-19
#> 539     539      anova full           FBXO7  33.625991 6.046891e-19
#> 540     540      anova full           PRDM8  33.617717 6.085505e-19
#> 541     541      anova full           MAP1B  33.558816 6.367810e-19
#> 542     542      anova full          LINGO1  33.531445 6.503546e-19
#> 543     543      anova full            FTH1  33.502479 6.650428e-19
#> 544     544      anova full        TMEM178B  33.500720 6.659460e-19
#> 545     545      anova full           ARNT2  33.437785 6.990928e-19
#> 546     546      anova full             PKM  33.424064 7.065422e-19
#> 547     547      anova full         SLCO1A2  33.413097 7.125548e-19
#> 548     548      anova full           NRSN1  33.385269 7.280484e-19
#> 549     549      anova full          DLGAP1  33.370942 7.361600e-19
#> 550     550      anova full          FRRS1L  33.339313 7.543975e-19
#> 551     551      anova full           ATG4C  33.306192 7.739939e-19
#> 552     552      anova full           NDST3  33.291839 7.826478e-19
#> 553     553      anova full         TSPAN15  33.192384 8.454099e-19
#> 554     554      anova full         ZDHHC20  33.154754 8.704861e-19
#> 555     555      anova full           VDAC1  33.094757 9.120583e-19
#> 556     556      anova full           HPRT1  33.093663 9.128355e-19
#> 557     557      anova full          VSTM2L  33.086619 9.178526e-19
#> 558     558      anova full           MAT2B  33.059222 9.376384e-19
#> 559     559      anova full            DIO2  33.004464 9.785074e-19
#> 560     560      anova full           MAGT1  32.974801 1.001408e-18
#> 561     561      anova full          GOLGA7  32.954798 1.017160e-18
#> 562     562      anova full         SLC48A1  32.916610 1.047945e-18
#> 563     563      anova full          PCDH19  32.865390 1.090745e-18
#> 564     564      anova full          DIRAS1  32.861845 1.093773e-18
#> 565     565      anova full           OLIG1  32.852992 1.101373e-18
#> 566     566      anova full            HIP1  32.848814 1.104977e-18
#> 567     567      anova full        CDC42EP4  32.839558 1.113008e-18
#> 568     568      anova full            GOT1  32.824826 1.125913e-18
#> 569     569      anova full           AP2M1  32.776116 1.169689e-18
#> 570     570      anova full          CAMKK2  32.700794 1.240855e-18
#> 571     571      anova full           DACT1  32.682565 1.258737e-18
#> 572     572      anova full            DNM2  32.680218 1.261058e-18
#> 573     573      anova full             TOX  32.678639 1.262623e-18
#> 574     574      anova full           EPDR1  32.648278 1.293093e-18
#> 575     575      anova full           PSAT1  32.576661 1.367999e-18
#> 576     576      anova full           RNF13  32.573991 1.370876e-18
#> 577     577      anova full           CPNE5  32.549954 1.397062e-18
#> 578     578      anova full           YWHAB  32.522227 1.427906e-18
#> 579     579      anova full           RTL8C  32.519763 1.430681e-18
#> 580     580      anova full         C1QTNF4  32.501589 1.451318e-18
#> 581     581      anova full            NCAN  32.479403 1.476927e-18
#> 582     582      anova full          ELAVL2  32.467698 1.490625e-18
#> 583     583      anova full          GABRA5  32.445933 1.516442e-18
#> 584     584      anova full          TMED10  32.433071 1.531916e-18
#> 585     585      anova full           SYPL1  32.421644 1.545797e-18
#> 586     586      anova full            MPC2  32.377199 1.601035e-18
#> 587     587      anova full           APBA2  32.372936 1.606439e-18
#> 588     588      anova full           OXCT1  32.370278 1.609818e-18
#> 589     589      anova full           LIMK1  32.369615 1.610661e-18
#> 590     590      anova full          FAXDC2  32.320949 1.673864e-18
#> 591     591      anova full            NPTN  32.309760 1.688753e-18
#> 592     592      anova full           FBXO9  32.308676 1.690203e-18
#> 593     593      anova full           CPLX2  32.255328 1.763148e-18
#> 594     594      anova full          CAMK2A  32.236343 1.789880e-18
#> 595     595      anova full            DNM1  32.215879 1.819163e-18
#> 596     596      anova full            MCM7  32.206511 1.832732e-18
#> 597     597      anova full           CALM1  32.168045 1.889546e-18
#> 598     598      anova full            PKP4  32.125841 1.953969e-18
#> 599     599      anova full            CD82  32.072916 2.037959e-18
#> 600     600      anova full            GNB5  32.061223 2.057011e-18
#> 601     601      anova full        KIAA0930  32.045799 2.082422e-18
#> 602     602      anova full          SPOCK1  32.043690 2.085921e-18
#> 603     603      anova full          NDUFA5  32.031882 2.105627e-18
#> 604     604      anova full           ABCA2  32.019353 2.126745e-18
#> 605     605      anova full         ATP6V1H  32.011228 2.140556e-18
#> 606     606      anova full          ATP1B2  31.986290 2.183525e-18
#> 607     607      anova full        SH3BGRL2  31.917114 2.307420e-18
#> 608     608      anova full           CREB5  31.916165 2.309169e-18
#> 609     609      anova full            SNX6  31.910324 2.319965e-18
#> 610     610      anova full          LGALS1  31.885923 2.365625e-18
#> 611     611      anova full          EIF4A2  31.832763 2.468328e-18
#> 612     612      anova full            CHN1  31.828623 2.476517e-18
#> 613     613      anova full         PTTG1IP  31.825183 2.483342e-18
#> 614     614      anova full         SLC24A4  31.823427 2.486833e-18
#> 615     615      anova full          HDAC11  31.812210 2.509254e-18
#> 616     616      anova full          MAPK10  31.806960 2.519820e-18
#> 617     617      anova full           STX1A  31.796687 2.540627e-18
#> 618     618      anova full           UNC5B  31.710176 2.723000e-18
#> 619     619      anova full          ZNF365  31.687773 2.772388e-18
#> 620     620      anova full           PI4KA  31.667905 2.816955e-18
#> 621     621      anova full         DYNC1I1  31.666197 2.820820e-18
#> 622     622      anova full           FEZF2  31.656742 2.842317e-18
#> 623     623      anova full         HEPACAM  31.652548 2.851907e-18
#> 624     624      anova full          CTDSP1  31.627747 2.909298e-18
#> 625     625      anova full            JPH4  31.567344 3.054096e-18
#> 626     626      anova full           KIF3C  31.564885 3.060144e-18
#> 627     627      anova full          DYNLT3  31.535257 3.134006e-18
#> 628     628      anova full            ARL6  31.529528 3.148498e-18
#> 629     629      anova full           TMTC4  31.513574 3.189220e-18
#> 630     630      anova full            SCG2  31.466434 3.312735e-18
#> 631     631      anova full           PCDH7  31.453299 3.348018e-18
#> 632     632      anova full            SCD5  31.447168 3.364620e-18
#> 633     633      anova full           FNBP1  31.436066 3.394898e-18
#> 634     634      anova full           ANXA5  31.420980 3.436490e-18
#> 635     635      anova full          SEZ6L2  31.368835 3.584333e-18
#> 636     636      anova full         DYNC1I2  31.354602 3.625810e-18
#> 637     637      anova full            BEX3  31.336784 3.678435e-18
#> 638     638      anova full           KCNQ5  31.298552 3.794011e-18
#> 639     639      anova full          CAMTA2  31.283399 3.840846e-18
#> 640     640      anova full           CBLN2  31.255375 3.929033e-18
#> 641     641      anova full           RAB6B  31.253339 3.935523e-18
#> 642     642      anova full           OLFM3  31.252640 3.937753e-18
#> 643     643      anova full           KLHL5  31.244976 3.962285e-18
#> 644     644      anova full          ATP1A3  31.232738 4.001788e-18
#> 645     645      anova full          KIFAP3  31.213238 4.065572e-18
#> 646     646      anova full         ATP5F1A  31.199164 4.112253e-18
#> 647     647      anova full             PTN  31.156438 4.257379e-18
#> 648     648      anova full         FAM222A  31.145846 4.294163e-18
#> 649     649      anova full           GLRX2  31.133201 4.338503e-18
#> 650     650      anova full          AGPAT4  31.128090 4.356559e-18
#> 651     651      anova full           ICAM5  31.118193 4.391746e-18
#> 652     652      anova full            APOE  31.085011 4.511853e-18
#> 653     653      anova full          FRMD4B  31.057966 4.612240e-18
#> 654     654      anova full            GAD1  31.053281 4.629864e-18
#> 655     655      anova full            MAP7  31.036956 4.691812e-18
#> 656     656      anova full           GHITM  31.035141 4.698751e-18
#> 657     657      anova full           PHGDH  31.017682 4.766049e-18
#> 658     658      anova full             CA2  31.001933 4.827604e-18
#> 659     659      anova full            DGKG  30.987206 4.885900e-18
#> 660     660      anova full            FNTA  30.963927 4.979535e-18
#> 661     661      anova full            RAC1  30.949611 5.038035e-18
#> 662     662      anova full           ANXA6  30.928080 5.127343e-18
#> 663     663      anova full        SLC39A10  30.895668 5.264869e-18
#> 664     664      anova full            ST18  30.873545 5.360912e-18
#> 665     665      anova full            RNH1  30.853410 5.449885e-18
#> 666     666      anova full           H3F3A  30.844939 5.487771e-18
#> 667     667      anova full           NDEL1  30.811476 5.640095e-18
#> 668     668      anova full       LINC01827  30.781230 5.781518e-18
#> 669     669      anova full          SNAP91  30.780881 5.783170e-18
#> 670     670      anova full            TMX4  30.779375 5.790306e-18
#> 671     671      anova full           PGAM1  30.755547 5.904459e-18
#> 672     672      anova full            MDM4  30.750773 5.927607e-18
#> 673     673      anova full         TMEM74B  30.707232 6.143074e-18
#> 674     674      anova full            FSD1  30.690788 6.226533e-18
#> 675     675      anova full           VAMP2  30.672902 6.318626e-18
#> 676     676      anova full          PPP3CA  30.625020 6.572132e-18
#> 677     677      anova full            TKFC  30.595383 6.734261e-18
#> 678     678      anova full          DLGAP3  30.588150 6.774446e-18
#> 679     679      anova full           SYNPR  30.542275 7.035139e-18
#> 680     680      anova full            AATK  30.519355 7.169225e-18
#> 681     681      anova full           RPL19  30.499702 7.286293e-18
#> 682     682      anova full           SYT13  30.471998 7.454659e-18
#> 683     683      anova full           HTR2A  30.467497 7.482386e-18
#> 684     684      anova full           MYO9B  30.461606 7.518841e-18
#> 685     685      anova full           KIF1C  30.448502 7.600586e-18
#> 686     686      anova full           RPL30  30.382914 8.023670e-18
#> 687     687      anova full           CALB1  30.376784 8.064432e-18
#> 688     688      anova full           SNX22  30.356770 8.198995e-18
#> 689     689      anova full           HSPA8  30.356646 8.199834e-18
#> 690     690      anova full            TPBG  30.280366 8.734289e-18
#> 691     691      anova full         CAMK2N2  30.278534 8.747555e-18
#> 692     692      anova full           LRRN3  30.248478 8.968199e-18
#> 693     693      anova full             BSN  30.226767 9.131134e-18
#> 694     694      anova full           PTPN5  30.224957 9.144858e-18
#> 695     695      anova full             CRH  30.194739 9.377071e-18
#> 696     696      anova full          ATP1A2  30.176661 9.518886e-18
#> 697     697      anova full            SYN1  30.171048 9.563365e-18
#> 698     698      anova full          ARPP21  30.156918 9.676280e-18
#> 699     699      anova full          ADARB2  30.072105 1.038345e-17
#> 700     700      anova full            PID1  30.065003 1.044503e-17
#> 701     701      anova full            CYCS  30.022179 1.082437e-17
#> 702     702      anova full          NAP1L2  30.019656 1.084715e-17
#> 703     703      anova full           RELL2  30.009983 1.093497e-17
#> 704     704      anova full           PCMT1  30.009082 1.094319e-17
#> 705     705      anova full          RNF213  29.986319 1.115290e-17
#> 706     706      anova full          ZBTB18  29.969108 1.131421e-17
#> 707     707      anova full           KCTD4  29.953185 1.146557e-17
#> 708     708      anova full            PLD1  29.813320 1.288797e-17
#> 709     709      anova full             DDN  29.811681 1.290567e-17
#> 710     710      anova full             VIP  29.763888 1.343303e-17
#> 711     711      anova full         IRF2BP2  29.704063 1.412451e-17
#> 712     712      anova full            LDB2  29.681681 1.439253e-17
#> 713     713      anova full          STAMBP  29.653709 1.473485e-17
#> 714     714      anova full            LNX1  29.639551 1.491129e-17
#> 715     715      anova full          ADRA1D  29.638599 1.492322e-17
#> 716     716      anova full      AC011603.3  29.620568 1.515127e-17
#> 717     717      anova full          PLXNB1  29.608522 1.530562e-17
#> 718     718      anova full         NTM-AS1  29.601404 1.539757e-17
#> 719     719      anova full        C15orf61  29.600316 1.541168e-17
#> 720     720      anova full           ITFG1  29.594233 1.549078e-17
#> 721     721      anova full          ZNF536  29.567700 1.584077e-17
#> 722     722      anova full           VAT1L  29.559361 1.595244e-17
#> 723     723      anova full            GNAS  29.543983 1.616050e-17
#> 724     724      anova full          LYSMD2  29.536016 1.626937e-17
#> 725     725      anova full           MTURN  29.501714 1.674685e-17
#> 726     726      anova full          PICALM  29.456051 1.740491e-17
#> 727     727      anova full          DNAJC6  29.392299 1.836837e-17
#> 728     728      anova full        SLC25A12  29.366063 1.878064e-17
#> 729     729      anova full          CTNNA3  29.357392 1.891898e-17
#> 730     730      anova full           FBLL1  29.354156 1.897089e-17
#> 731     731      anova full         SMARCA2  29.327780 1.939935e-17
#> 732     732      anova full         SLC6A17  29.307643 1.973316e-17
#> 733     733      anova full         SLC13A4  29.241577 2.087040e-17
#> 734     734      anova full           SATB2  29.239628 2.090495e-17
#> 735     735      anova full           RTN4R  29.210557 2.142739e-17
#> 736     736      anova full           PLCB1  29.175294 2.207918e-17
#> 737     737      anova full           PIANP  29.171351 2.215331e-17
#> 738     738      anova full        LGALS3BP  29.150175 2.255585e-17
#> 739     739      anova full        SLC39A11  29.115186 2.323752e-17
#> 740     740      anova full          CERCAM  29.025623 2.508060e-17
#> 741     741      anova full          GRIN2A  29.001638 2.559920e-17
#> 742     742      anova full           CPNE6  28.969892 2.630266e-17
#> 743     743      anova full             CIT  28.938300 2.702241e-17
#> 744     744      anova full           PTK2B  28.936386 2.706666e-17
#> 745     745      anova full          MAP2K1  28.912594 2.762300e-17
#> 746     746      anova full           SORT1  28.892524 2.810144e-17
#> 747     747      anova full           LAMP1  28.883706 2.831432e-17
#> 748     748      anova full          PPFIA2  28.874116 2.854775e-17
#> 749     749      anova full          RPS15A  28.859019 2.891920e-17
#> 750     750      anova full          ATP1B1  28.840679 2.937714e-17
#> 751     751      anova full            SCG3  28.834502 2.953306e-17
#> 752     752      anova full           RAP1A  28.811274 3.012699e-17
#> 753     753      anova full         STXBP5L  28.792893 3.060567e-17
#> 754     754      anova full          CHRDL1  28.773042 3.113145e-17
#> 755     755      anova full          NECAB1  28.755133 3.161374e-17
#> 756     756      anova full           FXYD6  28.753108 3.166877e-17
#> 757     757      anova full           TMOD2  28.742605 3.195568e-17
#> 758     758      anova full          STXBP6  28.734506 3.217877e-17
#> 759     759      anova full           PSRC1  28.707259 3.294106e-17
#> 760     760      anova full          RBFOX3  28.689400 3.345075e-17
#> 761     761      anova full            PDP1  28.686076 3.354653e-17
#> 762     762      anova full           CTXN1  28.641867 3.484721e-17
#> 763     763      anova full          CAPZA2  28.631074 3.517259e-17
#> 764     764      anova full         SLC25A3  28.625022 3.535637e-17
#> 765     765      anova full          NFE2L2  28.621481 3.546437e-17
#> 766     766      anova full         ZNF385B  28.619624 3.552115e-17
#> 767     767      anova full          TCEAL2  28.567821 3.714310e-17
#> 768     768      anova full           USP11  28.553341 3.760993e-17
#> 769     769      anova full            RPS9  28.532607 3.828893e-17
#> 770     770      anova full            DOK6  28.532222 3.830165e-17
#> 771     771      anova full          KCNIP2  28.498802 3.942310e-17
#> 772     772      anova full           TNNT2  28.494680 3.956375e-17
#> 773     773      anova full           KIF5B  28.463450 4.064616e-17
#> 774     774      anova full          SH3BP4  28.458216 4.083052e-17
#> 775     775      anova full          PIK3R1  28.457664 4.085004e-17
#> 776     776      anova full         CARHSP1  28.444517 4.131715e-17
#> 777     777      anova full           ITGB1  28.415308 4.237473e-17
#> 778     778      anova full            CLTC  28.411114 4.252884e-17
#> 779     779      anova full         TMEM59L  28.378705 4.373941e-17
#> 780     780      anova full          KCNJ10  28.368317 4.413489e-17
#> 781     781      anova full           USP54  28.358792 4.450074e-17
#> 782     782      anova full          GALNT6  28.345238 4.502671e-17
#> 783     783      anova full           CREG2  28.313998 4.626351e-17
#> 784     784      anova full          SEPT10  28.284686 4.745572e-17
#> 785     785      anova full           TMED5  28.273729 4.790943e-17
#> 786     786      anova full           RPS23  28.259852 4.849047e-17
#> 787     787      anova full        SERPINB6  28.259624 4.850009e-17
#> 788     788      anova full          MYCBP2  28.248343 4.897786e-17
#> 789     789      anova full           PRMT7  28.194133 5.134217e-17
#> 790     790      anova full            SPTB  28.164209 5.269717e-17
#> 791     791      anova full          ELMOD1  28.154922 5.312517e-17
#> 792     792      anova full          KLHDC3  28.132194 5.418764e-17
#> 793     793      anova full           SMOC1  28.105975 5.544052e-17
#> 794     794      anova full           DACH1  28.084191 5.650408e-17
#> 795     795      anova full           FNDC4  28.061276 5.764555e-17
#> 796     796      anova full           NCEH1  28.042706 5.858794e-17
#> 797     797      anova full            PGK1  28.026761 5.940971e-17
#> 798     798      anova full           NELL2  27.967149 6.258850e-17
#> 799     799      anova full            CTSH  27.951913 6.342864e-17
#> 800     800      anova full          CKMT1A  27.887758 6.709550e-17
#> 801     801      anova full         TGFBR3L  27.873285 6.795239e-17
#> 802     802      anova full          BAIAP2  27.858747 6.882451e-17
#> 803     803      anova full            LDB3  27.843893 6.972745e-17
#> 804     804      anova full           ZFAS1  27.839469 6.999867e-17
#> 805     805      anova full           PSEN1  27.838021 7.008771e-17
#> 806     806      anova full         TMEM87A  27.796794 7.267176e-17
#> 807     807      anova full          TALDO1  27.779628 7.377643e-17
#> 808     808      anova full           HIP1R  27.766367 7.464157e-17
#> 809     809      anova full          MFSD4A  27.760398 7.503442e-17
#> 810     810      anova full         CNTNAP4  27.745363 7.603328e-17
#> 811     811      anova full           PRDX6  27.720704 7.770126e-17
#> 812     812      anova full           MAP1S  27.714824 7.810451e-17
#> 813     813      anova full          RASL12  27.697119 7.933178e-17
#> 814     814      anova full            CLMN  27.693056 7.961617e-17
#> 815     815      anova full           FREM3  27.678336 8.065542e-17
#> 816     816      anova full          NDFIP1  27.668095 8.138664e-17
#> 817     817      anova full           KNDC1  27.657777 8.213027e-17
#> 818     818      anova full            ATL1  27.639047 8.349805e-17
#> 819     819      anova full         FAM198B  27.594597 8.683863e-17
#> 820     820      anova full        C12orf76  27.587698 8.736926e-17
#> 821     821      anova full           PNMA2  27.585932 8.750562e-17
#> 822     822      anova full            PAK1  27.583864 8.766560e-17
#> 823     823      anova full            ABL1  27.572926 8.851672e-17
#> 824     824      anova full         ZFP36L2  27.559224 8.959493e-17
#> 825     825      anova full            CD99  27.548239 9.046912e-17
#> 826     826      anova full          PNMA8A  27.495311 9.480543e-17
#> 827     827      anova full           PADI2  27.463740 9.749319e-17
#> 828     828      anova full        DYNC1LI2  27.384040 1.046323e-16
#> 829     829      anova full           COX5A  27.370806 1.058687e-16
#> 830     830      anova full           SNORC  27.365325 1.063852e-16
#> 831     831      anova full           VPS41  27.347740 1.080598e-16
#> 832     832      anova full           RPL11  27.336226 1.091709e-16
#> 833     833      anova full        MAPK8IP2  27.304253 1.123184e-16
#> 834     834      anova full           CEBPD  27.276132 1.151636e-16
#> 835     835      anova full           UQCRH  27.251547 1.177119e-16
#> 836     836      anova full          SUCLA2  27.226844 1.203307e-16
#> 837     837      anova full          MAP7D2  27.185553 1.248425e-16
#> 838     838      anova full          ATRNL1  27.157347 1.280242e-16
#> 839     839      anova full             HRK  27.148096 1.290857e-16
#> 840     840      anova full            CAP2  27.147632 1.291392e-16
#> 841     841      anova full          SFT2D1  27.145163 1.294243e-16
#> 842     842      anova full             SYP  27.117356 1.326787e-16
#> 843     843      anova full        ATP6V0D1  27.065549 1.389683e-16
#> 844     844      anova full           TRIM2  27.061078 1.395253e-16
#> 845     845      anova full            GNG5  27.037280 1.425287e-16
#> 846     846      anova full          RBFOX1  27.035671 1.427341e-16
#> 847     847      anova full            ASNS  27.026591 1.438992e-16
#> 848     848      anova full            MYLK  27.024045 1.442276e-16
#> 849     849      anova full            RBP7  27.020031 1.447470e-16
#> 850     850      anova full            PON2  26.972912 1.509896e-16
#> 851     851      anova full          SHANK3  26.968902 1.515335e-16
#> 852     852      anova full           PAQR8  26.968042 1.516504e-16
#> 853     853      anova full           BEND6  26.967969 1.516604e-16
#> 854     854      anova full      AC093330.1  26.947745 1.544366e-16
#> 855     855      anova full           EFNA1  26.928341 1.571494e-16
#> 856     856      anova full            BIN1  26.919483 1.584040e-16
#> 857     857      anova full            TPPP  26.902058 1.609021e-16
#> 858     858      anova full           FABP3  26.854532 1.679237e-16
#> 859     859      anova full          MAPRE3  26.845134 1.693491e-16
#> 860     860      anova full             TST  26.843615 1.695806e-16
#> 861     861      anova full          SEMA3C  26.842510 1.697493e-16
#> 862     862      anova full            MYL9  26.790381 1.779041e-16
#> 863     863      anova full           SFRP2  26.777339 1.800067e-16
#> 864     864      anova full         TMEM14A  26.774158 1.805235e-16
#> 865     865      anova full            MLC1  26.762677 1.824008e-16
#> 866     866      anova full           ARPC5  26.762508 1.824288e-16
#> 867     867      anova full         ATP6V1A  26.742408 1.857647e-16
#> 868     868      anova full           RPL12  26.733912 1.871937e-16
#> 869     869      anova full             MVP  26.729153 1.879989e-16
#> 870     870      anova full         TMEM165  26.717834 1.899286e-16
#> 871     871      anova full            RGS6  26.714026 1.905824e-16
#> 872     872      anova full        SLC9A3R1  26.696676 1.935906e-16
#> 873     873      anova full           RPL10  26.675146 1.973912e-16
#> 874     874      anova full          GPR162  26.642204 2.033558e-16
#> 875     875      anova full           ALDOC  26.637662 2.041925e-16
#> 876     876      anova full             MET  26.621081 2.072774e-16
#> 877     877      anova full         SPATS2L  26.582023 2.147350e-16
#> 878     878      anova full            ADI1  26.576918 2.157298e-16
#> 879     879      anova full             PAM  26.570431 2.170009e-16
#> 880     880      anova full          ANKS1B  26.545514 2.219553e-16
#> 881     881      anova full         ATP6V1D  26.523503 2.264284e-16
#> 882     882      anova full           GFRA1  26.485690 2.343302e-16
#> 883     883      anova full            SOX9  26.476813 2.362259e-16
#> 884     884      anova full            SYN2  26.475180 2.365765e-16
#> 885     885      anova full          HMGCS1  26.454501 2.410609e-16
#> 886     886      anova full        FAM114A1  26.449281 2.422068e-16
#> 887     887      anova full          HMG20B  26.442092 2.437938e-16
#> 888     888      anova full            NAPA  26.437385 2.448388e-16
#> 889     889      anova full          SYNGR3  26.434208 2.455467e-16
#> 890     890      anova full           RPL21  26.428587 2.468044e-16
#> 891     891      anova full          ADAM23  26.426623 2.472452e-16
#> 892     892      anova full           NCALD  26.418806 2.490084e-16
#> 893     893      anova full          UBE2V2  26.408598 2.513304e-16
#> 894     894      anova full         TMEM235  26.388839 2.558883e-16
#> 895     895      anova full          ATP2B1  26.289577 2.801051e-16
#> 896     896      anova full         FAM241B  26.285066 2.812599e-16
#> 897     897      anova full           OLFM2  26.240718 2.928782e-16
#> 898     898      anova full          ZBTB20  26.220821 2.982500e-16
#> 899     899      anova full      AP001999.1  26.220379 2.983703e-16
#> 900     900      anova full            PDK2  26.219404 2.986362e-16
#> 901     901      anova full          GABRB2  26.189304 3.069669e-16
#> 902     902      anova full          ADAM22  26.162876 3.144781e-16
#> 903     903      anova full           NLRP1  26.161946 3.147457e-16
#> 904     904      anova full              F3  26.121840 3.265172e-16
#> 905     905      anova full        HSP90AA1  26.107913 3.307100e-16
#> 906     906      anova full      PRKAG2-AS1  26.069213 3.426535e-16
#> 907     907      anova full         EFCAB14  26.061238 3.451695e-16
#> 908     908      anova full          COL4A5  26.033739 3.539910e-16
#> 909     909      anova full            NPM2  26.030665 3.549913e-16
#> 910     910      anova full          SLC9A6  26.026726 3.562775e-16
#> 911     911      anova full           CADM3  26.017329 3.593652e-16
#> 912     912      anova full            PNOC  25.965019 3.770636e-16
#> 913     913      anova full           CAMK4  25.963342 3.776456e-16
#> 914     914      anova full           EPS15  25.957045 3.798391e-16
#> 915     915      anova full          MAN1C1  25.943100 3.847435e-16
#> 916     916      anova full           APLP1  25.937481 3.867382e-16
#> 917     917      anova full           PRRT1  25.913635 3.953216e-16
#> 918     918      anova full           PRDX2  25.904560 3.986393e-16
#> 919     919      anova full           SSBP3  25.884679 4.060079e-16
#> 920     920      anova full          PPP4R4  25.878811 4.082096e-16
#> 921     921      anova full          HAPLN2  25.860937 4.149915e-16
#> 922     922      anova full          TRIM59  25.860604 4.151189e-16
#> 923     923      anova full            OPTN  25.858785 4.158159e-16
#> 924     924      anova full            CHGB  25.851825 4.184936e-16
#> 925     925      anova full           REEP2  25.851161 4.187497e-16
#> 926     926      anova full            BCAN  25.848101 4.199332e-16
#> 927     927      anova full         RTN4RL2  25.827062 4.281645e-16
#> 928     928      anova full            KRT8  25.824583 4.291448e-16
#> 929     929      anova full           PTPRN  25.807459 4.359829e-16
#> 930     930      anova full        ARHGEF37  25.794558 4.412082e-16
#> 931     931      anova full           BTBD8  25.784765 4.452173e-16
#> 932     932      anova full            NSMF  25.768062 4.521425e-16
#> 933     933      anova full            CHL1  25.766817 4.526631e-16
#> 934     934      anova full         TBC1D12  25.752213 4.588159e-16
#> 935     935      anova full      AL358216.1  25.747464 4.608352e-16
#> 936     936      anova full        HSP90AB1  25.709489 4.773145e-16
#> 937     937      anova full          PFKFB2  25.693856 4.842731e-16
#> 938     938      anova full            MT1E  25.687750 4.870194e-16
#> 939     939      anova full         FAM102B  25.673728 4.933864e-16
#> 940     940      anova full        ATP6V0E1  25.671013 4.946294e-16
#> 941     941      anova full            SCOC  25.666909 4.965137e-16
#> 942     942      anova full          AMOTL2  25.665864 4.969948e-16
#> 943     943      anova full            ARF5  25.658268 5.005057e-16
#> 944     944      anova full         PPP2R1A  25.650981 5.038982e-16
#> 945     945      anova full            STUM  25.642503 5.078746e-16
#> 946     946      anova full            RFFL  25.639805 5.091469e-16
#> 947     947      anova full          GABRA3  25.610569 5.231440e-16
#> 948     948      anova full            SYT4  25.585953 5.352361e-16
#> 949     949      anova full           EXTL2  25.546863 5.550313e-16
#> 950     950      anova full          TSPAN7  25.544508 5.562479e-16
#> 951     951      anova full           RPS15  25.544242 5.563853e-16
#> 952     952      anova full           PDE4A  25.538465 5.593817e-16
#> 953     953      anova full             CAT  25.531245 5.631494e-16
#> 954     954      anova full       LINC02552  25.467761 5.974238e-16
#> 955     955      anova full         S100A16  25.445062 6.101934e-16
#> 956     956      anova full            CMAS  25.444008 6.107926e-16
#> 957     957      anova full           NELL1  25.430804 6.183567e-16
#> 958     958      anova full          RAB40B  25.411965 6.293161e-16
#> 959     959      anova full           HSPH1  25.402450 6.349272e-16
#> 960     960      anova full            SGK1  25.388981 6.429578e-16
#> 961     961      anova full           FBXO2  25.370261 6.542927e-16
#> 962     962      anova full           MGST1  25.352870 6.650068e-16
#> 963     963      anova full           RASD2  25.338995 6.736841e-16
#> 964     964      anova full           PCBP4  25.331242 6.785837e-16
#> 965     965      anova full        TMEM178A  25.311411 6.912824e-16
#> 966     966      anova full           DCAF6  25.310295 6.920040e-16
#> 967     967      anova full           RPL37  25.302033 6.973723e-16
#> 968     968      anova full         TMEM130  25.296029 7.013004e-16
#> 969     969      anova full          CCP110  25.288771 7.060792e-16
#> 970     970      anova full           MAPK9  25.275464 7.149276e-16
#> 971     971      anova full           DIP2B  25.274230 7.157540e-16
#> 972     972      anova full            NCK2  25.263744 7.228147e-16
#> 973     973      anova full         EHBP1L1  25.213884 7.573831e-16
#> 974     974      anova full           OTUB1  25.209458 7.605329e-16
#> 975     975      anova full       LINC00937  25.170643 7.887368e-16
#> 976     976      anova full          SSX2IP  25.161817 7.952989e-16
#> 977     977      anova full            THY1  25.148221 8.055166e-16
#> 978     978      anova full         ALDH6A1  25.146207 8.070421e-16
#> 979     979      anova full           SEPT7  25.143620 8.090049e-16
#> 980     980      anova full          PTGES3  25.143445 8.091382e-16
#> 981     981      anova full          RPL27A  25.140098 8.116863e-16
#> 982     982      anova full           CISD1  25.121151 8.262650e-16
#> 983     983      anova full          HNRNPC  25.089483 8.512361e-16
#> 984     984      anova full        C11orf87  25.076239 8.619082e-16
#> 985     985      anova full           RRBP1  25.073984 8.637392e-16
#> 986     986      anova full           FMNL2  25.072028 8.653307e-16
#> 987     987      anova full           KIF17  25.068130 8.685109e-16
#> 988     988      anova full             NLK  25.044876 8.877331e-16
#> 989     989      anova full           TRHDE  25.040011 8.918097e-16
#> 990     990      anova full           KCNV1  25.035401 8.956896e-16
#> 991     991      anova full          PRUNE2  25.025810 9.038190e-16
#> 992     992      anova full            NEO1  25.017462 9.109566e-16
#> 993     993      anova full         LDLRAP1  25.013481 9.143802e-16
#> 994     994      anova full           NUDT4  25.012238 9.154525e-16
#> 995     995      anova full            BEX2  25.005803 9.210213e-16
#> 996     996      anova full           HERC1  25.002405 9.239768e-16
#> 997     997      anova full             ID4  25.001298 9.249414e-16
#> 998     998      anova full           RPS19  24.998505 9.273802e-16
#> 999     999      anova full           DDX54  24.998497 9.273870e-16
#> 1000   1000      anova full           ATCAY  24.992444 9.326949e-16
#> 1001   1001      anova full            RGCC  24.951841 9.691175e-16
#> 1002   1002      anova full           MYH11  24.886917 1.030421e-15
#> 1003   1003      anova full          NKAIN4  24.882997 1.034248e-15
#> 1004   1004      anova full            IPO5  24.829293 1.088169e-15
#> 1005   1005      anova full           GNAI2  24.824896 1.092710e-15
#> 1006   1006      anova full           YWHAQ  24.789361 1.130129e-15
#> 1007   1007      anova full            BEX4  24.776542 1.143948e-15
#> 1008   1008      anova full            MT1M  24.763186 1.158531e-15
#> 1009   1009      anova full          HNRNPF  24.719915 1.207105e-15
#> 1010   1010      anova full           BSCL2  24.719220 1.207902e-15
#> 1011   1011      anova full          IQSEC3  24.710556 1.217884e-15
#> 1012   1012      anova full          NAP1L3  24.703968 1.225529e-15
#> 1013   1013      anova full         SLC20A1  24.693484 1.237799e-15
#> 1014   1014      anova full           NDRG3  24.692955 1.238422e-15
#> 1015   1015      anova full             AK5  24.653266 1.286052e-15
#> 1016   1016      anova full             MMD  24.644985 1.296225e-15
#> 1017   1017      anova full        KIAA1147  24.639257 1.303310e-15
#> 1018   1018      anova full           PDE8A  24.624061 1.322300e-15
#> 1019   1019      anova full            PJA2  24.622804 1.323883e-15
#> 1020   1020      anova full            LMNA  24.618635 1.329149e-15
#> 1021   1021      anova full            CNN3  24.598881 1.354395e-15
#> 1022   1022      anova full          DYNLL2  24.555499 1.411581e-15
#> 1023   1023      anova full         GAL3ST1  24.549835 1.419228e-15
#> 1024   1024      anova full           RCAN2  24.545126 1.425617e-15
#> 1025   1025      anova full           PPME1  24.526993 1.450502e-15
#> 1026   1026      anova full           IL17D  24.518774 1.461928e-15
#> 1027   1027      anova full      AL365255.1  24.498361 1.490707e-15
#> 1028   1028      anova full           GNAO1  24.489846 1.502884e-15
#> 1029   1029      anova full          CACNG3  24.460213 1.546060e-15
#> 1030   1030      anova full            RPSA  24.458037 1.549281e-15
#> 1031   1031      anova full            SDC4  24.444442 1.569557e-15
#> 1032   1032      anova full           FSTL5  24.433229 1.586487e-15
#> 1033   1033      anova full           TPGS2  24.430794 1.590188e-15
#> 1034   1034      anova full       KIAA1549L  24.422958 1.602159e-15
#> 1035   1035      anova full          SMIM32  24.362075 1.698379e-15
#> 1036   1036      anova full           MFGE8  24.358177 1.704738e-15
#> 1037   1037      anova full        C12orf10  24.346300 1.724266e-15
#> 1038   1038      anova full          SPOCK2  24.322721 1.763716e-15
#> 1039   1039      anova full           RPL28  24.313517 1.779365e-15
#> 1040   1040      anova full          TMEM59  24.287886 1.823703e-15
#> 1041   1041      anova full            OTOA  24.285161 1.828484e-15
#> 1042   1042      anova full           MYO1B  24.269589 1.856049e-15
#> 1043   1043      anova full           FABP6  24.216358 1.953543e-15
#> 1044   1044      anova full           YWHAZ  24.208208 1.968929e-15
#> 1045   1045      anova full            ANO3  24.204396 1.976167e-15
#> 1046   1046      anova full           KCNB1  24.197690 1.988968e-15
#> 1047   1047      anova full            MSX1  24.191597 2.000672e-15
#> 1048   1048      anova full           SARAF  24.172846 2.037138e-15
#> 1049   1049      anova full         RASGRP3  24.144795 2.092971e-15
#> 1050   1050      anova full          TMEM65  24.123502 2.136399e-15
#> 1051   1051      anova full          NDFIP2  24.111716 2.160836e-15
#> 1052   1052      anova full           SEZ6L  24.044695 2.305357e-15
#> 1053   1053      anova full          MPPED1  24.040567 2.314576e-15
#> 1054   1054      anova full           TUBB3  24.033723 2.329946e-15
#> 1055   1055      anova full         ANKRD40  24.024380 2.351096e-15
#> 1056   1056      anova full           PRMT8  23.972778 2.471522e-15
#> 1057   1057      anova full            SV2B  23.968649 2.481429e-15
#> 1058   1058      anova full            FDX2  23.968285 2.482302e-15
#> 1059   1059      anova full           P2RX7  23.955370 2.513564e-15
#> 1060   1060      anova full          UQCRC2  23.950112 2.526404e-15
#> 1061   1061      anova full            MAFB  23.947693 2.532336e-15
#> 1062   1062      anova full            PMP2  23.935082 2.563488e-15
#> 1063   1063      anova full          PTPRZ1  23.933561 2.567271e-15
#> 1064   1064      anova full          KCTD16  23.929684 2.576941e-15
#> 1065   1065      anova full          PDLIM5  23.928010 2.581128e-15
#> 1066   1066      anova full          DOCK10  23.921247 2.598116e-15
#> 1067   1067      anova full             RAN  23.909390 2.628177e-15
#> 1068   1068      anova full          ATP2B4  23.907494 2.633016e-15
#> 1069   1069      anova full         GPRASP1  23.899397 2.653787e-15
#> 1070   1070      anova full            PEG3  23.881569 2.700120e-15
#> 1071   1071      anova full     SLC26A4-AS1  23.879692 2.705045e-15
#> 1072   1072      anova full          BCL11A  23.871462 2.726753e-15
#> 1073   1073      anova full          B4GAT1  23.869642 2.731579e-15
#> 1074   1074      anova full           PELI3  23.852065 2.778629e-15
#> 1075   1075      anova full           PRKCG  23.846839 2.792777e-15
#> 1076   1076      anova full          RNF208  23.834672 2.826005e-15
#> 1077   1077      anova full        OLMALINC  23.808826 2.897949e-15
#> 1078   1078      anova full           SMIM5  23.791771 2.946450e-15
#> 1079   1079      anova full            RPS3  23.791315 2.947757e-15
#> 1080   1080      anova full           NPTX2  23.788764 2.955085e-15
#> 1081   1081      anova full            DOK5  23.787845 2.957730e-15
#> 1082   1082      anova full         CACNA1A  23.781223 2.976862e-15
#> 1083   1083      anova full            TAC3  23.777631 2.987293e-15
#> 1084   1084      anova full            AAK1  23.767829 3.015945e-15
#> 1085   1085      anova full         SPATA13  23.759512 3.040479e-15
#> 1086   1086      anova full          FBXL16  23.744564 3.085092e-15
#> 1087   1087      anova full          ATP2B2  23.717143 3.168687e-15
#> 1088   1088      anova full            CDK5  23.690941 3.250741e-15
#> 1089   1089      anova full            PCLO  23.687299 3.262316e-15
#> 1090   1090      anova full         RASGRF1  23.682939 3.276231e-15
#> 1091   1091      anova full           FLRT2  23.678358 3.290918e-15
#> 1092   1092      anova full          C2CD4C  23.669312 3.320117e-15
#> 1093   1093      anova full             OAT  23.651853 3.377226e-15
#> 1094   1094      anova full          CYFIP2  23.649013 3.386609e-15
#> 1095   1095      anova full           PLIN3  23.642413 3.408524e-15
#> 1096   1096      anova full           COX7B  23.634477 3.435065e-15
#> 1097   1097      anova full          SRCIN1  23.616888 3.494656e-15
#> 1098   1098      anova full      AL020994.2  23.602908 3.542773e-15
#> 1099   1099      anova full      ST6GALNAC5  23.595981 3.566866e-15
#> 1100   1100      anova full          RFPL1S  23.587313 3.597254e-15
#> 1101   1101      anova full           ACSL6  23.571033 3.655047e-15
#> 1102   1102      anova full        SERPINF1  23.569521 3.660462e-15
#> 1103   1103      anova full           TGFB3  23.564634 3.678024e-15
#> 1104   1104      anova full           CRMP1  23.563963 3.680440e-15
#> 1105   1105      anova full        SLC25A22  23.561554 3.689133e-15
#> 1106   1106      anova full         GDAP1L1  23.535884 3.783099e-15
#> 1107   1107      anova full         NEUROD2  23.519942 3.842690e-15
#> 1108   1108      anova full            PPIA  23.500099 3.918212e-15
#> 1109   1109      anova full        C11orf96  23.496489 3.932111e-15
#> 1110   1110      anova full          ACTL6B  23.495838 3.934627e-15
#> 1111   1111      anova full            SGTB  23.463618 4.061060e-15
#> 1112   1112      anova full           DDAH2  23.434396 4.179340e-15
#> 1113   1113      anova full           GSG1L  23.429858 4.198024e-15
#> 1114   1114      anova full          TMBIM1  23.410853 4.277204e-15
#> 1115   1115      anova full            TPRN  23.408177 4.288479e-15
#> 1116   1116      anova full         PACSIN1  23.405704 4.298922e-15
#> 1117   1117      anova full          KRT222  23.379375 4.411747e-15
#> 1118   1118      anova full         FAM19A1  23.376199 4.425561e-15
#> 1119   1119      anova full          NIPAL3  23.359826 4.497484e-15
#> 1120   1120      anova full            DMTN  23.345131 4.563058e-15
#> 1121   1121      anova full           WASF2  23.342303 4.575792e-15
#> 1122   1122      anova full           LRRN1  23.341477 4.579515e-15
#> 1123   1123      anova full          PCSK1N  23.329557 4.633630e-15
#> 1124   1124      anova full         S100A11  23.311804 4.715444e-15
#> 1125   1125      anova full            SOD1  23.309721 4.725138e-15
#> 1126   1126      anova full           PRKCE  23.290853 4.813907e-15
#> 1127   1127      anova full            MPST  23.288578 4.824723e-15
#> 1128   1128      anova full         FAM124A  23.276483 4.882663e-15
#> 1129   1129      anova full          CAMK1D  23.271160 4.908388e-15
#> 1130   1130      anova full          NECAP1  23.252872 4.997831e-15
#> 1131   1131      anova full           NOP53  23.231634 5.103809e-15
#> 1132   1132      anova full           SCRG1  23.204544 5.242349e-15
#> 1133   1133      anova full          KIF21A  23.200184 5.265003e-15
#> 1134   1134      anova full          BTBD16  23.178306 5.380211e-15
#> 1135   1135      anova full          IGFBP7  23.168111 5.434781e-15
#> 1136   1136      anova full            STOM  23.166650 5.442651e-15
#> 1137   1137      anova full          ARPC5L  23.166090 5.445669e-15
#> 1138   1138      anova full           GNAI1  23.162973 5.462502e-15
#> 1139   1139      anova full            MYO6  23.161455 5.470716e-15
#> 1140   1140      anova full            TAC1  23.115434 5.725939e-15
#> 1141   1141      anova full           TIAM2  23.091096 5.865831e-15
#> 1142   1142      anova full          DAZAP2  23.058176 6.060654e-15
#> 1143   1143      anova full         COL16A1  23.042799 6.153925e-15
#> 1144   1144      anova full         SERINC5  23.027985 6.245179e-15
#> 1145   1145      anova full            CDS1  23.026492 6.254449e-15
#> 1146   1146      anova full          SPRYD3  23.020076 6.294461e-15
#> 1147   1147      anova full         ANGPTL2  23.018043 6.307194e-15
#> 1148   1148      anova full         SLC17A7  22.981194 6.542632e-15
#> 1149   1149      anova full           NCAM1  22.973961 6.589900e-15
#> 1150   1150      anova full           NTRK3  22.946203 6.774565e-15
#> 1151   1151      anova full            RGMA  22.938387 6.827517e-15
#> 1152   1152      anova full           ISOC1  22.906735 7.046337e-15
#> 1153   1153      anova full            PKIG  22.890825 7.159036e-15
#> 1154   1154      anova full            FAR1  22.887173 7.185166e-15
#> 1155   1155      anova full          COX7A1  22.881152 7.228460e-15
#> 1156   1156      anova full           RAMP2  22.873881 7.281100e-15
#> 1157   1157      anova full          COQ10B  22.871605 7.297653e-15
#> 1158   1158      anova full           AP2S1  22.838043 7.546366e-15
#> 1159   1159      anova full           CDC37  22.835776 7.563472e-15
#> 1160   1160      anova full         FAM213A  22.826863 7.631136e-15
#> 1161   1161      anova full          RPL23A  22.819301 7.689023e-15
#> 1162   1162      anova full           MFSD6  22.816483 7.710710e-15
#> 1163   1163      anova full           GRIN1  22.800811 7.832485e-15
#> 1164   1164      anova full          PHYHIP  22.795907 7.870991e-15
#> 1165   1165      anova full           AKAP6  22.788136 7.932410e-15
#> 1166   1166      anova full            ADD2  22.782867 7.974336e-15
#> 1167   1167      anova full           APLP2  22.751522 8.228496e-15
#> 1168   1168      anova full           MAST3  22.742381 8.304168e-15
#> 1169   1169      anova full           IFIT2  22.736502 8.353224e-15
#> 1170   1170      anova full           HMGN1  22.736280 8.355081e-15
#> 1171   1171      anova full          NCKAP1  22.726561 8.436833e-15
#> 1172   1172      anova full           REEP1  22.680438 8.836186e-15
#> 1173   1173      anova full           ITPK1  22.675487 8.880193e-15
#> 1174   1174      anova full           KIF3A  22.673358 8.899185e-15
#> 1175   1175      anova full            RTN4  22.667133 8.954961e-15
#> 1176   1176      anova full           STMN3  22.649815 9.112015e-15
#> 1177   1177      anova full        FAM177A1  22.647229 9.135708e-15
#> 1178   1178      anova full            FRZB  22.644025 9.165158e-15
#> 1179   1179      anova full           NCBP3  22.614358 9.442472e-15
#> 1180   1180      anova full          ENDOD1  22.585139 9.724025e-15
#> 1181   1181      anova full          TUBB4B  22.562435 9.948753e-15
#> 1182   1182      anova full       LINC01202  22.542555 1.014991e-14
#> 1183   1183      anova full           DAGLA  22.519222 1.039135e-14
#> 1184   1184      anova full           PRDX1  22.502713 1.056573e-14
#> 1185   1185      anova full           KCNK3  22.500805 1.058607e-14
#> 1186   1186      anova full           DCLK2  22.494948 1.064879e-14
#> 1187   1187      anova full           PRSS3  22.479597 1.081497e-14
#> 1188   1188      anova full       SECISBP2L  22.477795 1.083464e-14
#> 1189   1189      anova full      AC138647.1  22.462772 1.100017e-14
#> 1190   1190      anova full          SPTAN1  22.451310 1.112820e-14
#> 1191   1191      anova full           DMRT3  22.438949 1.126799e-14
#> 1192   1192      anova full           RPL13  22.437380 1.128586e-14
#> 1193   1193      anova full        CDC42EP2  22.435066 1.131228e-14
#> 1194   1194      anova full             GLS  22.433869 1.132596e-14
#> 1195   1195      anova full            TUBB  22.433669 1.132825e-14
#> 1196   1196      anova full         CHCHD10  22.404759 1.166412e-14
#> 1197   1197      anova full          SEMA5A  22.396667 1.175996e-14
#> 1198   1198      anova full           KALRN  22.381466 1.194217e-14
#> 1199   1199      anova full          SPOCK3  22.360492 1.219836e-14
#> 1200   1200      anova full         SLC35B2  22.355241 1.226339e-14
#> 1201   1201      anova full          MAD2L2  22.337591 1.248455e-14
#> 1202   1202      anova full         FAM216A  22.333429 1.253730e-14
#> 1203   1203      anova full          TM6SF1  22.331577 1.256084e-14
#> 1204   1204      anova full          SH3GL3  22.312900 1.280085e-14
#> 1205   1205      anova full            TPT1  22.291465 1.308211e-14
#> 1206   1206      anova full           SAR1B  22.262699 1.346957e-14
#> 1207   1207      anova full           APBB2  22.261736 1.348275e-14
#> 1208   1208      anova full         PITPNM2  22.260072 1.350554e-14
#> 1209   1209      anova full          PBXIP1  22.259634 1.351155e-14
#> 1210   1210      anova full          BEGAIN  22.253970 1.358947e-14
#> 1211   1211      anova full        ANKRD13A  22.233256 1.387838e-14
#> 1212   1212      anova full           SERF2  22.228169 1.395030e-14
#> 1213   1213      anova full            FHL1  22.225169 1.399289e-14
#> 1214   1214      anova full           PNMA1  22.220137 1.406463e-14
#> 1215   1215      anova full            RPS8  22.217884 1.409687e-14
#> 1216   1216      anova full          SEMA3A  22.206301 1.426382e-14
#> 1217   1217      anova full           PAQR4  22.197387 1.439370e-14
#> 1218   1218      anova full            SCAI  22.195275 1.442465e-14
#> 1219   1219      anova full           FBXW7  22.193647 1.444855e-14
#> 1220   1220      anova full          SEMA4D  22.183670 1.459592e-14
#> 1221   1221      anova full      AL031056.1  22.182256 1.461695e-14
#> 1222   1222      anova full           WFDC1  22.179298 1.466099e-14
#> 1223   1223      anova full          GPR158  22.166643 1.485103e-14
#> 1224   1224      anova full       LINC00599  22.164828 1.487849e-14
#> 1225   1225      anova full            AMPH  22.158045 1.498158e-14
#> 1226   1226      anova full            TLN1  22.137971 1.529098e-14
#> 1227   1227      anova full           NRXN3  22.130712 1.540447e-14
#> 1228   1228      anova full          MAGED1  22.128849 1.543374e-14
#> 1229   1229      anova full           CHST1  22.125798 1.548180e-14
#> 1230   1230      anova full          NMNAT2  22.124235 1.550648e-14
#> 1231   1231      anova full            UACA  22.120980 1.555800e-14
#> 1232   1232      anova full           RACK1  22.110991 1.571721e-14
#> 1233   1233      anova full           PDE8B  22.097340 1.593750e-14
#> 1234   1234      anova full           TRIP6  22.075754 1.629234e-14
#> 1235   1235      anova full           CPNE7  22.072640 1.634419e-14
#> 1236   1236      anova full         FAM19A5  22.057608 1.659689e-14
#> 1237   1237      anova full           AP1S1  22.046512 1.678601e-14
#> 1238   1238      anova full           RPS20  22.034341 1.699599e-14
#> 1239   1239      anova full            MGLL  22.024051 1.717562e-14
#> 1240   1240      anova full            RYBP  22.002516 1.755791e-14
#> 1241   1241      anova full         GPRASP2  21.985774 1.786113e-14
#> 1242   1242      anova full        PRICKLE1  21.977400 1.801482e-14
#> 1243   1243      anova full            HCN1  21.975425 1.805126e-14
#> 1244   1244      anova full           STT3B  21.965337 1.823860e-14
#> 1245   1245      anova full          SMIM37  21.961413 1.831200e-14
#> 1246   1246      anova full           ROCK2  21.950476 1.851822e-14
#> 1247   1247      anova full           CELF5  21.949528 1.853620e-14
#> 1248   1248      anova full            GJA1  21.946801 1.858804e-14
#> 1249   1249      anova full         ATP5F1C  21.938380 1.874905e-14
#> 1250   1250      anova full             RFK  21.933093 1.885088e-14
#> 1251   1251      anova full           SSTR1  21.917782 1.914898e-14
#> 1252   1252      anova full           LRRC4  21.890064 1.970101e-14
#> 1253   1253      anova full            SYBU  21.887165 1.975969e-14
#> 1254   1254      anova full          PITHD1  21.884719 1.980933e-14
#> 1255   1255      anova full            RYR2  21.866506 2.018305e-14
#> 1256   1256      anova full      AC007953.2  21.841694 2.070386e-14
#> 1257   1257      anova full            CD44  21.839661 2.074715e-14
#> 1258   1258      anova full            FEZ1  21.829470 2.096551e-14
#> 1259   1259      anova full          STXBP3  21.822267 2.112126e-14
#> 1260   1260      anova full            DLC1  21.819398 2.118364e-14
#> 1261   1261      anova full        TMEM179B  21.815318 2.127266e-14
#> 1262   1262      anova full            BTG1  21.809960 2.139016e-14
#> 1263   1263      anova full          GABRA4  21.795526 2.171002e-14
#> 1264   1264      anova full           RUFY3  21.793319 2.175935e-14
#> 1265   1265      anova full           UBE2M  21.790006 2.183361e-14
#> 1266   1266      anova full            NBEA  21.789700 2.184049e-14
#> 1267   1267      anova full            SOD2  21.783367 2.198326e-14
#> 1268   1268      anova full         TMEM189  21.783336 2.198395e-14
#> 1269   1269      anova full            SVIP  21.782289 2.200764e-14
#> 1270   1270      anova full           ROCK1  21.781566 2.202403e-14
#> 1271   1271      anova full           EGLN3  21.745395 2.285958e-14
#> 1272   1272      anova full         RTN4RL1  21.742117 2.293688e-14
#> 1273   1273      anova full          MTMR10  21.725572 2.333124e-14
#> 1274   1274      anova full          FILIP1  21.716035 2.356171e-14
#> 1275   1275      anova full           NXPE3  21.707856 2.376121e-14
#> 1276   1276      anova full           MCTP1  21.697772 2.400958e-14
#> 1277   1277      anova full           SNTG1  21.680403 2.444368e-14
#> 1278   1278      anova full             HK1  21.678434 2.449339e-14
#> 1279   1279      anova full             ME3  21.667771 2.476444e-14
#> 1280   1280      anova full            CD81  21.658732 2.499660e-14
#> 1281   1281      anova full            RARB  21.626030 2.585544e-14
#> 1282   1282      anova full       HIST1H2AC  21.622426 2.595192e-14
#> 1283   1283      anova full           HSBP1  21.619803 2.602237e-14
#> 1284   1284      anova full          DYNLT1  21.609042 2.631348e-14
#> 1285   1285      anova full           AMPD2  21.583221 2.702572e-14
#> 1286   1286      anova full            DDX1  21.541823 2.820925e-14
#> 1287   1287      anova full          R3HDM1  21.531116 2.852393e-14
#> 1288   1288      anova full            CDH8  21.521792 2.880091e-14
#> 1289   1289      anova full          GUCA1C  21.510200 2.914910e-14
#> 1290   1290      anova full           ERMP1  21.507234 2.923889e-14
#> 1291   1291      anova full         FAM234A  21.500187 2.945336e-14
#> 1292   1292      anova full           G3BP2  21.498276 2.951182e-14
#> 1293   1293      anova full          DNAJB2  21.497240 2.954353e-14
#> 1294   1294      anova full            JPH3  21.495130 2.960826e-14
#> 1295   1295      anova full           CELF4  21.489686 2.977595e-14
#> 1296   1296      anova full          LRRTM1  21.488612 2.980914e-14
#> 1297   1297      anova full             MPL  21.484000 2.995216e-14
#> 1298   1298      anova full          ADAM10  21.483890 2.995557e-14
#> 1299   1299      anova full         GRAMD1B  21.458040 3.077025e-14
#> 1300   1300      anova full           CPEB3  21.417311 3.210035e-14
#> 1301   1301      anova full           ALDOA  21.409075 3.237643e-14
#> 1302   1302      anova full           RBM39  21.381359 3.332352e-14
#> 1303   1303      anova full           HLA-A  21.378749 3.341415e-14
#> 1304   1304      anova full           PRDX5  21.361743 3.401097e-14
#> 1305   1305      anova full            RND1  21.359415 3.409355e-14
#> 1306   1306      anova full         MORF4L1  21.348799 3.447259e-14
#> 1307   1307      anova full           NORAD  21.329582 3.516981e-14
#> 1308   1308      anova full            DOHH  21.317950 3.559886e-14
#> 1309   1309      anova full          SLC4A2  21.310388 3.588065e-14
#> 1310   1310      anova full            PTK2  21.298348 3.633409e-14
#> 1311   1311      anova full          SMIM13  21.280770 3.700667e-14
#> 1312   1312      anova full         CCDC88A  21.273477 3.728945e-14
#> 1313   1313      anova full             LTK  21.270691 3.739805e-14
#> 1314   1314      anova full          TSPYL2  21.231138 3.897562e-14
#> 1315   1315      anova full          KCNMB4  21.223119 3.930370e-14
#> 1316   1316      anova full           CPNE9  21.205971 4.001484e-14
#> 1317   1317      anova full            TGFA  21.195189 4.046873e-14
#> 1318   1318      anova full          PNMA8B  21.192456 4.058462e-14
#> 1319   1319      anova full           RPS4X  21.188585 4.074935e-14
#> 1320   1320      anova full           L1CAM  21.186127 4.085430e-14
#> 1321   1321      anova full          CCDC92  21.185782 4.086908e-14
#> 1322   1322      anova full          GABRB3  21.183417 4.097034e-14
#> 1323   1323      anova full            YARS  21.169938 4.155257e-14
#> 1324   1324      anova full          SLC4A4  21.168886 4.159834e-14
#> 1325   1325      anova full            FGD1  21.157710 4.208807e-14
#> 1326   1326      anova full            EMX2  21.153113 4.229123e-14
#> 1327   1327      anova full          ZNF146  21.142115 4.278134e-14
#> 1328   1328      anova full           PCSK2  21.089253 4.521992e-14
#> 1329   1329      anova full           RPLP0  21.083502 4.549370e-14
#> 1330   1330      anova full            IER5  21.072513 4.602157e-14
#> 1331   1331      anova full           AEBP1  21.069337 4.617533e-14
#> 1332   1332      anova full            DAB1  21.055132 4.686940e-14
#> 1333   1333      anova full          ATP5MD  21.052783 4.698521e-14
#> 1334   1334      anova full            LIPA  21.021908 4.853494e-14
#> 1335   1335      anova full           ACAT2  21.006032 4.935217e-14
#> 1336   1336      anova full         KHDRBS2  20.993502 5.000715e-14
#> 1337   1337      anova full           TAGLN  20.968267 5.135346e-14
#> 1338   1338      anova full           CTXN3  20.960634 5.176802e-14
#> 1339   1339      anova full            GNB1  20.943247 5.272513e-14
#> 1340   1340      anova full         UBE2QL1  20.936265 5.311457e-14
#> 1341   1341      anova full      AC005944.1  20.929323 5.350470e-14
#> 1342   1342      anova full           FAIM2  20.929272 5.350759e-14
#> 1343   1343      anova full          THSD7A  20.927338 5.361680e-14
#> 1344   1344      anova full          FBXO34  20.926790 5.364779e-14
#> 1345   1345      anova full           HTRA1  20.909732 5.462172e-14
#> 1346   1346      anova full          NANOS3  20.907005 5.477904e-14
#> 1347   1347      anova full          GRIN2B  20.906271 5.482150e-14
#> 1348   1348      anova full            FLNA  20.865329 5.724292e-14
#> 1349   1349      anova full           FGF13  20.861128 5.749752e-14
#> 1350   1350      anova full            CA11  20.850864 5.812446e-14
#> 1351   1351      anova full             AES  20.850551 5.814372e-14
#> 1352   1352      anova full          LIMCH1  20.849304 5.822039e-14
#> 1353   1353      anova full           CHADL  20.836153 5.903532e-14
#> 1354   1354      anova full          UBE2E3  20.835374 5.908394e-14
#> 1355   1355      anova full             VXN  20.797428 6.150383e-14
#> 1356   1356      anova full             ELN  20.795056 6.165838e-14
#> 1357   1357      anova full          SORBS2  20.794310 6.170709e-14
#> 1358   1358      anova full           ZMAT4  20.787860 6.212987e-14
#> 1359   1359      anova full         ZNF385A  20.776146 6.290533e-14
#> 1360   1360      anova full          CAVIN1  20.737843 6.551100e-14
#> 1361   1361      anova full            CMIP  20.736833 6.558118e-14
#> 1362   1362      anova full           SLIT1  20.714394 6.716063e-14
#> 1363   1363      anova full           PNMA3  20.710543 6.743566e-14
#> 1364   1364      anova full      AC011603.2  20.692043 6.877284e-14
#> 1365   1365      anova full           NRSN2  20.686120 6.920667e-14
#> 1366   1366      anova full          CAMK1G  20.680328 6.963368e-14
#> 1367   1367      anova full           KRT18  20.676293 6.993270e-14
#> 1368   1368      anova full        SLC2A4RG  20.665514 7.073811e-14
#> 1369   1369      anova full           NR2F2  20.665237 7.075891e-14
#> 1370   1370      anova full            MAP9  20.664630 7.080451e-14
#> 1371   1371      anova full           GRIK3  20.656095 7.144965e-14
#> 1372   1372      anova full         RHOBTB2  20.640193 7.266766e-14
#> 1373   1373      anova full          KCNAB2  20.620896 7.417447e-14
#> 1374   1374      anova full         C3orf14  20.592690 7.643492e-14
#> 1375   1375      anova full            MT1H  20.584472 7.710673e-14
#> 1376   1376      anova full             GPI  20.581124 7.738217e-14
#> 1377   1377      anova full          ADGRG1  20.569366 7.835748e-14
#> 1378   1378      anova full         TERF2IP  20.567074 7.854905e-14
#> 1379   1379      anova full             OMG  20.546989 8.024871e-14
#> 1380   1380      anova full           COX7C  20.538423 8.098509e-14
#> 1381   1381      anova full           AGAP1  20.536304 8.116831e-14
#> 1382   1382      anova full      AC096564.1  20.533258 8.143245e-14
#> 1383   1383      anova full          CLSTN3  20.525852 8.207827e-14
#> 1384   1384      anova full           BACE1  20.523553 8.227984e-14
#> 1385   1385      anova full         FAM120A  20.516243 8.292415e-14
#> 1386   1386      anova full         UQCRFS1  20.512862 8.322386e-14
#> 1387   1387      anova full           SCN2A  20.506525 8.378868e-14
#> 1388   1388      anova full      AC009041.2  20.492149 8.508460e-14
#> 1389   1389      anova full          BTBD10  20.483837 8.584329e-14
#> 1390   1390      anova full           KCND2  20.480400 8.615900e-14
#> 1391   1391      anova full          PPP2CA  20.468340 8.727635e-14
#> 1392   1392      anova full           TTLL7  20.466817 8.741855e-14
#> 1393   1393      anova full         NDUFA12  20.435490 9.039606e-14
#> 1394   1394      anova full           TUSC3  20.421288 9.178006e-14
#> 1395   1395      anova full          CFAP36  20.389769 9.492991e-14
#> 1396   1396      anova full             AK2  20.386620 9.525063e-14
#> 1397   1397      anova full            LIX1  20.379354 9.599500e-14
#> 1398   1398      anova full            MADD  20.361032 9.789857e-14
#> 1399   1399      anova full           RNF11  20.359008 9.811120e-14
#> 1400   1400      anova full          COL9A3  20.358230 9.819310e-14
#> 1401   1401      anova full          UQCRC1  20.353516 9.869064e-14
#> 1402   1402      anova full           SULF1  20.338384 1.003053e-13
#> 1403   1403      anova full           PTPRF  20.326500 1.015923e-13
#> 1404   1404      anova full         TMEM35A  20.310313 1.033728e-13
#> 1405   1405      anova full           NUMA1  20.307331 1.037044e-13
#> 1406   1406      anova full           YPEL4  20.295623 1.050165e-13
#> 1407   1407      anova full         MAP3K11  20.274618 1.074134e-13
#> 1408   1408      anova full          CTDSP2  20.270648 1.078726e-13
#> 1409   1409      anova full            EHD3  20.268938 1.080712e-13
#> 1410   1410      anova full         CREB3L1  20.260963 1.090016e-13
#> 1411   1411      anova full           PRKCI  20.257531 1.094046e-13
#> 1412   1412      anova full             FRY  20.256760 1.094953e-13
#> 1413   1413      anova full            THRA  20.254118 1.098068e-13
#> 1414   1414      anova full           SEPT8  20.251027 1.101725e-13
#> 1415   1415      anova full            CFL1  20.248860 1.104296e-13
#> 1416   1416      anova full            DAD1  20.234431 1.121570e-13
#> 1417   1417      anova full           LMTK2  20.224714 1.133361e-13
#> 1418   1418      anova full         ZCCHC12  20.224104 1.134105e-13
#> 1419   1419      anova full          FAM98A  20.220890 1.138035e-13
#> 1420   1420      anova full        PAFAH1B1  20.216378 1.143576e-13
#> 1421   1421      anova full          HOMER1  20.214882 1.145420e-13
#> 1422   1422      anova full           TMTC2  20.209937 1.151535e-13
#> 1423   1423      anova full          FAM84B  20.189554 1.177095e-13
#> 1424   1424      anova full            RPS2  20.189371 1.177328e-13
#> 1425   1425      anova full           EIF1B  20.176816 1.193364e-13
#> 1426   1426      anova full            FNTB  20.156430 1.219884e-13
#> 1427   1427      anova full           VDAC3  20.146009 1.233674e-13
#> 1428   1428      anova full         STARD13  20.128494 1.257212e-13
#> 1429   1429      anova full        MAP1LC3B  20.109659 1.283040e-13
#> 1430   1430      anova full           CNTN3  20.093578 1.305523e-13
#> 1431   1431      anova full            ISCU  20.093177 1.306089e-13
#> 1432   1432      anova full          ADORA1  20.093009 1.306326e-13
#> 1433   1433      anova full          MBOAT2  20.085721 1.316654e-13
#> 1434   1434      anova full          CLSTN1  20.058854 1.355463e-13
#> 1435   1435      anova full          SIGIRR  20.039153 1.384663e-13
#> 1436   1436      anova full           SCN2B  20.037157 1.387659e-13
#> 1437   1437      anova full          IQGAP1  20.036039 1.389339e-13
#> 1438   1438      anova full            NGEF  20.033381 1.393342e-13
#> 1439   1439      anova full        C21orf91  20.032373 1.394863e-13
#> 1440   1440      anova full           SYT17  20.026948 1.403078e-13
#> 1441   1441      anova full          ZNF706  20.023592 1.408185e-13
#> 1442   1442      anova full            ENAH  20.022721 1.409514e-13
#> 1443   1443      anova full           KCNS1  20.018714 1.415643e-13
#> 1444   1444      anova full           ARL8A  20.009670 1.429577e-13
#> 1445   1445      anova full            DLG4  19.988777 1.462310e-13
#> 1446   1446      anova full           GPR62  19.986428 1.466037e-13
#> 1447   1447      anova full         ALDH9A1  19.971049 1.490687e-13
#> 1448   1448      anova full          PPP3CB  19.961859 1.505619e-13
#> 1449   1449      anova full         TMEM163  19.951335 1.522908e-13
#> 1450   1450      anova full            ASB2  19.946533 1.530865e-13
#> 1451   1451      anova full          RNF175  19.929731 1.559041e-13
#> 1452   1452      anova full          BRINP1  19.929444 1.559527e-13
#> 1453   1453      anova full          CHCHD6  19.909637 1.593440e-13
#> 1454   1454      anova full           EGFL7  19.903424 1.604233e-13
#> 1455   1455      anova full         SLCO3A1  19.894170 1.620447e-13
#> 1456   1456      anova full           PCDH9  19.889843 1.628087e-13
#> 1457   1457      anova full           P4HTM  19.888357 1.630719e-13
#> 1458   1458      anova full         FAM181B  19.887083 1.632979e-13
#> 1459   1459      anova full      AC008780.2  19.884546 1.637490e-13
#> 1460   1460      anova full            SIK3  19.882121 1.641812e-13
#> 1461   1461      anova full          PGM2L1  19.869783 1.663991e-13
#> 1462   1462      anova full            MPP1  19.860641 1.680623e-13
#> 1463   1463      anova full          RNF157  19.837836 1.722857e-13
#> 1464   1464      anova full           RAB26  19.835055 1.728082e-13
#> 1465   1465      anova full        CALCOCO2  19.823902 1.749200e-13
#> 1466   1466      anova full       ADCYAP1R1  19.820185 1.756296e-13
#> 1467   1467      anova full        ARHGEF11  19.819834 1.756967e-13
#> 1468   1468      anova full           CADPS  19.817163 1.762087e-13
#> 1469   1469      anova full           RPS18  19.807910 1.779943e-13
#> 1470   1470      anova full            FRYL  19.805299 1.785014e-13
#> 1471   1471      anova full           GRIA2  19.795428 1.804323e-13
#> 1472   1472      anova full            SNX1  19.783645 1.827653e-13
#> 1473   1473      anova full            AKT3  19.769900 1.855259e-13
#> 1474   1474      anova full            ZHX2  19.761875 1.871575e-13
#> 1475   1475      anova full           SEPT3  19.757595 1.880338e-13
#> 1476   1476      anova full           METRN  19.755446 1.884754e-13
#> 1477   1477      anova full          CGREF1  19.745170 1.906015e-13
#> 1478   1478      anova full            LRMP  19.739888 1.917039e-13
#> 1479   1479      anova full          B3GAT1  19.737575 1.921887e-13
#> 1480   1480      anova full          ELOVL4  19.699796 2.002880e-13
#> 1481   1481      anova full          AHNAK2  19.662804 2.085586e-13
#> 1482   1482      anova full            LHX2  19.652518 2.109201e-13
#> 1483   1483      anova full            ANK2  19.647328 2.121220e-13
#> 1484   1484      anova full          UNC13A  19.631842 2.157505e-13
#> 1485   1485      anova full           UBE2O  19.625706 2.172057e-13
#> 1486   1486      anova full          APCDD1  19.621018 2.183244e-13
#> 1487   1487      anova full          ANP32A  19.619337 2.187270e-13
#> 1488   1488      anova full        TMEM132A  19.599683 2.234907e-13
#> 1489   1489      anova full            RIN2  19.594208 2.248365e-13
#> 1490   1490      anova full        ATXN7L3B  19.575810 2.294205e-13
#> 1491   1491      anova full        HHIP-AS1  19.569160 2.311010e-13
#> 1492   1492      anova full            DLX1  19.559799 2.334880e-13
#> 1493   1493      anova full         B4GALT6  19.556944 2.342210e-13
#> 1494   1494      anova full         HSPA12A  19.541743 2.381639e-13
#> 1495   1495      anova full            TNS1  19.531273 2.409192e-13
#> 1496   1496      anova full         ZFYVE16  19.531000 2.409915e-13
#> 1497   1497      anova full           ENPP4  19.520868 2.436898e-13
#> 1498   1498      anova full            ELK1  19.500377 2.492424e-13
#> 1499   1499      anova full           NXPH3  19.498955 2.496326e-13
#> 1500   1500      anova full            JPH1  19.498317 2.498078e-13
#> 1501   1501      anova full            NNAT  19.486675 2.530277e-13
#> 1502   1502      anova full          LRRC8A  19.484593 2.536080e-13
#> 1503   1503      anova full        HLA-DPB1  19.481142 2.545730e-13
#> 1504   1504      anova full         TSC22D1  19.477939 2.554719e-13
#> 1505   1505      anova full         ARHGDIG  19.475607 2.561283e-13
#> 1506   1506      anova full           HMGN3  19.475000 2.562994e-13
#> 1507   1507      anova full          KIF13B  19.472847 2.569076e-13
#> 1508   1508      anova full         LDLRAD4  19.452768 2.626506e-13
#> 1509   1509      anova full            BCHE  19.442395 2.656693e-13
#> 1510   1510      anova full          TMBIM4  19.419362 2.724997e-13
#> 1511   1511      anova full            RHOC  19.390645 2.812693e-13
#> 1512   1512      anova full          C9orf3  19.370084 2.877259e-13
#> 1513   1513      anova full           GSTO1  19.368015 2.883837e-13
#> 1514   1514      anova full           YPEL5  19.357668 2.916981e-13
#> 1515   1515      anova full           RPL22  19.348463 2.946796e-13
#> 1516   1516      anova full           SYT12  19.308712 3.079186e-13
#> 1517   1517      anova full            TFEB  19.306854 3.085521e-13
#> 1518   1518      anova full            TNS2  19.306421 3.087001e-13
#> 1519   1519      anova full            ANK1  19.301519 3.103787e-13
#> 1520   1520      anova full           TSHZ2  19.299590 3.110419e-13
#> 1521   1521      anova full         RAPGEF4  19.289075 3.146828e-13
#> 1522   1522      anova full           RAB6A  19.280818 3.175722e-13
#> 1523   1523      anova full            RGS5  19.268968 3.217669e-13
#> 1524   1524      anova full            MKL2  19.266834 3.225283e-13
#> 1525   1525      anova full           SYNJ1  19.263030 3.238901e-13
#> 1526   1526      anova full            MLF2  19.248839 3.290231e-13
#> 1527   1527      anova full           RPS11  19.240402 3.321145e-13
#> 1528   1528      anova full          CNKSR2  19.240020 3.322550e-13
#> 1529   1529      anova full         FAM171B  19.228977 3.363482e-13
#> 1530   1530      anova full            DYSF  19.219541 3.398862e-13
#> 1531   1531      anova full         CYP26B1  19.213418 3.422029e-13
#> 1532   1532      anova full           PRKCB  19.209261 3.437850e-13
#> 1533   1533      anova full           CPNE3  19.200770 3.470395e-13
#> 1534   1534      anova full           GFOD1  19.196516 3.486820e-13
#> 1535   1535      anova full          SCAMP2  19.191747 3.505325e-13
#> 1536   1536      anova full           PRRG1  19.186466 3.525940e-13
#> 1537   1537      anova full            SYT5  19.173443 3.577303e-13
#> 1538   1538      anova full           RPS24  19.155001 3.651362e-13
#> 1539   1539      anova full           WASF1  19.147613 3.681470e-13
#> 1540   1540      anova full           RPLP1  19.137493 3.723124e-13
#> 1541   1541      anova full           RFTN2  19.136236 3.728333e-13
#> 1542   1542      anova full             BGN  19.132387 3.744325e-13
#> 1543   1543      anova full         CASKIN1  19.119992 3.796309e-13
#> 1544   1544      anova full          STEAP2  19.109911 3.839135e-13
#> 1545   1545      anova full             JUP  19.109260 3.841920e-13
#> 1546   1546      anova full          PABPC1  19.106481 3.853821e-13
#> 1547   1547      anova full            GLRB  19.105720 3.857084e-13
#> 1548   1548      anova full         CCDC85A  19.094391 3.906041e-13
#> 1549   1549      anova full           PACS2  19.093384 3.910422e-13
#> 1550   1550      anova full          FAM49A  19.093241 3.911043e-13
#> 1551   1551      anova full           CTBP1  19.074091 3.995361e-13
#> 1552   1552      anova full          BABAM1  19.073566 3.997697e-13
#> 1553   1553      anova full           KCNG1  19.071921 4.005032e-13
#> 1554   1554      anova full          IGFBP6  19.069949 4.013841e-13
#> 1555   1555      anova full            LIPE  19.068374 4.020892e-13
#> 1556   1556      anova full        SLC25A29  19.060017 4.058517e-13
#> 1557   1557      anova full             SMS  19.056432 4.074767e-13
#> 1558   1558      anova full           MMP11  19.041911 4.141280e-13
#> 1559   1559      anova full          PLPPR4  19.035744 4.169860e-13
#> 1560   1560      anova full       HNRNPA2B1  19.026952 4.210962e-13
#> 1561   1561      anova full           CCND1  19.025783 4.216455e-13
#> 1562   1562      anova full       LINC01877  19.016349 4.261081e-13
#> 1563   1563      anova full            BROX  19.008282 4.299626e-13
#> 1564   1564      anova full         RAPGEF5  19.000488 4.337202e-13
#> 1565   1565      anova full         BHLHE22  18.989710 4.389726e-13
#> 1566   1566      anova full           FOXN2  18.988802 4.394180e-13
#> 1567   1567      anova full        C10orf90  18.985673 4.409566e-13
#> 1568   1568      anova full         CARMIL2  18.967083 4.502128e-13
#> 1569   1569      anova full           FBXL2  18.964151 4.516907e-13
#> 1570   1570      anova full           PPM1L  18.959302 4.541462e-13
#> 1571   1571      anova full            CD63  18.951579 4.580851e-13
#> 1572   1572      anova full         PLEKHA2  18.921165 4.739408e-13
#> 1573   1573      anova full          PTPRN2  18.914759 4.773521e-13
#> 1574   1574      anova full           KCNF1  18.873166 5.001214e-13
#> 1575   1575      anova full            BST2  18.853904 5.110409e-13
#> 1576   1576      anova full          FBXO44  18.848608 5.140858e-13
#> 1577   1577      anova full          SLC1A2  18.844887 5.162366e-13
#> 1578   1578      anova full           CNDP2  18.835786 5.215357e-13
#> 1579   1579      anova full       INHBA-AS1  18.835329 5.218030e-13
#> 1580   1580      anova full          BAIAP3  18.830513 5.246312e-13
#> 1581   1581      anova full           UNC5D  18.827621 5.263375e-13
#> 1582   1582      anova full         S100A13  18.827223 5.265723e-13
#> 1583   1583      anova full            CAPG  18.824963 5.279104e-13
#> 1584   1584      anova full         EPB41L2  18.824452 5.282133e-13
#> 1585   1585      anova full         PHACTR1  18.820042 5.308348e-13
#> 1586   1586      anova full        MAPKAPK2  18.807889 5.381297e-13
#> 1587   1587      anova full           TMCC3  18.788829 5.497786e-13
#> 1588   1588      anova full        Z82214.2  18.785328 5.519459e-13
#> 1589   1589      anova full           RASD1  18.772835 5.597526e-13
#> 1590   1590      anova full            EMX1  18.767965 5.628270e-13
#> 1591   1591      anova full            MTDH  18.757183 5.696945e-13
#> 1592   1592      anova full            GAB2  18.754865 5.711816e-13
#> 1593   1593      anova full           RPL32  18.751654 5.732492e-13
#> 1594   1594      anova full           TYRP1  18.743425 5.785824e-13
#> 1595   1595      anova full           RPS14  18.724483 5.910530e-13
#> 1596   1596      anova full          RBFOX2  18.723444 5.917450e-13
#> 1597   1597      anova full           PARP1  18.711423 5.998120e-13
#> 1598   1598      anova full          IFITM2  18.692444 6.127787e-13
#> 1599   1599      anova full        B4GALNT1  18.685057 6.179037e-13
#> 1600   1600      anova full         SLC5A11  18.678923 6.221923e-13
#> 1601   1601      anova full          SPTBN2  18.677635 6.230968e-13
#> 1602   1602      anova full            DKK3  18.671601 6.273519e-13
#> 1603   1603      anova full          FBXL15  18.647493 6.446517e-13
#> 1604   1604      anova full            PLTP  18.639525 6.504768e-13
#> 1605   1605      anova full             GAL  18.639453 6.505299e-13
#> 1606   1606      anova full            TESC  18.629967 6.575363e-13
#> 1607   1607      anova full          TCEAL5  18.627380 6.594605e-13
#> 1608   1608      anova full           RAB13  18.618002 6.664834e-13
#> 1609   1609      anova full           ZNF24  18.617550 6.668243e-13
#> 1610   1610      anova full            RFX3  18.610410 6.722256e-13
#> 1611   1611      anova full           RAPH1  18.607831 6.741879e-13
#> 1612   1612      anova full           ZFHX3  18.599592 6.804960e-13
#> 1613   1613      anova full            CD22  18.585934 6.910866e-13
#> 1614   1614      anova full           AP2A1  18.569359 7.041670e-13
#> 1615   1615      anova full           SSBP4  18.565841 7.069760e-13
#> 1616   1616      anova full            CST3  18.552437 7.177842e-13
#> 1617   1617      anova full            BDNF  18.552237 7.179465e-13
#> 1618   1618      anova full          PLXNA4  18.549526 7.201540e-13
#> 1619   1619      anova full           OPCML  18.548741 7.207942e-13
#> 1620   1620      anova full           PLOD3  18.544217 7.244964e-13
#> 1621   1621      anova full           DEGS1  18.543282 7.252634e-13
#> 1622   1622      anova full           NACAD  18.539017 7.287753e-13
#> 1623   1623      anova full         POMGNT2  18.534141 7.328115e-13
#> 1624   1624      anova full            TMC7  18.521533 7.433552e-13
#> 1625   1625      anova full           HSPB6  18.521054 7.437586e-13
#> 1626   1626      anova full          CAMK2G  18.496502 7.647510e-13
#> 1627   1627      anova full         TMEM246  18.495184 7.658952e-13
#> 1628   1628      anova full          ADGRL2  18.459019 7.979805e-13
#> 1629   1629      anova full         CNTNAP1  18.446822 8.091112e-13
#> 1630   1630      anova full          SLC6A1  18.444025 8.116851e-13
#> 1631   1631      anova full          SEMA6A  18.438056 8.172079e-13
#> 1632   1632      anova full         RHOBTB3  18.435040 8.200135e-13
#> 1633   1633      anova full            TSPO  18.433346 8.215937e-13
#> 1634   1634      anova full            PPIF  18.427011 8.275294e-13
#> 1635   1635      anova full           FARSA  18.407367 8.462193e-13
#> 1636   1636      anova full          TUBB2B  18.385724 8.673130e-13
#> 1637   1637      anova full           PLPP3  18.381449 8.715430e-13
#> 1638   1638      anova full           ITGAV  18.379018 8.739583e-13
#> 1639   1639      anova full           KCTD3  18.378535 8.744389e-13
#> 1640   1640      anova full           GPM6A  18.360597 8.924813e-13
#> 1641   1641      anova full       KIAA1324L  18.357019 8.961263e-13
#> 1642   1642      anova full            TBCB  18.349513 9.038213e-13
#> 1643   1643      anova full       LINC00460  18.339469 9.142248e-13
#> 1644   1644      anova full          DNAJA1  18.289595 9.677369e-13
#> 1645   1645      anova full          SLC6A7  18.235030 1.029980e-12
#> 1646   1646      anova full           LARP6  18.232255 1.033253e-12
#> 1647   1647      anova full      AC025244.1  18.220406 1.047351e-12
#> 1648   1648      anova full           SMYD1  18.218754 1.049332e-12
#> 1649   1649      anova full         TRAPPC1  18.206988 1.063553e-12
#> 1650   1650      anova full            PLD3  18.175408 1.102712e-12
#> 1651   1651      anova full           FXYD1  18.151096 1.133865e-12
#> 1652   1652      anova full           ADCY2  18.150462 1.134690e-12
#> 1653   1653      anova full           NEAT1  18.144507 1.142464e-12
#> 1654   1654      anova full           WDR47  18.140939 1.147147e-12
#> 1655   1655      anova full          MAP4K5  18.130666 1.160743e-12
#> 1656   1656      anova full           GSK3B  18.123558 1.170248e-12
#> 1657   1657      anova full           EFR3B  18.119893 1.175179e-12
#> 1658   1658      anova full           KANK1  18.085485 1.222533e-12
#> 1659   1659      anova full           CHST6  18.082801 1.226308e-12
#> 1660   1660      anova full          LSM14A  18.076976 1.234542e-12
#> 1661   1661      anova full         PRKAR1A  18.054861 1.266327e-12
#> 1662   1662      anova full         SLC4A10  18.050672 1.272442e-12
#> 1663   1663      anova full           STRBP  18.041785 1.285514e-12
#> 1664   1664      anova full            PDK4  18.020790 1.316949e-12
#> 1665   1665      anova full           HADHA  18.005008 1.341098e-12
#> 1666   1666      anova full           KLF16  18.002613 1.344802e-12
#> 1667   1667      anova full          CADPS2  17.973402 1.390836e-12
#> 1668   1668      anova full          NDUFS2  17.970687 1.395197e-12
#> 1669   1669      anova full            OPN3  17.961873 1.409449e-12
#> 1670   1670      anova full           EXOC6  17.958128 1.415549e-12
#> 1671   1671      anova full           PANX2  17.947548 1.432930e-12
#> 1672   1672      anova full           MAPK4  17.946944 1.433929e-12
#> 1673   1673      anova full             HLF  17.936214 1.451794e-12
#> 1674   1674      anova full        TMEM132E  17.933945 1.455601e-12
#> 1675   1675      anova full          ADGRB2  17.932895 1.457366e-12
#> 1676   1676      anova full             TUB  17.915239 1.487380e-12
#> 1677   1677      anova full           CAPN5  17.911253 1.494243e-12
#> 1678   1678      anova full           CAPN2  17.908627 1.498782e-12
#> 1679   1679      anova full         TRABD2A  17.901495 1.511183e-12
#> 1680   1680      anova full           FADS1  17.892245 1.527422e-12
#> 1681   1681      anova full           PDE1B  17.890824 1.529933e-12
#> 1682   1682      anova full           PART1  17.883602 1.542758e-12
#> 1683   1683      anova full           PTPRU  17.873650 1.560613e-12
#> 1684   1684      anova full            MTPN  17.852365 1.599517e-12
#> 1685   1685      anova full           PCNX2  17.850974 1.602093e-12
#> 1686   1686      anova full          SPTLC2  17.843528 1.615960e-12
#> 1687   1687      anova full            CD74  17.842694 1.617520e-12
#> 1688   1688      anova full        ATP6V1C1  17.817528 1.665353e-12
#> 1689   1689      anova full           EIF5B  17.812966 1.674177e-12
#> 1690   1690      anova full           PDE7B  17.807637 1.684548e-12
#> 1691   1691      anova full           SERP2  17.804672 1.690345e-12
#> 1692   1692      anova full          LRRC49  17.796866 1.705709e-12
#> 1693   1693      anova full           CDK19  17.794970 1.709461e-12
#> 1694   1694      anova full         FAM102A  17.785889 1.727555e-12
#> 1695   1695      anova full         C6orf48  17.785247 1.728842e-12
#> 1696   1696      anova full        CDK5RAP2  17.781023 1.737331e-12
#> 1697   1697      anova full            ETS2  17.777823 1.743793e-12
#> 1698   1698      anova full           DMXL2  17.768610 1.762529e-12
#> 1699   1699      anova full           MAST1  17.765596 1.768705e-12
#> 1700   1700      anova full          GOLIM4  17.759904 1.780426e-12
#> 1701   1701      anova full            GNB4  17.758014 1.784336e-12
#> 1702   1702      anova full           ACSL1  17.735661 1.831252e-12
#> 1703   1703      anova full           ARL4A  17.730744 1.841741e-12
#> 1704   1704      anova full         ATP5MPL  17.712506 1.881188e-12
#> 1705   1705      anova full            DLG1  17.712014 1.882265e-12
#> 1706   1706      anova full           KCNK1  17.705618 1.896311e-12
#> 1707   1707      anova full           MAPK1  17.704721 1.898290e-12
#> 1708   1708      anova full           PRRT2  17.701848 1.904641e-12
#> 1709   1709      anova full         RPS6KA2  17.700442 1.907758e-12
#> 1710   1710      anova full           LRP10  17.695059 1.919737e-12
#> 1711   1711      anova full           PDE2A  17.684354 1.943790e-12
#> 1712   1712      anova full       HIST2H2BE  17.679856 1.953990e-12
#> 1713   1713      anova full            STRN  17.664392 1.989473e-12
#> 1714   1714      anova full          NKX2-2  17.661170 1.996951e-12
#> 1715   1715      anova full           NFASC  17.649799 2.023567e-12
#> 1716   1716      anova full         TP53TG5  17.643030 2.039586e-12
#> 1717   1717      anova full           DUSP8  17.640733 2.045049e-12
#> 1718   1718      anova full        KIAA1755  17.626207 2.079959e-12
#> 1719   1719      anova full          CX3CL1  17.624214 2.084796e-12
#> 1720   1720      anova full           GPR83  17.618416 2.098934e-12
#> 1721   1721      anova full          ATP5MF  17.615753 2.105462e-12
#> 1722   1722      anova full            FBN2  17.614763 2.107892e-12
#> 1723   1723      anova full           PNRC1  17.604306 2.133756e-12
#> 1724   1724      anova full           NR1D1  17.578662 2.198564e-12
#> 1725   1725      anova full       SMIM10L2A  17.571249 2.217674e-12
#> 1726   1726      anova full          PCDH18  17.565954 2.231426e-12
#> 1727   1727      anova full           ASGR1  17.563543 2.237717e-12
#> 1728   1728      anova full         ARFGEF3  17.562470 2.240524e-12
#> 1729   1729      anova full            HRH3  17.559857 2.247373e-12
#> 1730   1730      anova full          OCIAD1  17.556787 2.255445e-12
#> 1731   1731      anova full           UNC5C  17.553871 2.263142e-12
#> 1732   1732      anova full          TRIM56  17.545812 2.284552e-12
#> 1733   1733      anova full            PREP  17.541319 2.296579e-12
#> 1734   1734      anova full           RPL18  17.530864 2.324815e-12
#> 1735   1735      anova full           MICU3  17.524265 2.342821e-12
#> 1736   1736      anova full             CPD  17.515033 2.368252e-12
#> 1737   1737      anova full            COMT  17.507346 2.389644e-12
#> 1738   1738      anova full            GLUL  17.506559 2.391845e-12
#> 1739   1739      anova full           UCHL5  17.505819 2.393918e-12
#> 1740   1740      anova full           EPHB6  17.505191 2.395678e-12
#> 1741   1741      anova full           TJAP1  17.503996 2.399030e-12
#> 1742   1742      anova full          ETNPPL  17.500874 2.407808e-12
#> 1743   1743      anova full            A1BG  17.492403 2.431799e-12
#> 1744   1744      anova full        RAP1GDS1  17.489703 2.439497e-12
#> 1745   1745      anova full        MIR7-3HG  17.459840 2.526324e-12
#> 1746   1746      anova full          ADAM15  17.458983 2.528863e-12
#> 1747   1747      anova full          LRRC73  17.458083 2.531532e-12
#> 1748   1748      anova full           GRIK1  17.455007 2.540672e-12
#> 1749   1749      anova full          DHCR24  17.449804 2.556213e-12
#> 1750   1750      anova full           RPS25  17.436332 2.596905e-12
#> 1751   1751      anova full           TRAM1  17.434206 2.603387e-12
#> 1752   1752      anova full            PIGT  17.427717 2.623275e-12
#> 1753   1753      anova full          TRIM23  17.426917 2.625738e-12
#> 1754   1754      anova full           STAU2  17.425751 2.629332e-12
#> 1755   1755      anova full        TMEM183A  17.423488 2.636322e-12
#> 1756   1756      anova full           CDH24  17.422310 2.639967e-12
#> 1757   1757      anova full       LINC01630  17.414292 2.664919e-12
#> 1758   1758      anova full            ACHE  17.411989 2.672129e-12
#> 1759   1759      anova full           DNM1L  17.410255 2.677574e-12
#> 1760   1760      anova full         ARHGEF1  17.399585 2.711317e-12
#> 1761   1761      anova full            MT1X  17.395173 2.725398e-12
#> 1762   1762      anova full           CRYL1  17.393411 2.731042e-12
#> 1763   1763      anova full            LGR5  17.385438 2.756735e-12
#> 1764   1764      anova full          PHLDA2  17.379086 2.777379e-12
#> 1765   1765      anova full           KCNC4  17.371298 2.802908e-12
#> 1766   1766      anova full          IFNGR1  17.348726 2.878273e-12
#> 1767   1767      anova full           GSTP1  17.347529 2.882326e-12
#> 1768   1768      anova full           GPR26  17.345816 2.888137e-12
#> 1769   1769      anova full           HINT1  17.343220 2.896968e-12
#> 1770   1770      anova full            CRB2  17.341163 2.903986e-12
#> 1771   1771      anova full            BMI1  17.323807 2.963893e-12
#> 1772   1772      anova full            SARS  17.319099 2.980360e-12
#> 1773   1773      anova full          RAB27B  17.303871 3.034275e-12
#> 1774   1774      anova full           CHRM3  17.293530 3.071454e-12
#> 1775   1775      anova full          PGRMC1  17.289624 3.085620e-12
#> 1776   1776      anova full           HABP4  17.265189 3.175773e-12
#> 1777   1777      anova full           BTBD3  17.239576 3.273183e-12
#> 1778   1778      anova full         MMP24OS  17.229186 3.313565e-12
#> 1779   1779      anova full         SPARCL1  17.227072 3.321843e-12
#> 1780   1780      anova full           MYO10  17.226898 3.322526e-12
#> 1781   1781      anova full           NCOA7  17.222786 3.338695e-12
#> 1782   1782      anova full           KCTD1  17.222404 3.340203e-12
#> 1783   1783      anova full           DHCR7  17.220300 3.348507e-12
#> 1784   1784      anova full          PPFIA3  17.217510 3.359560e-12
#> 1785   1785      anova full          SPTBN4  17.217480 3.359679e-12
#> 1786   1786      anova full            ICA1  17.212902 3.377890e-12
#> 1787   1787      anova full        ANKRD34A  17.207151 3.400913e-12
#> 1788   1788      anova full          RPL37A  17.204935 3.409828e-12
#> 1789   1789      anova full         SLC32A1  17.204660 3.410937e-12
#> 1790   1790      anova full           RAP1B  17.204317 3.412316e-12
#> 1791   1791      anova full      AC105446.1  17.200077 3.429453e-12
#> 1792   1792      anova full          NDUFB1  17.194832 3.450774e-12
#> 1793   1793      anova full           CHST2  17.186986 3.482919e-12
#> 1794   1794      anova full           RRAGA  17.186182 3.486231e-12
#> 1795   1795      anova full            CCNI  17.184463 3.493324e-12
#> 1796   1796      anova full           MYO1E  17.174295 3.535573e-12
#> 1797   1797      anova full           RPS13  17.171094 3.548982e-12
#> 1798   1798      anova full            GRM5  17.162896 3.583560e-12
#> 1799   1799      anova full            TPP1  17.145386 3.658580e-12
#> 1800   1800      anova full           GDAP1  17.144882 3.660764e-12
#> 1801   1801      anova full          RHBDD2  17.137073 3.694762e-12
#> 1802   1802      anova full         ATP6AP2  17.134516 3.705962e-12
#> 1803   1803      anova full           SYNPO  17.129641 3.727417e-12
#> 1804   1804      anova full          NOTCH2  17.126852 3.739749e-12
#> 1805   1805      anova full            FADD  17.114949 3.792849e-12
#> 1806   1806      anova full         TP53I11  17.105015 3.837762e-12
#> 1807   1807      anova full          IGFBP5  17.104466 3.840258e-12
#> 1808   1808      anova full           TMTC1  17.104011 3.842328e-12
#> 1809   1809      anova full          PPP1R7  17.102369 3.849814e-12
#> 1810   1810      anova full         SLC25A5  17.099448 3.863168e-12
#> 1811   1811      anova full           POSTN  17.097760 3.870906e-12
#> 1812   1812      anova full            NOL4  17.096422 3.877050e-12
#> 1813   1813      anova full          CNRIP1  17.093093 3.892380e-12
#> 1814   1814      anova full            BAG3  17.090448 3.904605e-12
#> 1815   1815      anova full           LRP1B  17.068077 4.009600e-12
#> 1816   1816      anova full           TRAF4  17.063110 4.033301e-12
#> 1817   1817      anova full            PAK2  17.047384 4.109301e-12
#> 1818   1818      anova full           COX8A  17.043150 4.130014e-12
#> 1819   1819      anova full          RPL10A  17.042691 4.132265e-12
#> 1820   1820      anova full          PSMD12  17.037321 4.158703e-12
#> 1821   1821      anova full          NUDCD2  17.036289 4.163800e-12
#> 1822   1822      anova full            CERK  17.033951 4.175381e-12
#> 1823   1823      anova full          TOMM34  17.030268 4.193689e-12
#> 1824   1824      anova full           BAZ2B  17.020812 4.241072e-12
#> 1825   1825      anova full           STRAP  17.016230 4.264229e-12
#> 1826   1826      anova full            RPL4  17.002098 4.336474e-12
#> 1827   1827      anova full           CNTN5  17.001103 4.341610e-12
#> 1828   1828      anova full           LUZP1  16.993311 4.382029e-12
#> 1829   1829      anova full         PLEKHA5  16.987207 4.413963e-12
#> 1830   1830      anova full          VSTM2B  16.968075 4.515609e-12
#> 1831   1831      anova full          TMEM25  16.966884 4.522016e-12
#> 1832   1832      anova full           SMIM6  16.964915 4.532627e-12
#> 1833   1833      anova full            IST1  16.943590 4.649212e-12
#> 1834   1834      anova full           MYT1L  16.942423 4.655685e-12
#> 1835   1835      anova full          MINDY1  16.939073 4.674301e-12
#> 1836   1836      anova full         RASL10A  16.931619 4.716005e-12
#> 1837   1837      anova full             DST  16.924904 4.753902e-12
#> 1838   1838      anova full           ARAP1  16.921914 4.770882e-12
#> 1839   1839      anova full           LZTS1  16.917723 4.794776e-12
#> 1840   1840      anova full            SYT3  16.915177 4.809357e-12
#> 1841   1841      anova full           SYNE1  16.911975 4.827752e-12
#> 1842   1842      anova full         GALNT18  16.890806 4.951228e-12
#> 1843   1843      anova full         PLEKHG5  16.884209 4.990363e-12
#> 1844   1844      anova full           SSNA1  16.883981 4.991724e-12
#> 1845   1845      anova full            BMP7  16.881362 5.007354e-12
#> 1846   1846      anova full           RALYL  16.872667 5.059603e-12
#> 1847   1847      anova full         TMEM233  16.863312 5.116451e-12
#> 1848   1848      anova full            WDR7  16.856265 5.159704e-12
#> 1849   1849      anova full           USH1C  16.852653 5.182014e-12
#> 1850   1850      anova full         C3orf80  16.843340 5.240010e-12
#> 1851   1851      anova full           MAST4  16.839834 5.262015e-12
#> 1852   1852      anova full          TPRG1L  16.831882 5.312282e-12
#> 1853   1853      anova full            GRM3  16.829550 5.327115e-12
#> 1854   1854      anova full          ATP2B3  16.828551 5.333478e-12
#> 1855   1855      anova full         CACNA1E  16.828369 5.334640e-12
#> 1856   1856      anova full           CNPY3  16.825502 5.352959e-12
#> 1857   1857      anova full           SCRIB  16.825137 5.355297e-12
#> 1858   1858      anova full          FAM53B  16.821229 5.380391e-12
#> 1859   1859      anova full           DOC2B  16.807275 5.470961e-12
#> 1860   1860      anova full            SYT2  16.802850 5.500011e-12
#> 1861   1861      anova full         TMEM145  16.791728 5.573720e-12
#> 1862   1862      anova full           DDX24  16.791246 5.576938e-12
#> 1863   1863      anova full           KCNN3  16.781613 5.641639e-12
#> 1864   1864      anova full         TMEM38A  16.781155 5.644732e-12
#> 1865   1865      anova full             TNC  16.775029 5.686307e-12
#> 1866   1866      anova full            PSD3  16.763583 5.764822e-12
#> 1867   1867      anova full            GARS  16.757572 5.806498e-12
#> 1868   1868      anova full         SMARCC1  16.753626 5.834029e-12
#> 1869   1869      anova full          UBE2E2  16.747079 5.880001e-12
#> 1870   1870      anova full          MAP2K4  16.739377 5.934558e-12
#> 1871   1871      anova full           HLA-C  16.733907 5.973615e-12
#> 1872   1872      anova full           KIF5A  16.729052 6.008508e-12
#> 1873   1873      anova full      AP000345.2  16.725923 6.031106e-12
#> 1874   1874      anova full           NUPR1  16.716834 6.097245e-12
#> 1875   1875      anova full      CDKN2AIPNL  16.696559 6.247480e-12
#> 1876   1876      anova full          PLSCR4  16.695693 6.253982e-12
#> 1877   1877      anova full          SPTSSB  16.690875 6.290276e-12
#> 1878   1878      anova full           GNA12  16.687558 6.315390e-12
#> 1879   1879      anova full           LRFN5  16.686267 6.325189e-12
#> 1880   1880      anova full           KIF1B  16.682697 6.352382e-12
#> 1881   1881      anova full         FAM131A  16.675679 6.406178e-12
#> 1882   1882      anova full            CAV2  16.673173 6.425495e-12
#> 1883   1883      anova full         PIP4K2C  16.669648 6.452776e-12
#> 1884   1884      anova full            GAMT  16.663085 6.503894e-12
#> 1885   1885      anova full            LY6H  16.640587 6.682276e-12
#> 1886   1886      anova full           MCTP2  16.638243 6.701153e-12
#> 1887   1887      anova full           EIF3E  16.632717 6.745862e-12
#> 1888   1888      anova full          SLC1A3  16.587084 7.126973e-12
#> 1889   1889      anova full           NXPH4  16.579819 7.189662e-12
#> 1890   1890      anova full          SLC1A1  16.568229 7.290843e-12
#> 1891   1891      anova full           HADHB  16.550189 7.451245e-12
#> 1892   1892      anova full           ALCAM  16.545336 7.495013e-12
#> 1893   1893      anova full           IFI27  16.532987 7.607575e-12
#> 1894   1894      anova full            MSRA  16.525122 7.680177e-12
#> 1895   1895      anova full          NECAP2  16.524762 7.683514e-12
#> 1896   1896      anova full           CERS4  16.506032 7.859354e-12
#> 1897   1897      anova full             A2M  16.503969 7.878978e-12
#> 1898   1898      anova full            CBX6  16.502427 7.893674e-12
#> 1899   1899      anova full         PIP5K1C  16.502105 7.896747e-12
#> 1900   1900      anova full            ABI2  16.498477 7.931443e-12
#> 1901   1901      anova full            EPN2  16.497890 7.937082e-12
#> 1902   1902      anova full        RAP1GAP2  16.474094 8.168791e-12
#> 1903   1903      anova full            IL20  16.473035 8.179261e-12
#> 1904   1904      anova full          CCDC80  16.471311 8.196338e-12
#> 1905   1905      anova full           CPNE8  16.469183 8.217462e-12
#> 1906   1906      anova full      AC110491.1  16.455426 8.355416e-12
#> 1907   1907      anova full           PTGR1  16.451684 8.393353e-12
#> 1908   1908      anova full          SLC2A3  16.446892 8.442198e-12
#> 1909   1909      anova full            LRP4  16.437450 8.539274e-12
#> 1910   1910      anova full            RAC3  16.436480 8.549318e-12
#> 1911   1911      anova full          ENTPD3  16.432585 8.589749e-12
#> 1912   1912      anova full           PRAG1  16.428257 8.634904e-12
#> 1913   1913      anova full             PIP  16.422820 8.691981e-12
#> 1914   1914      anova full         SERINC3  16.420238 8.719218e-12
#> 1915   1915      anova full           LYPD8  16.417795 8.745064e-12
#> 1916   1916      anova full      AL133410.1  16.417420 8.749047e-12
#> 1917   1917      anova full            LRP2  16.414993 8.774816e-12
#> 1918   1918      anova full            CHP1  16.414547 8.779567e-12
#> 1919   1919      anova full             SHD  16.410654 8.821087e-12
#> 1920   1920      anova full           RSRP1  16.407353 8.856461e-12
#> 1921   1921      anova full           BLCAP  16.399016 8.946442e-12
#> 1922   1922      anova full            NPPA  16.396729 8.971293e-12
#> 1923   1923      anova full           PNISR  16.393334 9.008314e-12
#> 1924   1924      anova full            SDHA  16.388482 9.061487e-12
#> 1925   1925      anova full           DOC2A  16.377059 9.187955e-12
#> 1926   1926      anova full            SVOP  16.367358 9.296780e-12
#> 1927   1927      anova full          DPYSL3  16.356965 9.414845e-12
#> 1928   1928      anova full            DGKZ  16.354113 9.447507e-12
#> 1929   1929      anova full           MYH10  16.345842 9.542903e-12
#> 1930   1930      anova full         ARL6IP5  16.338476 9.628689e-12
#> 1931   1931      anova full          NIPAL4  16.320558 9.840696e-12
#> 1932   1932      anova full           CNIH2  16.318338 9.867302e-12
#> 1933   1933      anova full           SNX32  16.316995 9.883420e-12
#> 1934   1934      anova full              C3  16.311670 9.947632e-12
#> 1935   1935      anova full         SLC27A1  16.292770 1.017902e-11
#> 1936   1936      anova full           OBSL1  16.290934 1.020179e-11
#> 1937   1937      anova full         ST8SIA3  16.286035 1.026280e-11
#> 1938   1938      anova full           LLGL2  16.281017 1.032568e-11
#> 1939   1939      anova full            GBA2  16.279703 1.034222e-11
#> 1940   1940      anova full          NDUFV1  16.278774 1.035392e-11
#> 1941   1941      anova full           NTNG1  16.275528 1.039493e-11
#> 1942   1942      anova full            CD83  16.275360 1.039705e-11
#> 1943   1943      anova full         NKIRAS1  16.267057 1.050272e-11
#> 1944   1944      anova full           CADM4  16.265019 1.052882e-11
#> 1945   1945      anova full          DICER1  16.264304 1.053799e-11
#> 1946   1946      anova full         RARRES3  16.255790 1.064787e-11
#> 1947   1947      anova full        DLX6-AS1  16.243029 1.081476e-11
#> 1948   1948      anova full          ZNF652  16.235223 1.091817e-11
#> 1949   1949      anova full           MRPL1  16.232627 1.095278e-11
#> 1950   1950      anova full            EML3  16.220813 1.111174e-11
#> 1951   1951      anova full           CHRM1  16.209793 1.126215e-11
#> 1952   1952      anova full      AL359924.1  16.208442 1.128074e-11
#> 1953   1953      anova full          CDK5R2  16.206964 1.130111e-11
#> 1954   1954      anova full          SLC7A2  16.205857 1.131639e-11
#> 1955   1955      anova full           KAT2B  16.195077 1.146628e-11
#> 1956   1956      anova full           AAMDC  16.191050 1.152279e-11
#> 1957   1957      anova full          TSPYL4  16.186878 1.158165e-11
#> 1958   1958      anova full            ATL3  16.167993 1.185195e-11
#> 1959   1959      anova full           HLA-E  16.160228 1.196496e-11
#> 1960   1960      anova full           PTPRD  16.159345 1.197788e-11
#> 1961   1961      anova full         PPFIBP2  16.149204 1.212730e-11
#> 1962   1962      anova full         NDUFAB1  16.144145 1.220256e-11
#> 1963   1963      anova full          GLB1L3  16.136412 1.231853e-11
#> 1964   1964      anova full            LMO3  16.128363 1.244044e-11
#> 1965   1965      anova full           KCND3  16.128236 1.244238e-11
#> 1966   1966      anova full         COL18A1  16.120778 1.255645e-11
#> 1967   1967      anova full      AC068490.1  16.103761 1.282078e-11
#> 1968   1968      anova full          OGFRL1  16.102657 1.283814e-11
#> 1969   1969      anova full          TCEAL4  16.100102 1.287837e-11
#> 1970   1970      anova full      AC120042.3  16.098065 1.291054e-11
#> 1971   1971      anova full          KCNIP3  16.096038 1.294264e-11
#> 1972   1972      anova full           KCNQ3  16.095002 1.295907e-11
#> 1973   1973      anova full           ITGA2  16.090274 1.303436e-11
#> 1974   1974      anova full            IARS  16.088900 1.305632e-11
#> 1975   1975      anova full            SMPX  16.087827 1.307349e-11
#> 1976   1976      anova full          NEURL1  16.083942 1.313588e-11
#> 1977   1977      anova full            COBL  16.083017 1.315076e-11
#> 1978   1978      anova full          MAPRE1  16.071957 1.333025e-11
#> 1979   1979      anova full           INSM2  16.070947 1.334677e-11
#> 1980   1980      anova full        SLC25A25  16.070765 1.334974e-11
#> 1981   1981      anova full            LRP3  16.068189 1.339198e-11
#> 1982   1982      anova full           CCND2  16.066373 1.342182e-11
#> 1983   1983      anova full           HSPB3  16.052074 1.365928e-11
#> 1984   1984      anova full           LRRC2  16.051009 1.367713e-11
#> 1985   1985      anova full           VEZF1  16.036541 1.392212e-11
#> 1986   1986      anova full           SSFA2  16.032386 1.399329e-11
#> 1987   1987      anova full            SNX5  16.025195 1.411738e-11
#> 1988   1988      anova full            ARF3  16.024875 1.412293e-11
#> 1989   1989      anova full          PNMA8C  16.023640 1.414437e-11
#> 1990   1990      anova full           KCNH5  16.022955 1.415626e-11
#> 1991   1991      anova full          MAGEE1  16.021935 1.417401e-11
#> 1992   1992      anova full           RCAN3  16.016352 1.427153e-11
#> 1993   1993      anova full            PRNP  16.001613 1.453229e-11
#> 1994   1994      anova full         GALNT15  15.997312 1.460930e-11
#> 1995   1995      anova full         GPIHBP1  15.987840 1.478038e-11
#> 1996   1996      anova full           CKS1B  15.976226 1.499297e-11
#> 1997   1997      anova full        ANKRD34C  15.970911 1.509130e-11
#> 1998   1998      anova full            FLNB  15.969765 1.511258e-11
#> 1999   1999      anova full          SQSTM1  15.967757 1.514996e-11
#> 2000   2000      anova full         RETREG2  15.963122 1.523659e-11
#> 2001   2001      anova full         SERINC1  15.950250 1.547988e-11
#> 2002   2002      anova full        ARHGEF25  15.947812 1.552641e-11
#> 2003   2003      anova full          DNAJB6  15.941523 1.564708e-11
#> 2004   2004      anova full           P4HA1  15.940609 1.566469e-11
#> 2005   2005      anova full           HACD2  15.935982 1.575421e-11
#> 2006   2006      anova full          CHRNA2  15.934068 1.579138e-11
#> 2007   2007      anova full           RAB2A  15.926187 1.594541e-11
#> 2008   2008      anova full           SUSD3  15.925576 1.595742e-11
#> 2009   2009      anova full           ADCY1  15.923453 1.599921e-11
#> 2010   2010      anova full           TENM2  15.920845 1.605071e-11
#> 2011   2011      anova full           GFRA2  15.919942 1.606857e-11
#> 2012   2012      anova full          PKD2L1  15.904039 1.638662e-11
#> 2013   2013      anova full           RAB15  15.900518 1.645792e-11
#> 2014   2014      anova full           VLDLR  15.894084 1.658900e-11
#> 2015   2015      anova full          LONRF2  15.893011 1.661096e-11
#> 2016   2016      anova full             APP  15.892169 1.662823e-11
#> 2017   2017      anova full        HSD11B1L  15.890777 1.665679e-11
#> 2018   2018      anova full           DCTN2  15.880516 1.686896e-11
#> 2019   2019      anova full          CAMK2B  15.874554 1.699352e-11
#> 2020   2020      anova full           CDR2L  15.872753 1.703132e-11
#> 2021   2021      anova full        TMEM191B  15.872465 1.703739e-11
#> 2022   2022      anova full           KCNQ2  15.863565 1.722557e-11
#> 2023   2023      anova full            JCAD  15.863528 1.722635e-11
#> 2024   2024      anova full           CHTOP  15.856745 1.737121e-11
#> 2025   2025      anova full          CYBRD1  15.855653 1.739467e-11
#> 2026   2026      anova full           DCTN3  15.840813 1.771643e-11
#> 2027   2027      anova full           NAT8L  15.839494 1.774531e-11
#> 2028   2028      anova full           CYTH2  15.834261 1.786043e-11
#> 2029   2029      anova full           ADIRF  15.826899 1.802366e-11
#> 2030   2030      anova full          MARCH1  15.821793 1.813778e-11
#> 2031   2031      anova full           AP1S2  15.814081 1.831153e-11
#> 2032   2032      anova full        CDC42SE2  15.807706 1.845648e-11
#> 2033   2033      anova full            SYT7  15.795594 1.873507e-11
#> 2034   2034      anova full          ATP1B3  15.776133 1.919182e-11
#> 2035   2035      anova full           TCAF1  15.773157 1.926267e-11
#> 2036   2036      anova full          SEC23A  15.767715 1.939291e-11
#> 2037   2037      anova full          KLHL32  15.766481 1.942258e-11
#> 2038   2038      anova full         TCERG1L  15.764465 1.947112e-11
#> 2039   2039      anova full            RTN2  15.761372 1.954587e-11
#> 2040   2040      anova full            KDSR  15.761181 1.955050e-11
#> 2041   2041      anova full          RNF187  15.757136 1.964871e-11
#> 2042   2042      anova full          CYP2J2  15.754626 1.970990e-11
#> 2043   2043      anova full      AC105999.2  15.748593 1.985778e-11
#> 2044   2044      anova full           TCEA1  15.745273 1.993966e-11
#> 2045   2045      anova full           SMAD3  15.736344 2.016159e-11
#> 2046   2046      anova full          ZNF184  15.736070 2.016843e-11
#> 2047   2047      anova full             KIT  15.731221 2.029006e-11
#> 2048   2048      anova full          PHLPP1  15.720558 2.056014e-11
#> 2049   2049      anova full            RBPJ  15.710043 2.083011e-11
#> 2050   2050      anova full            LRP1  15.705500 2.094786e-11
#> 2051   2051      anova full           CLDN5  15.694536 2.123489e-11
#> 2052   2052      anova full           NTRK2  15.693747 2.125571e-11
#> 2053   2053      anova full        SLC25A23  15.692117 2.129876e-11
#> 2054   2054      anova full           WSCD1  15.684289 2.150680e-11
#> 2055   2055      anova full         RAPGEF3  15.680316 2.161319e-11
#> 2056   2056      anova full             FAU  15.670969 2.186560e-11
#> 2057   2057      anova full         DYNLRB1  15.670147 2.188796e-11
#> 2058   2058      anova full           PLCH1  15.670064 2.189022e-11
#> 2059   2059      anova full          CACYBP  15.669462 2.190659e-11
#> 2060   2060      anova full          PCDH10  15.664509 2.204183e-11
#> 2061   2061      anova full             NDP  15.659505 2.217935e-11
#> 2062   2062      anova full          ACVR1C  15.655188 2.229868e-11
#> 2063   2063      anova full           RAB3B  15.650279 2.243520e-11
#> 2064   2064      anova full           UBA52  15.649427 2.245896e-11
#> 2065   2065      anova full           RPS29  15.632336 2.294149e-11
#> 2066   2066      anova full            NWD2  15.629225 2.303043e-11
#> 2067   2067      anova full         ST3GAL3  15.619316 2.331619e-11
#> 2068   2068      anova full           ARNTL  15.606671 2.368611e-11
#> 2069   2069      anova full         SLC44A2  15.603603 2.377678e-11
#> 2070   2070      anova full            BTG2  15.598813 2.391905e-11
#> 2071   2071      anova full          SPHKAP  15.593250 2.408535e-11
#> 2072   2072      anova full           CYTH1  15.589891 2.418636e-11
#> 2073   2073      anova full          LRRTM4  15.586345 2.429347e-11
#> 2074   2074      anova full          CYB5R2  15.585202 2.432807e-11
#> 2075   2075      anova full            GLS2  15.576443 2.459509e-11
#> 2076   2076      anova full           POLE4  15.571726 2.474014e-11
#> 2077   2077      anova full         PLEKHB2  15.567428 2.487304e-11
#> 2078   2078      anova full             SST  15.566325 2.490727e-11
#> 2079   2079      anova full           TRNP1  15.561087 2.507049e-11
#> 2080   2080      anova full            GCLC  15.558490 2.515184e-11
#> 2081   2081      anova full          KCTD12  15.556457 2.521567e-11
#> 2082   2082      anova full        C1orf122  15.556119 2.522630e-11
#> 2083   2083      anova full             PPL  15.545942 2.554863e-11
#> 2084   2084      anova full            NDNF  15.544803 2.558494e-11
#> 2085   2085      anova full         SLC17A6  15.542950 2.564418e-11
#> 2086   2086      anova full            PLK2  15.524981 2.622584e-11
#> 2087   2087      anova full            SEZ6  15.514463 2.657261e-11
#> 2088   2088      anova full          AHCYL1  15.511901 2.665779e-11
#> 2089   2089      anova full          ACTR3B  15.504351 2.691041e-11
#> 2090   2090      anova full             RHO  15.502236 2.698162e-11
#> 2091   2091      anova full      AC245297.3  15.499329 2.707982e-11
#> 2092   2092      anova full           CELF2  15.495928 2.719516e-11
#> 2093   2093      anova full          MAN1A2  15.491803 2.733573e-11
#> 2094   2094      anova full            SLU7  15.491101 2.735971e-11
#> 2095   2095      anova full        C12orf29  15.485409 2.755511e-11
#> 2096   2096      anova full           DEGS2  15.485398 2.755547e-11
#> 2097   2097      anova full          RANBP9  15.483279 2.762858e-11
#> 2098   2098      anova full           CHIC1  15.483266 2.762904e-11
#> 2099   2099      anova full           NOVA1  15.480600 2.772128e-11
#> 2100   2100      anova full           MCCD1  15.471787 2.802853e-11
#> 2101   2101      anova full       LINC01331  15.466993 2.819713e-11
#> 2102   2102      anova full          NDUFA8  15.466094 2.822886e-11
#> 2103   2103      anova full          HNRNPU  15.460846 2.841482e-11
#> 2104   2104      anova full          COPS7A  15.460519 2.842645e-11
#> 2105   2105      anova full            GCSH  15.450276 2.879321e-11
#> 2106   2106      anova full           TIMP2  15.445578 2.896302e-11
#> 2107   2107      anova full           EFR3A  15.444524 2.900128e-11
#> 2108   2108      anova full          LAPTM5  15.443163 2.905073e-11
#> 2109   2109      anova full         SEC14L5  15.442401 2.907847e-11
#> 2110   2110      anova full           CPNE2  15.432296 2.944876e-11
#> 2111   2111      anova full        ATP6V0A1  15.429457 2.955368e-11
#> 2112   2112      anova full           ABTB1  15.421047 2.986672e-11
#> 2113   2113      anova full        MAP1LC3A  15.417252 3.000907e-11
#> 2114   2114      anova full            NAPG  15.406632 3.041120e-11
#> 2115   2115      anova full           VDAC2  15.384317 3.127427e-11
#> 2116   2116      anova full           HHATL  15.361761 3.217223e-11
#> 2117   2117      anova full           MXRA7  15.354955 3.244836e-11
#> 2118   2118      anova full            MAVS  15.344410 3.288096e-11
#> 2119   2119      anova full         PIK3C2B  15.335872 3.323560e-11
#> 2120   2120      anova full           FBLN7  15.335850 3.323652e-11
#> 2121   2121      anova full          UBQLN2  15.319298 3.393525e-11
#> 2122   2122      anova full         ATP5F1D  15.317534 3.401061e-11
#> 2123   2123      anova full           FGF14  15.317488 3.401256e-11
#> 2124   2124      anova full             CPE  15.315780 3.408571e-11
#> 2125   2125      anova full         TPD52L1  15.312688 3.421849e-11
#> 2126   2126      anova full           ACTN1  15.307779 3.443043e-11
#> 2127   2127      anova full           FEM1B  15.299513 3.479033e-11
#> 2128   2128      anova full            LGI4  15.299372 3.479647e-11
#> 2129   2129      anova full            DSEL  15.297232 3.489028e-11
#> 2130   2130      anova full          CACNB3  15.293750 3.504351e-11
#> 2131   2131      anova full          PAPSS1  15.285920 3.539054e-11
#> 2132   2132      anova full            HES1  15.282452 3.554539e-11
#> 2133   2133      anova full            CUL2  15.280013 3.565470e-11
#> 2134   2134      anova full          DLGAP2  15.274866 3.588654e-11
#> 2135   2135      anova full          AKR1B1  15.257251 3.669166e-11
#> 2136   2136      anova full         GALNT11  15.243745 3.732154e-11
#> 2137   2137      anova full         TP53BP2  15.237822 3.760129e-11
#> 2138   2138      anova full          IQSEC1  15.233706 3.779693e-11
#> 2139   2139      anova full           ISLR2  15.222674 3.832647e-11
#> 2140   2140      anova full          ARRDC2  15.197790 3.954919e-11
#> 2141   2141      anova full            GMFB  15.197279 3.957470e-11
#> 2142   2142      anova full          IL11RA  15.191567 3.986114e-11
#> 2143   2143      anova full            CHD7  15.190244 3.992779e-11
#> 2144   2144      anova full           TIAM1  15.179832 4.045639e-11
#> 2145   2145      anova full           ISCA1  15.173431 4.078488e-11
#> 2146   2146      anova full           YIF1A  15.169282 4.099930e-11
#> 2147   2147      anova full          NDUFA7  15.165127 4.121512e-11
#> 2148   2148      anova full           TNIP3  15.163411 4.130465e-11
#> 2149   2149      anova full            MRAS  15.148050 4.211466e-11
#> 2150   2150      anova full        ARHGAP23  15.141902 4.244343e-11
#> 2151   2151      anova full          PRKACB  15.124440 4.339167e-11
#> 2152   2152      anova full        SLC25A33  15.122355 4.350633e-11
#> 2153   2153      anova full            RPL7  15.108692 4.426545e-11
#> 2154   2154      anova full           GRASP  15.106491 4.438899e-11
#> 2155   2155      anova full          SEMA6B  15.103167 4.457630e-11
#> 2156   2156      anova full           TYRO3  15.102789 4.459761e-11
#> 2157   2157      anova full          NDUFB5  15.101873 4.464942e-11
#> 2158   2158      anova full          NT5DC3  15.097790 4.488093e-11
#> 2159   2159      anova full             LBH  15.087200 4.548724e-11
#> 2160   2160      anova full            MDM2  15.083302 4.571249e-11
#> 2161   2161      anova full           TRPS1  15.074337 4.623495e-11
#> 2162   2162      anova full        TRAPPC6B  15.073046 4.631072e-11
#> 2163   2163      anova full        EIF4EBP1  15.070982 4.643208e-11
#> 2164   2164      anova full            SNX3  15.064230 4.683135e-11
#> 2165   2165      anova full           SIRPA  15.054786 4.739577e-11
#> 2166   2166      anova full            CLN8  15.053088 4.749799e-11
#> 2167   2167      anova full           CDH13  15.049972 4.768612e-11
#> 2168   2168      anova full          ENOSF1  15.039667 4.831392e-11
#> 2169   2169      anova full          ATP8A2  15.037479 4.844830e-11
#> 2170   2170      anova full          COX7A2  15.036583 4.850343e-11
#> 2171   2171      anova full         KHDRBS3  15.036362 4.851706e-11
#> 2172   2172      anova full         PPP1R1B  15.024582 4.924817e-11
#> 2173   2173      anova full           P2RX6  15.017284 4.970686e-11
#> 2174   2174      anova full           HECW1  15.011675 5.006229e-11
#> 2175   2175      anova full          IGSF21  15.011545 5.007059e-11
#> 2176   2176      anova full            LIFR  14.992551 5.129408e-11
#> 2177   2177      anova full          GRIN3A  14.991636 5.135379e-11
#> 2178   2178      anova full          DPYSL5  14.989814 5.147293e-11
#> 2179   2179      anova full            RBMX  14.985710 5.174219e-11
#> 2180   2180      anova full        METTL21C  14.982764 5.193647e-11
#> 2181   2181      anova full          SCCPDH  14.975550 5.241524e-11
#> 2182   2182      anova full           MED10  14.971667 5.267483e-11
#> 2183   2183      anova full          ATP5PF  14.963803 5.320454e-11
#> 2184   2184      anova full         HTATIP2  14.956340 5.371240e-11
#> 2185   2185      anova full             STS  14.955348 5.378027e-11
#> 2186   2186      anova full            SOX2  14.954585 5.383248e-11
#> 2187   2187      anova full          HOMER3  14.951917 5.401568e-11
#> 2188   2188      anova full           PRRX1  14.947942 5.428977e-11
#> 2189   2189      anova full            RPS5  14.941682 5.472430e-11
#> 2190   2190      anova full           GSK3A  14.935163 5.518057e-11
#> 2191   2191      anova full          PTGFRN  14.932920 5.533849e-11
#> 2192   2192      anova full      AC239585.2  14.921842 5.612524e-11
#> 2193   2193      anova full       NR2F1-AS1  14.920841 5.619687e-11
#> 2194   2194      anova full            STAR  14.920304 5.623533e-11
#> 2195   2195      anova full          ADGRL1  14.912822 5.677426e-11
#> 2196   2196      anova full         ARL6IP6  14.911525 5.686823e-11
#> 2197   2197      anova full            MSX2  14.909606 5.700751e-11
#> 2198   2198      anova full           TTYH1  14.908671 5.707557e-11
#> 2199   2199      anova full            EHD2  14.905493 5.730734e-11
#> 2200   2200      anova full           SLIT2  14.903359 5.746345e-11
#> 2201   2201      anova full           USP22  14.892830 5.824042e-11
#> 2202   2202      anova full         SLCO2A1  14.880405 5.917121e-11
#> 2203   2203      anova full            RIF1  14.875942 5.950921e-11
#> 2204   2204      anova full            LSM4  14.873414 5.970163e-11
#> 2205   2205      anova full           RAB31  14.867521 6.015248e-11
#> 2206   2206      anova full          LRRC58  14.852411 6.132467e-11
#> 2207   2207      anova full         SLC16A1  14.851459 6.139924e-11
#> 2208   2208      anova full           NEGR1  14.848000 6.167125e-11
#> 2209   2209      anova full           TM2D3  14.843540 6.202368e-11
#> 2210   2210      anova full         ARHGEF4  14.838756 6.240410e-11
#> 2211   2211      anova full           CDK17  14.838660 6.241174e-11
#> 2212   2212      anova full            RPL8  14.823191 6.365841e-11
#> 2213   2213      anova full            HBP1  14.808393 6.487485e-11
#> 2214   2214      anova full          TUBB4A  14.802536 6.536290e-11
#> 2215   2215      anova full          FRMPD4  14.791333 6.630691e-11
#> 2216   2216      anova full           KCMF1  14.784646 6.687713e-11
#> 2217   2217      anova full           IDH3A  14.783381 6.698552e-11
#> 2218   2218      anova full           CPLX3  14.781823 6.711933e-11
#> 2219   2219      anova full          ERICH3  14.775703 6.764750e-11
#> 2220   2220      anova full         KIRREL3  14.760579 6.897118e-11
#> 2221   2221      anova full           CRTC3  14.755065 6.946035e-11
#> 2222   2222      anova full            CNBP  14.752824 6.966016e-11
#> 2223   2223      anova full            CSF1  14.750287 6.988712e-11
#> 2224   2224      anova full       RAB11FIP5  14.748577 7.004054e-11
#> 2225   2225      anova full          SCAMP5  14.726368 7.206440e-11
#> 2226   2226      anova full      AC093503.2  14.723259 7.235247e-11
#> 2227   2227      anova full          PRPF19  14.722936 7.238244e-11
#> 2228   2228      anova full         COL26A1  14.712869 7.332378e-11
#> 2229   2229      anova full         SNRNP25  14.705745 7.399746e-11
#> 2230   2230      anova full           FARSB  14.703083 7.425083e-11
#> 2231   2231      anova full       SMIM10L2B  14.699735 7.457081e-11
#> 2232   2232      anova full           ALDH2  14.697695 7.476641e-11
#> 2233   2233      anova full           HMCES  14.695674 7.496077e-11
#> 2234   2234      anova full         PPP2R2B  14.690613 7.544976e-11
#> 2235   2235      anova full           CRIP2  14.688883 7.561761e-11
#> 2236   2236      anova full         TMEM158  14.686842 7.581618e-11
#> 2237   2237      anova full           FGFR3  14.686391 7.586014e-11
#> 2238   2238      anova full          RPS27A  14.682392 7.625097e-11
#> 2239   2239      anova full         MSC-AS1  14.675486 7.693069e-11
#> 2240   2240      anova full          RPL18A  14.670143 7.746090e-11
#> 2241   2241      anova full          USP27X  14.662877 7.818806e-11
#> 2242   2242      anova full            RPL3  14.658919 7.858702e-11
#> 2243   2243      anova full           POC1B  14.651199 7.937130e-11
#> 2244   2244      anova full          LARGE1  14.643191 8.019329e-11
#> 2245   2245      anova full            CCM2  14.621622 8.245119e-11
#> 2246   2246      anova full           DOCK1  14.618457 8.278791e-11
#> 2247   2247      anova full           FBLN1  14.605677 8.416217e-11
#> 2248   2248      anova full           SNU13  14.598854 8.490541e-11
#> 2249   2249      anova full            BUB3  14.598331 8.496267e-11
#> 2250   2250      anova full         RNASET2  14.597564 8.504669e-11
#> 2251   2251      anova full          FKBP1B  14.593848 8.545508e-11
#> 2252   2252      anova full           FADS2  14.576772 8.735749e-11
#> 2253   2253      anova full          SEC16B  14.576445 8.739439e-11
#> 2254   2254      anova full          MBOAT7  14.575512 8.749956e-11
#> 2255   2255      anova full            APOO  14.574630 8.759919e-11
#> 2256   2256      anova full           OR4D1  14.573435 8.773436e-11
#> 2257   2257      anova full            SLF2  14.569431 8.818863e-11
#> 2258   2258      anova full           IL6ST  14.568506 8.829395e-11
#> 2259   2259      anova full          SNHG25  14.564570 8.874346e-11
#> 2260   2260      anova full           RFTN1  14.562972 8.892666e-11
#> 2261   2261      anova full           REEP5  14.553608 9.000787e-11
#> 2262   2262      anova full           KCNT1  14.552505 9.013616e-11
#> 2263   2263      anova full           LMTK3  14.548811 9.056705e-11
#> 2264   2264      anova full         TMEM198  14.547237 9.075123e-11
#> 2265   2265      anova full          DNAJA2  14.541443 9.143280e-11
#> 2266   2266      anova full           MED31  14.530659 9.271524e-11
#> 2267   2267      anova full         SLC38A1  14.527960 9.303910e-11
#> 2268   2268      anova full          RIIAD1  14.527743 9.306512e-11
#> 2269   2269      anova full           PEX5L  14.525700 9.331120e-11
#> 2270   2270      anova full            EGR4  14.524940 9.340287e-11
#> 2271   2271      anova full          PFKFB3  14.523490 9.357798e-11
#> 2272   2272      anova full            PIGN  14.523020 9.363483e-11
#> 2273   2273      anova full           GAPDH  14.518126 9.422898e-11
#> 2274   2274      anova full           SMC1A  14.515759 9.451764e-11
#> 2275   2275      anova full            PJA1  14.512561 9.490922e-11
#> 2276   2276      anova full           PHF24  14.503282 9.605464e-11
#> 2277   2277      anova full            OPA1  14.500676 9.637886e-11
#> 2278   2278      anova full           AFMID  14.500037 9.645855e-11
#> 2279   2279      anova full            TNS3  14.497439 9.678320e-11
#> 2280   2280      anova full            KRT5  14.497169 9.681704e-11
#> 2281   2281      anova full            CDK6  14.493363 9.729476e-11
#> 2282   2282      anova full          HSPA4L  14.490691 9.763171e-11
#> 2283   2283      anova full            BDH1  14.488606 9.789544e-11
#> 2284   2284      anova full          ZC3H13  14.478472 9.918752e-11
#> 2285   2285      anova full            ABAT  14.478392 9.919788e-11
#> 2286   2286      anova full           TANC1  14.475200 9.960852e-11
#> 2287   2287      anova full           SCN8A  14.471957 1.000275e-10
#> 2288   2288      anova full            HECA  14.436099 1.047831e-10
#> 2289   2289      anova full          SMURF1  14.433958 1.050743e-10
#> 2290   2290      anova full          SLC6A8  14.427494 1.059585e-10
#> 2291   2291      anova full           IPO13  14.419234 1.070995e-10
#> 2292   2292      anova full          MAN2A1  14.418418 1.072129e-10
#> 2293   2293      anova full            CA14  14.416910 1.074227e-10
#> 2294   2294      anova full          CAMKK1  14.391742 1.109888e-10
#> 2295   2295      anova full        HIST1H1C  14.371405 1.139591e-10
#> 2296   2296      anova full        EBNA1BP2  14.369749 1.142044e-10
#> 2297   2297      anova full         SLC45A4  14.368163 1.144400e-10
#> 2298   2298      anova full           GINM1  14.366192 1.147334e-10
#> 2299   2299      anova full           CLIP3  14.365284 1.148689e-10
#> 2300   2300      anova full           CCNE2  14.364413 1.149990e-10
#> 2301   2301      anova full            TOX2  14.362870 1.152298e-10
#> 2302   2302      anova full          RNF165  14.361838 1.153844e-10
#> 2303   2303      anova full           MTUS2  14.356794 1.161432e-10
#> 2304   2304      anova full            FIG4  14.354179 1.165387e-10
#> 2305   2305      anova full        KIAA0513  14.347727 1.175203e-10
#> 2306   2306      anova full         CCDC106  14.345542 1.178547e-10
#> 2307   2307      anova full           UBXN4  14.342134 1.183781e-10
#> 2308   2308      anova full            KLF3  14.339489 1.187859e-10
#> 2309   2309      anova full            NAIP  14.334291 1.195917e-10
#> 2310   2310      anova full         SLC2A13  14.309157 1.235678e-10
#> 2311   2311      anova full      AL121749.1  14.307858 1.237770e-10
#> 2312   2312      anova full          COL3A1  14.306136 1.240549e-10
#> 2313   2313      anova full         PPP2R2C  14.304066 1.243897e-10
#> 2314   2314      anova full           ABCG4  14.299434 1.251422e-10
#> 2315   2315      anova full          CACNG2  14.291317 1.264723e-10
#> 2316   2316      anova full          RALGDS  14.288600 1.269207e-10
#> 2317   2317      anova full         JAKMIP1  14.287143 1.271620e-10
#> 2318   2318      anova full            NRG4  14.265328 1.308295e-10
#> 2319   2319      anova full            FUT8  14.263642 1.311174e-10
#> 2320   2320      anova full          SEMA5B  14.261528 1.314793e-10
#> 2321   2321      anova full           CAMK1  14.252465 1.330427e-10
#> 2322   2322      anova full           DCLK3  14.237081 1.357403e-10
#> 2323   2323      anova full            NQO2  14.237050 1.357458e-10
#> 2324   2324      anova full          ZYG11B  14.236869 1.357780e-10
#> 2325   2325      anova full        SLC22A15  14.235435 1.360323e-10
#> 2326   2326      anova full           SYNE3  14.230497 1.369119e-10
#> 2327   2327      anova full          LRRC8D  14.227731 1.374072e-10
#> 2328   2328      anova full           AGAP2  14.222705 1.383120e-10
#> 2329   2329      anova full            MAP2  14.218753 1.390276e-10
#> 2330   2330      anova full          MYL12A  14.217940 1.391754e-10
#> 2331   2331      anova full             LSS  14.216198 1.394923e-10
#> 2332   2332      anova full          PRIMA1  14.214175 1.398615e-10
#> 2333   2333      anova full            PCNA  14.209939 1.406374e-10
#> 2334   2334      anova full           PSMC3  14.209544 1.407101e-10
#> 2335   2335      anova full           ACTA2  14.182965 1.456842e-10
#> 2336   2336      anova full             ID2  14.179745 1.462990e-10
#> 2337   2337      anova full      AL078639.1  14.179273 1.463894e-10
#> 2338   2338      anova full           PARP4  14.178176 1.465996e-10
#> 2339   2339      anova full          ANKIB1  14.175424 1.471282e-10
#> 2340   2340      anova full            TOB2  14.172610 1.476707e-10
#> 2341   2341      anova full            MATK  14.168627 1.484422e-10
#> 2342   2342      anova full           PWAR6  14.167282 1.487037e-10
#> 2343   2343      anova full         TIMM17A  14.167202 1.487192e-10
#> 2344   2344      anova full            CDH6  14.157445 1.506303e-10
#> 2345   2345      anova full        ARHGAP10  14.156898 1.507381e-10
#> 2346   2346      anova full           FNDC9  14.156356 1.508451e-10
#> 2347   2347      anova full         HSD11B1  14.141170 1.538742e-10
#> 2348   2348      anova full           PRAP1  14.139584 1.541942e-10
#> 2349   2349      anova full           EPHX4  14.131794 1.557755e-10
#> 2350   2350      anova full             NTM  14.124476 1.572762e-10
#> 2351   2351      anova full            RALY  14.124311 1.573102e-10
#> 2352   2352      anova full          CALML5  14.118140 1.585876e-10
#> 2353   2353      anova full         GALNT10  14.116689 1.588896e-10
#> 2354   2354      anova full         RAPGEF2  14.104709 1.614047e-10
#> 2355   2355      anova full        PPARGC1A  14.098131 1.628030e-10
#> 2356   2356      anova full            AACS  14.092734 1.639597e-10
#> 2357   2357      anova full            CTSV  14.091111 1.643090e-10
#> 2358   2358      anova full          MRPL21  14.090263 1.644920e-10
#> 2359   2359      anova full         GALNT17  14.086801 1.652408e-10
#> 2360   2360      anova full           DCTN1  14.083466 1.659656e-10
#> 2361   2361      anova full          CRELD1  14.082191 1.662434e-10
#> 2362   2362      anova full            DLK2  14.076481 1.674940e-10
#> 2363   2363      anova full          MUM1L1  14.070664 1.687777e-10
#> 2364   2364      anova full      AC027031.2  14.066871 1.696203e-10
#> 2365   2365      anova full           AIFM3  14.064396 1.701725e-10
#> 2366   2366      anova full            DNM3  14.050739 1.732526e-10
#> 2367   2367      anova full           HBEGF  14.050614 1.732811e-10
#> 2368   2368      anova full            SV2C  14.046298 1.742664e-10
#> 2369   2369      anova full            PFKL  14.045705 1.744022e-10
#> 2370   2370      anova full            ELF1  14.043104 1.749995e-10
#> 2371   2371      anova full           LMAN1  14.042932 1.750390e-10
#> 2372   2372      anova full          MED12L  14.016624 1.811990e-10
#> 2373   2373      anova full          ACTL6A  14.010853 1.825799e-10
#> 2374   2374      anova full            SS18  14.006021 1.837444e-10
#> 2375   2375      anova full           SULF2  14.005265 1.839273e-10
#> 2376   2376      anova full           PXDC1  14.004472 1.841193e-10
#> 2377   2377      anova full          PDLIM3  13.998161 1.856548e-10
#> 2378   2378      anova full           WDFY2  13.990403 1.875606e-10
#> 2379   2379      anova full         SMARCD3  13.970309 1.925906e-10
#> 2380   2380      anova full           SIPA1  13.970245 1.926066e-10
#> 2381   2381      anova full           ZMAT2  13.969213 1.928688e-10
#> 2382   2382      anova full           AP3S1  13.968223 1.931205e-10
#> 2383   2383      anova full        RAPGEFL1  13.967308 1.933535e-10
#> 2384   2384      anova full            FAT3  13.958101 1.957139e-10
#> 2385   2385      anova full           STK24  13.951325 1.974697e-10
#> 2386   2386      anova full            GCC2  13.951152 1.975148e-10
#> 2387   2387      anova full           SMAP1  13.949442 1.979607e-10
#> 2388   2388      anova full       LINC01411  13.945323 1.990387e-10
#> 2389   2389      anova full           SRPK2  13.944570 1.992364e-10
#> 2390   2390      anova full            THRB  13.944008 1.993841e-10
#> 2391   2391      anova full           CSE1L  13.940289 2.003643e-10
#> 2392   2392      anova full            COA4  13.939197 2.006533e-10
#> 2393   2393      anova full            BDH2  13.933338 2.022100e-10
#> 2394   2394      anova full         DYNC1H1  13.926463 2.040524e-10
#> 2395   2395      anova full            BHMT  13.922343 2.051651e-10
#> 2396   2396      anova full        TMEM176A  13.920266 2.057281e-10
#> 2397   2397      anova full          PDGFRA  13.919568 2.059176e-10
#> 2398   2398      anova full           WIPI2  13.913681 2.075240e-10
#> 2399   2399      anova full          NUP188  13.902093 2.107238e-10
#> 2400   2400      anova full            CANX  13.897483 2.120108e-10
#> 2401   2401      anova full           CNTN1  13.894529 2.128398e-10
#> 2402   2402      anova full          DPYSL2  13.894204 2.129312e-10
#> 2403   2403      anova full          SEMA6D  13.890942 2.138508e-10
#> 2404   2404      anova full           CENPB  13.889801 2.141733e-10
#> 2405   2405      anova full            CFC1  13.886231 2.151859e-10
#> 2406   2406      anova full            HARS  13.882710 2.161895e-10
#> 2407   2407      anova full            MRC2  13.874583 2.185244e-10
#> 2408   2408      anova full        C1orf216  13.867742 2.205097e-10
#> 2409   2409      anova full           MAP1A  13.865988 2.210220e-10
#> 2410   2410      anova full           GUCD1  13.864951 2.213252e-10
#> 2411   2411      anova full          IFI44L  13.864899 2.213405e-10
#> 2412   2412      anova full           HTR2C  13.857009 2.236623e-10
#> 2413   2413      anova full             NOV  13.856097 2.239323e-10
#> 2414   2414      anova full            PLEC  13.845388 2.271278e-10
#> 2415   2415      anova full            MDH2  13.842669 2.279463e-10
#> 2416   2416      anova full          CITED1  13.842199 2.280881e-10
#> 2417   2417      anova full          SRGAP3  13.841727 2.282308e-10
#> 2418   2418      anova full            MEPE  13.838909 2.290835e-10
#> 2419   2419      anova full     C3orf67-AS1  13.836699 2.297547e-10
#> 2420   2420      anova full           PLBD2  13.816596 2.359530e-10
#> 2421   2421      anova full         C9orf24  13.816023 2.361323e-10
#> 2422   2422      anova full        TMEM132B  13.808806 2.384010e-10
#> 2423   2423      anova full          SPTSSA  13.797630 2.419582e-10
#> 2424   2424      anova full           LMCD1  13.795817 2.425406e-10
#> 2425   2425      anova full         WFDC10A  13.793175 2.433915e-10
#> 2426   2426      anova full            ST13  13.792344 2.436599e-10
#> 2427   2427      anova full           PDS5B  13.791727 2.438592e-10
#> 2428   2428      anova full          GABRA2  13.784289 2.462764e-10
#> 2429   2429      anova full           GNG12  13.783631 2.464914e-10
#> 2430   2430      anova full           COX5B  13.781525 2.471808e-10
#> 2431   2431      anova full           AP2A2  13.776023 2.489914e-10
#> 2432   2432      anova full          GLIPR2  13.772848 2.500424e-10
#> 2433   2433      anova full          CKMT1B  13.762133 2.536230e-10
#> 2434   2434      anova full         PLEKHM3  13.746757 2.588535e-10
#> 2435   2435      anova full          SPRED2  13.743570 2.599514e-10
#> 2436   2436      anova full            PIGU  13.742334 2.603785e-10
#> 2437   2437      anova full          NT5C3B  13.740271 2.610929e-10
#> 2438   2438      anova full           SYCE1  13.738827 2.615944e-10
#> 2439   2439      anova full           HDAC1  13.737287 2.621299e-10
#> 2440   2440      anova full           LTBP3  13.730582 2.644756e-10
#> 2441   2441      anova full             SLN  13.730455 2.645201e-10
#> 2442   2442      anova full            SOST  13.727544 2.655452e-10
#> 2443   2443      anova full           RAB1A  13.726691 2.658466e-10
#> 2444   2444      anova full          PWWP2B  13.725916 2.661203e-10
#> 2445   2445      anova full           SPART  13.721589 2.676553e-10
#> 2446   2446      anova full           SF3B1  13.718389 2.687963e-10
#> 2447   2447      anova full            IQCK  13.716530 2.694612e-10
#> 2448   2448      anova full            NEK3  13.715175 2.699472e-10
#> 2449   2449      anova full           CDH10  13.711453 2.712864e-10
#> 2450   2450      anova full           PDE1C  13.708500 2.723538e-10
#> 2451   2451      anova full          CHRNB2  13.705955 2.732771e-10
#> 2452   2452      anova full            CDH7  13.699739 2.755458e-10
#> 2453   2453      anova full         POMGNT1  13.690792 2.788450e-10
#> 2454   2454      anova full            ARL9  13.689668 2.792624e-10
#> 2455   2455      anova full           RIMS1  13.684627 2.811423e-10
#> 2456   2456      anova full            GLCE  13.678378 2.834903e-10
#> 2457   2457      anova full          GALNT7  13.675547 2.845609e-10
#> 2458   2458      anova full            SHC3  13.674935 2.847929e-10
#> 2459   2459      anova full         SLITRK5  13.672558 2.856956e-10
#> 2460   2460      anova full          SH3BP5  13.670469 2.864915e-10
#> 2461   2461      anova full           SNHG8  13.670442 2.865015e-10
#> 2462   2462      anova full         GUCY1A2  13.642322 2.974384e-10
#> 2463   2463      anova full         SLC16A9  13.642075 2.975366e-10
#> 2464   2464      anova full           KIFC2  13.640273 2.982519e-10
#> 2465   2465      anova full          SAMD14  13.636493 2.997586e-10
#> 2466   2466      anova full           LAMB2  13.628489 3.029750e-10
#> 2467   2467      anova full           BBIP1  13.623479 3.050062e-10
#> 2468   2468      anova full           SH2D5  13.622796 3.052843e-10
#> 2469   2469      anova full           ITGA7  13.621904 3.056476e-10
#> 2470   2470      anova full           ACSL3  13.621512 3.058074e-10
#> 2471   2471      anova full          ATP11A  13.614953 3.084949e-10
#> 2472   2472      anova full      AC020909.2  13.612667 3.094374e-10
#> 2473   2473      anova full            RTKN  13.609134 3.108999e-10
#> 2474   2474      anova full           HMOX2  13.606939 3.118116e-10
#> 2475   2475      anova full            CHD5  13.604413 3.128649e-10
#> 2476   2476      anova full          POLR2B  13.598110 3.155084e-10
#> 2477   2477      anova full            KLK5  13.597755 3.156581e-10
#> 2478   2478      anova full        FGFR1OP2  13.595146 3.167592e-10
#> 2479   2479      anova full           LNPEP  13.590583 3.186951e-10
#> 2480   2480      anova full           DOCK3  13.581273 3.226825e-10
#> 2481   2481      anova full           GRHPR  13.578948 3.236864e-10
#> 2482   2482      anova full            KLF7  13.576360 3.248075e-10
#> 2483   2483      anova full           LMBR1  13.574246 3.257263e-10
#> 2484   2484      anova full          ATP2A2  13.571772 3.268051e-10
#> 2485   2485      anova full        KIAA0355  13.568890 3.280660e-10
#> 2486   2486      anova full            MEI1  13.563305 3.305242e-10
#> 2487   2487      anova full            LDHA  13.562456 3.308994e-10
#> 2488   2488      anova full        KIAA1191  13.553359 3.349484e-10
#> 2489   2489      anova full           NACC2  13.546252 3.381473e-10
#> 2490   2490      anova full            PAX2  13.540705 3.406653e-10
#> 2491   2491      anova full         TMEM30A  13.539557 3.411890e-10
#> 2492   2492      anova full            PPID  13.537648 3.420614e-10
#> 2493   2493      anova full           CLVS2  13.531076 3.450830e-10
#> 2494   2494      anova full           PLCD3  13.525601 3.476209e-10
#> 2495   2495      anova full          CACNB1  13.523307 3.486898e-10
#> 2496   2496      anova full          SLC6A9  13.515987 3.521238e-10
#> 2497   2497      anova full         C1orf61  13.510033 3.549426e-10
#> 2498   2498      anova full        C17orf51  13.506713 3.565243e-10
#> 2499   2499      anova full          LPGAT1  13.501415 3.590633e-10
#> 2500   2500      anova full           TANC2  13.495474 3.619327e-10
#> 2501   2501      anova full         PITPNM1  13.489008 3.650824e-10
#> 2502   2502      anova full         C9orf16  13.486602 3.662619e-10
#> 2503   2503      anova full       LINC01106  13.484362 3.673629e-10
#> 2504   2504      anova full           CPEB2  13.482532 3.682656e-10
#> 2505   2505      anova full            POGK  13.477356 3.708301e-10
#> 2506   2506      anova full           UNC5A  13.476146 3.714319e-10
#> 2507   2507      anova full          ANGEL2  13.474684 3.721607e-10
#> 2508   2508      anova full            GIT1  13.474614 3.721960e-10
#> 2509   2509      anova full         TMEM273  13.471793 3.736066e-10
#> 2510   2510      anova full         RNF144A  13.470695 3.741570e-10
#> 2511   2511      anova full           CDH11  13.468631 3.751940e-10
#> 2512   2512      anova full           CELF1  13.461037 3.790355e-10
#> 2513   2513      anova full           HMGCR  13.458503 3.803265e-10
#> 2514   2514      anova full           GSKIP  13.457114 3.810359e-10
#> 2515   2515      anova full          RAB3IP  13.456550 3.813245e-10
#> 2516   2516      anova full            SMC3  13.443579 3.880209e-10
#> 2517   2517      anova full         METTL7A  13.432580 3.937938e-10
#> 2518   2518      anova full            RGS8  13.428324 3.960511e-10
#> 2519   2519      anova full            BAG4  13.426674 3.969302e-10
#> 2520   2520      anova full             RET  13.424803 3.979289e-10
#> 2521   2521      anova full          PIEZO1  13.419588 4.007264e-10
#> 2522   2522      anova full            ATF3  13.418051 4.015552e-10
#> 2523   2523      anova full          POLR2G  13.409910 4.059726e-10
#> 2524   2524      anova full           DIP2A  13.398955 4.119955e-10
#> 2525   2525      anova full           KCNH3  13.388622 4.177606e-10
#> 2526   2526      anova full           EID2B  13.386366 4.190300e-10
#> 2527   2527      anova full         NDUFAF4  13.385251 4.196593e-10
#> 2528   2528      anova full           CHD1L  13.373833 4.261562e-10
#> 2529   2529      anova full          RNF220  13.370271 4.282039e-10
#> 2530   2530      anova full          TMEM47  13.367867 4.295920e-10
#> 2531   2531      anova full          KCNJ16  13.365038 4.312312e-10
#> 2532   2532      anova full            EMP3  13.364177 4.317312e-10
#> 2533   2533      anova full           RPL35  13.358952 4.347793e-10
#> 2534   2534      anova full      AL355974.2  13.356173 4.364090e-10
#> 2535   2535      anova full           ESYT1  13.354318 4.375006e-10
#> 2536   2536      anova full          TRIOBP  13.335217 4.489052e-10
#> 2537   2537      anova full           APBB1  13.332674 4.504464e-10
#> 2538   2538      anova full         RAP1GAP  13.321594 4.572250e-10
#> 2539   2539      anova full           CASQ1  13.318981 4.588387e-10
#> 2540   2540      anova full         RASGRP1  13.310601 4.640540e-10
#> 2541   2541      anova full        TMEM151A  13.302321 4.692667e-10
#> 2542   2542      anova full           IGSF1  13.301940 4.695076e-10
#> 2543   2543      anova full      FP565260.3  13.301398 4.698509e-10
#> 2544   2544      anova full             ABR  13.296868 4.727319e-10
#> 2545   2545      anova full           FBXL7  13.294200 4.744372e-10
#> 2546   2546      anova full        AASDHPPT  13.284711 4.805535e-10
#> 2547   2547      anova full          ARL2BP  13.282949 4.816979e-10
#> 2548   2548      anova full            CBX7  13.281936 4.823576e-10
#> 2549   2549      anova full          PPP3R1  13.281359 4.827336e-10
#> 2550   2550      anova full         PRKAR2B  13.277201 4.854514e-10
#> 2551   2551      anova full          PNMA6A  13.260438 4.965699e-10
#> 2552   2552      anova full             DLD  13.259616 4.971222e-10
#> 2553   2553      anova full             FN1  13.254339 5.006799e-10
#> 2554   2554      anova full           INPP1  13.251196 5.028115e-10
#> 2555   2555      anova full         C5orf63  13.250597 5.032191e-10
#> 2556   2556      anova full        SLC16A14  13.244051 5.076919e-10
#> 2557   2557      anova full           ITGB2  13.242647 5.086565e-10
#> 2558   2558      anova full         PIK3IP1  13.241054 5.097537e-10
#> 2559   2559      anova full           TAF13  13.239929 5.105297e-10
#> 2560   2560      anova full          MRPL37  13.235866 5.133427e-10
#> 2561   2561      anova full         HLA-DRA  13.219824 5.246057e-10
#> 2562   2562      anova full          TCEAL7  13.217884 5.259849e-10
#> 2563   2563      anova full          RNF141  13.211114 5.308269e-10
#> 2564   2564      anova full          KIF13A  13.204577 5.355454e-10
#> 2565   2565      anova full           MDGA1  13.203296 5.364755e-10
#> 2566   2566      anova full         PHACTR4  13.201717 5.376238e-10
#> 2567   2567      anova full         TMEM221  13.199329 5.393647e-10
#> 2568   2568      anova full            ODR4  13.197772 5.405035e-10
#> 2569   2569      anova full         GALNTL6  13.194526 5.428855e-10
#> 2570   2570      anova full           CFLAR  13.194420 5.429629e-10
#> 2571   2571      anova full           BAALC  13.189611 5.465119e-10
#> 2572   2572      anova full          HPCAL4  13.183780 5.508465e-10
#> 2573   2573      anova full          MAPRE2  13.178438 5.548487e-10
#> 2574   2574      anova full            TAF9  13.176268 5.564834e-10
#> 2575   2575      anova full         TMEM196  13.172470 5.593556e-10
#> 2576   2576      anova full           MYLK3  13.167882 5.628454e-10
#> 2577   2577      anova full            ZER1  13.164000 5.658157e-10
#> 2578   2578      anova full           TMCC2  13.162015 5.673412e-10
#> 2579   2579      anova full           CENPN  13.157134 5.711089e-10
#> 2580   2580      anova full         PPP1R1A  13.156493 5.716061e-10
#> 2581   2581      anova full            UFL1  13.156354 5.717135e-10
#> 2582   2582      anova full           TMED7  13.152340 5.748351e-10
#> 2583   2583      anova full            RHOF  13.150220 5.764911e-10
#> 2584   2584      anova full             CPQ  13.147872 5.783304e-10
#> 2585   2585      anova full            GSG1  13.145676 5.800559e-10
#> 2586   2586      anova full            LGI2  13.139166 5.852035e-10
#> 2587   2587      anova full            ANO5  13.137992 5.861367e-10
#> 2588   2588      anova full             IDS  13.130708 5.919608e-10
#> 2589   2589      anova full            FAXC  13.122107 5.989153e-10
#> 2590   2590      anova full          ATP5PO  13.111294 6.077768e-10
#> 2591   2591      anova full          SLC8A1  13.102346 6.152113e-10
#> 2592   2592      anova full           CAMKV  13.099818 6.173290e-10
#> 2593   2593      anova full          SEC11A  13.095264 6.211625e-10
#> 2594   2594      anova full            DLAT  13.092301 6.236692e-10
#> 2595   2595      anova full        PPP1R15B  13.079914 6.342634e-10
#> 2596   2596      anova full         TMEM160  13.077202 6.366077e-10
#> 2597   2597      anova full            GCN1  13.076191 6.374837e-10
#> 2598   2598      anova full        TNFRSF1A  13.073957 6.394244e-10
#> 2599   2599      anova full            MYL6  13.066790 6.456904e-10
#> 2600   2600      anova full           ASTN1  13.058632 6.528991e-10
#> 2601   2601      anova full           GSTM3  13.042172 6.676973e-10
#> 2602   2602      anova full            PLP2  13.040594 6.691336e-10
#> 2603   2603      anova full          CHMP4B  13.038969 6.706162e-10
#> 2604   2604      anova full            PNKD  13.029792 6.790540e-10
#> 2605   2605      anova full             MSN  13.027475 6.812008e-10
#> 2606   2606      anova full           PSMC5  13.013996 6.938323e-10
#> 2607   2607      anova full           STAG2  13.007468 7.000361e-10
#> 2608   2608      anova full            AGPS  13.006644 7.008229e-10
#> 2609   2609      anova full    MIR1-1HG-AS1  13.005619 7.018035e-10
#> 2610   2610      anova full            ICE2  13.003865 7.034842e-10
#> 2611   2611      anova full            TPMT  13.001072 7.061697e-10
#> 2612   2612      anova full          MYBPC1  12.999535 7.076520e-10
#> 2613   2613      anova full           CDIP1  12.995060 7.119854e-10
#> 2614   2614      anova full           PRPS2  12.994915 7.121257e-10
#> 2615   2615      anova full             CPM  12.991248 7.156978e-10
#> 2616   2616      anova full           PSME4  12.990599 7.163321e-10
#> 2617   2617      anova full             ID1  12.989941 7.169760e-10
#> 2618   2618      anova full            TPM2  12.985994 7.208484e-10
#> 2619   2619      anova full            RIT2  12.980057 7.267130e-10
#> 2620   2620      anova full            HRH2  12.974458 7.322896e-10
#> 2621   2621      anova full            CNST  12.957460 7.494894e-10
#> 2622   2622      anova full          MPPED2  12.950512 7.566384e-10
#> 2623   2623      anova full            PI16  12.942063 7.654269e-10
#> 2624   2624      anova full         FAM217B  12.939593 7.680150e-10
#> 2625   2625      anova full         DNAJB14  12.939174 7.684555e-10
#> 2626   2626      anova full          TMEM70  12.939139 7.684921e-10
#> 2627   2627      anova full         PLA2G4C  12.934358 7.735325e-10
#> 2628   2628      anova full          MAP7D1  12.929282 7.789207e-10
#> 2629   2629      anova full          BTBD11  12.928484 7.797708e-10
#> 2630   2630      anova full           RPL29  12.927121 7.812263e-10
#> 2631   2631      anova full          IGLON5  12.925151 7.833335e-10
#> 2632   2632      anova full          CUEDC1  12.919710 7.891862e-10
#> 2633   2633      anova full           CAB39  12.916816 7.923173e-10
#> 2634   2634      anova full          DAB2IP  12.912528 7.969788e-10
#> 2635   2635      anova full            GPD1  12.911911 7.976527e-10
#> 2636   2636      anova full           KLF13  12.908217 8.016955e-10
#> 2637   2637      anova full           STON2  12.907074 8.029502e-10
#> 2638   2638      anova full            MSI2  12.907028 8.030007e-10
#> 2639   2639      anova full          PKNOX2  12.905393 8.047998e-10
#> 2640   2640      anova full            NPPC  12.901743 8.088316e-10
#> 2641   2641      anova full            FIS1  12.897699 8.133215e-10
#> 2642   2642      anova full            ART3  12.892657 8.189569e-10
#> 2643   2643      anova full          FAM13A  12.890244 8.216671e-10
#> 2644   2644      anova full          SLC9A9  12.889923 8.220290e-10
#> 2645   2645      anova full           KAT6A  12.880902 8.322501e-10
#> 2646   2646      anova full            KLK7  12.878579 8.349022e-10
#> 2647   2647      anova full           ACER3  12.876681 8.370764e-10
#> 2648   2648      anova full      AC103770.1  12.874303 8.398084e-10
#> 2649   2649      anova full            DRD5  12.871371 8.431904e-10
#> 2650   2650      anova full          HS3ST5  12.869353 8.455251e-10
#> 2651   2651      anova full          PITPNB  12.868217 8.468429e-10
#> 2652   2652      anova full         FAM126B  12.861128 8.551130e-10
#> 2653   2653      anova full           THBS1  12.856326 8.607613e-10
#> 2654   2654      anova full           RPH3A  12.852299 8.655275e-10
#> 2655   2655      anova full          FBXO33  12.849982 8.682832e-10
#> 2656   2656      anova full           KCTD9  12.840070 8.801698e-10
#> 2657   2657      anova full            PTMS  12.838239 8.823843e-10
#> 2658   2658      anova full            OCLN  12.838108 8.825425e-10
#> 2659   2659      anova full           PSMB9  12.835098 8.861952e-10
#> 2660   2660      anova full       LINC01549  12.830486 8.918225e-10
#> 2661   2661      anova full           GLUD1  12.828849 8.938282e-10
#> 2662   2662      anova full          SLC8A2  12.815545 9.103049e-10
#> 2663   2663      anova full          LUC7L3  12.813088 9.133827e-10
#> 2664   2664      anova full            KLF9  12.802531 9.267242e-10
#> 2665   2665      anova full            PMM1  12.802270 9.270570e-10
#> 2666   2666      anova full            KRAS  12.798823 9.314586e-10
#> 2667   2667      anova full            APLN  12.794880 9.365193e-10
#> 2668   2668      anova full           TRIM7  12.794447 9.370771e-10
#> 2669   2669      anova full          CCDC34  12.792762 9.392495e-10
#> 2670   2670      anova full            CCT4  12.778712 9.575682e-10
#> 2671   2671      anova full           HOXD1  12.773415 9.645700e-10
#> 2672   2672      anova full         ATP6V1F  12.772171 9.662211e-10
#> 2673   2673      anova full           MUCL1  12.769611 9.696303e-10
#> 2674   2674      anova full            SNPH  12.765158 9.755881e-10
#> 2675   2675      anova full        CACNA2D1  12.763161 9.782719e-10
#> 2676   2676      anova full           H2AFV  12.762446 9.792350e-10
#> 2677   2677      anova full            RALB  12.761331 9.807383e-10
#> 2678   2678      anova full            MAL2  12.759539 9.831598e-10
#> 2679   2679      anova full           FOXO1  12.758763 9.842102e-10
#> 2680   2680      anova full          NLGN4X  12.748157 9.986840e-10
#> 2681   2681      anova full           DDX17  12.746232 1.001334e-09
#> 2682   2682      anova full           RPL15  12.741014 1.008554e-09
#> 2683   2683      anova full            IMMT  12.736847 1.014359e-09
#> 2684   2684      anova full        MAPK8IP1  12.735420 1.016355e-09
#> 2685   2685      anova full           SFRP1  12.733156 1.019528e-09
#> 2686   2686      anova full          FNDC10  12.730214 1.023668e-09
#> 2687   2687      anova full            WDR1  12.720216 1.037868e-09
#> 2688   2688      anova full          UAP1L1  12.718509 1.040312e-09
#> 2689   2689      anova full          GOLGA4  12.714507 1.046067e-09
#> 2690   2690      anova full           TUNAR  12.705578 1.059023e-09
#> 2691   2691      anova full            CIB1  12.702846 1.063020e-09
#> 2692   2692      anova full           KCNH8  12.702808 1.063076e-09
#> 2693   2693      anova full          KCTD15  12.700787 1.066042e-09
#> 2694   2694      anova full         TMEM218  12.691222 1.080200e-09
#> 2695   2695      anova full           FBXW4  12.683800 1.091318e-09
#> 2696   2696      anova full            BRD7  12.680166 1.096806e-09
#> 2697   2697      anova full            EMP1  12.670114 1.112130e-09
#> 2698   2698      anova full           ATOH8  12.667938 1.115476e-09
#> 2699   2699      anova full         ATXN7L3  12.666986 1.116944e-09
#> 2700   2700      anova full           NOMO1  12.666692 1.117397e-09
#> 2701   2701      anova full         RASL10B  12.655795 1.134341e-09
#> 2702   2702      anova full          ARMCX2  12.650597 1.142516e-09
#> 2703   2703      anova full           DUSP6  12.645944 1.149885e-09
#> 2704   2704      anova full          VKORC1  12.643604 1.153610e-09
#> 2705   2705      anova full           CLCA4  12.641457 1.157037e-09
#> 2706   2706      anova full      AJ009632.2  12.635231 1.167038e-09
#> 2707   2707      anova full           LACC1  12.613554 1.202553e-09
#> 2708   2708      anova full          TNNI3K  12.608134 1.211605e-09
#> 2709   2709      anova full            DEXI  12.599750 1.225745e-09
#> 2710   2710      anova full           APOL2  12.597481 1.229601e-09
#> 2711   2711      anova full           FNDC5  12.596270 1.231665e-09
#> 2712   2712      anova full           MARK1  12.595437 1.233085e-09
#> 2713   2713      anova full             AXL  12.591616 1.239626e-09
#> 2714   2714      anova full             NMU  12.591342 1.240097e-09
#> 2715   2715      anova full         CCDC85C  12.587759 1.246265e-09
#> 2716   2716      anova full          FBXO11  12.585917 1.249448e-09
#> 2717   2717      anova full         IL13RA1  12.583867 1.253001e-09
#> 2718   2718      anova full       LINC01445  12.582948 1.254596e-09
#> 2719   2719      anova full            PRCD  12.582850 1.254767e-09
#> 2720   2720      anova full           FCGBP  12.579227 1.261080e-09
#> 2721   2721      anova full            CCT8  12.577109 1.264785e-09
#> 2722   2722      anova full            LIPC  12.563867 1.288207e-09
#> 2723   2723      anova full        RNASEH2C  12.557472 1.299677e-09
#> 2724   2724      anova full            MXD4  12.548397 1.316134e-09
#> 2725   2725      anova full           IGSF8  12.546154 1.320235e-09
#> 2726   2726      anova full           CCKBR  12.544441 1.323377e-09
#> 2727   2727      anova full           EPHA5  12.538478 1.334368e-09
#> 2728   2728      anova full           NABP2  12.532054 1.346314e-09
#> 2729   2729      anova full          EIF4G3  12.531529 1.347295e-09
#> 2730   2730      anova full           WIPF3  12.531308 1.347708e-09
#> 2731   2731      anova full            GRK2  12.527224 1.355369e-09
#> 2732   2732      anova full          SMIM12  12.521991 1.365251e-09
#> 2733   2733      anova full          SEMA4A  12.517032 1.374681e-09
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#> 2735   2735      anova full      AC116565.1  12.515252 1.378083e-09
#> 2736   2736      anova full         ARHGEF3  12.515009 1.378548e-09
#> 2737   2737      anova full          CLEC4G  12.512722 1.382932e-09
#> 2738   2738      anova full          S100A4  12.512173 1.383988e-09
#> 2739   2739      anova full           HMGB1  12.503800 1.400176e-09
#> 2740   2740      anova full             OAF  12.490107 1.427070e-09
#> 2741   2741      anova full           GPR22  12.487568 1.432116e-09
#> 2742   2742      anova full            NME7  12.487008 1.433231e-09
#> 2743   2743      anova full        TMEM132C  12.484491 1.438254e-09
#> 2744   2744      anova full         ARHGAP4  12.479013 1.449249e-09
#> 2745   2745      anova full           JAZF1  12.477421 1.452461e-09
#> 2746   2746      anova full            FLNC  12.468022 1.471570e-09
#> 2747   2747      anova full           HLA-B  12.457976 1.492280e-09
#> 2748   2748      anova full         JAKMIP3  12.450914 1.507019e-09
#> 2749   2749      anova full           PTHLH  12.450566 1.507748e-09
#> 2750   2750      anova full           ZNF25  12.430250 1.551007e-09
#> 2751   2751      anova full         RNPEPL1  12.430143 1.551237e-09
#> 2752   2752      anova full          CDC14B  12.425516 1.561268e-09
#> 2753   2753      anova full           OBSCN  12.424220 1.564090e-09
#> 2754   2754      anova full          ENTPD6  12.420722 1.571731e-09
#> 2755   2755      anova full          SAMD4B  12.409415 1.596695e-09
#> 2756   2756      anova full          CAPZA1  12.409262 1.597035e-09
#> 2757   2757      anova full          GLIPR1  12.405933 1.604464e-09
#> 2758   2758      anova full          GPRIN1  12.404187 1.608374e-09
#> 2759   2759      anova full          COX6A1  12.386659 1.648177e-09
#> 2760   2760      anova full          UBALD1  12.385307 1.651287e-09
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#> 2762   2762      anova full          NUDT10  12.375972 1.672938e-09
#> 2763   2763      anova full            RGS2  12.375424 1.674218e-09
#> 2764   2764      anova full            VRK2  12.363775 1.701667e-09
#> 2765   2765      anova full           SPEF1  12.361628 1.706776e-09
#> 2766   2766      anova full         NAPEPLD  12.360003 1.710655e-09
#> 2767   2767      anova full         LYPLAL1  12.359211 1.712548e-09
#> 2768   2768      anova full           GLRA3  12.357054 1.717713e-09
#> 2769   2769      anova full           FEM1C  12.344568 1.747938e-09
#> 2770   2770      anova full         ABHD14A  12.342765 1.752348e-09
#> 2771   2771      anova full          COMMD3  12.341069 1.756505e-09
#> 2772   2772      anova full         SELENON  12.340562 1.757751e-09
#> 2773   2773      anova full           EPHX1  12.337323 1.765726e-09
#> 2774   2774      anova full          FAM57B  12.333723 1.774632e-09
#> 2775   2775      anova full           CXXC5  12.330576 1.782457e-09
#> 2776   2776      anova full        ARHGAP20  12.328852 1.786759e-09
#> 2777   2777      anova full         N4BP2L2  12.328640 1.787287e-09
#> 2778   2778      anova full            WFS1  12.327175 1.790952e-09
#> 2779   2779      anova full            CLK1  12.326915 1.791605e-09
#> 2780   2780      anova full          TYROBP  12.325693 1.794669e-09
#> 2781   2781      anova full           PSIP1  12.321913 1.804178e-09
#> 2782   2782      anova full          SEPT11  12.321774 1.804531e-09
#> 2783   2783      anova full          CSRNP3  12.321719 1.804669e-09
#> 2784   2784      anova full            DGKH  12.315269 1.821023e-09
#> 2785   2785      anova full       KIDINS220  12.313980 1.824309e-09
#> 2786   2786      anova full            TLN2  12.313771 1.824842e-09
#> 2787   2787      anova full          SHKBP1  12.306668 1.843068e-09
#> 2788   2788      anova full          TRIM28  12.306295 1.844028e-09
#> 2789   2789      anova full         IFITM10  12.305673 1.845636e-09
#> 2790   2790      anova full           ACTN2  12.300847 1.858141e-09
#> 2791   2791      anova full          TSPYL5  12.299500 1.861648e-09
#> 2792   2792      anova full            CTTN  12.294334 1.875159e-09
#> 2793   2793      anova full           MRAP2  12.292374 1.880311e-09
#> 2794   2794      anova full          ZNHIT1  12.288846 1.889623e-09
#> 2795   2795      anova full            ANK3  12.286292 1.896393e-09
#> 2796   2796      anova full           RPL26  12.284978 1.899883e-09
#> 2797   2797      anova full             PNN  12.283671 1.903364e-09
#> 2798   2798      anova full          SEC22C  12.274917 1.926846e-09
#> 2799   2799      anova full           AP3B2  12.268209 1.945041e-09
#> 2800   2800      anova full         SLC45A3  12.262892 1.959587e-09
#> 2801   2801      anova full           DDX25  12.261646 1.963012e-09
#> 2802   2802      anova full          NIPAL2  12.257676 1.973968e-09
#> 2803   2803      anova full         CIAPIN1  12.254353 1.983183e-09
#> 2804   2804      anova full            PFN1  12.245092 2.009104e-09
#> 2805   2805      anova full          EIF4G2  12.240695 2.021533e-09
#> 2806   2806      anova full            NBR1  12.236270 2.034121e-09
#> 2807   2807      anova full           LYNX1  12.233874 2.040970e-09
#> 2808   2808      anova full           STAT4  12.223615 2.070566e-09
#> 2809   2809      anova full           OPRK1  12.221765 2.075948e-09
#> 2810   2810      anova full       KIAA1211L  12.213447 2.100333e-09
#> 2811   2811      anova full           SCN3B  12.209998 2.110529e-09
#> 2812   2812      anova full           USP31  12.207775 2.117128e-09
#> 2813   2813      anova full           COPS4  12.204414 2.127145e-09
#> 2814   2814      anova full      AC129507.4  12.199180 2.142844e-09
#> 2815   2815      anova full       LINC00943  12.194843 2.155940e-09
#> 2816   2816      anova full            SSPN  12.190866 2.168021e-09
#> 2817   2817      anova full            HES6  12.188726 2.174552e-09
#> 2818   2818      anova full         C7orf43  12.188040 2.176648e-09
#> 2819   2819      anova full         TBC1D15  12.181343 2.197236e-09
#> 2820   2820      anova full          MARCH4  12.180074 2.201157e-09
#> 2821   2821      anova full         BLOC1S6  12.180073 2.201161e-09
#> 2822   2822      anova full          SHISA9  12.179075 2.204253e-09
#> 2823   2823      anova full           GREM2  12.173659 2.221100e-09
#> 2824   2824      anova full        COLGALT2  12.172691 2.224127e-09
#> 2825   2825      anova full            HDGF  12.164633 2.249475e-09
#> 2826   2826      anova full           ANXA1  12.147550 2.304203e-09
#> 2827   2827      anova full           SMKR1  12.144718 2.313406e-09
#> 2828   2828      anova full          BRINP2  12.138084 2.335113e-09
#> 2829   2829      anova full          ZFAND3  12.128719 2.366116e-09
#> 2830   2830      anova full           ORAI1  12.125102 2.378201e-09
#> 2831   2831      anova full            INF2  12.124626 2.379797e-09
#> 2832   2832      anova full           OXGR1  12.122667 2.386374e-09
#> 2833   2833      anova full            ELP4  12.117711 2.403094e-09
#> 2834   2834      anova full        SLC9A3R2  12.114398 2.414341e-09
#> 2835   2835      anova full         TMEM128  12.098898 2.467673e-09
#> 2836   2836      anova full           IDH3B  12.097512 2.472503e-09
#> 2837   2837      anova full           KLHL2  12.094627 2.482580e-09
#> 2838   2838      anova full            G0S2  12.091920 2.492077e-09
#> 2839   2839      anova full         GALNT14  12.091904 2.492135e-09
#> 2840   2840      anova full          SEMA4F  12.090642 2.496573e-09
#> 2841   2841      anova full          TOMM20  12.076022 2.548608e-09
#> 2842   2842      anova full           PDGFA  12.074000 2.555890e-09
#> 2843   2843      anova full           BNIP2  12.067808 2.578329e-09
#> 2844   2844      anova full           PDGFD  12.067033 2.581151e-09
#> 2845   2845      anova full      AL356417.1  12.063696 2.593339e-09
#> 2846   2846      anova full            GRM8  12.060414 2.605386e-09
#> 2847   2847      anova full          SLC4A3  12.059973 2.607008e-09
#> 2848   2848      anova full           SYT16  12.058085 2.613967e-09
#> 2849   2849      anova full           CDH19  12.051076 2.639974e-09
#> 2850   2850      anova full           AQP11  12.046820 2.655896e-09
#> 2851   2851      anova full            JPH2  12.044553 2.664417e-09
#> 2852   2852      anova full           MYL6B  12.043142 2.669734e-09
#> 2853   2853      anova full          TMSB4X  12.032105 2.711703e-09
#> 2854   2854      anova full         HPN-AS1  12.030636 2.717341e-09
#> 2855   2855      anova full           PRMT2  12.030045 2.719612e-09
#> 2856   2856      anova full          WNT10B  12.025077 2.738782e-09
#> 2857   2857      anova full            CBFB  12.024706 2.740220e-09
#> 2858   2858      anova full           PTPRO  12.022410 2.749129e-09
#> 2859   2859      anova full        GRM5-AS1  12.020813 2.755347e-09
#> 2860   2860      anova full          AKR7A2  12.013844 2.782640e-09
#> 2861   2861      anova full          DLGAP4  12.001777 2.830554e-09
#> 2862   2862      anova full      AC026790.1  11.997479 2.847828e-09
#> 2863   2863      anova full           COPG1  11.993290 2.864764e-09
#> 2864   2864      anova full           SOGA1  11.991713 2.871167e-09
#> 2865   2865      anova full          RICTOR  11.990507 2.876074e-09
#> 2866   2866      anova full            EID2  11.987626 2.887830e-09
#> 2867   2867      anova full           KCNJ4  11.987450 2.888548e-09
#> 2868   2868      anova full        ARHGAP32  11.986807 2.891181e-09
#> 2869   2869      anova full           CSPG5  11.986233 2.893530e-09
#> 2870   2870      anova full           ACSS1  11.985415 2.896883e-09
#> 2871   2871      anova full           NPAS3  11.984767 2.899545e-09
#> 2872   2872      anova full          RASAL1  11.979105 2.922890e-09
#> 2873   2873      anova full           RPL39  11.973979 2.944191e-09
#> 2874   2874      anova full          SPINT1  11.969386 2.963412e-09
#> 2875   2875      anova full         CEP170B  11.967883 2.969727e-09
#> 2876   2876      anova full             GDA  11.967759 2.970250e-09
#> 2877   2877      anova full            TIA1  11.965592 2.979385e-09
#> 2878   2878      anova full           IFT57  11.963942 2.986358e-09
#> 2879   2879      anova full          HIVEP2  11.962659 2.991794e-09
#> 2880   2880      anova full         SEC14L1  11.957347 3.014404e-09
#> 2881   2881      anova full          DUSP14  11.955517 3.022234e-09
#> 2882   2882      anova full          ARMCX1  11.949226 3.049316e-09
#> 2883   2883      anova full         CYP26A1  11.944626 3.069270e-09
#> 2884   2884      anova full           PRTN3  11.940517 3.087211e-09
#> 2885   2885      anova full          TGFBR1  11.922997 3.164918e-09
#> 2886   2886      anova full           ARPC2  11.912666 3.211679e-09
#> 2887   2887      anova full            HMSD  11.905442 3.244796e-09
#> 2888   2888      anova full         EPB41L1  11.904000 3.251449e-09
#> 2889   2889      anova full          TUBA3D  11.903561 3.253475e-09
#> 2890   2890      anova full          NKAIN1  11.899830 3.270764e-09
#> 2891   2891      anova full            MPP7  11.895259 3.292077e-09
#> 2892   2892      anova full           FUCA2  11.892265 3.306111e-09
#> 2893   2893      anova full          RB1CC1  11.885479 3.338148e-09
#> 2894   2894      anova full          TOMM22  11.883699 3.346608e-09
#> 2895   2895      anova full          ACTR1B  11.881086 3.359062e-09
#> 2896   2896      anova full          ORMDL2  11.880616 3.361305e-09
#> 2897   2897      anova full        EPB41L4B  11.871596 3.404693e-09
#> 2898   2898      anova full          NUDT11  11.871427 3.405509e-09
#> 2899   2899      anova full            DPF1  11.862351 3.449759e-09
#> 2900   2900      anova full          FAM49B  11.860299 3.459847e-09
#> 2901   2901      anova full          AKR1C1  11.858588 3.468279e-09
#> 2902   2902      anova full           SNHG9  11.858025 3.471058e-09
#> 2903   2903      anova full      MIR124-2HG  11.856295 3.479613e-09
#> 2904   2904      anova full            PHF3  11.856134 3.480411e-09
#> 2905   2905      anova full           KCNS2  11.855919 3.481474e-09
#> 2906   2906      anova full            ROM1  11.855190 3.485089e-09
#> 2907   2907      anova full         TBC1D24  11.854565 3.488190e-09
#> 2908   2908      anova full          CAPNS1  11.854149 3.490256e-09
#> 2909   2909      anova full          INPP4A  11.851569 3.503090e-09
#> 2910   2910      anova full             HPN  11.851096 3.505453e-09
#> 2911   2911      anova full            WBP2  11.845909 3.531427e-09
#> 2912   2912      anova full            ABI1  11.842870 3.546740e-09
#> 2913   2913      anova full       OBSCN-AS1  11.840860 3.556903e-09
#> 2914   2914      anova full           BCAS2  11.840007 3.561226e-09
#> 2915   2915      anova full         LRRC10B  11.837324 3.574853e-09
#> 2916   2916      anova full            MAPT  11.832325 3.600393e-09
#> 2917   2917      anova full            ATF2  11.827562 3.624904e-09
#> 2918   2918      anova full           MOCS2  11.824232 3.642142e-09
#> 2919   2919      anova full             DCN  11.817558 3.676942e-09
#> 2920   2920      anova full            FZD3  11.814934 3.690713e-09
#> 2921   2921      anova full       DPP10-AS1  11.814567 3.692647e-09
#> 2922   2922      anova full           EFNB3  11.810619 3.713482e-09
#> 2923   2923      anova full          NDUFB4  11.809728 3.718199e-09
#> 2924   2924      anova full         TWISTNB  11.808208 3.726266e-09
#> 2925   2925      anova full           MGST3  11.805477 3.740803e-09
#> 2926   2926      anova full         SLC45A1  11.804099 3.748158e-09
#> 2927   2927      anova full            PHIP  11.797416 3.784048e-09
#> 2928   2928      anova full       LINC00645  11.796988 3.786358e-09
#> 2929   2929      anova full         SLC39A1  11.795473 3.794545e-09
#> 2930   2930      anova full            NME4  11.793570 3.804856e-09
#> 2931   2931      anova full            RXRG  11.789739 3.825705e-09
#> 2932   2932      anova full      AC108863.1  11.779679 3.881015e-09
#> 2933   2933      anova full          PPFIA1  11.777826 3.891290e-09
#> 2934   2934      anova full           EFNA3  11.774079 3.912157e-09
#> 2935   2935      anova full          EEF1B2  11.772090 3.923277e-09
#> 2936   2936      anova full      AC015468.3  11.769109 3.940011e-09
#> 2937   2937      anova full          COL1A1  11.768517 3.943343e-09
#> 2938   2938      anova full          SCAMP4  11.767276 3.950336e-09
#> 2939   2939      anova full            TPM4  11.761596 3.982501e-09
#> 2940   2940      anova full         ARHGEF9  11.755619 4.016641e-09
#> 2941   2941      anova full            MCUB  11.753286 4.030052e-09
#> 2942   2942      anova full           DOCK4  11.748438 4.058055e-09
#> 2943   2943      anova full          NDUFS5  11.746665 4.068349e-09
#> 2944   2944      anova full           ASCL1  11.735184 4.135652e-09
#> 2945   2945      anova full           SHOC2  11.733092 4.148038e-09
#> 2946   2946      anova full         SLC12A9  11.725533 4.193114e-09
#> 2947   2947      anova full          NDUFA1  11.713949 4.263163e-09
#> 2948   2948      anova full           FOXG1  11.712121 4.274325e-09
#> 2949   2949      anova full         TMEM38B  11.708545 4.296252e-09
#> 2950   2950      anova full            RCN2  11.704482 4.321299e-09
#> 2951   2951      anova full           TUBA8  11.702289 4.334886e-09
#> 2952   2952      anova full          SLC9A7  11.699474 4.352385e-09
#> 2953   2953      anova full           NPHP3  11.696975 4.367983e-09
#> 2954   2954      anova full            EMC2  11.694294 4.384779e-09
#> 2955   2955      anova full         ALDH1A1  11.693184 4.391751e-09
#> 2956   2956      anova full           RAP2A  11.689595 4.414377e-09
#> 2957   2957      anova full         MSANTD1  11.686541 4.433726e-09
#> 2958   2958      anova full            SNRK  11.683729 4.451615e-09
#> 2959   2959      anova full            RGS9  11.681892 4.463341e-09
#> 2960   2960      anova full            NOS2  11.678757 4.483428e-09
#> 2961   2961      anova full         SLITRK4  11.676230 4.499687e-09
#> 2962   2962      anova full         SLC10A4  11.674400 4.511499e-09
#> 2963   2963      anova full          POU3F1  11.669603 4.542615e-09
#> 2964   2964      anova full           TRBC2  11.662843 4.586841e-09
#> 2965   2965      anova full        HSD17B10  11.656531 4.628532e-09
#> 2966   2966      anova full           PRR5L  11.654537 4.641784e-09
#> 2967   2967      anova full           STK39  11.654194 4.644062e-09
#> 2968   2968      anova full      GABPB1-AS1  11.646755 4.693870e-09
#> 2969   2969      anova full           ELFN1  11.645665 4.701212e-09
#> 2970   2970      anova full      AC079834.2  11.634385 4.777903e-09
#> 2971   2971      anova full          BCL2L2  11.631256 4.799405e-09
#> 2972   2972      anova full           ZFHX4  11.631243 4.799494e-09
#> 2973   2973      anova full            NMT2  11.630574 4.804105e-09
#> 2974   2974      anova full         DENND5A  11.630313 4.805908e-09
#> 2975   2975      anova full        C11orf58  11.629647 4.810501e-09
#> 2976   2976      anova full         TMEM171  11.624743 4.844479e-09
#> 2977   2977      anova full           GATA3  11.620711 4.872603e-09
#> 2978   2978      anova full             FOS  11.619683 4.879793e-09
#> 2979   2979      anova full         SLITRK6  11.618939 4.885013e-09
#> 2980   2980      anova full          NDUFB8  11.617526 4.894930e-09
#> 2981   2981      anova full           BCAR1  11.613787 4.921280e-09
#> 2982   2982      anova full           PSMC6  11.612832 4.928036e-09
#> 2983   2983      anova full           RNF41  11.608619 4.957942e-09
#> 2984   2984      anova full            VWC2  11.604122 4.990073e-09
#> 2985   2985      anova full          LMBRD2  11.600871 5.013428e-09
#> 2986   2986      anova full           SESN3  11.599915 5.020319e-09
#> 2987   2987      anova full             LPL  11.597030 5.041173e-09
#> 2988   2988      anova full           CSDC2  11.593656 5.065678e-09
#> 2989   2989      anova full          COL6A2  11.593520 5.066667e-09
#> 2990   2990      anova full            SNX9  11.587229 5.112680e-09
#> 2991   2991      anova full          ZNF217  11.580990 5.158743e-09
#> 2992   2992      anova full         ATP6V0B  11.579632 5.168828e-09
#> 2993   2993      anova full           CADM1  11.578515 5.177135e-09
#> 2994   2994      anova full        SLC22A23  11.576788 5.190007e-09
#> 2995   2995      anova full         GPR37L1  11.574874 5.204313e-09
#> 2996   2996      anova full          HAPLN1  11.563336 5.291408e-09
#> 2997   2997      anova full           EFNA5  11.561532 5.305153e-09
#> 2998   2998      anova full      AC009414.2  11.559639 5.319623e-09
#> 2999   2999      anova full            AGR2  11.555798 5.349113e-09
#> 3000   3000      anova full          STOML1  11.547552 5.412977e-09
#> 3001   3001      anova full           NR2E1  11.547167 5.415975e-09
#> 3002   3002      anova full          ANAPC5  11.545193 5.431393e-09
#> 3003   3003      anova full          RAB11A  11.539847 5.473357e-09
#> 3004   3004      anova full          ENTPD4  11.532164 5.534259e-09
#> 3005   3005      anova full           CNTFR  11.525545 5.587279e-09
#> 3006   3006      anova full             BTD  11.517561 5.651929e-09
#> 3007   3007      anova full           FANCL  11.514535 5.676639e-09
#> 3008   3008      anova full            GPD2  11.505359 5.752226e-09
#> 3009   3009      anova full             MDK  11.503725 5.765794e-09
#> 3010   3010      anova full            LST1  11.503052 5.771391e-09
#> 3011   3011      anova full           MOSMO  11.501509 5.784253e-09
#> 3012   3012      anova full            STK3  11.500990 5.788582e-09
#> 3013   3013      anova full          NT5DC1  11.491971 5.864369e-09
#> 3014   3014      anova full           LIN7B  11.491624 5.867306e-09
#> 3015   3015      anova full            GYG2  11.488197 5.896389e-09
#> 3016   3016      anova full      AC008708.2  11.482802 5.942472e-09
#> 3017   3017      anova full           MEF2D  11.481154 5.956617e-09
#> 3018   3018      anova full            BCOR  11.475076 6.009104e-09
#> 3019   3019      anova full           RCAN1  11.474905 6.010591e-09
#> 3020   3020      anova full            GDI1  11.464390 6.102539e-09
#> 3021   3021      anova full          PTPDC1  11.459795 6.143173e-09
#> 3022   3022      anova full          CX3CR1  11.456263 6.174594e-09
#> 3023   3023      anova full         SERTAD3  11.453326 6.200846e-09
#> 3024   3024      anova full             PXN  11.448237 6.246600e-09
#> 3025   3025      anova full           TUSC2  11.443126 6.292912e-09
#> 3026   3026      anova full          SERTM1  11.440080 6.320676e-09
#> 3027   3027      anova full        TNFSF13B  11.437938 6.340278e-09
#> 3028   3028      anova full            NACA  11.436347 6.354877e-09
#> 3029   3029      anova full           KHDC1  11.436214 6.356104e-09
#> 3030   3030      anova full           CLDN4  11.435929 6.358720e-09
#> 3031   3031      anova full            CAHM  11.431051 6.403728e-09
#> 3032   3032      anova full           P2RX2  11.426626 6.444831e-09
#> 3033   3033      anova full        HS3ST3A1  11.424972 6.460264e-09
#> 3034   3034      anova full           PRKCZ  11.418214 6.523722e-09
#> 3035   3035      anova full      AC015712.2  11.405394 6.645874e-09
#> 3036   3036      anova full          RILPL1  11.400000 6.697968e-09
#> 3037   3037      anova full          ADGRA1  11.398774 6.709860e-09
#> 3038   3038      anova full            RPN2  11.394445 6.752046e-09
#> 3039   3039      anova full           ARL8B  11.391417 6.781716e-09
#> 3040   3040      anova full             VWF  11.387642 6.818900e-09
#> 3041   3041      anova full           ACOT8  11.387107 6.824180e-09
#> 3042   3042      anova full      AC008574.1  11.377381 6.921013e-09
#> 3043   3043      anova full            WARS  11.375947 6.935399e-09
#> 3044   3044      anova full          CLASP2  11.375628 6.938614e-09
#> 3045   3045      anova full             AUH  11.375222 6.942693e-09
#> 3046   3046      anova full           MIGA1  11.369979 6.995643e-09
#> 3047   3047      anova full         BHLHE41  11.364444 7.051988e-09
#> 3048   3048      anova full           MMP14  11.363535 7.061295e-09
#> 3049   3049      anova full           MYPOP  11.363388 7.062798e-09
#> 3050   3050      anova full           NAA30  11.357646 7.121838e-09
#> 3051   3051      anova full           PALLD  11.332261 7.388985e-09
#> 3052   3052      anova full           CARD8  11.328506 7.429365e-09
#> 3053   3053      anova full            CAPS  11.327367 7.441665e-09
#> 3054   3054      anova full           GPR88  11.326221 7.454056e-09
#> 3055   3055      anova full          R3HDM2  11.313289 7.595347e-09
#> 3056   3056      anova full           TIMP1  11.311529 7.614785e-09
#> 3057   3057      anova full            TCP1  11.310622 7.624827e-09
#> 3058   3058      anova full          SEMA4C  11.307874 7.655320e-09
#> 3059   3059      anova full         IFI27L2  11.305637 7.680241e-09
#> 3060   3060      anova full        C11orf97  11.304308 7.695082e-09
#> 3061   3061      anova full            SAA1  11.303522 7.703876e-09
#> 3062   3062      anova full           NETO1  11.301765 7.723568e-09
#> 3063   3063      anova full         ST8SIA5  11.297199 7.774992e-09
#> 3064   3064      anova full          CEP350  11.296772 7.779815e-09
#> 3065   3065      anova full          IQSEC2  11.285472 7.908665e-09
#> 3066   3066      anova full       LINC00982  11.275052 8.029416e-09
#> 3067   3067      anova full           ATP9A  11.271728 8.068337e-09
#> 3068   3068      anova full           DTYMK  11.267761 8.115031e-09
#> 3069   3069      anova full          TOMM70  11.267135 8.122424e-09
#> 3070   3070      anova full           VAMP5  11.252210 8.300789e-09
#> 3071   3071      anova full           SCYL1  11.247151 8.362157e-09
#> 3072   3072      anova full        FAM171A1  11.244300 8.396936e-09
#> 3073   3073      anova full          LGALS9  11.242135 8.423459e-09
#> 3074   3074      anova full            TCF4  11.241567 8.430422e-09
#> 3075   3075      anova full           NEDD8  11.241518 8.431026e-09
#> 3076   3076      anova full            MPP5  11.235488 8.505408e-09
#> 3077   3077      anova full           PMPCB  11.231488 8.555108e-09
#> 3078   3078      anova full            SUB1  11.226523 8.617231e-09
#> 3079   3079      anova full             SPX  11.222352 8.669761e-09
#> 3080   3080      anova full          PHLDA3  11.214265 8.772566e-09
#> 3081   3081      anova full           PDZD4  11.212663 8.793087e-09
#> 3082   3082      anova full            RPL5  11.208131 8.851376e-09
#> 3083   3083      anova full            SGCB  11.196710 9.000069e-09
#> 3084   3084      anova full            ARG2  11.191558 9.067976e-09
#> 3085   3085      anova full          DIAPH1  11.190498 9.082009e-09
#> 3086   3086      anova full        CHRFAM7A  11.187657 9.119743e-09
#> 3087   3087      anova full           PTPRR  11.182459 9.189188e-09
#> 3088   3088      anova full            GUSB  11.177398 9.257335e-09
#> 3089   3089      anova full          INPP5F  11.169891 9.359360e-09
#> 3090   3090      anova full            MCF2  11.168409 9.379641e-09
#> 3091   3091      anova full            H1FX  11.161956 9.468465e-09
#> 3092   3092      anova full            MTX2  11.161926 9.468882e-09
#> 3093   3093      anova full            GM2A  11.160416 9.489793e-09
#> 3094   3094      anova full           MMP17  11.153963 9.579687e-09
#> 3095   3095      anova full           GALR1  11.153824 9.581626e-09
#> 3096   3096      anova full         SHROOM1  11.152786 9.596181e-09
#> 3097   3097      anova full          DYNLL1  11.141989 9.748816e-09
#> 3098   3098      anova full            NRG3  11.136612 9.825751e-09
#> 3099   3099      anova full          KLHDC2  11.129262 9.931940e-09
#> 3100   3100      anova full          HNRNPM  11.127747 9.953980e-09
#> 3101   3101      anova full         S100A10  11.127610 9.955966e-09
#> 3102   3102      anova full        FAM171A2  11.126626 9.970306e-09
#> 3103   3103      anova full            SDSL  11.123146 1.002120e-08
#> 3104   3104      anova full           RPL24  11.117863 1.009895e-08
#> 3105   3105      anova full         RARRES2  11.116865 1.011371e-08
#> 3106   3106      anova full           FCGRT  11.116020 1.012623e-08
#> 3107   3107      anova full       LINC01830  11.102596 1.032717e-08
#> 3108   3108      anova full            NKTR  11.096589 1.041841e-08
#> 3109   3109      anova full          CHMP4A  11.095158 1.044027e-08
#> 3110   3110      anova full          ARPC1A  11.094103 1.045640e-08
#> 3111   3111      anova full          FAM69C  11.093703 1.046254e-08
#> 3112   3112      anova full          GAREM1  11.093673 1.046300e-08
#> 3113   3113      anova full            GNG4  11.090152 1.051710e-08
#> 3114   3114      anova full           RPL38  11.086998 1.056581e-08
#> 3115   3115      anova full            NT5C  11.083561 1.061913e-08
#> 3116   3116      anova full           CCDC3  11.081167 1.065645e-08
#> 3117   3117      anova full         PPP2R2A  11.077282 1.071730e-08
#> 3118   3118      anova full           CBARP  11.070874 1.081843e-08
#> 3119   3119      anova full        RAB3GAP1  11.070729 1.082073e-08
#> 3120   3120      anova full          MARCH2  11.070419 1.082564e-08
#> 3121   3121      anova full           LTBP4  11.068528 1.085570e-08
#> 3122   3122      anova full           RGS14  11.067665 1.086945e-08
#> 3123   3123      anova full          ANKRD9  11.060817 1.097913e-08
#> 3124   3124      anova full             AK3  11.056884 1.104265e-08
#> 3125   3125      anova full           DUSP2  11.055607 1.106334e-08
#> 3126   3126      anova full            MMP9  11.055575 1.106387e-08
#> 3127   3127      anova full            NDE1  11.050946 1.113924e-08
#> 3128   3128      anova full          RPL35A  11.048839 1.117374e-08
#> 3129   3129      anova full          ZFYVE9  11.040810 1.130615e-08
#> 3130   3130      anova full         CCDC167  11.039849 1.132211e-08
#> 3131   3131      anova full        SERPINH1  11.038013 1.135267e-08
#> 3132   3132      anova full      AL353751.1  11.037187 1.136644e-08
#> 3133   3133      anova full          LGALS3  11.033382 1.143009e-08
#> 3134   3134      anova full            PEX2  11.032833 1.143931e-08
#> 3135   3135      anova full          PPFIA4  11.031879 1.145534e-08
#> 3136   3136      anova full            DTNA  11.029886 1.148892e-08
#> 3137   3137      anova full            SMC4  11.017550 1.169894e-08
#> 3138   3138      anova full           GSTA4  11.015876 1.172775e-08
#> 3139   3139      anova full         SLC25A1  11.014820 1.174595e-08
#> 3140   3140      anova full            DPYS  11.011652 1.180074e-08
#> 3141   3141      anova full           BCL7C  11.007991 1.186440e-08
#> 3142   3142      anova full           PRDX4  11.007422 1.187433e-08
#> 3143   3143      anova full           SPON2  11.000311 1.199907e-08
#> 3144   3144      anova full        ARHGAP44  10.997369 1.205108e-08
#> 3145   3145      anova full           RAB9A  10.997324 1.205187e-08
#> 3146   3146      anova full            VSIR  10.996187 1.207204e-08
#> 3147   3147      anova full          FERMT2  10.991087 1.216289e-08
#> 3148   3148      anova full        SLC25A18  10.984834 1.227524e-08
#> 3149   3149      anova full          PRKAG2  10.978733 1.238590e-08
#> 3150   3150      anova full         SLC30A9  10.977854 1.240193e-08
#> 3151   3151      anova full           GLP2R  10.976348 1.242943e-08
#> 3152   3152      anova full           APH1A  10.968258 1.257829e-08
#> 3153   3153      anova full          PPP1R2  10.961974 1.269516e-08
#> 3154   3154      anova full            DSTN  10.960034 1.273147e-08
#> 3155   3155      anova full           PLCL2  10.937389 1.316323e-08
#> 3156   3156      anova full      AC073349.1  10.934897 1.321166e-08
#> 3157   3157      anova full          CRTAC1  10.930149 1.330443e-08
#> 3158   3158      anova full           GNA13  10.927625 1.335400e-08
#> 3159   3159      anova full           SORL1  10.925358 1.339870e-08
#> 3160   3160      anova full          IL17RB  10.924578 1.341412e-08
#> 3161   3161      anova full             BBX  10.924367 1.341829e-08
#> 3162   3162      anova full           PLAC9  10.924021 1.342513e-08
#> 3163   3163      anova full           PSMD1  10.923750 1.343051e-08
#> 3164   3164      anova full          MRPL15  10.923116 1.344306e-08
#> 3165   3165      anova full           RAI14  10.923107 1.344324e-08
#> 3166   3166      anova full           G3BP1  10.919505 1.351482e-08
#> 3167   3167      anova full            NPM1  10.919090 1.352309e-08
#> 3168   3168      anova full            CHML  10.909134 1.372310e-08
#> 3169   3169      anova full           NDST1  10.904130 1.382478e-08
#> 3170   3170      anova full           CEBPB  10.903290 1.384193e-08
#> 3171   3171      anova full           DNAL1  10.902881 1.385028e-08
#> 3172   3172      anova full           HTR5A  10.901925 1.386983e-08
#> 3173   3173      anova full            TYMS  10.899597 1.391756e-08
#> 3174   3174      anova full           PSMD2  10.898037 1.394964e-08
#> 3175   3175      anova full         TSPAN13  10.897692 1.395673e-08
#> 3176   3176      anova full            EMP2  10.894663 1.401926e-08
#> 3177   3177      anova full           PSMB5  10.894201 1.402882e-08
#> 3178   3178      anova full          SERHL2  10.891816 1.407829e-08
#> 3179   3179      anova full          RNF19B  10.890417 1.410740e-08
#> 3180   3180      anova full           CDKL5  10.885757 1.420478e-08
#> 3181   3181      anova full         C1QTNF3  10.881027 1.430432e-08
#> 3182   3182      anova full           ITSN1  10.877297 1.438332e-08
#> 3183   3183      anova full      AL355472.1  10.872468 1.448627e-08
#> 3184   3184      anova full           EPPK1  10.864731 1.465282e-08
#> 3185   3185      anova full          SNHG18  10.864134 1.466574e-08
#> 3186   3186      anova full          TSPAN8  10.857785 1.480398e-08
#> 3187   3187      anova full            CYGB  10.857080 1.481943e-08
#> 3188   3188      anova full      AC096667.1  10.856850 1.482446e-08
#> 3189   3189      anova full         S100A14  10.853530 1.489738e-08
#> 3190   3190      anova full      AC109779.1  10.852969 1.490974e-08
#> 3191   3191      anova full            SLTM  10.852909 1.491106e-08
#> 3192   3192      anova full           CD200  10.849657 1.498292e-08
#> 3193   3193      anova full           GRIA1  10.847947 1.502085e-08
#> 3194   3194      anova full            TJP2  10.846682 1.504897e-08
#> 3195   3195      anova full          SLC2A8  10.845723 1.507033e-08
#> 3196   3196      anova full            CST1  10.839591 1.520760e-08
#> 3197   3197      anova full           ARL4D  10.839418 1.521150e-08
#> 3198   3198      anova full            RPL6  10.839256 1.521514e-08
#> 3199   3199      anova full            TDO2  10.838122 1.524067e-08
#> 3200   3200      anova full          TOMM40  10.835819 1.529267e-08
#> 3201   3201      anova full           RAB34  10.835299 1.530445e-08
#> 3202   3202      anova full          CLPTM1  10.825218 1.553442e-08
#> 3203   3203      anova full           MAGI1  10.824670 1.554701e-08
#> 3204   3204      anova full           CCNA1  10.820790 1.563655e-08
#> 3205   3205      anova full          LGALS8  10.819007 1.567788e-08
#> 3206   3206      anova full             LBR  10.817336 1.571669e-08
#> 3207   3207      anova full         ST3GAL4  10.816814 1.572885e-08
#> 3208   3208      anova full           CASC3  10.816300 1.574082e-08
#> 3209   3209      anova full           TIMP3  10.810317 1.588085e-08
#> 3210   3210      anova full        ARHGEF17  10.808521 1.592316e-08
#> 3211   3211      anova full           MMP15  10.806494 1.597102e-08
#> 3212   3212      anova full           KMT2C  10.806354 1.597432e-08
#> 3213   3213      anova full           NETO2  10.806197 1.597805e-08
#> 3214   3214      anova full            SAT1  10.800575 1.611163e-08
#> 3215   3215      anova full      AL133453.1  10.794960 1.624621e-08
#> 3216   3216      anova full       LINC00488  10.793960 1.627029e-08
#> 3217   3217      anova full           SMAD4  10.790936 1.634335e-08
#> 3218   3218      anova full           KNOP1  10.790316 1.635838e-08
#> 3219   3219      anova full           PDHA1  10.788458 1.640347e-08
#> 3220   3220      anova full           DHRS3  10.785235 1.648202e-08
#> 3221   3221      anova full        CTNNBIP1  10.784260 1.650586e-08
#> 3222   3222      anova full           NELFE  10.783174 1.653245e-08
#> 3223   3223      anova full            LGI1  10.782384 1.655181e-08
#> 3224   3224      anova full         HMGCLL1  10.769691 1.686622e-08
#> 3225   3225      anova full             ALB  10.766615 1.694336e-08
#> 3226   3226      anova full          TAGLN2  10.765179 1.697948e-08
#> 3227   3227      anova full          SESTD1  10.763013 1.703411e-08
#> 3228   3228      anova full           MXRA8  10.759456 1.712424e-08
#> 3229   3229      anova full           NDRG2  10.759332 1.712739e-08
#> 3230   3230      anova full           PRR36  10.753366 1.727967e-08
#> 3231   3231      anova full           MYOM2  10.749447 1.738046e-08
#> 3232   3232      anova full          WNT10A  10.747662 1.742655e-08
#> 3233   3233      anova full          DUSP16  10.743018 1.754710e-08
#> 3234   3234      anova full           ELMO1  10.742700 1.755539e-08
#> 3235   3235      anova full           RPRML  10.742653 1.755662e-08
#> 3236   3236      anova full          C2CD2L  10.741156 1.759568e-08
#> 3237   3237      anova full        KIAA1549  10.739984 1.762632e-08
#> 3238   3238      anova full          SNAP23  10.739422 1.764102e-08
#> 3239   3239      anova full           CLIP2  10.736668 1.771332e-08
#> 3240   3240      anova full          PLPPR2  10.736156 1.772679e-08
#> 3241   3241      anova full           DMTF1  10.735163 1.775295e-08
#> 3242   3242      anova full           WSCD2  10.733067 1.780829e-08
#> 3243   3243      anova full           JADE3  10.731577 1.784773e-08
#> 3244   3244      anova full            EHD1  10.729112 1.791319e-08
#> 3245   3245      anova full           CELF3  10.728658 1.792527e-08
#> 3246   3246      anova full          COL1A2  10.726292 1.798839e-08
#> 3247   3247      anova full          COL2A1  10.725402 1.801216e-08
#> 3248   3248      anova full         B4GALT5  10.724218 1.804388e-08
#> 3249   3249      anova full      AC090152.1  10.723473 1.806385e-08
#> 3250   3250      anova full           CLCN4  10.720488 1.814415e-08
#> 3251   3251      anova full           KCNN2  10.719049 1.818298e-08
#> 3252   3252      anova full             DCC  10.717615 1.822177e-08
#> 3253   3253      anova full          RIMKLA  10.715151 1.828863e-08
#> 3254   3254      anova full           FFAR4  10.707357 1.850169e-08
#> 3255   3255      anova full            EIF5  10.702834 1.862652e-08
#> 3256   3256      anova full          FAM81A  10.700272 1.869761e-08
#> 3257   3257      anova full          FAM69B  10.700087 1.870276e-08
#> 3258   3258      anova full            TLE1  10.695450 1.883218e-08
#> 3259   3259      anova full      AC098850.3  10.695177 1.883981e-08
#> 3260   3260      anova full           TRUB1  10.677384 1.934518e-08
#> 3261   3261      anova full      AL021368.2  10.675706 1.939356e-08
#> 3262   3262      anova full         BLOC1S2  10.673391 1.946049e-08
#> 3263   3263      anova full            IGF1  10.670015 1.955853e-08
#> 3264   3264      anova full            MPP6  10.669473 1.957435e-08
#> 3265   3265      anova full            HES5  10.669454 1.957488e-08
#> 3266   3266      anova full            GYPC  10.666651 1.965674e-08
#> 3267   3267      anova full           CXADR  10.658877 1.988562e-08
#> 3268   3268      anova full            SOS2  10.658526 1.989600e-08
#> 3269   3269      anova full            UBR3  10.656232 1.996410e-08
#> 3270   3270      anova full           SGSM1  10.654685 2.001017e-08
#> 3271   3271      anova full           GTF2I  10.650597 2.013239e-08
#> 3272   3272      anova full            RERG  10.649489 2.016565e-08
#> 3273   3273      anova full            PRR7  10.639171 2.047811e-08
#> 3274   3274      anova full           ADRB1  10.632060 2.069630e-08
#> 3275   3275      anova full          PITPNA  10.631104 2.072582e-08
#> 3276   3276      anova full           MLLT1  10.630003 2.075990e-08
#> 3277   3277      anova full         SOSTDC1  10.625680 2.089415e-08
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#> 3522   3522      anova full          PRSS12   9.903861 6.224634e-08
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#> 3527   3527      anova full          SEC23B   9.894900 6.310791e-08
#> 3528   3528      anova full            BBS7   9.890932 6.349327e-08
#> 3529   3529      anova full         RPL22L1   9.888813 6.370004e-08
#> 3530   3530      anova full           USP40   9.887498 6.382879e-08
#> 3531   3531      anova full      AC008780.1   9.887296 6.384858e-08
#> 3532   3532      anova full          ABLIM1   9.881484 6.442073e-08
#> 3533   3533      anova full      AC130466.1   9.881030 6.446566e-08
#> 3534   3534      anova full            DBN1   9.877734 6.479266e-08
#> 3535   3535      anova full           ADTRP   9.875124 6.505282e-08
#> 3536   3536      anova full         ST8SIA1   9.872538 6.531167e-08
#> 3537   3537      anova full          COBLL1   9.872518 6.531363e-08
#> 3538   3538      anova full           ADH1B   9.866461 6.592411e-08
#> 3539   3539      anova full            FAT1   9.863441 6.623063e-08
#> 3540   3540      anova full           ZDBF2   9.860437 6.653700e-08
#> 3541   3541      anova full          CAMTA1   9.855926 6.699982e-08
#> 3542   3542      anova full           ITGB5   9.855099 6.708498e-08
#> 3543   3543      anova full           LIX1L   9.855017 6.709345e-08
#> 3544   3544      anova full            SAV1   9.853302 6.727048e-08
#> 3545   3545      anova full         FAM110B   9.843514 6.829020e-08
#> 3546   3546      anova full            CD24   9.840192 6.863998e-08
#> 3547   3547      anova full          DNAJB9   9.834197 6.927564e-08
#> 3548   3548      anova full         HNRNPAB   9.833250 6.937663e-08
#> 3549   3549      anova full         SEC61A1   9.831146 6.960147e-08
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#> 3618   3618      anova full          ADRA2A   9.625853 9.556794e-08
#> 3619   3619      anova full        C19orf12   9.622555 9.605802e-08
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#> 3621   3621      anova full          SPRYD7   9.621571 9.620470e-08
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#> 3630   3630      anova full           ZG16B   9.605079 9.869788e-08
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#> 3637   3637      anova full           LIN7A   9.579929 1.026283e-07
#> 3638   3638      anova full           CYBC1   9.579301 1.027285e-07
#> 3639   3639      anova full           PAICS   9.573191 1.037083e-07
#> 3640   3640      anova full            IRGQ   9.572432 1.038308e-07
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#> 3642   3642      anova full           BEST1   9.567329 1.046574e-07
#> 3643   3643      anova full            CAST   9.565291 1.049895e-07
#> 3644   3644      anova full           ZFP36   9.565097 1.050212e-07
#> 3645   3645      anova full         NECTIN3   9.563335 1.053092e-07
#> 3646   3646      anova full             OGN   9.559471 1.059437e-07
#> 3647   3647      anova full         HNRNPH3   9.558020 1.061830e-07
#> 3648   3648      anova full           SCN4B   9.556590 1.064192e-07
#> 3649   3649      anova full         GALNTL5   9.553151 1.069900e-07
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#> 3652   3652      anova full      CYP1B1-AS1   9.536539 1.097907e-07
#> 3653   3653      anova full           CIRBP   9.533606 1.102931e-07
#> 3654   3654      anova full           CRTC1   9.533017 1.103943e-07
#> 3655   3655      anova full            ATRX   9.530176 1.108835e-07
#> 3656   3656      anova full          MAN2A2   9.528888 1.111060e-07
#> 3657   3657      anova full            PNMT   9.527005 1.114321e-07
#> 3658   3658      anova full            BTG3   9.524319 1.118990e-07
#> 3659   3659      anova full          TRAFD1   9.519672 1.127116e-07
#> 3660   3660      anova full            IGHE   9.517903 1.130225e-07
#> 3661   3661      anova full           RPAIN   9.510834 1.142737e-07
#> 3662   3662      anova full          SLC1A5   9.502512 1.157650e-07
#> 3663   3663      anova full           MUC12   9.496094 1.169287e-07
#> 3664   3664      anova full            DPF2   9.491644 1.177427e-07
#> 3665   3665      anova full          STXBP5   9.488051 1.184041e-07
#> 3666   3666      anova full         HSD17B4   9.483185 1.193058e-07
#> 3667   3667      anova full           FKBP8   9.482646 1.194061e-07
#> 3668   3668      anova full           REPS2   9.481919 1.195415e-07
#> 3669   3669      anova full             GCA   9.481541 1.196120e-07
#> 3670   3670      anova full          TARSL2   9.480267 1.198500e-07
#> 3671   3671      anova full           MORN4   9.479731 1.199502e-07
#> 3672   3672      anova full          RANBP6   9.478222 1.202329e-07
#> 3673   3673      anova full           HDDC2   9.474554 1.209227e-07
#> 3674   3674      anova full            GLRX   9.466863 1.223824e-07
#> 3675   3675      anova full          CPPED1   9.466660 1.224212e-07
#> 3676   3676      anova full            TTC9   9.462867 1.231481e-07
#> 3677   3677      anova full         FAM162B   9.451229 1.254058e-07
#> 3678   3678      anova full            LAYN   9.450984 1.254537e-07
#> 3679   3679      anova full          FBXL17   9.450332 1.255815e-07
#> 3680   3680      anova full         FAM153C   9.449524 1.257401e-07
#> 3681   3681      anova full           PEG10   9.442436 1.271396e-07
#> 3682   3682      anova full           TCEA2   9.442278 1.271710e-07
#> 3683   3683      anova full          ATXN10   9.442154 1.271957e-07
#> 3684   3684      anova full      AL356479.1   9.440972 1.274307e-07
#> 3685   3685      anova full          ZRANB1   9.440819 1.274612e-07
#> 3686   3686      anova full            PMF1   9.440017 1.276209e-07
#> 3687   3687      anova full          ANTXR1   9.433273 1.289726e-07
#> 3688   3688      anova full            DDX5   9.431207 1.293897e-07
#> 3689   3689      anova full             SP1   9.431201 1.293909e-07
#> 3690   3690      anova full           CNGB1   9.430872 1.294574e-07
#> 3691   3691      anova full          ANKFY1   9.428281 1.299826e-07
#> 3692   3692      anova full           PLCB4   9.426918 1.302599e-07
#> 3693   3693      anova full         RIPPLY2   9.426322 1.303813e-07
#> 3694   3694      anova full           CCT6A   9.423940 1.308675e-07
#> 3695   3695      anova full            DTX3   9.423734 1.309098e-07
#> 3696   3696      anova full            RTCA   9.416500 1.323986e-07
#> 3697   3697      anova full          KATNB1   9.414670 1.327779e-07
#> 3698   3698      anova full            CALU   9.413831 1.329523e-07
#> 3699   3699      anova full         MICALL1   9.412015 1.333303e-07
#> 3700   3700      anova full          DCAF11   9.405792 1.346343e-07
#> 3701   3701      anova full         BHLHE40   9.401570 1.355265e-07
#> 3702   3702      anova full           DISP2   9.401144 1.356170e-07
#> 3703   3703      anova full           MRPL4   9.400617 1.357288e-07
#> 3704   3704      anova full            SDC3   9.390840 1.378213e-07
#> 3705   3705      anova full           NEK11   9.388675 1.382892e-07
#> 3706   3706      anova full           PSMD4   9.382470 1.396390e-07
#> 3707   3707      anova full          KLHL24   9.378579 1.404923e-07
#> 3708   3708      anova full           TMCO1   9.377349 1.407631e-07
#> 3709   3709      anova full       LINC01963   9.374947 1.412936e-07
#> 3710   3710      anova full           PTH2R   9.373552 1.416026e-07
#> 3711   3711      anova full           CDC42   9.371171 1.421317e-07
#> 3712   3712      anova full          BHLHB9   9.370458 1.422906e-07
#> 3713   3713      anova full           TTC9C   9.370218 1.423441e-07
#> 3714   3714      anova full             MT3   9.368596 1.427062e-07
#> 3715   3715      anova full         HNRNPH2   9.368002 1.428391e-07
#> 3716   3716      anova full          DDX39A   9.366032 1.432806e-07
#> 3717   3717      anova full           GRIK2   9.358325 1.450214e-07
#> 3718   3718      anova full            VAPA   9.357573 1.451923e-07
#> 3719   3719      anova full           TRIB2   9.356019 1.455463e-07
#> 3720   3720      anova full      AC022893.2   9.351172 1.466565e-07
#> 3721   3721      anova full            DTX1   9.348632 1.472414e-07
#> 3722   3722      anova full          ATP10B   9.346712 1.476853e-07
#> 3723   3723      anova full      AP000426.1   9.343732 1.483770e-07
#> 3724   3724      anova full           ERBB2   9.337401 1.498576e-07
#> 3725   3725      anova full           ABCE1   9.336692 1.500244e-07
#> 3726   3726      anova full          TUBA1C   9.334969 1.504304e-07
#> 3727   3727      anova full         FAM172A   9.331697 1.512044e-07
#> 3728   3728      anova full             CA7   9.325708 1.526319e-07
#> 3729   3729      anova full            PKP2   9.325607 1.526562e-07
#> 3730   3730      anova full         SYNGAP1   9.325602 1.526574e-07
#> 3731   3731      anova full          COX6B1   9.324299 1.529698e-07
#> 3732   3732      anova full           IGSF3   9.319023 1.542417e-07
#> 3733   3733      anova full           MCF2L   9.318817 1.542915e-07
#> 3734   3734      anova full             PLN   9.318164 1.544497e-07
#> 3735   3735      anova full           FBXO3   9.316513 1.548507e-07
#> 3736   3736      anova full          NDUFB3   9.313567 1.555685e-07
#> 3737   3737      anova full       LINC01270   9.310355 1.563550e-07
#> 3738   3738      anova full           PLCD1   9.301843 1.584591e-07
#> 3739   3739      anova full             GGH   9.297533 1.595353e-07
#> 3740   3740      anova full            NPNT   9.290932 1.611985e-07
#> 3741   3741      anova full       LINC01637   9.288086 1.619212e-07
#> 3742   3742      anova full        ARHGEF12   9.287503 1.620696e-07
#> 3743   3743      anova full      AC010624.2   9.284274 1.628941e-07
#> 3744   3744      anova full           TCF12   9.283827 1.630086e-07
#> 3745   3745      anova full            USP1   9.283267 1.631522e-07
#> 3746   3746      anova full          POLR2M   9.278545 1.643678e-07
#> 3747   3747      anova full            PYGM   9.271627 1.661654e-07
#> 3748   3748      anova full           TTC19   9.268273 1.670442e-07
#> 3749   3749      anova full           DDHD2   9.267622 1.672154e-07
#> 3750   3750      anova full            YAF2   9.266775 1.674382e-07
#> 3751   3751      anova full            OMA1   9.262755 1.685003e-07
#> 3752   3752      anova full         CDK2AP1   9.260680 1.690513e-07
#> 3753   3753      anova full         CAMSAP3   9.257396 1.699270e-07
#> 3754   3754      anova full            FJX1   9.254128 1.708031e-07
#> 3755   3755      anova full           MESP1   9.253330 1.710178e-07
#> 3756   3756      anova full          RIMBP2   9.251647 1.714713e-07
#> 3757   3757      anova full           AAGAB   9.249759 1.719816e-07
#> 3758   3758      anova full            NME3   9.245543 1.731267e-07
#> 3759   3759      anova full           NRBP2   9.236689 1.755570e-07
#> 3760   3760      anova full           CDH18   9.231858 1.768978e-07
#> 3761   3761      anova full          NDUFA3   9.231466 1.770071e-07
#> 3762   3762      anova full           PEBP1   9.229965 1.774260e-07
#> 3763   3763      anova full           MARF1   9.227205 1.781990e-07
#> 3764   3764      anova full          NPFFR2   9.224780 1.788811e-07
#> 3765   3765      anova full            AIF1   9.221917 1.796898e-07
#> 3766   3766      anova full          SMIM24   9.220408 1.801176e-07
#> 3767   3767      anova full            GGA3   9.216154 1.813293e-07
#> 3768   3768      anova full           COPS8   9.215205 1.816006e-07
#> 3769   3769      anova full           QRFPR   9.213172 1.821835e-07
#> 3770   3770      anova full           FGFR1   9.211897 1.825498e-07
#> 3771   3771      anova full          PDZRN3   9.211477 1.826708e-07
#> 3772   3772      anova full             PNP   9.211466 1.826739e-07
#> 3773   3773      anova full           C2CD5   9.205740 1.843304e-07
#> 3774   3774      anova full       LINC01896   9.200125 1.859696e-07
#> 3775   3775      anova full            ALPL   9.199530 1.861442e-07
#> 3776   3776      anova full           GPSM2   9.198782 1.863640e-07
#> 3777   3777      anova full           STAT2   9.194353 1.876706e-07
#> 3778   3778      anova full            ELF3   9.193595 1.878951e-07
#> 3779   3779      anova full            SIL1   9.193353 1.879668e-07
#> 3780   3780      anova full           VPS50   9.193112 1.880383e-07
#> 3781   3781      anova full            PLS3   9.188016 1.895562e-07
#> 3782   3782      anova full            SDHB   9.187256 1.897835e-07
#> 3783   3783      anova full             CA8   9.185398 1.903406e-07
#> 3784   3784      anova full          ADARB1   9.181641 1.914726e-07
#> 3785   3785      anova full           PTPRG   9.179359 1.921634e-07
#> 3786   3786      anova full           RFPL2   9.177929 1.925977e-07
#> 3787   3787      anova full           EEPD1   9.169937 1.950430e-07
#> 3788   3788      anova full         PLEKHA1   9.169649 1.951317e-07
#> 3789   3789      anova full          FAM92A   9.169574 1.951549e-07
#> 3790   3790      anova full          NDUFV2   9.167467 1.958051e-07
#> 3791   3791      anova full           LMOD1   9.166568 1.960833e-07
#> 3792   3792      anova full         ANAPC13   9.161978 1.975098e-07
#> 3793   3793      anova full         SCGB1A1   9.159464 1.982956e-07
#> 3794   3794      anova full           TENM3   9.153661 2.001219e-07
#> 3795   3795      anova full           NAGPA   9.153189 2.002710e-07
#> 3796   3796      anova full           KRT31   9.148316 2.018192e-07
#> 3797   3797      anova full           ESRRG   9.147062 2.022197e-07
#> 3798   3798      anova full           CPT1C   9.145310 2.027804e-07
#> 3799   3799      anova full           PPM1E   9.144856 2.029257e-07
#> 3800   3800      anova full            CD47   9.142094 2.038138e-07
#> 3801   3801      anova full           RAB9B   9.140389 2.043637e-07
#> 3802   3802      anova full          ADGRL3   9.140092 2.044595e-07
#> 3803   3803      anova full     ADAMTS9-AS1   9.135422 2.059748e-07
#> 3804   3804      anova full            ALG5   9.131558 2.072371e-07
#> 3805   3805      anova full        DYNC1LI1   9.129610 2.078765e-07
#> 3806   3806      anova full            GAS7   9.128735 2.081644e-07
#> 3807   3807      anova full         HCFC1R1   9.125356 2.092799e-07
#> 3808   3808      anova full        PPP1R14C   9.124265 2.096412e-07
#> 3809   3809      anova full           BTBD6   9.124259 2.096432e-07
#> 3810   3810      anova full            CREM   9.122661 2.101739e-07
#> 3811   3811      anova full          TM7SF3   9.120384 2.109324e-07
#> 3812   3812      anova full      AC016597.1   9.117464 2.119090e-07
#> 3813   3813      anova full           KCTD7   9.113452 2.132586e-07
#> 3814   3814      anova full           ABCC8   9.110909 2.141187e-07
#> 3815   3815      anova full          UQCR10   9.110369 2.143018e-07
#> 3816   3816      anova full            PBX1   9.105318 2.160218e-07
#> 3817   3817      anova full             SP8   9.097507 2.187098e-07
#> 3818   3818      anova full             MSC   9.089050 2.216588e-07
#> 3819   3819      anova full            ORC4   9.084309 2.233301e-07
#> 3820   3820      anova full           KCNA4   9.079129 2.251704e-07
#> 3821   3821      anova full            PPA1   9.073074 2.273417e-07
#> 3822   3822      anova full           SYMPK   9.072227 2.276470e-07
#> 3823   3823      anova full            DPP4   9.068705 2.289216e-07
#> 3824   3824      anova full           RSPO2   9.058279 2.327376e-07
#> 3825   3825      anova full            VAPB   9.057383 2.330683e-07
#> 3826   3826      anova full         TMEM50A   9.056237 2.334926e-07
#> 3827   3827      anova full         ST3GAL2   9.054817 2.340189e-07
#> 3828   3828      anova full          HIGD1B   9.052042 2.350514e-07
#> 3829   3829      anova full          INPP5A   9.051138 2.353885e-07
#> 3830   3830      anova full          CRABP1   9.049035 2.361755e-07
#> 3831   3831      anova full           NAA38   9.048228 2.364781e-07
#> 3832   3832      anova full       LINC02217   9.046124 2.372686e-07
#> 3833   3833      anova full      AL591895.1   9.044518 2.378740e-07
#> 3834   3834      anova full           FRMD5   9.043442 2.382807e-07
#> 3835   3835      anova full        TMEM200C   9.040213 2.395049e-07
#> 3836   3836      anova full           MOB1B   9.039440 2.397987e-07
#> 3837   3837      anova full             BCR   9.039351 2.398328e-07
#> 3838   3838      anova full           LRFN1   9.039190 2.398939e-07
#> 3839   3839      anova full           PPM1A   9.038434 2.401819e-07
#> 3840   3840      anova full          SCAMP3   9.038310 2.402294e-07
#> 3841   3841      anova full           TTC32   9.033706 2.419914e-07
#> 3842   3842      anova full         SIPA1L2   9.033217 2.421794e-07
#> 3843   3843      anova full            UFD1   9.031495 2.428423e-07
#> 3844   3844      anova full           EIF4H   9.027942 2.442159e-07
#> 3845   3845      anova full          POPDC3   9.025989 2.449748e-07
#> 3846   3846      anova full          SH3TC2   9.022804 2.462170e-07
#> 3847   3847      anova full          LMBRD1   9.017997 2.481039e-07
#> 3848   3848      anova full           SREK1   9.016506 2.486925e-07
#> 3849   3849      anova full      AC124798.1   9.016373 2.487448e-07
#> 3850   3850      anova full          ZNF771   9.014389 2.495303e-07
#> 3851   3851      anova full           SZRD1   9.012634 2.502268e-07
#> 3852   3852      anova full          TRIM41   9.010136 2.512221e-07
#> 3853   3853      anova full           CCSAP   9.008777 2.517649e-07
#> 3854   3854      anova full      AL162511.1   9.007299 2.523572e-07
#> 3855   3855      anova full           EIF4B   9.006571 2.526492e-07
#> 3856   3856      anova full           CLIC1   9.005253 2.531789e-07
#> 3857   3857      anova full          TMIGD3   9.002458 2.543062e-07
#> 3858   3858      anova full          RAB33B   9.001482 2.547010e-07
#> 3859   3859      anova full           CAPSL   8.999642 2.554472e-07
#> 3860   3860      anova full           NRXN2   8.996847 2.565846e-07
#> 3861   3861      anova full           EIF4E   8.993626 2.579021e-07
#> 3862   3862      anova full            CHD4   8.992114 2.585228e-07
#> 3863   3863      anova full          ETFRF1   8.991386 2.588225e-07
#> 3864   3864      anova full          GPRC5C   8.990108 2.593491e-07
#> 3865   3865      anova full           TMED4   8.989474 2.596106e-07
#> 3866   3866      anova full          SLC1A6   8.988793 2.598920e-07
#> 3867   3867      anova full           LRFN2   8.979621 2.637113e-07
#> 3868   3868      anova full            IRX2   8.977535 2.645878e-07
#> 3869   3869      anova full         ONECUT2   8.973245 2.664003e-07
#> 3870   3870      anova full          TGFBR2   8.970878 2.674057e-07
#> 3871   3871      anova full          NDUFB6   8.967373 2.689016e-07
#> 3872   3872      anova full            CUL1   8.966874 2.691154e-07
#> 3873   3873      anova full           IARS2   8.960093 2.720362e-07
#> 3874   3874      anova full            RILP   8.957833 2.730169e-07
#> 3875   3875      anova full         GUCY1A1   8.957046 2.733590e-07
#> 3876   3876      anova full         UNC93B1   8.956775 2.734771e-07
#> 3877   3877      anova full      STARD4-AS1   8.954055 2.746643e-07
#> 3878   3878      anova full          ELOVL2   8.949866 2.765027e-07
#> 3879   3879      anova full          NDUFS4   8.947779 2.774237e-07
#> 3880   3880      anova full           UBFD1   8.947283 2.776428e-07
#> 3881   3881      anova full      AC010980.2   8.947227 2.776678e-07
#> 3882   3882      anova full             FEV   8.946483 2.779971e-07
#> 3883   3883      anova full            DPCD   8.946350 2.780559e-07
#> 3884   3884      anova full           PRKCD   8.945351 2.784989e-07
#> 3885   3885      anova full         MORF4L2   8.944946 2.786785e-07
#> 3886   3886      anova full      AL365361.1   8.944838 2.787266e-07
#> 3887   3887      anova full            PAX6   8.943718 2.792243e-07
#> 3888   3888      anova full            DLL1   8.942344 2.798362e-07
#> 3889   3889      anova full           MEAF6   8.941720 2.801148e-07
#> 3890   3890      anova full           RAB21   8.941644 2.801484e-07
#> 3891   3891      anova full      AL031710.1   8.939074 2.812979e-07
#> 3892   3892      anova full      AC023886.1   8.937293 2.820974e-07
#> 3893   3893      anova full           MCTS1   8.934110 2.835324e-07
#> 3894   3894      anova full           PRKCQ   8.932619 2.842067e-07
#> 3895   3895      anova full          CLASRP   8.931329 2.847916e-07
#> 3896   3896      anova full           OTUB2   8.929469 2.856374e-07
#> 3897   3897      anova full         FAM131B   8.927064 2.867345e-07
#> 3898   3898      anova full           TUBG2   8.923907 2.881814e-07
#> 3899   3899      anova full         SLC25A6   8.923252 2.884827e-07
#> 3900   3900      anova full           PDCL3   8.917086 2.913335e-07
#> 3901   3901      anova full            TRIO   8.916669 2.915270e-07
#> 3902   3902      anova full          TNRC6B   8.915836 2.919147e-07
#> 3903   3903      anova full           ACAA2   8.912292 2.935694e-07
#> 3904   3904      anova full          RAB39B   8.911403 2.939863e-07
#> 3905   3905      anova full            RGMB   8.910426 2.944447e-07
#> 3906   3906      anova full            PGA5   8.903128 2.978937e-07
#> 3907   3907      anova full           CNGA3   8.902147 2.983605e-07
#> 3908   3908      anova full           PNMA5   8.901049 2.988834e-07
#> 3909   3909      anova full        C15orf59   8.898948 2.998872e-07
#> 3910   3910      anova full          NFE2L1   8.896893 3.008726e-07
#> 3911   3911      anova full           CLDN3   8.895261 3.016575e-07
#> 3912   3912      anova full           PARVA   8.894274 3.021334e-07
#> 3913   3913      anova full           KDM5A   8.893106 3.026972e-07
#> 3914   3914      anova full           TREM2   8.887615 3.053624e-07
#> 3915   3915      anova full           RGS10   8.886976 3.056742e-07
#> 3916   3916      anova full          ADGRA3   8.886225 3.060410e-07
#> 3917   3917      anova full           FLOT1   8.886035 3.061340e-07
#> 3918   3918      anova full            IL34   8.885144 3.065698e-07
#> 3919   3919      anova full           NOVA2   8.884048 3.071068e-07
#> 3920   3920      anova full            ASPH   8.883083 3.075803e-07
#> 3921   3921      anova full       LINC01094   8.882041 3.080929e-07
#> 3922   3922      anova full           EVA1B   8.882001 3.081124e-07
#> 3923   3923      anova full        C11orf74   8.874720 3.117167e-07
#> 3924   3924      anova full           UBE3C   8.874327 3.119124e-07
#> 3925   3925      anova full         C3orf70   8.873313 3.124186e-07
#> 3926   3926      anova full             TRO   8.871861 3.131439e-07
#> 3927   3927      anova full        KIAA0319   8.869177 3.144899e-07
#> 3928   3928      anova full          CYP1B1   8.869052 3.145528e-07
#> 3929   3929      anova full          PPP4R1   8.864225 3.169884e-07
#> 3930   3930      anova full       PABPC1L2B   8.861037 3.186079e-07
#> 3931   3931      anova full        ARHGAP22   8.859206 3.195417e-07
#> 3932   3932      anova full      AC104417.2   8.858755 3.197722e-07
#> 3933   3933      anova full           OSBP2   8.858329 3.199903e-07
#> 3934   3934      anova full            FMN2   8.858154 3.200799e-07
#> 3935   3935      anova full            GALC   8.855951 3.212090e-07
#> 3936   3936      anova full        C11orf68   8.855216 3.215866e-07
#> 3937   3937      anova full        SLC25A27   8.851656 3.234224e-07
#> 3938   3938      anova full          PYCARD   8.851281 3.236167e-07
#> 3939   3939      anova full        ARHGAP36   8.850390 3.240779e-07
#> 3940   3940      anova full         TMEM127   8.848202 3.252138e-07
#> 3941   3941      anova full           SRRM1   8.846659 3.260174e-07
#> 3942   3942      anova full            CLTB   8.845535 3.266038e-07
#> 3943   3943      anova full           PLCL1   8.842391 3.282508e-07
#> 3944   3944      anova full          TROVE2   8.839730 3.296511e-07
#> 3945   3945      anova full      AC008124.1   8.831132 3.342176e-07
#> 3946   3946      anova full          NDUFC1   8.826889 3.364949e-07
#> 3947   3947      anova full           FLRT3   8.826783 3.365522e-07
#> 3948   3948      anova full     NECTIN3-AS1   8.826656 3.366205e-07
#> 3949   3949      anova full        ARHGEF40   8.825626 3.371761e-07
#> 3950   3950      anova full          PRPF31   8.823910 3.381036e-07
#> 3951   3951      anova full           OSTF1   8.820494 3.399578e-07
#> 3952   3952      anova full            OSTN   8.818264 3.411739e-07
#> 3953   3953      anova full           KCNK2   8.817152 3.417816e-07
#> 3954   3954      anova full          GPRIN3   8.814033 3.434930e-07
#> 3955   3955      anova full              XK   8.810568 3.454046e-07
#> 3956   3956      anova full         NR2C2AP   8.809705 3.458825e-07
#> 3957   3957      anova full          NFKBIA   8.805379 3.482874e-07
#> 3958   3958      anova full         RASGRP2   8.795626 3.537734e-07
#> 3959   3959      anova full          POLR2F   8.789578 3.572194e-07
#> 3960   3960      anova full         C4orf54   8.784567 3.601009e-07
#> 3961   3961      anova full           PIAS4   8.782752 3.611505e-07
#> 3962   3962      anova full            MYH9   8.782711 3.611743e-07
#> 3963   3963      anova full       LINC00592   8.778459 3.636455e-07
#> 3964   3964      anova full      AC074387.1   8.776121 3.650112e-07
#> 3965   3965      anova full          CFAP97   8.775163 3.655724e-07
#> 3966   3966      anova full           DDIT4   8.773722 3.664184e-07
#> 3967   3967      anova full             SLA   8.770814 3.681322e-07
#> 3968   3968      anova full           NPAS2   8.770498 3.683184e-07
#> 3969   3969      anova full            OAS3   8.767845 3.698894e-07
#> 3970   3970      anova full            CHD3   8.763814 3.722901e-07
#> 3971   3971      anova full         SHROOM4   8.763595 3.724205e-07
#> 3972   3972      anova full           SOCS7   8.763400 3.725371e-07
#> 3973   3973      anova full        C19orf66   8.760008 3.745711e-07
#> 3974   3974      anova full            RLIM   8.759788 3.747033e-07
#> 3975   3975      anova full             DAP   8.757849 3.758709e-07
#> 3976   3976      anova full      AC007527.2   8.752880 3.788814e-07
#> 3977   3977      anova full            RGL1   8.751331 3.798244e-07
#> 3978   3978      anova full          ADAM11   8.749735 3.807991e-07
#> 3979   3979      anova full           KCNE4   8.749144 3.811607e-07
#> 3980   3980      anova full          ARMCX3   8.748861 3.813340e-07
#> 3981   3981      anova full         SHROOM2   8.747692 3.820502e-07
#> 3982   3982      anova full          BNIP3L   8.747289 3.822974e-07
#> 3983   3983      anova full            WNT2   8.744314 3.841282e-07
#> 3984   3984      anova full           AHSA1   8.740565 3.864485e-07
#> 3985   3985      anova full        MAPK8IP3   8.740009 3.867936e-07
#> 3986   3986      anova full            JPT1   8.739450 3.871407e-07
#> 3987   3987      anova full          COL5A2   8.738797 3.875474e-07
#> 3988   3988      anova full           KCNJ3   8.738354 3.878235e-07
#> 3989   3989      anova full            SDC1   8.732274 3.916300e-07
#> 3990   3990      anova full            LCAT   8.731879 3.918784e-07
#> 3991   3991      anova full            NAB2   8.730807 3.925543e-07
#> 3992   3992      anova full           EIF2D   8.730452 3.927782e-07
#> 3993   3993      anova full           NAA80   8.730342 3.928474e-07
#> 3994   3994      anova full         CASKIN2   8.726389 3.953507e-07
#> 3995   3995      anova full          GTF2F2   8.725545 3.958873e-07
#> 3996   3996      anova full            IDH2   8.724091 3.968140e-07
#> 3997   3997      anova full           RGS20   8.723052 3.974770e-07
#> 3998   3998      anova full         LRRFIP1   8.722182 3.980334e-07
#> 3999   3999      anova full           BAZ1A   8.719616 3.996785e-07
#> 4000   4000      anova full           EVI2B   8.714936 4.026968e-07
#> 4001   4001      anova full          PMEPA1   8.713235 4.037998e-07
#> 4002   4002      anova full          FBXO41   8.711451 4.049598e-07
#> 4003   4003      anova full         DSCAML1   8.710998 4.052547e-07
#> 4004   4004      anova full           THOC3   8.706377 4.082777e-07
#> 4005   4005      anova full          CTNNB1   8.704293 4.096485e-07
#> 4006   4006      anova full          MRPL24   8.701595 4.114308e-07
#> 4007   4007      anova full           RAB4A   8.696993 4.144881e-07
#> 4008   4008      anova full            SOBP   8.696197 4.150194e-07
#> 4009   4009      anova full           NUMBL   8.686541 4.215192e-07
#> 4010   4010      anova full          LHFPL6   8.685889 4.219617e-07
#> 4011   4011      anova full           CIDEC   8.683685 4.234614e-07
#> 4012   4012      anova full           NMRK1   8.671723 4.316971e-07
#> 4013   4013      anova full           RBM8A   8.671058 4.321600e-07
#> 4014   4014      anova full      AL008729.2   8.667270 4.348044e-07
#> 4015   4015      anova full              CS   8.664883 4.364796e-07
#> 4016   4016      anova full      AC008105.1   8.664627 4.366597e-07
#> 4017   4017      anova full          CC2D1B   8.663536 4.374285e-07
#> 4018   4018      anova full           AP4S1   8.660499 4.395738e-07
#> 4019   4019      anova full          ZNF451   8.657170 4.419387e-07
#> 4020   4020      anova full            ZBBX   8.655224 4.433267e-07
#> 4021   4021      anova full          NUP133   8.651954 4.456694e-07
#> 4022   4022      anova full         SLC39A6   8.651280 4.461535e-07
#> 4023   4023      anova full         SELENOS   8.650882 4.464398e-07
#> 4024   4024      anova full           FOCAD   8.650176 4.469485e-07
#> 4025   4025      anova full           NXPH1   8.647559 4.488384e-07
#> 4026   4026      anova full          EXOC6B   8.647152 4.491328e-07
#> 4027   4027      anova full            CYBA   8.643357 4.518892e-07
#> 4028   4028      anova full             WLS   8.642572 4.524614e-07
#> 4029   4029      anova full          KISS1R   8.642150 4.527695e-07
#> 4030   4030      anova full         NCKIPSD   8.641655 4.531314e-07
#> 4031   4031      anova full         PLEKHA6   8.640022 4.543264e-07
#> 4032   4032      anova full            NAF1   8.636743 4.567353e-07
#> 4033   4033      anova full          TRMT13   8.632873 4.595948e-07
#> 4034   4034      anova full          PIP4P2   8.632600 4.597976e-07
#> 4035   4035      anova full        SLC25A11   8.628420 4.629083e-07
#> 4036   4036      anova full          PWWP2A   8.628017 4.632100e-07
#> 4037   4037      anova full          TWIST1   8.619947 4.692814e-07
#> 4038   4038      anova full           GNG11   8.619936 4.692894e-07
#> 4039   4039      anova full        ITPRIPL2   8.618723 4.702097e-07
#> 4040   4040      anova full        FAM189A1   8.618362 4.704836e-07
#> 4041   4041      anova full          ZNHIT3   8.617107 4.714373e-07
#> 4042   4042      anova full         ABHD17B   8.616569 4.718467e-07
#> 4043   4043      anova full         ALOX15B   8.616537 4.718716e-07
#> 4044   4044      anova full          FCHSD2   8.614755 4.732305e-07
#> 4045   4045      anova full          RANBP2   8.614467 4.734506e-07
#> 4046   4046      anova full           LRRC1   8.611485 4.757357e-07
#> 4047   4047      anova full            PPA2   8.605875 4.800644e-07
#> 4048   4048      anova full         FAM120C   8.605111 4.806569e-07
#> 4049   4049      anova full            CKS2   8.604724 4.809575e-07
#> 4050   4050      anova full             DEK   8.604485 4.811431e-07
#> 4051   4051      anova full      AL359764.1   8.603072 4.822427e-07
#> 4052   4052      anova full           PTBP1   8.601688 4.833221e-07
#> 4053   4053      anova full            GRM1   8.601198 4.837044e-07
#> 4054   4054      anova full           NR3C2   8.598161 4.860832e-07
#> 4055   4055      anova full          RNF146   8.596552 4.873480e-07
#> 4056   4056      anova full           CYB5A   8.594504 4.889634e-07
#> 4057   4057      anova full           ANXA4   8.591505 4.913383e-07
#> 4058   4058      anova full           RAB24   8.588409 4.938024e-07
#> 4059   4059      anova full      AL031056.2   8.582026 4.989230e-07
#> 4060   4060      anova full            NFIX   8.581830 4.990811e-07
#> 4061   4061      anova full           APH1B   8.579126 5.012674e-07
#> 4062   4062      anova full       LINC01238   8.576444 5.034460e-07
#> 4063   4063      anova full            ZEB1   8.576228 5.036217e-07
#> 4064   4064      anova full          HECTD1   8.573994 5.054439e-07
#> 4065   4065      anova full          CRABP2   8.571007 5.078910e-07
#> 4066   4066      anova full         MAP3K10   8.569815 5.088717e-07
#> 4067   4067      anova full           CDK20   8.568367 5.100641e-07
#> 4068   4068      anova full            CARS   8.564149 5.135563e-07
#> 4069   4069      anova full           ROBO2   8.562410 5.150031e-07
#> 4070   4070      anova full           DLEC1   8.559563 5.173806e-07
#> 4071   4071      anova full          SNRPD3   8.559397 5.175193e-07
#> 4072   4072      anova full            LMO7   8.558506 5.182662e-07
#> 4073   4073      anova full         LRRC75A   8.556566 5.198949e-07
#> 4074   4074      anova full           SYNRG   8.555690 5.206325e-07
#> 4075   4075      anova full             JPX   8.554556 5.215894e-07
#> 4076   4076      anova full         DPY19L4   8.552874 5.230106e-07
#> 4077   4077      anova full            POP7   8.551342 5.243091e-07
#> 4078   4078      anova full         SLC12A8   8.547730 5.273830e-07
#> 4079   4079      anova full            ERFE   8.542047 5.322571e-07
#> 4080   4080      anova full           SSU72   8.539593 5.343762e-07
#> 4081   4081      anova full            DDA1   8.536657 5.369230e-07
#> 4082   4082      anova full            FEZ2   8.533482 5.396905e-07
#> 4083   4083      anova full           BAMBI   8.529136 5.435035e-07
#> 4084   4084      anova full           GSDMD   8.525695 5.465409e-07
#> 4085   4085      anova full           FOXA1   8.522058 5.497713e-07
#> 4086   4086      anova full            GRK3   8.520396 5.512537e-07
#> 4087   4087      anova full          TCEAL9   8.514300 5.567265e-07
#> 4088   4088      anova full            STAM   8.514008 5.569902e-07
#> 4089   4089      anova full           AFAP1   8.510235 5.604070e-07
#> 4090   4090      anova full          DNAJC5   8.509590 5.609933e-07
#> 4091   4091      anova full      AC106707.1   8.507050 5.633082e-07
#> 4092   4092      anova full           TDRD9   8.505006 5.651782e-07
#> 4093   4093      anova full            P4HB   8.503679 5.663958e-07
#> 4094   4094      anova full           RBBP7   8.500393 5.694218e-07
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#> 4155   4155      anova full           RCHY1   8.396840 6.737808e-07
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#> 4157   4157      anova full            DSG2   8.387055 6.846048e-07
#> 4158   4158      anova full           PDE6B   8.383782 6.882654e-07
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#> 4162   4162      anova full           NINJ1   8.367632 7.066228e-07
#> 4163   4163      anova full           LLGL1   8.367422 7.068641e-07
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#> 4188   4188      anova full            MAU2   8.299213 7.901301e-07
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#> 4192   4192      anova full           HMGN5   8.287372 8.055795e-07
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#> 4195   4195      anova full           KRCC1   8.267868 8.317031e-07
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#> 4197   4197      anova full            MCAT   8.263100 8.382202e-07
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#> 4205   4205      anova full           ERBB4   8.236125 8.760895e-07
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#> 4207   4207      anova full      AC068888.1   8.235267 8.773231e-07
#> 4208   4208      anova full          ALKBH6   8.233198 8.803032e-07
#> 4209   4209      anova full            HUNK   8.232488 8.813285e-07
#> 4210   4210      anova full            CST9   8.227034 8.892447e-07
#> 4211   4211      anova full           NSRP1   8.219212 9.007244e-07
#> 4212   4212      anova full         SLCO1C1   8.215906 9.056211e-07
#> 4213   4213      anova full            CD93   8.210168 9.141861e-07
#> 4214   4214      anova full           SFTPD   8.207535 9.181451e-07
#> 4215   4215      anova full           GPR19   8.205856 9.206775e-07
#> 4216   4216      anova full           PDIA4   8.205185 9.216924e-07
#> 4217   4217      anova full            TOB1   8.199010 9.310800e-07
#> 4218   4218      anova full         SLC26A9   8.197613 9.332189e-07
#> 4219   4219      anova full         SYNDIG1   8.195942 9.357814e-07
#> 4220   4220      anova full            SSR4   8.193502 9.395372e-07
#> 4221   4221      anova full          ZNF703   8.192717 9.407498e-07
#> 4222   4222      anova full         TMEM139   8.192215 9.415254e-07
#> 4223   4223      anova full          SAMD12   8.191135 9.431962e-07
#> 4224   4224      anova full            ENO1   8.189636 9.455204e-07
#> 4225   4225      anova full           LSAMP   8.189210 9.461819e-07
#> 4226   4226      anova full          IGFBP4   8.187463 9.489009e-07
#> 4227   4227      anova full           GPR85   8.185823 9.514601e-07
#> 4228   4228      anova full          DCAF13   8.184758 9.531253e-07
#> 4229   4229      anova full        SLC38A11   8.183952 9.543877e-07
#> 4230   4230      anova full      AC010998.3   8.183471 9.551424e-07
#> 4231   4231      anova full            HCN4   8.183304 9.554037e-07
#> 4232   4232      anova full           SGPL1   8.182453 9.567410e-07
#> 4233   4233      anova full           SAMD1   8.182203 9.571341e-07
#> 4234   4234      anova full           MBNL2   8.181961 9.575143e-07
#> 4235   4235      anova full           VCAM1   8.177664 9.642968e-07
#> 4236   4236      anova full          FAM95C   8.174326 9.696005e-07
#> 4237   4237      anova full         CACNA1H   8.173978 9.701542e-07
#> 4238   4238      anova full        SERPINB1   8.172921 9.718409e-07
#> 4239   4239      anova full            RTF1   8.172858 9.719405e-07
#> 4240   4240      anova full            MMP2   8.172287 9.728538e-07
#> 4241   4241      anova full           DMGDH   8.170018 9.764872e-07
#> 4242   4242      anova full           PILRB   8.166074 9.828374e-07
#> 4243   4243      anova full             NMB   8.162294 9.889634e-07
#> 4244   4244      anova full           FUBP3   8.161902 9.896011e-07
#> 4245   4245      anova full           H2AFX   8.157508 9.967765e-07
#> 4246   4246      anova full      GPR158-AS1   8.157426 9.969104e-07
#> 4247   4247      anova full           PRKD2   8.155331 1.000350e-06
#> 4248   4248      anova full            MISP   8.154752 1.001304e-06
#> 4249   4249      anova full            PAK5   8.154220 1.002180e-06
#> 4250   4250      anova full           BOLA3   8.152157 1.005585e-06
#> 4251   4251      anova full            MSMB   8.150354 1.008571e-06
#> 4252   4252      anova full           ABCG1   8.150271 1.008709e-06
#> 4253   4253      anova full            NPR3   8.146694 1.014662e-06
#> 4254   4254      anova full          ATP5MG   8.145407 1.016811e-06
#> 4255   4255      anova full           ACBD7   8.138131 1.029057e-06
#> 4256   4256      anova full          ZFAND5   8.137069 1.030856e-06
#> 4257   4257      anova full           ABCD4   8.136053 1.032581e-06
#> 4258   4258      anova full          FKBP10   8.130263 1.042467e-06
#> 4259   4259      anova full           CRIP1   8.129722 1.043397e-06
#> 4260   4260      anova full          LRRC32   8.129409 1.043933e-06
#> 4261   4261      anova full             CFH   8.128457 1.045571e-06
#> 4262   4262      anova full           IL1R1   8.126988 1.048103e-06
#> 4263   4263      anova full          ATRAID   8.125849 1.050069e-06
#> 4264   4264      anova full            AFDN   8.125157 1.051267e-06
#> 4265   4265      anova full          LANCL1   8.124148 1.053015e-06
#> 4266   4266      anova full           PSMA6   8.121269 1.058019e-06
#> 4267   4267      anova full           ZMAT3   8.120440 1.059464e-06
#> 4268   4268      anova full          SORBS1   8.119903 1.060401e-06
#> 4269   4269      anova full         DDN-AS1   8.117864 1.063967e-06
#> 4270   4270      anova full           DNPH1   8.117839 1.064012e-06
#> 4271   4271      anova full          TBC1D7   8.114149 1.070496e-06
#> 4272   4272      anova full           RGS17   8.113501 1.071640e-06
#> 4273   4273      anova full          DNAJA4   8.113393 1.071830e-06
#> 4274   4274      anova full            PIM3   8.113314 1.071969e-06
#> 4275   4275      anova full          SPTBN1   8.110559 1.076845e-06
#> 4276   4276      anova full          COL6A3   8.108087 1.081241e-06
#> 4277   4277      anova full           EXPH5   8.107767 1.081810e-06
#> 4278   4278      anova full          ZNF503   8.104942 1.086856e-06
#> 4279   4279      anova full           DEPP1   8.104813 1.087088e-06
#> 4280   4280      anova full          NDUFA6   8.104295 1.088016e-06
#> 4281   4281      anova full          INSIG1   8.103270 1.089855e-06
#> 4282   4282      anova full           STMP1   8.103165 1.090044e-06
#> 4283   4283      anova full           TULP3   8.099740 1.096213e-06
#> 4284   4284      anova full           SBNO2   8.095827 1.103306e-06
#> 4285   4285      anova full            CCT2   8.095556 1.103800e-06
#> 4286   4286      anova full          GPRC5A   8.093275 1.107958e-06
#> 4287   4287      anova full          ASPHD2   8.092788 1.108847e-06
#> 4288   4288      anova full          PLXDC1   8.088352 1.116986e-06
#> 4289   4289      anova full            EEF2   8.087977 1.117677e-06
#> 4290   4290      anova full         CACNA1B   8.087756 1.118084e-06
#> 4291   4291      anova full          FCER1G   8.086095 1.121150e-06
#> 4292   4292      anova full         TMEM168   8.085841 1.121619e-06
#> 4293   4293      anova full           SNTB1   8.085352 1.122526e-06
#> 4294   4294      anova full        TNFRSF21   8.081297 1.130056e-06
#> 4295   4295      anova full           REEP4   8.078955 1.134429e-06
#> 4296   4296      anova full          MRPS23   8.078498 1.135286e-06
#> 4297   4297      anova full      AL118508.1   8.076621 1.138805e-06
#> 4298   4298      anova full          NSMCE1   8.076485 1.139060e-06
#> 4299   4299      anova full         GRAMD2B   8.075852 1.140251e-06
#> 4300   4300      anova full        TMEM126A   8.075702 1.140533e-06
#> 4301   4301      anova full          ZBTB44   8.075601 1.140724e-06
#> 4302   4302      anova full           CRHR2   8.073705 1.144296e-06
#> 4303   4303      anova full           UBE2Z   8.069441 1.152375e-06
#> 4304   4304      anova full           MEIS3   8.068000 1.155118e-06
#> 4305   4305      anova full           BRSK1   8.060707 1.169106e-06
#> 4306   4306      anova full            KNG1   8.057184 1.175924e-06
#> 4307   4307      anova full           MOB3B   8.056755 1.176757e-06
#> 4308   4308      anova full          DNAJC1   8.052564 1.184927e-06
#> 4309   4309      anova full          SPPL2A   8.051072 1.187851e-06
#> 4310   4310      anova full          ATP5PD   8.050320 1.189327e-06
#> 4311   4311      anova full          UBXN11   8.047340 1.195193e-06
#> 4312   4312      anova full            PMVK   8.046135 1.197575e-06
#> 4313   4313      anova full        SLC25A20   8.042860 1.204071e-06
#> 4314   4314      anova full          ZBTB7B   8.042380 1.205025e-06
#> 4315   4315      anova full           PYCR2   8.038577 1.212619e-06
#> 4316   4316      anova full          ACTR10   8.032487 1.224882e-06
#> 4317   4317      anova full           DZIP3   8.030959 1.227979e-06
#> 4318   4318      anova full         OSBPL10   8.030807 1.228289e-06
#> 4319   4319      anova full           SCNM1   8.030492 1.228928e-06
#> 4320   4320      anova full           SRSF6   8.028943 1.232077e-06
#> 4321   4321      anova full           GULP1   8.028337 1.233313e-06
#> 4322   4322      anova full         ADPRHL2   8.017828 1.254925e-06
#> 4323   4323      anova full           MAGOH   8.015659 1.259433e-06
#> 4324   4324      anova full         FAM213B   8.011964 1.267152e-06
#> 4325   4325      anova full          PI4K2A   8.011856 1.267378e-06
#> 4326   4326      anova full          NUDT12   8.008211 1.275043e-06
#> 4327   4327      anova full            GAS6   8.001997 1.288217e-06
#> 4328   4328      anova full           VSTM1   8.001908 1.288406e-06
#> 4329   4329      anova full           PAIP2   8.001261 1.289788e-06
#> 4330   4330      anova full            FAAH   8.000618 1.291160e-06
#> 4331   4331      anova full          ZNF469   8.000252 1.291942e-06
#> 4332   4332      anova full          MYO15B   7.996638 1.299691e-06
#> 4333   4333      anova full         PRPF38B   7.994194 1.304959e-06
#> 4334   4334      anova full          TSEN15   7.990495 1.312972e-06
#> 4335   4335      anova full          INAFM1   7.988297 1.317758e-06
#> 4336   4336      anova full          SRGAP1   7.983926 1.327329e-06
#> 4337   4337      anova full           SPAG9   7.983295 1.328716e-06
#> 4338   4338      anova full           ITGAM   7.982492 1.330483e-06
#> 4339   4339      anova full           ARID2   7.981291 1.333133e-06
#> 4340   4340      anova full            ENHO   7.979999 1.335987e-06
#> 4341   4341      anova full          IL17RA   7.976021 1.344818e-06
#> 4342   4342      anova full            LMO2   7.975510 1.345957e-06
#> 4343   4343      anova full          RGS7BP   7.972211 1.353331e-06
#> 4344   4344      anova full           JOSD2   7.971923 1.353976e-06
#> 4345   4345      anova full           BLVRA   7.971140 1.355734e-06
#> 4346   4346      anova full        TMEM126B   7.969259 1.359967e-06
#> 4347   4347      anova full           PSMB7   7.965480 1.368507e-06
#> 4348   4348      anova full            AMD1   7.962998 1.374146e-06
#> 4349   4349      anova full            JAM2   7.959993 1.381006e-06
#> 4350   4350      anova full            COG1   7.958762 1.383828e-06
#> 4351   4351      anova full           UBE2A   7.958649 1.384086e-06
#> 4352   4352      anova full       MTRNR2L12   7.957134 1.387566e-06
#> 4353   4353      anova full           TEX30   7.955594 1.391113e-06
#> 4354   4354      anova full          MAGEF1   7.954990 1.392505e-06
#> 4355   4355      anova full         MACROD2   7.954315 1.394065e-06
#> 4356   4356      anova full            ELOC   7.953427 1.396119e-06
#> 4357   4357      anova full        C11orf49   7.952528 1.398201e-06
#> 4358   4358      anova full             AHR   7.952527 1.398204e-06
#> 4359   4359      anova full           RWDD1   7.949728 1.404705e-06
#> 4360   4360      anova full        TMEM120B   7.948995 1.406415e-06
#> 4361   4361      anova full           PRR14   7.947745 1.409333e-06
#> 4362   4362      anova full          SAMM50   7.946508 1.412227e-06
#> 4363   4363      anova full      AC006450.3   7.946125 1.413123e-06
#> 4364   4364      anova full        C19orf33   7.945346 1.414951e-06
#> 4365   4365      anova full            AMOT   7.944221 1.417592e-06
#> 4366   4366      anova full         EMILIN1   7.942757 1.421039e-06
#> 4367   4367      anova full         SLC13A3   7.942713 1.421143e-06
#> 4368   4368      anova full           RBM22   7.937910 1.432507e-06
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#> 4432   4432      anova full      AC010266.2   7.807595 1.779181e-06
#> 4433   4433      anova full           CMTM3   7.806853 1.781382e-06
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#> 4436   4436      anova full          RASSF1   7.802810 1.793435e-06
#> 4437   4437      anova full            B9D1   7.798224 1.807205e-06
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#> 4458   4458      anova full          PAPOLG   7.767598 1.901989e-06
#> 4459   4459      anova full           PPDPF   7.766634 1.905053e-06
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#> 4463   4463      anova full          KLHL42   7.761540 1.921332e-06
#> 4464   4464      anova full           ANXA2   7.761045 1.922923e-06
#> 4465   4465      anova full           MCHR2   7.759551 1.927729e-06
#> 4466   4466      anova full           STIM1   7.758708 1.930443e-06
#> 4467   4467      anova full           COPS9   7.757753 1.933527e-06
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#> 4473   4473      anova full         TMEM39A   7.743888 1.978853e-06
#> 4474   4474      anova full        MIR497HG   7.743306 1.980778e-06
#> 4475   4475      anova full           ACYP1   7.742025 1.985027e-06
#> 4476   4476      anova full            PDYN   7.740722 1.989355e-06
#> 4477   4477      anova full          SCARA3   7.733120 2.014804e-06
#> 4478   4478      anova full           UBL4A   7.728050 2.031963e-06
#> 4479   4479      anova full           KCNJ6   7.726440 2.037443e-06
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#> 4482   4482      anova full           LIMS1   7.722894 2.049566e-06
#> 4483   4483      anova full           ENPP5   7.720084 2.059225e-06
#> 4484   4484      anova full          GNPTAB   7.716943 2.070080e-06
#> 4485   4485      anova full          MYBPHL   7.716706 2.070899e-06
#> 4486   4486      anova full           SPON1   7.714864 2.077292e-06
#> 4487   4487      anova full       PSMA3-AS1   7.712026 2.087183e-06
#> 4488   4488      anova full          SLC3A2   7.709168 2.097195e-06
#> 4489   4489      anova full           CAND1   7.708028 2.101202e-06
#> 4490   4490      anova full           WNT16   7.702474 2.120830e-06
#> 4491   4491      anova full            EPRS   7.700231 2.128811e-06
#> 4492   4492      anova full          ARID4B   7.699614 2.131012e-06
#> 4493   4493      anova full           KCNG3   7.695670 2.145136e-06
#> 4494   4494      anova full           ABCC9   7.695545 2.145586e-06
#> 4495   4495      anova full           PSMB4   7.693463 2.153081e-06
#> 4496   4496      anova full          MINOS1   7.691665 2.159575e-06
#> 4497   4497      anova full         C9orf72   7.690627 2.163333e-06
#> 4498   4498      anova full      ZNF350-AS1   7.686391 2.178743e-06
#> 4499   4499      anova full            DGKI   7.684262 2.186529e-06
#> 4500   4500      anova full           FSTL1   7.680320 2.201019e-06
#> 4501   4501      anova full          CLDN12   7.679935 2.202442e-06
#> 4502   4502      anova full           SNX18   7.678007 2.209570e-06
#> 4503   4503      anova full      AC005726.1   7.677919 2.209897e-06
#> 4504   4504      anova full          IFNGR2   7.676914 2.213624e-06
#> 4505   4505      anova full           ABCD3   7.675334 2.219494e-06
#> 4506   4506      anova full           WASF3   7.675149 2.220181e-06
#> 4507   4507      anova full         CREB3L4   7.669692 2.240588e-06
#> 4508   4508      anova full           PRPS1   7.669440 2.241532e-06
#> 4509   4509      anova full           FHOD3   7.667744 2.247916e-06
#> 4510   4510      anova full          NUP107   7.661019 2.273411e-06
#> 4511   4511      anova full          ZNF846   7.660242 2.276377e-06
#> 4512   4512      anova full          LRRC4C   7.659718 2.278380e-06
#> 4513   4513      anova full         NDUFAF2   7.654563 2.298167e-06
#> 4514   4514      anova full      AL365181.4   7.650773 2.312828e-06
#> 4515   4515      anova full            RRM2   7.647656 2.324959e-06
#> 4516   4516      anova full              MB   7.644793 2.336154e-06
#> 4517   4517      anova full           GPNMB   7.644616 2.336849e-06
#> 4518   4518      anova full          CACFD1   7.642313 2.345902e-06
#> 4519   4519      anova full            GNAQ   7.640458 2.353216e-06
#> 4520   4520      anova full         ZDHHC14   7.639328 2.357684e-06
#> 4521   4521      anova full      AC097467.3   7.638711 2.360129e-06
#> 4522   4522      anova full          MRPS36   7.638530 2.360846e-06
#> 4523   4523      anova full            SHC4   7.637153 2.366312e-06
#> 4524   4524      anova full           MRPS9   7.636529 2.368791e-06
#> 4525   4525      anova full         AFAP1L2   7.634279 2.377755e-06
#> 4526   4526      anova full          TAPBPL   7.634127 2.378363e-06
#> 4527   4527      anova full          ZNF749   7.633115 2.382407e-06
#> 4528   4528      anova full         PRKAR2A   7.632588 2.384515e-06
#> 4529   4529      anova full            MSL3   7.631197 2.390093e-06
#> 4530   4530      anova full          ADGRF5   7.630240 2.393936e-06
#> 4531   4531      anova full            NGFR   7.629372 2.397430e-06
#> 4532   4532      anova full           RAB7B   7.629324 2.397622e-06
#> 4533   4533      anova full          CEP104   7.628875 2.399431e-06
#> 4534   4534      anova full          LPCAT2   7.628108 2.402526e-06
#> 4535   4535      anova full           EFNB2   7.625413 2.413424e-06
#> 4536   4536      anova full            APEH   7.625078 2.414781e-06
#> 4537   4537      anova full            LNX2   7.624573 2.416831e-06
#> 4538   4538      anova full            FRS2   7.624256 2.418120e-06
#> 4539   4539      anova full          PLCXD2   7.621784 2.428180e-06
#> 4540   4540      anova full      AL365184.1   7.620618 2.432942e-06
#> 4541   4541      anova full            FCF1   7.620545 2.433240e-06
#> 4542   4542      anova full          REX1BD   7.619041 2.439397e-06
#> 4543   4543      anova full          CCDC25   7.618789 2.440429e-06
#> 4544   4544      anova full           BCL7B   7.618347 2.442244e-06
#> 4545   4545      anova full          CHCHD4   7.617563 2.445461e-06
#> 4546   4546      anova full            DEF8   7.617049 2.447576e-06
#> 4547   4547      anova full      AC092376.2   7.616809 2.448562e-06
#> 4548   4548      anova full            RPL9   7.608210 2.484204e-06
#> 4549   4549      anova full           CNNM1   7.606165 2.492757e-06
#> 4550   4550      anova full             UXT   7.605710 2.494664e-06
#> 4551   4551      anova full              HR   7.604912 2.498013e-06
#> 4552   4552      anova full      AC106881.1   7.603949 2.502060e-06
#> 4553   4553      anova full           RBM17   7.603580 2.503616e-06
#> 4554   4554      anova full          RABL2B   7.601197 2.513667e-06
#> 4555   4555      anova full           TXNL1   7.600663 2.515923e-06
#> 4556   4556      anova full           LIMK2   7.600526 2.516503e-06
#> 4557   4557      anova full           RAB2B   7.600041 2.518557e-06
#> 4558   4558      anova full           PCF11   7.600005 2.518708e-06
#> 4559   4559      anova full             MTR   7.598269 2.526073e-06
#> 4560   4560      anova full         SLC16A7   7.596535 2.533449e-06
#> 4561   4561      anova full          TBC1D5   7.589241 2.564720e-06
#> 4562   4562      anova full            ATG3   7.588579 2.567574e-06
#> 4563   4563      anova full        PRELID3B   7.587949 2.570300e-06
#> 4564   4564      anova full         AKIRIN2   7.584693 2.584414e-06
#> 4565   4565      anova full           CSF1R   7.583492 2.589644e-06
#> 4566   4566      anova full       HTR5A-AS1   7.581873 2.596705e-06
#> 4567   4567      anova full         TMEM268   7.581046 2.600325e-06
#> 4568   4568      anova full           IP6K3   7.580172 2.604151e-06
#> 4569   4569      anova full            KXD1   7.578546 2.611287e-06
#> 4570   4570      anova full           STX12   7.571746 2.641342e-06
#> 4571   4571      anova full            PHC2   7.570819 2.645470e-06
#> 4572   4572      anova full             KMO   7.570775 2.645662e-06
#> 4573   4573      anova full           H2AFJ   7.570199 2.648232e-06
#> 4574   4574      anova full     TSC22D1-AS1   7.570088 2.648728e-06
#> 4575   4575      anova full            EID1   7.568268 2.656853e-06
#> 4576   4576      anova full          EIF4E3   7.566940 2.662801e-06
#> 4577   4577      anova full          COL8A1   7.565886 2.667529e-06
#> 4578   4578      anova full            ACO1   7.565661 2.668539e-06
#> 4579   4579      anova full            NAV2   7.565317 2.670088e-06
#> 4580   4580      anova full            IRX3   7.563486 2.678331e-06
#> 4581   4581      anova full            CCNK   7.556119 2.711768e-06
#> 4582   4582      anova full      AC072039.2   7.553354 2.724427e-06
#> 4583   4583      anova full           MCMBP   7.549882 2.740408e-06
#> 4584   4584      anova full          AMIGO1   7.548035 2.748951e-06
#> 4585   4585      anova full          FAM69A   7.546607 2.755573e-06
#> 4586   4586      anova full           SNX29   7.545878 2.758961e-06
#> 4587   4587      anova full          BRI3BP   7.541851 2.777748e-06
#> 4588   4588      anova full           CDH12   7.540639 2.783425e-06
#> 4589   4589      anova full           HEBP2   7.539888 2.786952e-06
#> 4590   4590      anova full           RAB5B   7.539704 2.787820e-06
#> 4591   4591      anova full            SUCO   7.539625 2.788189e-06
#> 4592   4592      anova full           PREX2   7.539509 2.788732e-06
#> 4593   4593      anova full          IGFBP2   7.539080 2.790751e-06
#> 4594   4594      anova full           TEX41   7.536368 2.803537e-06
#> 4595   4595      anova full          LEPROT   7.535774 2.806344e-06
#> 4596   4596      anova full         PIP4K2B   7.529764 2.834927e-06
#> 4597   4597      anova full         SLC35D2   7.526835 2.848962e-06
#> 4598   4598      anova full            TGM2   7.524010 2.862568e-06
#> 4599   4599      anova full         AGTPBP1   7.522873 2.868063e-06
#> 4600   4600      anova full           FMNL1   7.522640 2.869191e-06
#> 4601   4601      anova full          TRIM36   7.522601 2.869378e-06
#> 4602   4602      anova full         ADAMTS1   7.521069 2.876803e-06
#> 4603   4603      anova full           ITGA9   7.518845 2.887616e-06
#> 4604   4604      anova full            XAF1   7.518621 2.888708e-06
#> 4605   4605      anova full        ITGB1BP1   7.513367 2.914425e-06
#> 4606   4606      anova full            UROS   7.512305 2.919653e-06
#> 4607   4607      anova full           ESRRA   7.511628 2.922992e-06
#> 4608   4608      anova full          ATP5PB   7.511595 2.923154e-06
#> 4609   4609      anova full           MEF2A   7.510234 2.929876e-06
#> 4610   4610      anova full          ACVR2A   7.509679 2.932619e-06
#> 4611   4611      anova full         CABLES1   7.509284 2.934573e-06
#> 4612   4612      anova full           FIBIN   7.508342 2.939245e-06
#> 4613   4613      anova full           DOT1L   7.507501 2.943416e-06
#> 4614   4614      anova full           COX6C   7.505646 2.952646e-06
#> 4615   4615      anova full          SORBS3   7.505244 2.954649e-06
#> 4616   4616      anova full        CCNB1IP1   7.504710 2.957316e-06
#> 4617   4617      anova full           SPRY1   7.501787 2.971941e-06
#> 4618   4618      anova full           MTMR4   7.501781 2.971972e-06
#> 4619   4619      anova full          NT5DC2   7.501482 2.973473e-06
#> 4620   4620      anova full           LRRK1   7.500007 2.980888e-06
#> 4621   4621      anova full           RAP2B   7.498834 2.986794e-06
#> 4622   4622      anova full          LRRC20   7.497332 2.994379e-06
#> 4623   4623      anova full            C1QB   7.492398 3.019427e-06
#> 4624   4624      anova full           CEP78   7.491072 3.026200e-06
#> 4625   4625      anova full          SLC2A6   7.487636 3.043810e-06
#> 4626   4626      anova full           CISD2   7.484071 3.062193e-06
#> 4627   4627      anova full           EIF3G   7.479354 3.086694e-06
#> 4628   4628      anova full           MED11   7.473779 3.115908e-06
#> 4629   4629      anova full           HYOU1   7.473761 3.116003e-06
#> 4630   4630      anova full            BRAF   7.473213 3.118889e-06
#> 4631   4631      anova full           UBE3D   7.471046 3.130334e-06
#> 4632   4632      anova full          SMIM29   7.470250 3.134551e-06
#> 4633   4633      anova full            ADAR   7.470003 3.135860e-06
#> 4634   4634      anova full           LIMA1   7.469576 3.138119e-06
#> 4635   4635      anova full            TP53   7.467896 3.147046e-06
#> 4636   4636      anova full            RAI1   7.466636 3.153756e-06
#> 4637   4637      anova full           RLBP1   7.465234 3.161236e-06
#> 4638   4638      anova full           ACTR2   7.464034 3.167660e-06
#> 4639   4639      anova full             HYI   7.463982 3.167938e-06
#> 4640   4640      anova full            SRPX   7.461706 3.180151e-06
#> 4641   4641      anova full          NUSAP1   7.461402 3.181785e-06
#> 4642   4642      anova full         ANKRD24   7.459597 3.191509e-06
#> 4643   4643      anova full             FES   7.458166 3.199241e-06
#> 4644   4644      anova full          KDELR2   7.454914 3.216883e-06
#> 4645   4645      anova full           PRELP   7.454666 3.218234e-06
#> 4646   4646      anova full           SRP54   7.454392 3.219727e-06
#> 4647   4647      anova full          SEMA3D   7.450706 3.239860e-06
#> 4648   4648      anova full            IBTK   7.450364 3.241737e-06
#> 4649   4649      anova full       TNFRSF12A   7.449956 3.243973e-06
#> 4650   4650      anova full          SRD5A1   7.443213 3.281191e-06
#> 4651   4651      anova full             NPW   7.440703 3.295156e-06
#> 4652   4652      anova full        SELENBP1   7.440438 3.296637e-06
#> 4653   4653      anova full           DELE1   7.439317 3.302898e-06
#> 4654   4654      anova full       SATB2-AS1   7.435012 3.327050e-06
#> 4655   4655      anova full          REPIN1   7.432221 3.342805e-06
#> 4656   4656      anova full      AC112220.3   7.429245 3.359686e-06
#> 4657   4657      anova full      AC091138.1   7.427787 3.367987e-06
#> 4658   4658      anova full        TMEM200A   7.426665 3.374396e-06
#> 4659   4659      anova full            PDHX   7.426653 3.374462e-06
#> 4660   4660      anova full            IGIP   7.426326 3.376330e-06
#> 4661   4661      anova full           MLLT6   7.425394 3.381665e-06
#> 4662   4662      anova full          SREBF2   7.424197 3.388525e-06
#> 4663   4663      anova full           KCNJ9   7.422433 3.398660e-06
#> 4664   4664      anova full          POLR1D   7.421008 3.406873e-06
#> 4665   4665      anova full            SCTR   7.415326 3.439819e-06
#> 4666   4666      anova full           CYB5B   7.408687 3.478722e-06
#> 4667   4667      anova full          EIF4A3   7.403517 3.509333e-06
#> 4668   4668      anova full          NPEPPS   7.402723 3.514057e-06
#> 4669   4669      anova full          GTF3C5   7.400654 3.526402e-06
#> 4670   4670      anova full          CHMP1B   7.399937 3.530692e-06
#> 4671   4671      anova full           LYRM4   7.399184 3.535201e-06
#> 4672   4672      anova full         CXorf38   7.396166 3.553334e-06
#> 4673   4673      anova full            KLF2   7.396030 3.554149e-06
#> 4674   4674      anova full            SLF1   7.388916 3.597276e-06
#> 4675   4675      anova full            NMD3   7.387965 3.603085e-06
#> 4676   4676      anova full        TOGARAM1   7.385520 3.618053e-06
#> 4677   4677      anova full        CD200R1L   7.385213 3.619941e-06
#> 4678   4678      anova full           KCNJ5   7.383025 3.633400e-06
#> 4679   4679      anova full          MRPS30   7.382118 3.638989e-06
#> 4680   4680      anova full           TACC2   7.380200 3.650849e-06
#> 4681   4681      anova full            MEG3   7.379981 3.652205e-06
#> 4682   4682      anova full            PIRT   7.378264 3.662858e-06
#> 4683   4683      anova full          CALHM1   7.378257 3.662903e-06
#> 4684   4684      anova full           LUZP2   7.377090 3.670162e-06
#> 4685   4685      anova full             ENG   7.365150 3.745284e-06
#> 4686   4686      anova full         CCDC88C   7.363111 3.758264e-06
#> 4687   4687      anova full           RSPH1   7.362654 3.761184e-06
#> 4688   4688      anova full         C1orf52   7.359152 3.783610e-06
#> 4689   4689      anova full           NPY2R   7.356249 3.802303e-06
#> 4690   4690      anova full          TRMT9B   7.351204 3.835019e-06
#> 4691   4691      anova full      RAB11B-AS1   7.348219 3.854506e-06
#> 4692   4692      anova full         GPBP1L1   7.347968 3.856149e-06
#> 4693   4693      anova full           ELFN2   7.345535 3.872118e-06
#> 4694   4694      anova full         TACSTD2   7.345464 3.872586e-06
#> 4695   4695      anova full           ZC3H6   7.345227 3.874147e-06
#> 4696   4696      anova full            BPTF   7.344535 3.878703e-06
#> 4697   4697      anova full           KIFC3   7.341895 3.896135e-06
#> 4698   4698      anova full            UBL5   7.340559 3.904992e-06
#> 4699   4699      anova full             MIF   7.337741 3.923732e-06
#> 4700   4700      anova full            CDH9   7.336945 3.929046e-06
#> 4701   4701      anova full           CEBPA   7.336810 3.929946e-06
#> 4702   4702      anova full            LGI3   7.335009 3.941990e-06
#> 4703   4703      anova full           AKTIP   7.333171 3.954324e-06
#> 4704   4704      anova full            ANO4   7.332727 3.957309e-06
#> 4705   4705      anova full          PLCXD3   7.332188 3.960937e-06
#> 4706   4706      anova full            CD52   7.331664 3.964463e-06
#> 4707   4707      anova full        SH3PXD2B   7.331270 3.967120e-06
#> 4708   4708      anova full       LINC00654   7.330365 3.973222e-06
#> 4709   4709      anova full            MAP6   7.329661 3.977982e-06
#> 4710   4710      anova full           SYVN1   7.329554 3.978706e-06
#> 4711   4711      anova full            BTF3   7.328785 3.983911e-06
#> 4712   4712      anova full           HTRA3   7.326518 3.999293e-06
#> 4713   4713      anova full           EHBP1   7.325764 4.004418e-06
#> 4714   4714      anova full           KCNB2   7.324136 4.015523e-06
#> 4715   4715      anova full         TMEM121   7.321517 4.033436e-06
#> 4716   4716      anova full           GDPD5   7.317784 4.059122e-06
#> 4717   4717      anova full           HTR3A   7.313696 4.087443e-06
#> 4718   4718      anova full           TBRG1   7.313641 4.087826e-06
#> 4719   4719      anova full           VOPP1   7.313038 4.092020e-06
#> 4720   4720      anova full           RSPH9   7.308631 4.122810e-06
#> 4721   4721      anova full            AREG   7.308243 4.125533e-06
#> 4722   4722      anova full           PHF10   7.305302 4.146227e-06
#> 4723   4723      anova full          ISYNA1   7.303195 4.161113e-06
#> 4724   4724      anova full         TMEM63B   7.297217 4.203659e-06
#> 4725   4725      anova full            NFYB   7.292769 4.235609e-06
#> 4726   4726      anova full          CYP4V2   7.292109 4.240371e-06
#> 4727   4727      anova full           RHPN1   7.290415 4.252618e-06
#> 4728   4728      anova full             FBL   7.289718 4.257665e-06
#> 4729   4729      anova full            PHYH   7.289563 4.258789e-06
#> 4730   4730      anova full       C10orf105   7.288369 4.267452e-06
#> 4731   4731      anova full          ZNF746   7.284394 4.296434e-06
#> 4732   4732      anova full           CHRM2   7.283106 4.305871e-06
#> 4733   4733      anova full       PABPC1L2A   7.282937 4.307104e-06
#> 4734   4734      anova full            VAV2   7.282672 4.309054e-06
#> 4735   4735      anova full            BATF   7.281468 4.317896e-06
#> 4736   4736      anova full         ZDHHC23   7.279098 4.335356e-06
#> 4737   4737      anova full           SMPD4   7.278772 4.337767e-06
#> 4738   4738      anova full      AC103591.3   7.277088 4.350228e-06
#> 4739   4739      anova full             WAC   7.274422 4.370028e-06
#> 4740   4740      anova full           VIPR1   7.273869 4.374144e-06
#> 4741   4741      anova full           MYOZ3   7.273284 4.378505e-06
#> 4742   4742      anova full      ADARB2-AS1   7.271664 4.390606e-06
#> 4743   4743      anova full         TMEM243   7.269623 4.405899e-06
#> 4744   4744      anova full           SRPRB   7.263198 4.454407e-06
#> 4745   4745      anova full         PPP2R3A   7.261719 4.465644e-06
#> 4746   4746      anova full          TTLL12   7.261575 4.466740e-06
#> 4747   4747      anova full             UST   7.261358 4.468397e-06
#> 4748   4748      anova full            PRLR   7.258512 4.490124e-06
#> 4749   4749      anova full           IFT22   7.258035 4.493772e-06
#> 4750   4750      anova full          SECTM1   7.252618 4.535467e-06
#> 4751   4751      anova full            GOT2   7.251984 4.540370e-06
#> 4752   4752      anova full           KCNN1   7.251567 4.543603e-06
#> 4753   4753      anova full          MAP3K2   7.248686 4.565977e-06
#> 4754   4754      anova full          SPECC1   7.248673 4.566074e-06
#> 4755   4755      anova full        C11orf95   7.247226 4.577353e-06
#> 4756   4756      anova full           TPST2   7.242576 4.613802e-06
#> 4757   4757      anova full           FARP2   7.239131 4.640997e-06
#> 4758   4758      anova full           HAR1A   7.238599 4.645208e-06
#> 4759   4759      anova full        RASGEF1A   7.238200 4.648368e-06
#> 4760   4760      anova full            SSR3   7.238168 4.648622e-06
#> 4761   4761      anova full           CNGB3   7.236940 4.658370e-06
#> 4762   4762      anova full             NPY   7.233614 4.684885e-06
#> 4763   4763      anova full           NAA60   7.231883 4.698742e-06
#> 4764   4764      anova full           PTPRM   7.231688 4.700306e-06
#> 4765   4765      anova full            FAR2   7.227101 4.737242e-06
#> 4766   4766      anova full          ERLEC1   7.225694 4.748633e-06
#> 4767   4767      anova full           PANK4   7.222638 4.773465e-06
#> 4768   4768      anova full           ACSL4   7.222123 4.777665e-06
#> 4769   4769      anova full            NEK9   7.220890 4.787730e-06
#> 4770   4770      anova full            JDP2   7.217783 4.813193e-06
#> 4771   4771      anova full            WNT6   7.217176 4.818189e-06
#> 4772   4772      anova full          SERGEF   7.215290 4.833727e-06
#> 4773   4773      anova full         MICALL2   7.215251 4.834051e-06
#> 4774   4774      anova full         THEMIS2   7.213670 4.847114e-06
#> 4775   4775      anova full           LRIF1   7.213014 4.852551e-06
#> 4776   4776      anova full           ABHD2   7.212063 4.860440e-06
#> 4777   4777      anova full             C1R   7.211479 4.865288e-06
#> 4778   4778      anova full      AL596257.1   7.209020 4.885764e-06
#> 4779   4779      anova full          PIK3R2   7.208609 4.889195e-06
#> 4780   4780      anova full         SLITRK3   7.208503 4.890074e-06
#> 4781   4781      anova full           XRCC5   7.206995 4.902687e-06
#> 4782   4782      anova full            SRGN   7.206000 4.911032e-06
#> 4783   4783      anova full          TTC39B   7.205760 4.913039e-06
#> 4784   4784      anova full          KCNJ11   7.205526 4.915009e-06
#> 4785   4785      anova full            OFD1   7.202786 4.938067e-06
#> 4786   4786      anova full           FOSL2   7.201758 4.946746e-06
#> 4787   4787      anova full         SH3GLB1   7.201185 4.951592e-06
#> 4788   4788      anova full      AC008494.3   7.200817 4.954700e-06
#> 4789   4789      anova full          HS3ST1   7.199577 4.965212e-06
#> 4790   4790      anova full           PAMR1   7.198818 4.971651e-06
#> 4791   4791      anova full         CSNK1A1   7.198624 4.973303e-06
#> 4792   4792      anova full           TMED8   7.198345 4.975674e-06
#> 4793   4793      anova full           PADI4   7.197734 4.980869e-06
#> 4794   4794      anova full      AC073365.1   7.197730 4.980906e-06
#> 4795   4795      anova full           MCCC2   7.197069 4.986533e-06
#> 4796   4796      anova full          UNC13C   7.196742 4.989326e-06
#> 4797   4797      anova full         DENND5B   7.196167 4.994227e-06
#> 4798   4798      anova full          DMRTA2   7.194106 5.011844e-06
#> 4799   4799      anova full            RORC   7.193263 5.019071e-06
#> 4800   4800      anova full           NHLH2   7.193197 5.019642e-06
#> 4801   4801      anova full           IGHA2   7.192678 5.024096e-06
#> 4802   4802      anova full         ZDHHC22   7.191400 5.035076e-06
#> 4803   4803      anova full            CUL3   7.188775 5.057720e-06
#> 4804   4804      anova full           CCNG2   7.188751 5.057925e-06
#> 4805   4805      anova full            USO1   7.186779 5.075008e-06
#> 4806   4806      anova full           IKZF5   7.185982 5.081924e-06
#> 4807   4807      anova full            C1QC   7.177305 5.157882e-06
#> 4808   4808      anova full      AC012603.1   7.175710 5.171971e-06
#> 4809   4809      anova full           PIDD1   7.174219 5.185175e-06
#> 4810   4810      anova full           MKRN1   7.169837 5.224188e-06
#> 4811   4811      anova full         ATP5MC2   7.168913 5.232447e-06
#> 4812   4812      anova full            YES1   7.167494 5.245163e-06
#> 4813   4813      anova full      AC134312.1   7.166546 5.253684e-06
#> 4814   4814      anova full          CORO1A   7.164560 5.271566e-06
#> 4815   4815      anova full         ANKRD55   7.163700 5.279327e-06
#> 4816   4816      anova full        PKN2-AS1   7.162413 5.290965e-06
#> 4817   4817      anova full           RAB5A   7.162303 5.291963e-06
#> 4818   4818      anova full         SERINC2   7.159250 5.319682e-06
#> 4819   4819      anova full        C17orf97   7.158547 5.326080e-06
#> 4820   4820      anova full         ADAMTS2   7.156483 5.344933e-06
#> 4821   4821      anova full          ANAPC1   7.154052 5.367214e-06
#> 4822   4822      anova full             DPT   7.152418 5.382253e-06
#> 4823   4823      anova full           TNPO2   7.151910 5.386934e-06
#> 4824   4824      anova full           PTGIS   7.151570 5.390070e-06
#> 4825   4825      anova full            NEK2   7.149887 5.405616e-06
#> 4826   4826      anova full           ARAP2   7.148177 5.421469e-06
#> 4827   4827      anova full           RBM26   7.146070 5.441064e-06
#> 4828   4828      anova full          MAPK14   7.143146 5.468368e-06
#> 4829   4829      anova full          IMPDH2   7.142606 5.473426e-06
#> 4830   4830      anova full            COQ3   7.142276 5.476526e-06
#> 4831   4831      anova full           TRA2B   7.141660 5.482307e-06
#> 4832   4832      anova full           FLOT2   7.136682 5.529246e-06
#> 4833   4833      anova full      AC002546.1   7.136178 5.534023e-06
#> 4834   4834      anova full           PNRC2   7.135204 5.543264e-06
#> 4835   4835      anova full          NDUFV3   7.134586 5.549135e-06
#> 4836   4836      anova full            NRG1   7.133710 5.557469e-06
#> 4837   4837      anova full            CRY2   7.133637 5.558166e-06
#> 4838   4838      anova full           TUBG1   7.132981 5.564409e-06
#> 4839   4839      anova full          LRRC63   7.126300 5.628469e-06
#> 4840   4840      anova full           S100G   7.123630 5.654286e-06
#> 4841   4841      anova full          TCIRG1   7.123287 5.657609e-06
#> 4842   4842      anova full           PSMA1   7.120702 5.682729e-06
#> 4843   4843      anova full          HIGD1A   7.119510 5.694356e-06
#> 4844   4844      anova full           MTCL1   7.117414 5.714844e-06
#> 4845   4845      anova full          LRRTM3   7.114044 5.747956e-06
#> 4846   4846      anova full         C1orf54   7.111293 5.775137e-06
#> 4847   4847      anova full           DDAH1   7.107777 5.810060e-06
#> 4848   4848      anova full           ACBD5   7.107063 5.817179e-06
#> 4849   4849      anova full           MAPK6   7.105056 5.837236e-06
#> 4850   4850      anova full          MRPS25   7.104236 5.845443e-06
#> 4851   4851      anova full          DUSP22   7.101903 5.868882e-06
#> 4852   4852      anova full          ERLIN2   7.100520 5.882823e-06
#> 4853   4853      anova full            MXI1   7.095624 5.932445e-06
#> 4854   4854      anova full          CSTF2T   7.095420 5.934519e-06
#> 4855   4855      anova full          PCMTD2   7.090775 5.982004e-06
#> 4856   4856      anova full           NRCAM   7.090696 5.982813e-06
#> 4857   4857      anova full           HSDL1   7.090261 5.987285e-06
#> 4858   4858      anova full           INHBA   7.089368 5.996466e-06
#> 4859   4859      anova full           PDZD7   7.088621 6.004154e-06
#> 4860   4860      anova full       LINC01574   7.087658 6.014093e-06
#> 4861   4861      anova full            NT5M   7.087351 6.017258e-06
#> 4862   4862      anova full          ANXA11   7.084917 6.042446e-06
#> 4863   4863      anova full      AC007952.4   7.084398 6.047835e-06
#> 4864   4864      anova full          PIEZO2   7.083239 6.059874e-06
#> 4865   4865      anova full           EMC10   7.081757 6.075312e-06
#> 4866   4866      anova full           HYAL3   7.080739 6.085938e-06
#> 4867   4867      anova full          HOXB13   7.080551 6.087904e-06
#> 4868   4868      anova full           DCAF8   7.072659 6.170958e-06
#> 4869   4869      anova full         GOLGA8B   7.072510 6.172541e-06
#> 4870   4870      anova full          WRNIP1   7.071512 6.183123e-06
#> 4871   4871      anova full             UBC   7.071300 6.185376e-06
#> 4872   4872      anova full           IER5L   7.070451 6.194405e-06
#> 4873   4873      anova full            KRT7   7.070225 6.196804e-06
#> 4874   4874      anova full           SLIT3   7.065484 6.247472e-06
#> 4875   4875      anova full          TMEM64   7.063206 6.271964e-06
#> 4876   4876      anova full          MAP2K2   7.061969 6.285309e-06
#> 4877   4877      anova full          CHMP2B   7.061185 6.293782e-06
#> 4878   4878      anova full            MPC1   7.060339 6.302939e-06
#> 4879   4879      anova full           CEMIP   7.058934 6.318166e-06
#> 4880   4880      anova full          CCDC69   7.058128 6.326922e-06
#> 4881   4881      anova full          ALOXE3   7.058015 6.328157e-06
#> 4882   4882      anova full         PPP2R5E   7.053791 6.374252e-06
#> 4883   4883      anova full           RAB30   7.053115 6.381668e-06
#> 4884   4884      anova full          MIF4GD   7.050342 6.412146e-06
#> 4885   4885      anova full           CD207   7.047514 6.443399e-06
#> 4886   4886      anova full           DLEU7   7.041650 6.508677e-06
#> 4887   4887      anova full           NCAM2   7.041167 6.514085e-06
#> 4888   4888      anova full      AL445524.1   7.040091 6.526146e-06
#> 4889   4889      anova full           MATN2   7.038166 6.547791e-06
#> 4890   4890      anova full        PPP1R12C   7.035461 6.578319e-06
#> 4891   4891      anova full           HOXC9   7.034425 6.590047e-06
#> 4892   4892      anova full           USP33   7.033028 6.605899e-06
#> 4893   4893      anova full         SNRNP70   7.031600 6.622143e-06
#> 4894   4894      anova full            DERA   7.030054 6.639780e-06
#> 4895   4895      anova full         ANKRD39   7.029698 6.643847e-06
#> 4896   4896      anova full            SKP1   7.026988 6.674897e-06
#> 4897   4897      anova full            PHC1   7.024847 6.699522e-06
#> 4898   4898      anova full           KCNQ4   7.018697 6.770800e-06
#> 4899   4899      anova full          CRYBA2   7.017920 6.779864e-06
#> 4900   4900      anova full           TRGC2   7.017091 6.789544e-06
#> 4901   4901      anova full          CCDC47   7.017002 6.790582e-06
#> 4902   4902      anova full         SLC35A5   7.016858 6.792265e-06
#> 4903   4903      anova full           ICAM2   7.011530 6.854842e-06
#> 4904   4904      anova full          LINGO2   7.010264 6.869793e-06
#> 4905   4905      anova full           TOMM5   7.008440 6.891405e-06
#> 4906   4906      anova full           ERAP1   7.007000 6.908504e-06
#> 4907   4907      anova full            PAN2   7.005182 6.930168e-06
#> 4908   4908      anova full           ASAP3   7.003730 6.947509e-06
#> 4909   4909      anova full            DMWD   7.003532 6.949889e-06
#> 4910   4910      anova full           CAPN3   7.002417 6.963244e-06
#> 4911   4911      anova full           LSM11   7.001298 6.976676e-06
#> 4912   4912      anova full          HIVEP3   7.000984 6.980451e-06
#> 4913   4913      anova full         PPP1R26   7.000863 6.981901e-06
#> 4914   4914      anova full          POLR2A   6.997725 7.019739e-06
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#> 5122   5122      anova full         SLC36A4   6.691761 1.192833e-05
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#> 5140   5140      anova full          PNLDC1   6.653017 1.276251e-05
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#> 5144   5144      anova full           PARD3   6.644357 1.295699e-05
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#> 5146   5146      anova full          PAPOLA   6.640025 1.305539e-05
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#> 5148   5148      anova full            RPS7   6.636192 1.314312e-05
#> 5149   5149      anova full           SEH1L   6.635115 1.316788e-05
#> 5150   5150      anova full          TSPAN1   6.633321 1.320921e-05
#> 5151   5151      anova full          PARP14   6.633255 1.321074e-05
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#> 5154   5154      anova full         SEC23IP   6.629659 1.329400e-05
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#> 5156   5156      anova full        TCTEX1D1   6.628169 1.332867e-05
#> 5157   5157      anova full            VAT1   6.627115 1.335326e-05
#> 5158   5158      anova full          LZTFL1   6.625140 1.339942e-05
#> 5159   5159      anova full         HNRNPA1   6.622238 1.346758e-05
#> 5160   5160      anova full            SPI1   6.619740 1.352653e-05
#> 5161   5161      anova full           AGAP3   6.619326 1.353631e-05
#> 5162   5162      anova full      AC114947.2   6.616010 1.361503e-05
#> 5163   5163      anova full           LRFN3   6.614468 1.365178e-05
#> 5164   5164      anova full           CORO6   6.614197 1.365825e-05
#> 5165   5165      anova full           ASCL2   6.610250 1.375286e-05
#> 5166   5166      anova full          DENND3   6.608263 1.380074e-05
#> 5167   5167      anova full           ZFPM2   6.607832 1.381114e-05
#> 5168   5168      anova full            ASPN   6.607204 1.382632e-05
#> 5169   5169      anova full             SET   6.606586 1.384126e-05
#> 5170   5170      anova full          TRERF1   6.606492 1.384354e-05
#> 5171   5171      anova full          PABPC4   6.605589 1.386544e-05
#> 5172   5172      anova full          GRIN2C   6.605038 1.387880e-05
#> 5173   5173      anova full          GABBR1   6.603199 1.392352e-05
#> 5174   5174      anova full          CEP126   6.603119 1.392547e-05
#> 5175   5175      anova full           PDIA3   6.602687 1.393601e-05
#> 5176   5176      anova full         EMILIN3   6.601599 1.396256e-05
#> 5177   5177      anova full      AC037441.1   6.600204 1.399668e-05
#> 5178   5178      anova full         RABGAP1   6.598386 1.404126e-05
#> 5179   5179      anova full          IFITM1   6.597117 1.407248e-05
#> 5180   5180      anova full         SLC5A12   6.595076 1.412283e-05
#> 5181   5181      anova full         CACNA1C   6.594655 1.413324e-05
#> 5182   5182      anova full         SLC6A20   6.593990 1.414970e-05
#> 5183   5183      anova full             RP1   6.591396 1.421409e-05
#> 5184   5184      anova full          NDUFS1   6.587807 1.430365e-05
#> 5185   5185      anova full      AF106564.1   6.585370 1.436482e-05
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#> 5254   5254      anova full          CTXND1   6.484652 1.714065e-05
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#> 5303   5303      anova full            CBY1   6.410098 1.954420e-05
#> 5304   5304      anova full           GFPT2   6.408560 1.959726e-05
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#> 5307   5307      anova full          RHBDL1   6.400509 1.987741e-05
#> 5308   5308      anova full          ZNF711   6.396740 2.000998e-05
#> 5309   5309      anova full         NEUROG2   6.395941 2.003817e-05
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#> 5312   5312      anova full         ATP5MC1   6.394634 2.008442e-05
#> 5313   5313      anova full          PECAM1   6.392258 2.016876e-05
#> 5314   5314      anova full      SAPCD1-AS1   6.392170 2.017189e-05
#> 5315   5315      anova full           CCDC6   6.391940 2.018010e-05
#> 5316   5316      anova full          SEMA3G   6.391437 2.019799e-05
#> 5317   5317      anova full          SAYSD1   6.390420 2.023428e-05
#> 5318   5318      anova full          CACNG7   6.388536 2.030161e-05
#> 5319   5319      anova full           CDC40   6.388337 2.030875e-05
#> 5320   5320      anova full          INAFM2   6.387827 2.032706e-05
#> 5321   5321      anova full           STX16   6.387513 2.033831e-05
#> 5322   5322      anova full          LRRTM2   6.384580 2.044382e-05
#> 5323   5323      anova full       LINC01750   6.384216 2.045695e-05
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#> 5325   5325      anova full          ZNF33A   6.379265 2.063647e-05
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#> 5328   5328      anova full           PSMB8   6.376038 2.075432e-05
#> 5329   5329      anova full          GOLPH3   6.373171 2.085963e-05
#> 5330   5330      anova full          GABRG3   6.369505 2.099505e-05
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#> 5332   5332      anova full           FSTL4   6.369254 2.100437e-05
#> 5333   5333      anova full           TNNT1   6.367834 2.105710e-05
#> 5334   5334      anova full           BTBD1   6.367506 2.106929e-05
#> 5335   5335      anova full         FAM135B   6.362672 2.124992e-05
#> 5336   5336      anova full         C3orf58   6.362601 2.125256e-05
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#> 5338   5338      anova full           ABHD6   6.360052 2.134846e-05
#> 5339   5339      anova full          TRIM24   6.359411 2.137266e-05
#> 5340   5340      anova full      AC013275.1   6.359345 2.137514e-05
#> 5341   5341      anova full          TARDBP   6.358973 2.138919e-05
#> 5342   5342      anova full           MFSD3   6.358433 2.140960e-05
#> 5343   5343      anova full             MRO   6.356762 2.147289e-05
#> 5344   5344      anova full         LDLRAD3   6.356751 2.147331e-05
#> 5345   5345      anova full      AC004597.1   6.356357 2.148826e-05
#> 5346   5346      anova full         TMEM256   6.355121 2.153523e-05
#> 5347   5347      anova full            SETX   6.352245 2.164490e-05
#> 5348   5348      anova full            RBSN   6.352078 2.165131e-05
#> 5349   5349      anova full          MS4A6A   6.350976 2.169348e-05
#> 5350   5350      anova full             MVD   6.347022 2.184559e-05
#> 5351   5351      anova full           UQCRQ   6.346591 2.186223e-05
#> 5352   5352      anova full          LRRC38   6.342230 2.203135e-05
#> 5353   5353      anova full      AC011472.4   6.340853 2.208503e-05
#> 5354   5354      anova full           RPL27   6.340271 2.210776e-05
#> 5355   5355      anova full          ACTR1A   6.339850 2.212422e-05
#> 5356   5356      anova full         LAPTM4A   6.339745 2.212832e-05
#> 5357   5357      anova full           BAZ2A   6.338482 2.217780e-05
#> 5358   5358      anova full            NARS   6.335925 2.227826e-05
#> 5359   5359      anova full         CCDC74A   6.334697 2.232667e-05
#> 5360   5360      anova full           PSMA4   6.332763 2.240316e-05
#> 5361   5361      anova full           SEPT6   6.331091 2.246946e-05
#> 5362   5362      anova full           PRR13   6.330994 2.247333e-05
#> 5363   5363      anova full           HDAC2   6.330622 2.248810e-05
#> 5364   5364      anova full        HSD17B14   6.329953 2.251472e-05
#> 5365   5365      anova full          AKR7A3   6.327572 2.260971e-05
#> 5366   5366      anova full           ASTN2   6.326841 2.263896e-05
#> 5367   5367      anova full          CHI3L1   6.326791 2.264098e-05
#> 5368   5368      anova full             C1S   6.324590 2.272926e-05
#> 5369   5369      anova full         SLC20A2   6.324578 2.272976e-05
#> 5370   5370      anova full           CEP44   6.324430 2.273569e-05
#> 5371   5371      anova full            ACLY   6.324272 2.274204e-05
#> 5372   5372      anova full            MPDZ   6.323301 2.278115e-05
#> 5373   5373      anova full           ATP4A   6.319463 2.293632e-05
#> 5374   5374      anova full            PAXX   6.318488 2.297592e-05
#> 5375   5375      anova full           LOXL1   6.316226 2.306802e-05
#> 5376   5376      anova full           CNIH4   6.315465 2.309912e-05
#> 5377   5377      anova full         SLC26A2   6.314401 2.314264e-05
#> 5378   5378      anova full            ARL2   6.312126 2.323597e-05
#> 5379   5379      anova full            VBP1   6.308723 2.337633e-05
#> 5380   5380      anova full           AJAP1   6.304815 2.353857e-05
#> 5381   5381      anova full          CYFIP1   6.302693 2.362715e-05
#> 5382   5382      anova full          PDLIM7   6.301603 2.367276e-05
#> 5383   5383      anova full       LINC00326   6.300095 2.373606e-05
#> 5384   5384      anova full           PLCH2   6.299082 2.377865e-05
#> 5385   5385      anova full           GDF10   6.298874 2.378739e-05
#> 5386   5386      anova full           CMPK1   6.298386 2.380798e-05
#> 5387   5387      anova full            HPF1   6.296476 2.388863e-05
#> 5388   5388      anova full       LINC01170   6.295367 2.393557e-05
#> 5389   5389      anova full           TRAK2   6.292577 2.405410e-05
#> 5390   5390      anova full           PNPT1   6.291807 2.408691e-05
#> 5391   5391      anova full         CDK2AP2   6.291355 2.410622e-05
#> 5392   5392      anova full           ASAP2   6.291257 2.411039e-05
#> 5393   5393      anova full           COX11   6.290991 2.412175e-05
#> 5394   5394      anova full        FGD5-AS1   6.290890 2.412608e-05
#> 5395   5395      anova full          DBNDD2   6.289615 2.418062e-05
#> 5396   5396      anova full            EBF4   6.288847 2.421351e-05
#> 5397   5397      anova full           UBE2C   6.288278 2.423794e-05
#> 5398   5398      anova full         TMEM242   6.287452 2.427342e-05
#> 5399   5399      anova full       LINC01378   6.286874 2.429828e-05
#> 5400   5400      anova full            UBL7   6.285901 2.434020e-05
#> 5401   5401      anova full           VAMP7   6.283592 2.443993e-05
#> 5402   5402      anova full          EFEMP2   6.283460 2.444566e-05
#> 5403   5403      anova full      AC025253.1   6.282795 2.447446e-05
#> 5404   5404      anova full           THOC7   6.277203 2.471815e-05
#> 5405   5405      anova full           TTPAL   6.274962 2.481650e-05
#> 5406   5406      anova full            DAW1   6.272710 2.491571e-05
#> 5407   5407      anova full      AC026401.3   6.270965 2.499289e-05
#> 5408   5408      anova full           GRSF1   6.270115 2.503054e-05
#> 5409   5409      anova full           PPM1B   6.264957 2.526046e-05
#> 5410   5410      anova full        LEPROTL1   6.262968 2.534969e-05
#> 5411   5411      anova full           MYO9A   6.261245 2.542723e-05
#> 5412   5412      anova full           PSME2   6.259303 2.551495e-05
#> 5413   5413      anova full           CHST3   6.257979 2.557491e-05
#> 5414   5414      anova full      USP27X-AS1   6.257803 2.558286e-05
#> 5415   5415      anova full           SCN5A   6.257124 2.561370e-05
#> 5416   5416      anova full           CASC4   6.254855 2.571697e-05
#> 5417   5417      anova full         TMEM88B   6.254165 2.574843e-05
#> 5418   5418      anova full           ACAP2   6.253587 2.577484e-05
#> 5419   5419      anova full            CKLF   6.252877 2.580732e-05
#> 5420   5420      anova full            PLD4   6.252483 2.582536e-05
#> 5421   5421      anova full           WDR86   6.252465 2.582619e-05
#> 5422   5422      anova full            GBP3   6.252217 2.583755e-05
#> 5423   5423      anova full            AAAS   6.251163 2.588589e-05
#> 5424   5424      anova full           SYTL2   6.249610 2.595730e-05
#> 5425   5425      anova full          KCNE1B   6.249132 2.597932e-05
#> 5426   5426      anova full          MRPL34   6.247167 2.607004e-05
#> 5427   5427      anova full          SRSF12   6.245754 2.613547e-05
#> 5428   5428      anova full           FOXO3   6.242845 2.627069e-05
#> 5429   5429      anova full            CDS2   6.242437 2.628969e-05
#> 5430   5430      anova full           IKBKB   6.241914 2.631410e-05
#> 5431   5431      anova full          DEPTOR   6.240738 2.636906e-05
#> 5432   5432      anova full      AC066613.1   6.239335 2.643479e-05
#> 5433   5433      anova full         TSPAN14   6.239147 2.644363e-05
#> 5434   5434      anova full            MAF1   6.236860 2.655115e-05
#> 5435   5435      anova full           LARP1   6.236613 2.656279e-05
#> 5436   5436      anova full             CHM   6.235968 2.659320e-05
#> 5437   5437      anova full         SRGAP2C   6.234498 2.666268e-05
#> 5438   5438      anova full            ETV5   6.233148 2.672662e-05
#> 5439   5439      anova full           SLFN5   6.228533 2.694648e-05
#> 5440   5440      anova full             APC   6.225990 2.706840e-05
#> 5441   5441      anova full           PIAS1   6.224241 2.715257e-05
#> 5442   5442      anova full           PTPN1   6.222245 2.724900e-05
#> 5443   5443      anova full        CDC42SE1   6.222123 2.725489e-05
#> 5444   5444      anova full      ZNF710-AS1   6.220480 2.733449e-05
#> 5445   5445      anova full         DNAJC5B   6.220249 2.734571e-05
#> 5446   5446      anova full            SDC2   6.220189 2.734865e-05
#> 5447   5447      anova full      AC109587.1   6.219453 2.738440e-05
#> 5448   5448      anova full      AC090568.2   6.219308 2.739144e-05
#> 5449   5449      anova full           SMIM1   6.216699 2.751864e-05
#> 5450   5450      anova full           AVPI1   6.215538 2.757544e-05
#> 5451   5451      anova full           MYRIP   6.215393 2.758256e-05
#> 5452   5452      anova full           PDPK1   6.209910 2.785252e-05
#> 5453   5453      anova full           ECPAS   6.209802 2.785786e-05
#> 5454   5454      anova full           KRT78   6.208850 2.790502e-05
#> 5455   5455      anova full      AP003355.2   6.208229 2.793581e-05
#> 5456   5456      anova full         NDUFAF5   6.207862 2.795404e-05
#> 5457   5457      anova full           CECR2   6.206248 2.803430e-05
#> 5458   5458      anova full       LINC02389   6.205329 2.808012e-05
#> 5459   5459      anova full          RHEBL1   6.205126 2.809021e-05
#> 5460   5460      anova full          RFXANK   6.201515 2.827104e-05
#> 5461   5461      anova full         DHRS4L2   6.199293 2.838289e-05
#> 5462   5462      anova full            ATN1   6.198931 2.840117e-05
#> 5463   5463      anova full            SIAE   6.198511 2.842238e-05
#> 5464   5464      anova full           NIPBL   6.198016 2.844739e-05
#> 5465   5465      anova full             TSN   6.197104 2.849351e-05
#> 5466   5466      anova full          SRD5A3   6.196334 2.853256e-05
#> 5467   5467      anova full           KCNJ8   6.194878 2.860649e-05
#> 5468   5468      anova full          TECPR2   6.193501 2.867657e-05
#> 5469   5469      anova full           EGFL6   6.191580 2.877471e-05
#> 5470   5470      anova full          COL6A1   6.189607 2.887579e-05
#> 5471   5471      anova full            MIIP   6.189297 2.889172e-05
#> 5472   5472      anova full       LINC02192   6.189016 2.890612e-05
#> 5473   5473      anova full      AL451164.1   6.187792 2.896911e-05
#> 5474   5474      anova full             KHK   6.187719 2.897287e-05
#> 5475   5475      anova full           MAIP1   6.185574 2.908359e-05
#> 5476   5476      anova full          C4orf3   6.183579 2.918693e-05
#> 5477   5477      anova full           CMSS1   6.182876 2.922346e-05
#> 5478   5478      anova full          MGAT4A   6.182734 2.923083e-05
#> 5479   5479      anova full          DOLPP1   6.180358 2.935458e-05
#> 5480   5480      anova full         FAM173A   6.177922 2.948207e-05
#> 5481   5481      anova full          RNF126   6.177474 2.950554e-05
#> 5482   5482      anova full           MRPL3   6.175628 2.960261e-05
#> 5483   5483      anova full           MED30   6.174278 2.967379e-05
#> 5484   5484      anova full           EIF3F   6.174177 2.967908e-05
#> 5485   5485      anova full           PARP2   6.170505 2.987362e-05
#> 5486   5486      anova full           RNPC3   6.169504 2.992686e-05
#> 5487   5487      anova full            BCL6   6.169495 2.992736e-05
#> 5488   5488      anova full           HIBCH   6.168862 2.996105e-05
#> 5489   5489      anova full          FAM47E   6.168467 2.998215e-05
#> 5490   5490      anova full           FTSJ3   6.168424 2.998443e-05
#> 5491   5491      anova full          ZSWIM6   6.164689 3.018438e-05
#> 5492   5492      anova full          STRIP2   6.163344 3.025671e-05
#> 5493   5493      anova full             ZFR   6.162840 3.028386e-05
#> 5494   5494      anova full       BAIAP2-DT   6.162697 3.029154e-05
#> 5495   5495      anova full          GIMAP1   6.161971 3.033074e-05
#> 5496   5496      anova full           PCBP3   6.160166 3.042834e-05
#> 5497   5497      anova full          STARD3   6.159110 3.048554e-05
#> 5498   5498      anova full            LMF2   6.158366 3.052593e-05
#> 5499   5499      anova full         SUPV3L1   6.156657 3.061898e-05
#> 5500   5500      anova full            USP3   6.156192 3.064434e-05
#> 5501   5501      anova full            BAG5   6.154571 3.073285e-05
#> 5502   5502      anova full          OTUD7A   6.153228 3.080641e-05
#> 5503   5503      anova full       LINC02199   6.150879 3.093554e-05
#> 5504   5504      anova full           DGCR9   6.148000 3.109454e-05
#> 5505   5505      anova full        SLC25A32   6.147950 3.109728e-05
#> 5506   5506      anova full            RTP1   6.147028 3.114840e-05
#> 5507   5507      anova full            CBX3   6.143657 3.133594e-05
#> 5508   5508      anova full         FAM189B   6.143326 3.135440e-05
#> 5509   5509      anova full          ZBTB17   6.142537 3.139850e-05
#> 5510   5510      anova full         SELENOI   6.141079 3.148014e-05
#> 5511   5511      anova full         TBC1D23   6.140128 3.153351e-05
#> 5512   5512      anova full           CYTH4   6.140018 3.153972e-05
#> 5513   5513      anova full          UNC119   6.135305 3.180561e-05
#> 5514   5514      anova full          TM9SF4   6.134824 3.183290e-05
#> 5515   5515      anova full           MED19   6.134312 3.186190e-05
#> 5516   5516      anova full           ZNRF3   6.132483 3.196590e-05
#> 5517   5517      anova full          MANBAL   6.132382 3.197169e-05
#> 5518   5518      anova full            CD37   6.132196 3.198228e-05
#> 5519   5519      anova full           CMYA5   6.131165 3.204107e-05
#> 5520   5520      anova full       BASP1-AS1   6.130388 3.208546e-05
#> 5521   5521      anova full          AKAIN1   6.128844 3.217387e-05
#> 5522   5522      anova full           KHNYN   6.128394 3.219969e-05
#> 5523   5523      anova full        NIPSNAP2   6.127336 3.226042e-05
#> 5524   5524      anova full           GNPTG   6.124382 3.243073e-05
#> 5525   5525      anova full          ARID5B   6.124381 3.243079e-05
#> 5526   5526      anova full           GNAI3   6.121854 3.257718e-05
#> 5527   5527      anova full          HSPA13   6.119625 3.270686e-05
#> 5528   5528      anova full           PSMG1   6.119307 3.272543e-05
#> 5529   5529      anova full          VPS26B   6.118155 3.279272e-05
#> 5530   5530      anova full            ZNF3   6.117291 3.284327e-05
#> 5531   5531      anova full           MINK1   6.116047 3.291616e-05
#> 5532   5532      anova full      AC012507.2   6.115825 3.292920e-05
#> 5533   5533      anova full            GYG1   6.114722 3.299402e-05
#> 5534   5534      anova full      AC069133.1   6.113875 3.304386e-05
#> 5535   5535      anova full         PACSIN3   6.113182 3.308475e-05
#> 5536   5536      anova full       LRRC8C-DT   6.110869 3.322144e-05
#> 5537   5537      anova full       UHRF1BP1L   6.108854 3.334103e-05
#> 5538   5538      anova full           NUDT1   6.106780 3.346463e-05
#> 5539   5539      anova full         RUNX1T1   6.105751 3.352609e-05
#> 5540   5540      anova full          ABCC12   6.104844 3.358037e-05
#> 5541   5541      anova full          TRIM17   6.103901 3.363691e-05
#> 5542   5542      anova full           PDZD8   6.103761 3.364529e-05
#> 5543   5543      anova full           BTBD9   6.102039 3.374877e-05
#> 5544   5544      anova full          RASAL2   6.101591 3.377576e-05
#> 5545   5545      anova full         ALDH3B1   6.100795 3.382374e-05
#> 5546   5546      anova full      AC174065.1   6.099562 3.389827e-05
#> 5547   5547      anova full        LRP4-AS1   6.097462 3.402548e-05
#> 5548   5548      anova full           IFT74   6.097038 3.405120e-05
#> 5549   5549      anova full           MMP16   6.095316 3.415602e-05
#> 5550   5550      anova full            SMTN   6.095006 3.417490e-05
#> 5551   5551      anova full       LINC02009   6.092958 3.430005e-05
#> 5552   5552      anova full      AC139491.1   6.092452 3.433102e-05
#> 5553   5553      anova full           RFLNB   6.088469 3.457592e-05
#> 5554   5554      anova full        TMEM229B   6.086994 3.466702e-05
#> 5555   5555      anova full          ZNF766   6.081126 3.503205e-05
#> 5556   5556      anova full             DES   6.080833 3.505038e-05
#> 5557   5557      anova full           CLBA1   6.080765 3.505467e-05
#> 5558   5558      anova full           DISP3   6.080178 3.509140e-05
#> 5559   5559      anova full      AC005082.1   6.077426 3.526425e-05
#> 5560   5560      anova full           SNX30   6.076536 3.532035e-05
#> 5561   5561      anova full           AZGP1   6.076434 3.532674e-05
#> 5562   5562      anova full            ILF3   6.075388 3.539282e-05
#> 5563   5563      anova full            CPOX   6.074994 3.541774e-05
#> 5564   5564      anova full          POU3F4   6.073519 3.551110e-05
#> 5565   5565      anova full            GPC4   6.072231 3.559288e-05
#> 5566   5566      anova full          SH3GL1   6.071659 3.562928e-05
#> 5567   5567      anova full      AC009148.1   6.069987 3.573579e-05
#> 5568   5568      anova full        CACNA2D2   6.069466 3.576911e-05
#> 5569   5569      anova full           MTFMT   6.068803 3.581144e-05
#> 5570   5570      anova full           SEC62   6.066547 3.595606e-05
#> 5571   5571      anova full           WBP11   6.065745 3.600761e-05
#> 5572   5572      anova full           FOXP1   6.064120 3.611231e-05
#> 5573   5573      anova full         OSBPL1A   6.064038 3.611757e-05
#> 5574   5574      anova full           DYRK2   6.063910 3.612582e-05
#> 5575   5575      anova full         ANAPC15   6.062883 3.619219e-05
#> 5576   5576      anova full          UBE2L3   6.059673 3.640032e-05
#> 5577   5577      anova full           STAB1   6.059196 3.643135e-05
#> 5578   5578      anova full           LPIN2   6.058447 3.648015e-05
#> 5579   5579      anova full           LRTM2   6.056546 3.660426e-05
#> 5580   5580      anova full             MAF   6.054994 3.670592e-05
#> 5581   5581      anova full          SYCE1L   6.049144 3.709169e-05
#> 5582   5582      anova full         TMEM181   6.048626 3.712605e-05
#> 5583   5583      anova full           ITGAX   6.047518 3.719965e-05
#> 5584   5584      anova full         HNRNPH1   6.047251 3.721740e-05
#> 5585   5585      anova full           TCFL5   6.047157 3.722367e-05
#> 5586   5586      anova full         ST6GAL2   6.045957 3.730359e-05
#> 5587   5587      anova full          LSM14B   6.045377 3.734233e-05
#> 5588   5588      anova full          SPPL2B   6.043936 3.743864e-05
#> 5589   5589      anova full           NTPCR   6.042379 3.754300e-05
#> 5590   5590      anova full           AGBL4   6.041893 3.757565e-05
#> 5591   5591      anova full          MAGOHB   6.040878 3.764388e-05
#> 5592   5592      anova full           SRARP   6.040686 3.765679e-05
#> 5593   5593      anova full         PHACTR3   6.038689 3.779148e-05
#> 5594   5594      anova full           UBAP2   6.037474 3.787368e-05
#> 5595   5595      anova full         FAM234B   6.036737 3.792368e-05
#> 5596   5596      anova full            DDR2   6.036331 3.795121e-05
#> 5597   5597      anova full          SHISA4   6.033005 3.817763e-05
#> 5598   5598      anova full         PPP2R3B   6.032993 3.817842e-05
#> 5599   5599      anova full      AF111167.2   6.030717 3.833418e-05
#> 5600   5600      anova full           MTMR6   6.029792 3.839765e-05
#> 5601   5601      anova full           RAB12   6.029568 3.841306e-05
#> 5602   5602      anova full           SCYL2   6.029543 3.841473e-05
#> 5603   5603      anova full        ATP6V0E2   6.029354 3.842777e-05
#> 5604   5604      anova full          IGSF11   6.028902 3.845884e-05
#> 5605   5605      anova full            POGZ   6.028720 3.847133e-05
#> 5606   5606      anova full         ZCCHC18   6.028650 3.847616e-05
#> 5607   5607      anova full           RAB37   6.027447 3.855906e-05
#> 5608   5608      anova full          ZDHHC2   6.026415 3.863028e-05
#> 5609   5609      anova full        ANKRD33B   6.025403 3.870028e-05
#> 5610   5610      anova full            YBEY   6.022931 3.887182e-05
#> 5611   5611      anova full           DPP10   6.017988 3.921715e-05
#> 5612   5612      anova full           NR1D2   6.016788 3.930150e-05
#> 5613   5613      anova full           CDHR3   6.016745 3.930454e-05
#> 5614   5614      anova full            UBTF   6.010189 3.976843e-05
#> 5615   5615      anova full         CXorf57   6.006397 4.003930e-05
#> 5616   5616      anova full            ANO6   6.005844 4.007894e-05
#> 5617   5617      anova full           BIRC5   6.005475 4.010548e-05
#> 5618   5618      anova full            NTF3   6.005299 4.011810e-05
#> 5619   5619      anova full            SYNM   6.004481 4.017691e-05
#> 5620   5620      anova full             PAH   6.004015 4.021040e-05
#> 5621   5621      anova full          ZNF614   6.003397 4.025491e-05
#> 5622   5622      anova full           SNRPE   6.002564 4.031500e-05
#> 5623   5623      anova full           LTBP1   6.001747 4.037408e-05
#> 5624   5624      anova full         B4GALT1   6.001400 4.039914e-05
#> 5625   5625      anova full         LRRFIP2   6.000252 4.048231e-05
#> 5626   5626      anova full            GRK4   5.996968 4.072104e-05
#> 5627   5627      anova full            DCTD   5.996471 4.075734e-05
#> 5628   5628      anova full          RNF152   5.994535 4.089886e-05
#> 5629   5629      anova full           EFNB1   5.994480 4.090295e-05
#> 5630   5630      anova full       PACRG-AS3   5.992720 4.103205e-05
#> 5631   5631      anova full          CCDC43   5.989338 4.128143e-05
#> 5632   5632      anova full          ADIPOQ   5.988807 4.132070e-05
#> 5633   5633      anova full           TIGD3   5.988557 4.133921e-05
#> 5634   5634      anova full            DRGX   5.985032 4.160113e-05
#> 5635   5635      anova full      AC006254.1   5.983119 4.174394e-05
#> 5636   5636      anova full          MTHFD1   5.982864 4.176306e-05
#> 5637   5637      anova full           PYGO2   5.981528 4.186312e-05
#> 5638   5638      anova full            UBL3   5.981162 4.189064e-05
#> 5639   5639      anova full            MIDN   5.980283 4.195663e-05
#> 5640   5640      anova full           GSPT2   5.976825 4.221746e-05
#> 5641   5641      anova full            API5   5.976629 4.223234e-05
#> 5642   5642      anova full           MEX3C   5.974668 4.238105e-05
#> 5643   5643      anova full           NEIL2   5.970583 4.269250e-05
#> 5644   5644      anova full        TMEM121B   5.970580 4.269273e-05
#> 5645   5645      anova full           G6PC3   5.969394 4.278358e-05
#> 5646   5646      anova full            MKKS   5.969206 4.279802e-05
#> 5647   5647      anova full         PPP1R9A   5.969163 4.280131e-05
#> 5648   5648      anova full           EPHA3   5.966041 4.304157e-05
#> 5649   5649      anova full            MRC1   5.964661 4.314825e-05
#> 5650   5650      anova full           ABCD2   5.964651 4.314900e-05
#> 5651   5651      anova full           SDAD1   5.964250 4.318000e-05
#> 5652   5652      anova full          DUSP23   5.962414 4.332244e-05
#> 5653   5653      anova full           NRIP3   5.959867 4.352076e-05
#> 5654   5654      anova full           KCTD5   5.957532 4.370343e-05
#> 5655   5655      anova full      AC067838.1   5.956724 4.376683e-05
#> 5656   5656      anova full          GGNBP2   5.956100 4.381582e-05
#> 5657   5657      anova full          BCAP31   5.955729 4.384497e-05
#> 5658   5658      anova full          PPP6R3   5.954497 4.394199e-05
#> 5659   5659      anova full          GOLGA5   5.954098 4.397341e-05
#> 5660   5660      anova full         CREB3L2   5.952564 4.409461e-05
#> 5661   5661      anova full            TET2   5.951300 4.419476e-05
#> 5662   5662      anova full      AP002893.1   5.946000 4.461697e-05
#> 5663   5663      anova full            IMP4   5.944293 4.475386e-05
#> 5664   5664      anova full            HBA1   5.943401 4.482559e-05
#> 5665   5665      anova full            ESAM   5.942392 4.490684e-05
#> 5666   5666      anova full          CDKN2A   5.942121 4.492864e-05
#> 5667   5667      anova full            CCNQ   5.938141 4.525074e-05
#> 5668   5668      anova full         KRTCAP2   5.937816 4.527713e-05
#> 5669   5669      anova full           ASCC2   5.935050 4.550251e-05
#> 5670   5670      anova full            WWC3   5.933148 4.565814e-05
#> 5671   5671      anova full            RNF8   5.932252 4.573168e-05
#> 5672   5672      anova full          NFATC4   5.931994 4.575283e-05
#> 5673   5673      anova full          RUVBL2   5.926053 4.624350e-05
#> 5674   5674      anova full            BRF1   5.924308 4.638866e-05
#> 5675   5675      anova full          CREBZF   5.923115 4.648814e-05
#> 5676   5676      anova full      AC093424.1   5.921512 4.662223e-05
#> 5677   5677      anova full           TENM4   5.920073 4.674285e-05
#> 5678   5678      anova full          UQCR11   5.919735 4.677125e-05
#> 5679   5679      anova full          ZDHHC8   5.918387 4.688463e-05
#> 5680   5680      anova full           ADCY5   5.917817 4.693268e-05
#> 5681   5681      anova full           ARL5A   5.915756 4.710674e-05
#> 5682   5682      anova full           DOCK7   5.914991 4.717150e-05
#> 5683   5683      anova full         ZFYVE28   5.914343 4.722649e-05
#> 5684   5684      anova full            GPX4   5.914320 4.722842e-05
#> 5685   5685      anova full           RPL34   5.913692 4.728174e-05
#> 5686   5686      anova full        PDZK1IP1   5.913221 4.732177e-05
#> 5687   5687      anova full           SH2B2   5.910777 4.753005e-05
#> 5688   5688      anova full           KCNJ2   5.909315 4.765502e-05
#> 5689   5689      anova full             OGT   5.908827 4.769685e-05
#> 5690   5690      anova full           RIMS4   5.907927 4.777409e-05
#> 5691   5691      anova full           CEP85   5.907479 4.781255e-05
#> 5692   5692      anova full           IFI16   5.906482 4.789823e-05
#> 5693   5693      anova full           MBNL1   5.905631 4.797158e-05
#> 5694   5694      anova full          RNF112   5.901169 4.835788e-05
#> 5695   5695      anova full          ZNF461   5.900857 4.838501e-05
#> 5696   5696      anova full           DHRS2   5.900555 4.841122e-05
#> 5697   5697      anova full        C6orf136   5.896205 4.879128e-05
#> 5698   5698      anova full           AHDC1   5.895770 4.882942e-05
#> 5699   5699      anova full           SAP18   5.895561 4.884777e-05
#> 5700   5700      anova full             EBP   5.894631 4.892955e-05
#> 5701   5701      anova full           LDOC1   5.894490 4.894200e-05
#> 5702   5702      anova full           PSMF1   5.892976 4.907539e-05
#> 5703   5703      anova full          ZBTB16   5.892850 4.908651e-05
#> 5704   5704      anova full          PTPN13   5.890130 4.932717e-05
#> 5705   5705      anova full          ZNF326   5.889858 4.935128e-05
#> 5706   5706      anova full           RBPMS   5.889433 4.938897e-05
#> 5707   5707      anova full            CSTA   5.889187 4.941088e-05
#> 5708   5708      anova full          PPP1CB   5.886116 4.968453e-05
#> 5709   5709      anova full           MARK4   5.885198 4.976663e-05
#> 5710   5710      anova full         CCDC181   5.884854 4.979738e-05
#> 5711   5711      anova full          SLC7A7   5.884850 4.979772e-05
#> 5712   5712      anova full           ACTG2   5.884802 4.980205e-05
#> 5713   5713      anova full        SH3BGRL3   5.884583 4.982166e-05
#> 5714   5714      anova full          LPCAT3   5.883577 4.991193e-05
#> 5715   5715      anova full          RIPOR2   5.881918 5.006108e-05
#> 5716   5716      anova full            TAF3   5.881912 5.006161e-05
#> 5717   5717      anova full          RCBTB2   5.881877 5.006477e-05
#> 5718   5718      anova full           CNTN4   5.879156 5.031040e-05
#> 5719   5719      anova full           SLIRP   5.879108 5.031480e-05
#> 5720   5720      anova full         GADD45B   5.878436 5.037566e-05
#> 5721   5721      anova full         MYBBP1A   5.876446 5.055629e-05
#> 5722   5722      anova full           HIPK1   5.876293 5.057022e-05
#> 5723   5723      anova full        RASGEF1C   5.875124 5.067671e-05
#> 5724   5724      anova full           BRPF3   5.872135 5.094998e-05
#> 5725   5725      anova full           SUGP2   5.871098 5.104516e-05
#> 5726   5726      anova full            BAP1   5.870043 5.114213e-05
#> 5727   5727      anova full           PPARG   5.869141 5.122524e-05
#> 5728   5728      anova full           TAOK1   5.866420 5.147666e-05
#> 5729   5729      anova full        SYNDIG1L   5.862535 5.183793e-05
#> 5730   5730      anova full          MTMR12   5.862386 5.185182e-05
#> 5731   5731      anova full      AC103706.1   5.862274 5.186225e-05
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#> 5790   5790      anova full           TRADD   5.781841 5.995513e-05
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#> 5796   5796      anova full            RHOB   5.775528 6.064244e-05
#> 5797   5797      anova full           HLA-F   5.774345 6.077216e-05
#> 5798   5798      anova full          RNF217   5.772692 6.095392e-05
#> 5799   5799      anova full          GPR161   5.772313 6.099569e-05
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#> 5801   5801      anova full          U2SURP   5.770215 6.122726e-05
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#> 5803   5803      anova full      BX255925.3   5.767699 6.150613e-05
#> 5804   5804      anova full            FECH   5.767116 6.157096e-05
#> 5805   5805      anova full             DBP   5.763254 6.200207e-05
#> 5806   5806      anova full             XPC   5.763159 6.201269e-05
#> 5807   5807      anova full           YIPF6   5.762840 6.204844e-05
#> 5808   5808      anova full            HAS1   5.762736 6.206003e-05
#> 5809   5809      anova full           RAB25   5.761865 6.215779e-05
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#> 5812   5812      anova full            FMO2   5.760323 6.233123e-05
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#> 5815   5815      anova full            USB1   5.759179 6.246024e-05
#> 5816   5816      anova full         TP53TG1   5.757439 6.265691e-05
#> 5817   5817      anova full           TNNC2   5.756759 6.273394e-05
#> 5818   5818      anova full           PDCD4   5.755906 6.283079e-05
#> 5819   5819      anova full            CNN1   5.754678 6.297038e-05
#> 5820   5820      anova full            DPH1   5.753921 6.305663e-05
#> 5821   5821      anova full          DHRS7B   5.753250 6.313317e-05
#> 5822   5822      anova full          B3GLCT   5.752113 6.326303e-05
#> 5823   5823      anova full          MRPL51   5.749647 6.354565e-05
#> 5824   5824      anova full         C4orf48   5.749352 6.357953e-05
#> 5825   5825      anova full        KIAA2012   5.749134 6.360452e-05
#> 5826   5826      anova full       LINC01123   5.748817 6.364106e-05
#> 5827   5827      anova full           TNPO1   5.746916 6.386017e-05
#> 5828   5828      anova full           PSMC1   5.744553 6.413349e-05
#> 5829   5829      anova full           ROGDI   5.743112 6.430088e-05
#> 5830   5830      anova full         CAPRIN2   5.742541 6.436726e-05
#> 5831   5831      anova full          FBXL19   5.742449 6.437802e-05
#> 5832   5832      anova full           ANXA3   5.741969 6.443382e-05
#> 5833   5833      anova full           VIPR2   5.741360 6.450489e-05
#> 5834   5834      anova full           UBE2U   5.740523 6.460251e-05
#> 5835   5835      anova full           CHTF8   5.736346 6.509243e-05
#> 5836   5836      anova full           DNPEP   5.734857 6.526794e-05
#> 5837   5837      anova full         ANKRD37   5.733406 6.543947e-05
#> 5838   5838      anova full           COPZ2   5.732156 6.558758e-05
#> 5839   5839      anova full        KIAA0040   5.731087 6.571450e-05
#> 5840   5840      anova full           SUSD6   5.731046 6.571936e-05
#> 5841   5841      anova full          SLC6A6   5.730805 6.574811e-05
#> 5842   5842      anova full          PET100   5.730344 6.580294e-05
#> 5843   5843      anova full      DLGAP1-AS3   5.730186 6.582174e-05
#> 5844   5844      anova full          SH3YL1   5.727067 6.619418e-05
#> 5845   5845      anova full           TAOK3   5.726774 6.622930e-05
#> 5846   5846      anova full           GSTM5   5.725493 6.638300e-05
#> 5847   5847      anova full      AC012645.3   5.725096 6.643064e-05
#> 5848   5848      anova full            EMC9   5.724656 6.648351e-05
#> 5849   5849      anova full             BIK   5.723738 6.659410e-05
#> 5850   5850      anova full         MFSD13A   5.723276 6.664978e-05
#> 5851   5851      anova full          SEC11C   5.721563 6.685676e-05
#> 5852   5852      anova full         TMEM215   5.718117 6.727490e-05
#> 5853   5853      anova full          CCDC50   5.717751 6.731955e-05
#> 5854   5854      anova full           CALCR   5.715949 6.753947e-05
#> 5855   5855      anova full          CHMP1A   5.715878 6.754812e-05
#> 5856   5856      anova full         PCDHB10   5.715690 6.757110e-05
#> 5857   5857      anova full      AC010864.1   5.714575 6.770761e-05
#> 5858   5858      anova full            ELK3   5.714229 6.774997e-05
#> 5859   5859      anova full           TEX29   5.712883 6.791533e-05
#> 5860   5860      anova full            NEBL   5.712561 6.795487e-05
#> 5861   5861      anova full           COPS2   5.708631 6.844005e-05
#> 5862   5862      anova full        ARHGAP33   5.708016 6.851637e-05
#> 5863   5863      anova full           TSNAX   5.707472 6.858387e-05
#> 5864   5864      anova full           TCF25   5.705082 6.888127e-05
#> 5865   5865      anova full             HK2   5.704540 6.894892e-05
#> 5866   5866      anova full            PEX5   5.704024 6.901337e-05
#> 5867   5867      anova full           NR3C1   5.703668 6.905788e-05
#> 5868   5868      anova full      AL645608.1   5.699662 6.956061e-05
#> 5869   5869      anova full         SLC17A9   5.698355 6.972548e-05
#> 5870   5870      anova full           PTH1R   5.697984 6.977235e-05
#> 5871   5871      anova full             KLB   5.697626 6.981767e-05
#> 5872   5872      anova full           COX17   5.693488 7.034287e-05
#> 5873   5873      anova full           CANT1   5.692598 7.045638e-05
#> 5874   5874      anova full           PTCH1   5.691434 7.060508e-05
#> 5875   5875      anova full            KIF6   5.690767 7.069048e-05
#> 5876   5876      anova full      AL137003.2   5.690287 7.075197e-05
#> 5877   5877      anova full          CASC15   5.689901 7.080144e-05
#> 5878   5878      anova full            PIGK   5.689888 7.080316e-05
#> 5879   5879      anova full          NDUFA9   5.689859 7.080688e-05
#> 5880   5880      anova full         PPP2R5B   5.689529 7.084925e-05
#> 5881   5881      anova full          MARCKS   5.689142 7.089891e-05
#> 5882   5882      anova full          ENOPH1   5.688881 7.093242e-05
#> 5883   5883      anova full          APPBP2   5.687558 7.110266e-05
#> 5884   5884      anova full            RTCB   5.686441 7.124674e-05
#> 5885   5885      anova full            QPRT   5.686433 7.124775e-05
#> 5886   5886      anova full           WDR45   5.685704 7.134194e-05
#> 5887   5887      anova full            LYST   5.683563 7.161927e-05
#> 5888   5888      anova full      AP000757.1   5.680941 7.196035e-05
#> 5889   5889      anova full           DDIT3   5.680656 7.199757e-05
#> 5890   5890      anova full            NKRF   5.678847 7.223396e-05
#> 5891   5891      anova full          MINDY2   5.672612 7.305495e-05
#> 5892   5892      anova full           RAB14   5.670711 7.330716e-05
#> 5893   5893      anova full          TNRC6C   5.667217 7.377299e-05
#> 5894   5894      anova full           COPB1   5.667129 7.378477e-05
#> 5895   5895      anova full           DCAF7   5.666801 7.382871e-05
#> 5896   5896      anova full         FAM181A   5.666003 7.393566e-05
#> 5897   5897      anova full            HPS6   5.665979 7.393885e-05
#> 5898   5898      anova full            DSG3   5.665314 7.402801e-05
#> 5899   5899      anova full        ARHGAP30   5.665028 7.406641e-05
#> 5900   5900      anova full         SPATA2L   5.664832 7.409273e-05
#> 5901   5901      anova full          PHLDA1   5.664225 7.417441e-05
#> 5902   5902      anova full           YIPF5   5.663860 7.422345e-05
#> 5903   5903      anova full          LRPAP1   5.663805 7.423086e-05
#> 5904   5904      anova full          ZNF160   5.663573 7.426215e-05
#> 5905   5905      anova full           FBXL5   5.663199 7.431247e-05
#> 5906   5906      anova full          LRRCC1   5.662231 7.444314e-05
#> 5907   5907      anova full          GXYLT1   5.658105 7.500224e-05
#> 5908   5908      anova full           DDX18   5.654882 7.544204e-05
#> 5909   5909      anova full         ARHGEF2   5.654764 7.545814e-05
#> 5910   5910      anova full          FAM78A   5.653260 7.566435e-05
#> 5911   5911      anova full            CAV1   5.652848 7.572097e-05
#> 5912   5912      anova full          CDKN2B   5.652421 7.577962e-05
#> 5913   5913      anova full          TRIM32   5.649204 7.622317e-05
#> 5914   5914      anova full             FTO   5.648204 7.636161e-05
#> 5915   5915      anova full            CLK2   5.647788 7.641927e-05
#> 5916   5916      anova full          MRPL16   5.647075 7.651821e-05
#> 5917   5917      anova full          EEF1E1   5.646262 7.663112e-05
#> 5918   5918      anova full      AL121603.2   5.645818 7.669290e-05
#> 5919   5919      anova full          KLHL14   5.645583 7.672560e-05
#> 5920   5920      anova full           TECTA   5.644328 7.690058e-05
#> 5921   5921      anova full         FAM71E1   5.643876 7.696369e-05
#> 5922   5922      anova full          OGFOD3   5.643516 7.701398e-05
#> 5923   5923      anova full           TACC1   5.643440 7.702466e-05
#> 5924   5924      anova full           ACSM5   5.643383 7.703257e-05
#> 5925   5925      anova full          ABHD11   5.641583 7.728461e-05
#> 5926   5926      anova full        SLC25A44   5.641490 7.729767e-05
#> 5927   5927      anova full         C7orf61   5.639143 7.762769e-05
#> 5928   5928      anova full          PIP4P1   5.635983 7.807415e-05
#> 5929   5929      anova full          ARMCX6   5.635208 7.818415e-05
#> 5930   5930      anova full            PCM1   5.634408 7.829775e-05
#> 5931   5931      anova full           PTOV1   5.631504 7.871162e-05
#> 5932   5932      anova full           LIN7C   5.631182 7.875771e-05
#> 5933   5933      anova full        SLC16A11   5.631154 7.876168e-05
#> 5934   5934      anova full      AL121820.2   5.631031 7.877927e-05
#> 5935   5935      anova full      AL359397.2   5.629746 7.896334e-05
#> 5936   5936      anova full           MED16   5.629742 7.896387e-05
#> 5937   5937      anova full             NOG   5.628579 7.913078e-05
#> 5938   5938      anova full         SULT1A1   5.627175 7.933278e-05
#> 5939   5939      anova full         SUPT20H   5.626895 7.937311e-05
#> 5940   5940      anova full          MRPL22   5.625307 7.960233e-05
#> 5941   5941      anova full            ASPG   5.623644 7.984316e-05
#> 5942   5942      anova full            HBQ1   5.623406 7.987768e-05
#> 5943   5943      anova full      AP002449.1   5.623201 7.990734e-05
#> 5944   5944      anova full        NUDT16L1   5.623103 7.992157e-05
#> 5945   5945      anova full          MRPL46   5.622384 8.002604e-05
#> 5946   5946      anova full            AAR2   5.618355 8.061378e-05
#> 5947   5947      anova full            MYOF   5.616765 8.084706e-05
#> 5948   5948      anova full           PDCD5   5.616364 8.090592e-05
#> 5949   5949      anova full       IL12A-AS1   5.615539 8.102727e-05
#> 5950   5950      anova full          HSPB11   5.613884 8.127129e-05
#> 5951   5951      anova full            GANC   5.612643 8.145468e-05
#> 5952   5952      anova full          TRIM22   5.609397 8.193650e-05
#> 5953   5953      anova full           ARIH2   5.608250 8.210755e-05
#> 5954   5954      anova full            CDC7   5.608146 8.212298e-05
#> 5955   5955      anova full         CACNA1G   5.607311 8.224765e-05
#> 5956   5956      anova full           NCOR2   5.604237 8.270853e-05
#> 5957   5957      anova full         TCP11L2   5.601907 8.305950e-05
#> 5958   5958      anova full           PCYT2   5.600165 8.332285e-05
#> 5959   5959      anova full         SLC50A1   5.598760 8.353590e-05
#> 5960   5960      anova full           BMP8B   5.597915 8.366428e-05
#> 5961   5961      anova full         NKIRAS2   5.596055 8.394775e-05
#> 5962   5962      anova full          SEMA4B   5.593409 8.435254e-05
#> 5963   5963      anova full          YTHDC1   5.590501 8.479972e-05
#> 5964   5964      anova full            ARF6   5.587768 8.522227e-05
#> 5965   5965      anova full          ZNF397   5.586040 8.549042e-05
#> 5966   5966      anova full            HEY1   5.585667 8.554843e-05
#> 5967   5967      anova full      AC079341.3   5.585417 8.558734e-05
#> 5968   5968      anova full            HID1   5.583618 8.586781e-05
#> 5969   5969      anova full             AK7   5.579524 8.650966e-05
#> 5970   5970      anova full          ATP11B   5.578577 8.665888e-05
#> 5971   5971      anova full      AC021092.1   5.577856 8.677260e-05
#> 5972   5972      anova full           ACTR6   5.576066 8.705562e-05
#> 5973   5973      anova full          NFATC3   5.575775 8.710169e-05
#> 5974   5974      anova full            UBR1   5.574526 8.729990e-05
#> 5975   5975      anova full            QPCT   5.572747 8.758288e-05
#> 5976   5976      anova full           WDFY3   5.571525 8.777788e-05
#> 5977   5977      anova full           TPTE2   5.571480 8.778501e-05
#> 5978   5978      anova full           NUDT5   5.568509 8.826088e-05
#> 5979   5979      anova full             TEK   5.567287 8.845740e-05
#> 5980   5980      anova full         TMEM259   5.567120 8.848421e-05
#> 5981   5981      anova full          PRRC2C   5.566847 8.852823e-05
#> 5982   5982      anova full           KANK2   5.565215 8.879152e-05
#> 5983   5983      anova full         CNEP1R1   5.563532 8.906401e-05
#> 5984   5984      anova full           MTFP1   5.562896 8.916709e-05
#> 5985   5985      anova full           LRRC7   5.562181 8.928326e-05
#> 5986   5986      anova full         CAPRIN1   5.557807 8.999708e-05
#> 5987   5987      anova full      AC026391.1   5.557650 9.002270e-05
#> 5988   5988      anova full      AC106795.2   5.553997 9.062345e-05
#> 5989   5989      anova full         HNRNPDL   5.553794 9.065696e-05
#> 5990   5990      anova full           SAP30   5.553638 9.068274e-05
#> 5991   5991      anova full           DHX30   5.552573 9.085864e-05
#> 5992   5992      anova full            BRD3   5.552333 9.089841e-05
#> 5993   5993      anova full            PDXK   5.552012 9.095154e-05
#> 5994   5994      anova full           SRRM2   5.551186 9.108848e-05
#> 5995   5995      anova full           ENPP6   5.550316 9.123290e-05
#> 5996   5996      anova full          SRSF11   5.548444 9.154437e-05
#> 5997   5997      anova full           CERS6   5.548214 9.158284e-05
#> 5998   5998      anova full          ARMC10   5.547740 9.166198e-05
#> 5999   5999      anova full            RXRA   5.546305 9.190169e-05
#> 6000   6000      anova full      AC234582.1   5.545882 9.197255e-05
#> 6001   6001      anova full             PIR   5.545419 9.205018e-05
#> 6002   6002      anova full           BECN1   5.542992 9.245808e-05
#> 6003   6003      anova full            CHDH   5.542820 9.248695e-05
#> 6004   6004      anova full      AC104024.2   5.542569 9.252926e-05
#> 6005   6005      anova full           ACAP3   5.540101 9.294612e-05
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#> 6012   6012      anova full          PIK3CA   5.534418 9.391348e-05
#> 6013   6013      anova full           RECQL   5.531948 9.433706e-05
#> 6014   6014      anova full           DIP2C   5.531616 9.439415e-05
#> 6015   6015      anova full           NUPR2   5.530839 9.452797e-05
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#> 6026   6026      anova full           THOC1   5.515886 9.713989e-05
#> 6027   6027      anova full            WEE1   5.515695 9.717363e-05
#> 6028   6028      anova full            ESR1   5.515603 9.718995e-05
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#> 6040   6040      anova full       LINC01361   5.496660 1.006067e-04
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#> 6042   6042      anova full         CSNK1G2   5.494675 1.009717e-04
#> 6043   6043      anova full           RMDN2   5.493461 1.011957e-04
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#> 6045   6045      anova full         UGT2B11   5.491944 1.014762e-04
#> 6046   6046      anova full           KPNA5   5.485173 1.027380e-04
#> 6047   6047      anova full          ZNF248   5.484951 1.027795e-04
#> 6048   6048      anova full            ANO9   5.481853 1.033625e-04
#> 6049   6049      anova full            SFR1   5.479005 1.039013e-04
#> 6050   6050      anova full           GABPA   5.476626 1.043537e-04
#> 6051   6051      anova full            ATF5   5.472510 1.051409e-04
#> 6052   6052      anova full            PUM1   5.470351 1.055563e-04
#> 6053   6053      anova full           VSTM5   5.470282 1.055696e-04
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#> 6055   6055      anova full      AL133325.3   5.468324 1.059477e-04
#> 6056   6056      anova full          MAPK13   5.466294 1.063412e-04
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#> 6058   6058      anova full          CDKN2C   5.465443 1.065067e-04
#> 6059   6059      anova full      AC135457.1   5.464252 1.067386e-04
#> 6060   6060      anova full           SNX24   5.463515 1.068824e-04
#> 6061   6061      anova full        C16orf91   5.462731 1.070356e-04
#> 6062   6062      anova full           AMPD3   5.462642 1.070531e-04
#> 6063   6063      anova full            LIPG   5.461083 1.073583e-04
#> 6064   6064      anova full          VCPKMT   5.459864 1.075977e-04
#> 6065   6065      anova full           AP3M2   5.459802 1.076099e-04
#> 6066   6066      anova full      AL691432.2   5.457143 1.081340e-04
#> 6067   6067      anova full          ABRACL   5.456690 1.082235e-04
#> 6068   6068      anova full          PSENEN   5.456542 1.082528e-04
#> 6069   6069      anova full            UROD   5.456438 1.082733e-04
#> 6070   6070      anova full           TYW1B   5.452997 1.089564e-04
#> 6071   6071      anova full           EIF3D   5.452994 1.089569e-04
#> 6072   6072      anova full         HTATSF1   5.450312 1.094923e-04
#> 6073   6073      anova full           ENKUR   5.449545 1.096459e-04
#> 6074   6074      anova full      DLGAP1-AS1   5.449229 1.097092e-04
#> 6075   6075      anova full         MYADML2   5.448903 1.097747e-04
#> 6076   6076      anova full      AC011374.1   5.448890 1.097772e-04
#> 6077   6077      anova full           NUP62   5.445792 1.104005e-04
#> 6078   6078      anova full            LTBR   5.445756 1.104078e-04
#> 6079   6079      anova full          PHYKPL   5.444253 1.107116e-04
#> 6080   6080      anova full         PPFIBP1   5.443934 1.107762e-04
#> 6081   6081      anova full          OSGIN2   5.443011 1.109632e-04
#> 6082   6082      anova full           CASP3   5.442973 1.109710e-04
#> 6083   6083      anova full         TSPAN17   5.442782 1.110097e-04
#> 6084   6084      anova full         FAM184A   5.442517 1.110636e-04
#> 6085   6085      anova full         NSMCE4A   5.441792 1.112108e-04
#> 6086   6086      anova full            SPEN   5.438502 1.118819e-04
#> 6087   6087      anova full            PRCP   5.436773 1.122359e-04
#> 6088   6088      anova full      AL805961.2   5.436495 1.122930e-04
#> 6089   6089      anova full      AC084149.1   5.434969 1.126070e-04
#> 6090   6090      anova full            FBP1   5.434602 1.126824e-04
#> 6091   6091      anova full         C12orf4   5.434215 1.127621e-04
#> 6092   6092      anova full        NIPSNAP1   5.431496 1.133242e-04
#> 6093   6093      anova full            PDXP   5.431389 1.133466e-04
#> 6094   6094      anova full           RPS28   5.429921 1.136513e-04
#> 6095   6095      anova full          CCDC32   5.429207 1.137997e-04
#> 6096   6096      anova full           FOXJ1   5.427874 1.140775e-04
#> 6097   6097      anova full         RACGAP1   5.420712 1.155821e-04
#> 6098   6098      anova full      AC005726.5   5.419417 1.158562e-04
#> 6099   6099      anova full          SDHAF4   5.419244 1.158928e-04
#> 6100   6100      anova full         PHACTR2   5.419090 1.159254e-04
#> 6101   6101      anova full          MRPL12   5.417109 1.163465e-04
#> 6102   6102      anova full          EMX2OS   5.416358 1.165064e-04
#> 6103   6103      anova full            ECI2   5.414556 1.168912e-04
#> 6104   6104      anova full          LRRC61   5.413936 1.170239e-04
#> 6105   6105      anova full          EFCAB2   5.413283 1.171638e-04
#> 6106   6106      anova full            LSG1   5.413157 1.171910e-04
#> 6107   6107      anova full          INTS10   5.412671 1.172951e-04
#> 6108   6108      anova full         TMEM232   5.410573 1.177464e-04
#> 6109   6109      anova full             F12   5.410402 1.177833e-04
#> 6110   6110      anova full            OLR1   5.409175 1.180480e-04
#> 6111   6111      anova full       RAB11FIP2   5.407986 1.183052e-04
#> 6112   6112      anova full         RPL36AL   5.402137 1.195787e-04
#> 6113   6113      anova full      PPP4R1-AS1   5.401971 1.196152e-04
#> 6114   6114      anova full          ZNF350   5.401879 1.196353e-04
#> 6115   6115      anova full        U91328.1   5.401756 1.196622e-04
#> 6116   6116      anova full            FMR1   5.401556 1.197061e-04
#> 6117   6117      anova full         ZCCHC14   5.401331 1.197554e-04
#> 6118   6118      anova full            AFF3   5.400523 1.199327e-04
#> 6119   6119      anova full          TRIP12   5.399762 1.200998e-04
#> 6120   6120      anova full            LCP2   5.399547 1.201472e-04
#> 6121   6121      anova full       LINC01503   5.397962 1.204964e-04
#> 6122   6122      anova full            COA1   5.397291 1.206446e-04
#> 6123   6123      anova full        C18orf54   5.396119 1.209037e-04
#> 6124   6124      anova full            FLI1   5.394898 1.211742e-04
#> 6125   6125      anova full      AL356740.1   5.394773 1.212020e-04
#> 6126   6126      anova full            DVL2   5.394530 1.212560e-04
#> 6127   6127      anova full             SRI   5.393918 1.213918e-04
#> 6128   6128      anova full           SAMD8   5.392720 1.216585e-04
#> 6129   6129      anova full           DTWD1   5.392661 1.216716e-04
#> 6130   6130      anova full          EXOSC8   5.391774 1.218696e-04
#> 6131   6131      anova full      AL137025.1   5.391703 1.218854e-04
#> 6132   6132      anova full            TLR4   5.390781 1.220913e-04
#> 6133   6133      anova full         ANKRD12   5.388170 1.226767e-04
#> 6134   6134      anova full           SMIM8   5.387957 1.227245e-04
#> 6135   6135      anova full         TNFSF12   5.385808 1.232086e-04
#> 6136   6136      anova full      AL365205.3   5.384992 1.233930e-04
#> 6137   6137      anova full           PAM16   5.384242 1.235626e-04
#> 6138   6138      anova full          COL4A2   5.378992 1.247568e-04
#> 6139   6139      anova full      AC009549.1   5.378815 1.247973e-04
#> 6140   6140      anova full            UBA3   5.378321 1.249103e-04
#> 6141   6141      anova full         PRPF38A   5.377201 1.251670e-04
#> 6142   6142      anova full            XRN2   5.376350 1.253623e-04
#> 6143   6143      anova full         LRRC75B   5.376325 1.253680e-04
#> 6144   6144      anova full           WDR54   5.376068 1.254270e-04
#> 6145   6145      anova full      AC016831.1   5.375315 1.256003e-04
#> 6146   6146      anova full           MCHR1   5.374648 1.257538e-04
#> 6147   6147      anova full      AC020934.1   5.374107 1.258786e-04
#> 6148   6148      anova full            GNG7   5.372410 1.262707e-04
#> 6149   6149      anova full          KLHL20   5.367363 1.274440e-04
#> 6150   6150      anova full            URM1   5.367356 1.274458e-04
#> 6151   6151      anova full       LINC01715   5.367114 1.275024e-04
#> 6152   6152      anova full       ZBED3-AS1   5.365465 1.278883e-04
#> 6153   6153      anova full           RSPO3   5.365345 1.279163e-04
#> 6154   6154      anova full            HEY2   5.364608 1.280893e-04
#> 6155   6155      anova full      AC097478.1   5.362583 1.285657e-04
#> 6156   6156      anova full        ANKRD18A   5.362449 1.285975e-04
#> 6157   6157      anova full            LY6E   5.361128 1.289092e-04
#> 6158   6158      anova full            PLK5   5.360528 1.290511e-04
#> 6159   6159      anova full             ICK   5.359328 1.293353e-04
#> 6160   6160      anova full            CTSD   5.355877 1.301565e-04
#> 6161   6161      anova full             IVD   5.355877 1.301565e-04
#> 6162   6162      anova full           FAHD1   5.355507 1.302447e-04
#> 6163   6163      anova full           BICD1   5.355083 1.303461e-04
#> 6164   6164      anova full          MGAT4B   5.354089 1.305838e-04
#> 6165   6165      anova full            PDHB   5.354048 1.305936e-04
#> 6166   6166      anova full          NCAPH2   5.353826 1.306469e-04
#> 6167   6167      anova full         SERTAD1   5.351954 1.310961e-04
#> 6168   6168      anova full           TRPM6   5.351580 1.311862e-04
#> 6169   6169      anova full          CHRAC1   5.349667 1.316471e-04
#> 6170   6170      anova full           FXYD5   5.349606 1.316619e-04
#> 6171   6171      anova full          AHCYL2   5.349014 1.318051e-04
#> 6172   6172      anova full            EHD4   5.347985 1.320540e-04
#> 6173   6173      anova full           JKAMP   5.344794 1.328293e-04
#> 6174   6174      anova full           KCNK4   5.343570 1.331278e-04
#> 6175   6175      anova full           WDR60   5.341368 1.336668e-04
#> 6176   6176      anova full           FRMD3   5.339132 1.342163e-04
#> 6177   6177      anova full         PPP1R3C   5.336783 1.347960e-04
#> 6178   6178      anova full      AC005220.1   5.336028 1.349830e-04
#> 6179   6179      anova full            PERP   5.334811 1.352846e-04
#> 6180   6180      anova full           IGLC3   5.334735 1.353036e-04
#> 6181   6181      anova full           SNX21   5.333316 1.356565e-04
#> 6182   6182      anova full            CTSO   5.332885 1.357637e-04
#> 6183   6183      anova full       LINC00323   5.332867 1.357682e-04
#> 6184   6184      anova full          PARP12   5.332798 1.357854e-04
#> 6185   6185      anova full          PPP3CC   5.332626 1.358284e-04
#> 6186   6186      anova full           KCNK6   5.332455 1.358710e-04
#> 6187   6187      anova full          CACNG4   5.331456 1.361204e-04
#> 6188   6188      anova full           PPM1J   5.329220 1.366800e-04
#> 6189   6189      anova full         ZNF585A   5.329045 1.367241e-04
#> 6190   6190      anova full           BTAF1   5.327929 1.370045e-04
#> 6191   6191      anova full           PXMP4   5.323715 1.380684e-04
#> 6192   6192      anova full            NUDC   5.323430 1.381405e-04
#> 6193   6193      anova full          ADGRE5   5.323359 1.381585e-04
#> 6194   6194      anova full           NAGLU   5.323339 1.381638e-04
#> 6195   6195      anova full          FCGR3A   5.322478 1.383821e-04
#> 6196   6196      anova full        CYB561D2   5.321033 1.387500e-04
#> 6197   6197      anova full         SLC12A4   5.320220 1.389573e-04
#> 6198   6198      anova full            UBR7   5.320008 1.390111e-04
#> 6199   6199      anova full            FUT9   5.318971 1.392761e-04
#> 6200   6200      anova full          KBTBD6   5.318513 1.393933e-04
#> 6201   6201      anova full          VPS13A   5.313607 1.406550e-04
#> 6202   6202      anova full          CACNG8   5.312512 1.409382e-04
#> 6203   6203      anova full           CRYGD   5.311725 1.411420e-04
#> 6204   6204      anova full           NUAK2   5.309898 1.416163e-04
#> 6205   6205      anova full         ANKRD42   5.309536 1.417106e-04
#> 6206   6206      anova full        U47924.2   5.309118 1.418194e-04
#> 6207   6207      anova full      AC011287.1   5.307059 1.423568e-04
#> 6208   6208      anova full            RIN3   5.306569 1.424849e-04
#> 6209   6209      anova full           NR4A3   5.305545 1.427532e-04
#> 6210   6210      anova full            CRYZ   5.304299 1.430804e-04
#> 6211   6211      anova full         SAP30BP   5.303882 1.431901e-04
#> 6212   6212      anova full          EFEMP1   5.303710 1.432352e-04
#> 6213   6213      anova full         DNAJC30   5.302870 1.434565e-04
#> 6214   6214      anova full         SULT1A2   5.301537 1.438084e-04
#> 6215   6215      anova full            NFU1   5.300001 1.442147e-04
#> 6216   6216      anova full       C14orf180   5.298584 1.445908e-04
#> 6217   6217      anova full           PLIN4   5.298160 1.447035e-04
#> 6218   6218      anova full          PGPEP1   5.297885 1.447766e-04
#> 6219   6219      anova full            ATIC   5.294121 1.457813e-04
#> 6220   6220      anova full            ARAF   5.293806 1.458659e-04
#> 6221   6221      anova full           ABCC4   5.293542 1.459368e-04
#> 6222   6222      anova full            GJB6   5.291884 1.463822e-04
#> 6223   6223      anova full            PNPO   5.290186 1.468395e-04
#> 6224   6224      anova full        FAM160A1   5.288498 1.472960e-04
#> 6225   6225      anova full        PPP1R15A   5.284950 1.482597e-04
#> 6226   6226      anova full      AL355001.2   5.282806 1.488454e-04
#> 6227   6227      anova full          CDC25B   5.281248 1.492723e-04
#> 6228   6228      anova full          STARD5   5.278774 1.499529e-04
#> 6229   6229      anova full            UCP2   5.278500 1.500285e-04
#> 6230   6230      anova full          ALKAL2   5.277657 1.502611e-04
#> 6231   6231      anova full         L3MBTL3   5.277557 1.502889e-04
#> 6232   6232      anova full           EP300   5.274693 1.510824e-04
#> 6233   6233      anova full            MON2   5.274638 1.510976e-04
#> 6234   6234      anova full      AC046130.2   5.273910 1.513001e-04
#> 6235   6235      anova full          AKAP13   5.273901 1.513025e-04
#> 6236   6236      anova full            SPEG   5.273737 1.513483e-04
#> 6237   6237      anova full          FIGNL2   5.273022 1.515475e-04
#> 6238   6238      anova full          PLGRKT   5.272310 1.517461e-04
#> 6239   6239      anova full            CYS1   5.272235 1.517671e-04
#> 6240   6240      anova full          BCL2L1   5.272152 1.517901e-04
#> 6241   6241      anova full      AP000679.1   5.271780 1.518940e-04
#> 6242   6242      anova full         PPP1R11   5.271301 1.520279e-04
#> 6243   6243      anova full         CDC37L1   5.268521 1.528072e-04
#> 6244   6244      anova full            MYH7   5.264130 1.540465e-04
#> 6245   6245      anova full            RFX4   5.261792 1.547106e-04
#> 6246   6246      anova full           EIPR1   5.261249 1.548652e-04
#> 6247   6247      anova full         FAM167A   5.260686 1.550259e-04
#> 6248   6248      anova full      AC067969.1   5.258228 1.557285e-04
#> 6249   6249      anova full          TVP23C   5.258180 1.557424e-04
#> 6250   6250      anova full            ADA2   5.257330 1.559862e-04
#> 6251   6251      anova full        SLC22A18   5.255730 1.564460e-04
#> 6252   6252      anova full           RNPS1   5.254287 1.568621e-04
#> 6253   6253      anova full         EFCAB11   5.253726 1.570241e-04
#> 6254   6254      anova full           STK11   5.253237 1.571656e-04
#> 6255   6255      anova full         TMEM104   5.252723 1.573144e-04
#> 6256   6256      anova full          MARCH6   5.252694 1.573228e-04
#> 6257   6257      anova full             FUS   5.252669 1.573298e-04
#> 6258   6258      anova full         ALDH1B1   5.251593 1.576417e-04
#> 6259   6259      anova full            UMPS   5.251547 1.576550e-04
#> 6260   6260      anova full           SASH1   5.251133 1.577752e-04
#> 6261   6261      anova full            NAV1   5.250295 1.580188e-04
#> 6262   6262      anova full           C1QBP   5.249162 1.583487e-04
#> 6263   6263      anova full           CNOT7   5.248683 1.584885e-04
#> 6264   6264      anova full           GPBP1   5.247115 1.589465e-04
#> 6265   6265      anova full           ACSF2   5.246742 1.590557e-04
#> 6266   6266      anova full           GDPD3   5.245841 1.593197e-04
#> 6267   6267      anova full           MUC5B   5.245428 1.594410e-04
#> 6268   6268      anova full           SRSF1   5.244296 1.597735e-04
#> 6269   6269      anova full         PPP1R21   5.243946 1.598766e-04
#> 6270   6270      anova full            CCT7   5.243083 1.601308e-04
#> 6271   6271      anova full           FGF18   5.241799 1.605098e-04
#> 6272   6272      anova full          ZNF358   5.240524 1.608871e-04
#> 6273   6273      anova full          TECPR1   5.240028 1.610338e-04
#> 6274   6274      anova full           SCRN1   5.239614 1.611569e-04
#> 6275   6275      anova full          CAVIN2   5.239250 1.612649e-04
#> 6276   6276      anova full      ERVMER34-1   5.238111 1.616035e-04
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#> 6288   6288      anova full      AC068234.3   5.224153 1.658118e-04
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#> 6313   6313      anova full            FBN1   5.203927 1.721094e-04
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#> 6316   6316      anova full            MSI1   5.203317 1.723029e-04
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#> 6318   6318      anova full          INO80B   5.201907 1.727516e-04
#> 6319   6319      anova full       FAM120AOS   5.201852 1.727692e-04
#> 6320   6320      anova full            WWP1   5.201451 1.728969e-04
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#> 6323   6323      anova full            PGM3   5.193444 1.754686e-04
#> 6324   6324      anova full           BCKDK   5.193042 1.755987e-04
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#> 6326   6326      anova full            TNIK   5.190524 1.764161e-04
#> 6327   6327      anova full           SYT11   5.190223 1.765143e-04
#> 6328   6328      anova full           SMPD3   5.189904 1.766179e-04
#> 6329   6329      anova full           NELFA   5.189663 1.766965e-04
#> 6330   6330      anova full       C10orf142   5.182159 1.791597e-04
#> 6331   6331      anova full         TMEM141   5.181802 1.792775e-04
#> 6332   6332      anova full           ODF3B   5.180854 1.795915e-04
#> 6333   6333      anova full         GPR137C   5.180093 1.798440e-04
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#> 6335   6335      anova full          MRPL40   5.178220 1.804665e-04
#> 6336   6336      anova full           DGAT2   5.177573 1.806820e-04
#> 6337   6337      anova full          MYOCOS   5.176059 1.811874e-04
#> 6338   6338      anova full            HAMP   5.175677 1.813154e-04
#> 6339   6339      anova full           UQCC1   5.174605 1.816743e-04
#> 6340   6340      anova full          FAM78B   5.173187 1.821505e-04
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#> 6342   6342      anova full          LRRC55   5.172279 1.824561e-04
#> 6343   6343      anova full            ARF1   5.170603 1.830211e-04
#> 6344   6344      anova full             ME1   5.168590 1.837025e-04
#> 6345   6345      anova full          ZNF577   5.167980 1.839097e-04
#> 6346   6346      anova full           CARM1   5.167762 1.839835e-04
#> 6347   6347      anova full          CNPPD1   5.167697 1.840056e-04
#> 6348   6348      anova full          ZC3H15   5.165541 1.847393e-04
#> 6349   6349      anova full         ANKRD44   5.164078 1.852389e-04
#> 6350   6350      anova full         TRAPPC9   5.163932 1.852890e-04
#> 6351   6351      anova full      AC018761.2   5.162881 1.856490e-04
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#> 6353   6353      anova full            WNT3   5.162281 1.858545e-04
#> 6354   6354      anova full           FNIP2   5.162227 1.858733e-04
#> 6355   6355      anova full          FAM43B   5.161549 1.861059e-04
#> 6356   6356      anova full            COG6   5.160078 1.866122e-04
#> 6357   6357      anova full           EPHB1   5.160066 1.866163e-04
#> 6358   6358      anova full           KMT2E   5.159929 1.866635e-04
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#> 6362   6362      anova full       LINC01354   5.158451 1.871736e-04
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#> 6364   6364      anova full         HNRNPA0   5.155927 1.880480e-04
#> 6365   6365      anova full         EXOC3L2   5.151644 1.895413e-04
#> 6366   6366      anova full           SPCS2   5.150786 1.898418e-04
#> 6367   6367      anova full   P2RX5-TAX1BP3   5.150304 1.900112e-04
#> 6368   6368      anova full        EPM2AIP1   5.149448 1.903118e-04
#> 6369   6369      anova full         ARFGAP3   5.149230 1.903885e-04
#> 6370   6370      anova full           SAFB2   5.148572 1.906197e-04
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#> 6373   6373      anova full            APRT   5.147596 1.909639e-04
#> 6374   6374      anova full            NET1   5.145846 1.915823e-04
#> 6375   6375      anova full           PALMD   5.145782 1.916049e-04
#> 6376   6376      anova full          MVB12A   5.145242 1.917959e-04
#> 6377   6377      anova full       LINC01785   5.144736 1.919754e-04
#> 6378   6378      anova full            DCXR   5.144114 1.921960e-04
#> 6379   6379      anova full            IER2   5.143456 1.924301e-04
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#> 6381   6381      anova full            AIM2   5.136855 1.947914e-04
#> 6382   6382      anova full           BACE2   5.136513 1.949144e-04
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#> 6384   6384      anova full           MRPS7   5.135648 1.952263e-04
#> 6385   6385      anova full           TCTE1   5.134864 1.955092e-04
#> 6386   6386      anova full         ZCCHC17   5.134621 1.955971e-04
#> 6387   6387      anova full             GCK   5.130883 1.969529e-04
#> 6388   6388      anova full           GFPT1   5.129840 1.973329e-04
#> 6389   6389      anova full          PRSS22   5.126597 1.985195e-04
#> 6390   6390      anova full           SUSD5   5.123131 1.997956e-04
#> 6391   6391      anova full             DTL   5.122327 2.000927e-04
#> 6392   6392      anova full           DDX23   5.121253 2.004907e-04
#> 6393   6393      anova full           SAP25   5.120324 2.008353e-04
#> 6394   6394      anova full           SEPT1   5.120099 2.009189e-04
#> 6395   6395      anova full          PDGFRL   5.118160 2.016405e-04
#> 6396   6396      anova full          FKBP15   5.117623 2.018407e-04
#> 6397   6397      anova full           SGPP1   5.116597 2.022242e-04
#> 6398   6398      anova full           SNX17   5.115388 2.026768e-04
#> 6399   6399      anova full           ACTA1   5.113881 2.032424e-04
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#> 6401   6401      anova full            EPN1   5.112155 2.038922e-04
#> 6402   6402      anova full           FADS6   5.111050 2.043091e-04
#> 6403   6403      anova full            TOX3   5.110074 2.046782e-04
#> 6404   6404      anova full           DUSP5   5.107302 2.057305e-04
#> 6405   6405      anova full          DCBLD2   5.104827 2.066747e-04
#> 6406   6406      anova full            ELK4   5.104673 2.067334e-04
#> 6407   6407      anova full         COLEC12   5.104530 2.067880e-04
#> 6408   6408      anova full          ANKRD2   5.103964 2.070048e-04
#> 6409   6409      anova full        IL1RAPL2   5.101211 2.080620e-04
#> 6410   6410      anova full       MBNL1-AS1   5.098542 2.090920e-04
#> 6411   6411      anova full          MRPS27   5.097976 2.093107e-04
#> 6412   6412      anova full           HGFAC   5.092799 2.113256e-04
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#> 6415   6415      anova full           APOC1   5.088854 2.128745e-04
#> 6416   6416      anova full           PTPN4   5.086882 2.136528e-04
#> 6417   6417      anova full           VASH1   5.084990 2.144024e-04
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#> 6419   6419      anova full         MIR22HG   5.083236 2.150996e-04
#> 6420   6420      anova full      GADD45GIP1   5.082767 2.152864e-04
#> 6421   6421      anova full      AC006441.4   5.081652 2.157315e-04
#> 6422   6422      anova full           HACE1   5.080528 2.161807e-04
#> 6423   6423      anova full           APOL3   5.079790 2.164763e-04
#> 6424   6424      anova full            CPB1   5.076954 2.176161e-04
#> 6425   6425      anova full           HBS1L   5.076265 2.178939e-04
#> 6426   6426      anova full          AARSD1   5.075820 2.180738e-04
#> 6427   6427      anova full           NHSL2   5.074417 2.186409e-04
#> 6428   6428      anova full      AC245452.1   5.073989 2.188142e-04
#> 6429   6429      anova full           ASB13   5.073896 2.188519e-04
#> 6430   6430      anova full      AC098936.1   5.071008 2.200258e-04
#> 6431   6431      anova full      AL021395.1   5.070424 2.202636e-04
#> 6432   6432      anova full           ATG9B   5.070059 2.204128e-04
#> 6433   6433      anova full          RANBP1   5.069288 2.207276e-04
#> 6434   6434      anova full          LILRB5   5.067829 2.213249e-04
#> 6435   6435      anova full          CERNA1   5.067399 2.215012e-04
#> 6436   6436      anova full            CD36   5.066489 2.218750e-04
#> 6437   6437      anova full           ESYT3   5.065956 2.220941e-04
#> 6438   6438      anova full          LRRC47   5.064778 2.225792e-04
#> 6439   6439      anova full           FOLR2   5.063726 2.230137e-04
#> 6440   6440      anova full           CD302   5.062781 2.234043e-04
#> 6441   6441      anova full            GCLM   5.062028 2.237163e-04
#> 6442   6442      anova full         C2orf40   5.061789 2.238154e-04
#> 6443   6443      anova full           STRA6   5.059316 2.248430e-04
#> 6444   6444      anova full         FAM117B   5.058982 2.249822e-04
#> 6445   6445      anova full         PITPNC1   5.056598 2.259782e-04
#> 6446   6446      anova full          CHST14   5.056032 2.262155e-04
#> 6447   6447      anova full            ATG7   5.055450 2.264595e-04
#> 6448   6448      anova full          HRASLS   5.055386 2.264862e-04
#> 6449   6449      anova full         ZDHHC12   5.054602 2.268157e-04
#> 6450   6450      anova full           RNFT2   5.053345 2.273447e-04
#> 6451   6451      anova full      UBXN10-AS1   5.051955 2.279311e-04
#> 6452   6452      anova full         SLC2A10   5.050871 2.283895e-04
#> 6453   6453      anova full           USP35   5.050560 2.285211e-04
#> 6454   6454      anova full          GTF3C1   5.048612 2.293476e-04
#> 6455   6455      anova full            GJB5   5.047178 2.299577e-04
#> 6456   6456      anova full           ABCA9   5.046713 2.301561e-04
#> 6457   6457      anova full            CDO1   5.045760 2.305630e-04
#> 6458   6458      anova full           PDE3A   5.044262 2.312044e-04
#> 6459   6459      anova full          RAD23B   5.044175 2.312415e-04
#> 6460   6460      anova full           MMP24   5.043217 2.316524e-04
#> 6461   6461      anova full          SH2D3C   5.041962 2.321923e-04
#> 6462   6462      anova full            TYK2   5.041337 2.324615e-04
#> 6463   6463      anova full            GJA5   5.041141 2.325459e-04
#> 6464   6464      anova full          ZNF524   5.037209 2.342475e-04
#> 6465   6465      anova full          PHLDB3   5.036878 2.343911e-04
#> 6466   6466      anova full          RASSF5   5.034903 2.352512e-04
#> 6467   6467      anova full             DAO   5.033694 2.357791e-04
#> 6468   6468      anova full           NUBP2   5.033471 2.358765e-04
#> 6469   6469      anova full          RIMKLB   5.032516 2.362948e-04
#> 6470   6470      anova full          METAP2   5.031226 2.368608e-04
#> 6471   6471      anova full            MMAB   5.029701 2.375314e-04
#> 6472   6472      anova full            VASP   5.027943 2.383071e-04
#> 6473   6473      anova full            SYT9   5.027454 2.385236e-04
#> 6474   6474      anova full           MORN3   5.024353 2.398996e-04
#> 6475   6475      anova full           SRSF7   5.023933 2.400864e-04
#> 6476   6476      anova full            PLAA   5.020010 2.418399e-04
#> 6477   6477      anova full          ZNF708   5.018101 2.426982e-04
#> 6478   6478      anova full          IZUMO4   5.018078 2.427084e-04
#> 6479   6479      anova full          RNF167   5.017842 2.428147e-04
#> 6480   6480      anova full            GLO1   5.017519 2.429602e-04
#> 6481   6481      anova full           RASA3   5.017218 2.430960e-04
#> 6482   6482      anova full         RAD54L2   5.016489 2.434253e-04
#> 6483   6483      anova full            PHAX   5.016233 2.435410e-04
#> 6484   6484      anova full             PML   5.014019 2.445433e-04
#> 6485   6485      anova full         PPP2R5D   5.013199 2.449160e-04
#> 6486   6486      anova full      AC245100.7   5.012457 2.452532e-04
#> 6487   6487      anova full         ZSCAN18   5.011725 2.455864e-04
#> 6488   6488      anova full          RNF215   5.009828 2.464529e-04
#> 6489   6489      anova full            IDNK   5.008809 2.469193e-04
#> 6490   6490      anova full           CD101   5.008704 2.469672e-04
#> 6491   6491      anova full      AC108002.1   5.007994 2.472931e-04
#> 6492   6492      anova full         SLC26A8   5.006971 2.477632e-04
#> 6493   6493      anova full        C12orf75   5.006928 2.477829e-04
#> 6494   6494      anova full           SOX18   5.006379 2.480354e-04
#> 6495   6495      anova full       LINC01551   5.004340 2.489757e-04
#> 6496   6496      anova full         POLDIP3   5.004318 2.489860e-04
#> 6497   6497      anova full           GLIS3   5.004197 2.490421e-04
#> 6498   6498      anova full         SLC7A14   5.003775 2.492372e-04
#> 6499   6499      anova full            SDK2   5.002572 2.497944e-04
#> 6500   6500      anova full            MLIP   5.002193 2.499703e-04
#> 6501   6501      anova full         LAPTM4B   4.999392 2.512734e-04
#> 6502   6502      anova full           CERKL   4.999030 2.514424e-04
#> 6503   6503      anova full          EIF1AX   4.998564 2.516599e-04
#> 6504   6504      anova full            DKK1   4.997814 2.520105e-04
#> 6505   6505      anova full            LY86   4.992887 2.543267e-04
#> 6506   6506      anova full         RABGGTB   4.989827 2.557758e-04
#> 6507   6507      anova full           MYLIP   4.988604 2.563576e-04
#> 6508   6508      anova full         CD300LG   4.987616 2.568283e-04
#> 6509   6509      anova full           SPNS1   4.987236 2.570099e-04
#> 6510   6510      anova full         ARHGAP9   4.985569 2.578066e-04
#> 6511   6511      anova full          TMEM8B   4.984790 2.581802e-04
#> 6512   6512      anova full           LATS1   4.983589 2.587566e-04
#> 6513   6513      anova full         ALDH1L1   4.983226 2.589311e-04
#> 6514   6514      anova full           MKNK1   4.982997 2.590416e-04
#> 6515   6515      anova full            FHIT   4.982227 2.594121e-04
#> 6516   6516      anova full           RNF44   4.980658 2.601694e-04
#> 6517   6517      anova full         PPP2R1B   4.980020 2.604777e-04
#> 6518   6518      anova full            PEF1   4.978342 2.612911e-04
#> 6519   6519      anova full        RABGAP1L   4.977547 2.616772e-04
#> 6520   6520      anova full        NAV2-AS2   4.976671 2.621038e-04
#> 6521   6521      anova full          SH3D21   4.976539 2.621678e-04
#> 6522   6522      anova full           BRSK2   4.975606 2.626225e-04
#> 6523   6523      anova full      AL021368.1   4.975461 2.626933e-04
#> 6524   6524      anova full           PRRT4   4.974637 2.630960e-04
#> 6525   6525      anova full          CHST11   4.974297 2.632622e-04
#> 6526   6526      anova full          CTDSPL   4.973984 2.634154e-04
#> 6527   6527      anova full          TCERG1   4.971114 2.648238e-04
#> 6528   6528      anova full           DCHS2   4.969134 2.658001e-04
#> 6529   6529      anova full            NMT1   4.968883 2.659241e-04
#> 6530   6530      anova full         CEACAM6   4.967984 2.663688e-04
#> 6531   6531      anova full      AC026691.1   4.967191 2.667615e-04
#> 6532   6532      anova full      AC007325.4   4.967033 2.668400e-04
#> 6533   6533      anova full          HMBOX1   4.964875 2.679126e-04
#> 6534   6534      anova full           RBMS3   4.964530 2.680846e-04
#> 6535   6535      anova full          DUSP28   4.963822 2.684374e-04
#> 6536   6536      anova full           ZNRD1   4.960515 2.700924e-04
#> 6537   6537      anova full          FAM89B   4.959321 2.706930e-04
#> 6538   6538      anova full      AF001548.2   4.957263 2.717302e-04
#> 6539   6539      anova full             ALK   4.955625 2.725592e-04
#> 6540   6540      anova full           PTBP2   4.952592 2.741008e-04
#> 6541   6541      anova full          CYB5R3   4.951884 2.744617e-04
#> 6542   6542      anova full         FAM166A   4.951250 2.747856e-04
#> 6543   6543      anova full            LCN8   4.951141 2.748412e-04
#> 6544   6544      anova full         NADSYN1   4.950156 2.753450e-04
#> 6545   6545      anova full            TBCC   4.948562 2.761626e-04
#> 6546   6546      anova full          FAM87A   4.948386 2.762530e-04
#> 6547   6547      anova full          EPS8L2   4.947729 2.765908e-04
#> 6548   6548      anova full            PPIB   4.947391 2.767643e-04
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#> 6746   6746      anova full           P2RX5   4.775329 3.814812e-04
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#> 6755   6755      anova full              C6   4.769411 3.857275e-04
#> 6756   6756      anova full RNASEK-C17orf49   4.765369 3.886545e-04
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#> 6758   6758      anova full         WASHC2A   4.763431 3.900666e-04
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#> 6772   6772      anova full           CSMD1   4.749057 4.007009e-04
#> 6773   6773      anova full      STEAP3-AS1   4.746038 4.029717e-04
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#> 6775   6775      anova full           NFAT5   4.744133 4.044118e-04
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#> 6777   6777      anova full          KLHDC9   4.743302 4.050408e-04
#> 6778   6778      anova full            GAS8   4.743258 4.050744e-04
#> 6779   6779      anova full          SEC61G   4.743083 4.052071e-04
#> 6780   6780      anova full        C19orf54   4.742856 4.053797e-04
#> 6781   6781      anova full           DUSP1   4.742802 4.054203e-04
#> 6782   6782      anova full         CCDC178   4.742352 4.057618e-04
#> 6783   6783      anova full           UQCRB   4.742090 4.059613e-04
#> 6784   6784      anova full         COL14A1   4.741770 4.062047e-04
#> 6785   6785      anova full            GIPR   4.741232 4.066139e-04
#> 6786   6786      anova full         APBB1IP   4.740750 4.069812e-04
#> 6787   6787      anova full           TROAP   4.740696 4.070223e-04
#> 6788   6788      anova full         C1orf56   4.739521 4.079187e-04
#> 6789   6789      anova full        C20orf96   4.737859 4.091896e-04
#> 6790   6790      anova full      AC104964.4   4.737223 4.096774e-04
#> 6791   6791      anova full         ST8SIA2   4.736923 4.099078e-04
#> 6792   6792      anova full            JAK1   4.736351 4.103470e-04
#> 6793   6793      anova full           ZFPL1   4.736251 4.104234e-04
#> 6794   6794      anova full      AL136985.3   4.735398 4.110796e-04
#> 6795   6795      anova full          FAM13B   4.735148 4.112725e-04
#> 6796   6796      anova full      AP000439.2   4.733524 4.125250e-04
#> 6797   6797      anova full           GLRX5   4.733012 4.129204e-04
#> 6798   6798      anova full           FAM3D   4.731269 4.142709e-04
#> 6799   6799      anova full          RPRD1A   4.730393 4.149511e-04
#> 6800   6800      anova full          ERICH5   4.730268 4.150484e-04
#> 6801   6801      anova full            PAX7   4.729192 4.158855e-04
#> 6802   6802      anova full           ASIC4   4.728938 4.160835e-04
#> 6803   6803      anova full           ITGA5   4.728420 4.164867e-04
#> 6804   6804      anova full            KNCN   4.727866 4.169196e-04
#> 6805   6805      anova full         TMEM205   4.727722 4.170321e-04
#> 6806   6806      anova full           APMAP   4.727676 4.170676e-04
#> 6807   6807      anova full          MCRIP1   4.727479 4.172218e-04
#> 6808   6808      anova full      AC062028.1   4.727103 4.175156e-04
#> 6809   6809      anova full           WNT7A   4.723353 4.204587e-04
#> 6810   6810      anova full           ENOX2   4.723227 4.205580e-04
#> 6811   6811      anova full          TLNRD1   4.722861 4.208461e-04
#> 6812   6812      anova full         FAM174A   4.722059 4.214788e-04
#> 6813   6813      anova full           LRRN2   4.722033 4.215001e-04
#> 6814   6814      anova full           LPAR5   4.721886 4.216156e-04
#> 6815   6815      anova full           HTR1D   4.721674 4.217832e-04
#> 6816   6816      anova full          PPP2CB   4.720968 4.223417e-04
#> 6817   6817      anova full        C11orf72   4.720314 4.228593e-04
#> 6818   6818      anova full           TEKT5   4.720103 4.230262e-04
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#> 7323   7323      anova full           SPG21   4.307287 9.211745e-04
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#> 7327   7327      anova full           WDR33   4.305676 9.239935e-04
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#> 7335   7335      anova full           KRT37   4.301034 9.321645e-04
#> 7336   7336      anova full            TRIL   4.300598 9.329358e-04
#> 7337   7337      anova full          NBPF19   4.299914 9.341472e-04
#> 7338   7338      anova full          RSBN1L   4.299352 9.351433e-04
#> 7339   7339      anova full          PLGLB1   4.297447 9.385284e-04
#> 7340   7340      anova full      AL662884.4   4.296914 9.394779e-04
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#> 7342   7342      anova full           RPL14   4.295545 9.419211e-04
#> 7343   7343      anova full        LKAAEAR1   4.295374 9.422263e-04
#> 7344   7344      anova full          RABL2A   4.294468 9.438458e-04
#> 7345   7345      anova full          NBPF12   4.294349 9.440595e-04
#> 7346   7346      anova full           MEX3A   4.294094 9.445166e-04
#> 7347   7347      anova full            FYB2   4.292949 9.465707e-04
#> 7348   7348      anova full        ANKRD34B   4.292106 9.480858e-04
#> 7349   7349      anova full           UTP18   4.289257 9.532234e-04
#> 7350   7350      anova full          TGOLN2   4.289175 9.533722e-04
#> 7351   7351      anova full            NAT9   4.287828 9.558117e-04
#> 7352   7352      anova full            RINL   4.287395 9.565963e-04
#> 7353   7353      anova full         C5orf24   4.287194 9.569628e-04
#> 7354   7354      anova full      CU634019.6   4.286498 9.582264e-04
#> 7355   7355      anova full           CASQ2   4.285127 9.607220e-04
#> 7356   7356      anova full      AC036176.1   4.284758 9.613960e-04
#> 7357   7357      anova full           CSKMT   4.284511 9.618462e-04
#> 7358   7358      anova full           SMAD7   4.284312 9.622101e-04
#> 7359   7359      anova full         PCDHB11   4.283547 9.636063e-04
#> 7360   7360      anova full         SLC39A4   4.283199 9.642443e-04
#> 7361   7361      anova full        C16orf89   4.282514 9.654984e-04
#> 7362   7362      anova full           TRPV6   4.282379 9.657450e-04
#> 7363   7363      anova full             LSR   4.282236 9.660071e-04
#> 7364   7364      anova full           RITA1   4.281845 9.667247e-04
#> 7365   7365      anova full        PRICKLE2   4.281751 9.668967e-04
#> 7366   7366      anova full          WFDC13   4.280179 9.697851e-04
#> 7367   7367      anova full        TBC1D22B   4.279393 9.712331e-04
#> 7368   7368      anova full            VAV3   4.279190 9.716079e-04
#> 7369   7369      anova full           PGAM2   4.278142 9.735420e-04
#> 7370   7370      anova full      SEC24B-AS1   4.277900 9.739886e-04
#> 7371   7371      anova full           EXOC5   4.277472 9.747813e-04
#> 7372   7372      anova full       LINC00839   4.277368 9.749724e-04
#> 7373   7373      anova full          MAP3K7   4.277350 9.750068e-04
#> 7374   7374      anova full      AC093323.1   4.276414 9.767407e-04
#> 7375   7375      anova full          UBE2L6   4.274980 9.794023e-04
#> 7376   7376      anova full          MARCH8   4.274698 9.799266e-04
#> 7377   7377      anova full          GPCPD1   4.274534 9.802316e-04
#> 7378   7378      anova full            CLTA   4.274331 9.806089e-04
#> 7379   7379      anova full           MOCS3   4.272382 9.842441e-04
#> 7380   7380      anova full           BET1L   4.271876 9.851892e-04
#> 7381   7381      anova full          LHFPL5   4.271631 9.856473e-04
#> 7382   7382      anova full           ATP9B   4.270848 9.871138e-04
#> 7383   7383      anova full           ENTR1   4.270273 9.881917e-04
#> 7384   7384      anova full            DKK2   4.269999 9.887061e-04
#> 7385   7385      anova full           CNNM2   4.269778 9.891196e-04
#> 7386   7386      anova full            MLPH   4.267674 9.930793e-04
#> 7387   7387      anova full           APPL1   4.267593 9.932315e-04
#> 7388   7388      anova full            DPYD   4.267115 9.941331e-04
#> 7389   7389      anova full         C3orf18   4.267016 9.943205e-04
#> 7390   7390      anova full           APPL2   4.266867 9.946011e-04
#> 7391   7391      anova full      AC007686.3   4.266786 9.947541e-04
#> 7392   7392      anova full         SLC26A4   4.265684 9.968370e-04
#> 7393   7393      anova full           TBX19   4.262681 1.002537e-03
#> 7394   7394      anova full           ZNF41   4.261650 1.004502e-03
#> 7395   7395      anova full         ALDH5A1   4.261543 1.004706e-03
#> 7396   7396      anova full            ATE1   4.261062 1.005623e-03
#> 7397   7397      anova full         GADD45A   4.260979 1.005782e-03
#> 7398   7398      anova full       LINC01505   4.259624 1.008373e-03
#> 7399   7399      anova full      SLC2A1-AS1   4.259295 1.009002e-03
#> 7400   7400      anova full       LINC01990   4.258507 1.010514e-03
#> 7401   7401      anova full           WNT2B   4.257454 1.012537e-03
#> 7402   7402      anova full          KCTD13   4.257061 1.013292e-03
#> 7403   7403      anova full       VLDLR-AS1   4.257057 1.013300e-03
#> 7404   7404      anova full          DNAJB5   4.256805 1.013785e-03
#> 7405   7405      anova full            IFI6   4.255264 1.016755e-03
#> 7406   7406      anova full         NEURL1B   4.254951 1.017361e-03
#> 7407   7407      anova full         TMPRSS5   4.253218 1.020715e-03
#> 7408   7408      anova full           UVSSA   4.251988 1.023102e-03
#> 7409   7409      anova full           KCTD8   4.251713 1.023635e-03
#> 7410   7410      anova full      AC026369.1   4.251055 1.024917e-03
#> 7411   7411      anova full           AP3M1   4.249905 1.027158e-03
#> 7412   7412      anova full           TEAD1   4.249756 1.027447e-03
#> 7413   7413      anova full       LINC01346   4.249231 1.028473e-03
#> 7414   7414      anova full          TRIM62   4.248938 1.029045e-03
#> 7415   7415      anova full      AC073335.2   4.248559 1.029785e-03
#> 7416   7416      anova full      AC080188.1   4.248479 1.029943e-03
#> 7417   7417      anova full          GTPBP6   4.247570 1.031722e-03
#> 7418   7418      anova full          ZCWPW1   4.246575 1.033673e-03
#> 7419   7419      anova full            AVEN   4.246084 1.034639e-03
#> 7420   7420      anova full          EFCAB7   4.245880 1.035040e-03
#> 7421   7421      anova full             GSR   4.242672 1.041367e-03
#> 7422   7422      anova full            CCL5   4.242425 1.041856e-03
#> 7423   7423      anova full           SPAG7   4.240763 1.045150e-03
#> 7424   7424      anova full           PTGES   4.240733 1.045209e-03
#> 7425   7425      anova full             GAA   4.240515 1.045643e-03
#> 7426   7426      anova full            RIN1   4.240040 1.046586e-03
#> 7427   7427      anova full       LINC01197   4.239727 1.047208e-03
#> 7428   7428      anova full         METTL2B   4.239651 1.047359e-03
#> 7429   7429      anova full           NCOA6   4.239159 1.048339e-03
#> 7430   7430      anova full      AC005261.1   4.237578 1.051493e-03
#> 7431   7431      anova full         KLHDC10   4.236891 1.052867e-03
#> 7432   7432      anova full            IGKC   4.236852 1.052945e-03
#> 7433   7433      anova full         TRAPPC5   4.236728 1.053191e-03
#> 7434   7434      anova full         TRMT10B   4.234856 1.056944e-03
#> 7435   7435      anova full        C10orf95   4.234768 1.057120e-03
#> 7436   7436      anova full         TBC1D3L   4.234356 1.057949e-03
#> 7437   7437      anova full           CXCL2   4.233083 1.060512e-03
#> 7438   7438      anova full         METTL26   4.232919 1.060841e-03
#> 7439   7439      anova full         C8orf33   4.232365 1.061958e-03
#> 7440   7440      anova full          TRANK1   4.232227 1.062238e-03
#> 7441   7441      anova full         FAM168A   4.231169 1.064376e-03
#> 7442   7442      anova full        C10orf88   4.231106 1.064503e-03
#> 7443   7443      anova full          SAMHD1   4.229939 1.066866e-03
#> 7444   7444      anova full            ANO1   4.229312 1.068139e-03
#> 7445   7445      anova full          ZNF429   4.228165 1.070469e-03
#> 7446   7446      anova full          UBE2D2   4.228113 1.070575e-03
#> 7447   7447      anova full        HLA-DRB5   4.227177 1.072481e-03
#> 7448   7448      anova full          FBRSL1   4.226508 1.073844e-03
#> 7449   7449      anova full           PRODH   4.225968 1.074948e-03
#> 7450   7450      anova full            SHC1   4.225797 1.075296e-03
#> 7451   7451      anova full          PNPLA2   4.225120 1.076680e-03
#> 7452   7452      anova full          TVP23A   4.224453 1.078046e-03
#> 7453   7453      anova full        PPARGC1B   4.224175 1.078616e-03
#> 7454   7454      anova full           LTA4H   4.223341 1.080328e-03
#> 7455   7455      anova full          EIF2S1   4.222579 1.081893e-03
#> 7456   7456      anova full           INSM1   4.218655 1.089992e-03
#> 7457   7457      anova full        C11orf54   4.218211 1.090914e-03
#> 7458   7458      anova full            RAG1   4.218141 1.091058e-03
#> 7459   7459      anova full       LINC01507   4.217751 1.091867e-03
#> 7460   7460      anova full          KCNAB3   4.217480 1.092431e-03
#> 7461   7461      anova full            RTTN   4.216508 1.094450e-03
#> 7462   7462      anova full           RBBP8   4.216258 1.094969e-03
#> 7463   7463      anova full           UBE2I   4.216144 1.095208e-03
#> 7464   7464      anova full          CLASP1   4.214600 1.098427e-03
#> 7465   7465      anova full      AC112484.3   4.214059 1.099558e-03
#> 7466   7466      anova full          ATF7IP   4.213861 1.099971e-03
#> 7467   7467      anova full            USP7   4.212724 1.102351e-03
#> 7468   7468      anova full           SNIP1   4.212474 1.102875e-03
#> 7469   7469      anova full      AC023154.1   4.210015 1.108044e-03
#> 7470   7470      anova full         FAAP100   4.208683 1.110853e-03
#> 7471   7471      anova full            ARSD   4.208290 1.111683e-03
#> 7472   7472      anova full              F8   4.207895 1.112518e-03
#> 7473   7473      anova full           SF3B5   4.207727 1.112873e-03
#> 7474   7474      anova full            IDH1   4.205583 1.117421e-03
#> 7475   7475      anova full           PRDM5   4.204302 1.120146e-03
#> 7476   7476      anova full         MAP3K20   4.203357 1.122160e-03
#> 7477   7477      anova full            PGLS   4.202776 1.123400e-03
#> 7478   7478      anova full      AC010336.6   4.202566 1.123850e-03
#> 7479   7479      anova full           PRRT3   4.202041 1.124971e-03
#> 7480   7480      anova full      AC025259.1   4.202011 1.125036e-03
#> 7481   7481      anova full      AC007938.3   4.201384 1.126377e-03
#> 7482   7482      anova full            CYBB   4.201312 1.126532e-03
#> 7483   7483      anova full          PDLIM2   4.201079 1.127032e-03
#> 7484   7484      anova full           ISG20   4.200831 1.127563e-03
#> 7485   7485      anova full       LINC01102   4.200210 1.128895e-03
#> 7486   7486      anova full      CCDC13-AS1   4.199870 1.129626e-03
#> 7487   7487      anova full           GPHA2   4.199541 1.130333e-03
#> 7488   7488      anova full      AP003721.1   4.199058 1.131372e-03
#> 7489   7489      anova full          DUSP27   4.199025 1.131443e-03
#> 7490   7490      anova full          CYP4F3   4.198915 1.131678e-03
#> 7491   7491      anova full           ADCY7   4.198739 1.132057e-03
#> 7492   7492      anova full           C1QL1   4.198054 1.133534e-03
#> 7493   7493      anova full         ISG20L2   4.198019 1.133609e-03
#> 7494   7494      anova full            BCO2   4.197990 1.133671e-03
#> 7495   7495      anova full           TCL1B   4.196698 1.136460e-03
#> 7496   7496      anova full          COMMD6   4.195115 1.139887e-03
#> 7497   7497      anova full            ASB4   4.191844 1.147002e-03
#> 7498   7498      anova full         DNAJC21   4.191296 1.148199e-03
#> 7499   7499      anova full           WDR37   4.190368 1.150227e-03
#> 7500   7500      anova full          SNAP29   4.189829 1.151407e-03
#> 7501   7501      anova full          IMPAD1   4.189414 1.152317e-03
#> 7502   7502      anova full            GNL1   4.189370 1.152412e-03
#> 7503   7503      anova full      AL358781.1   4.186250 1.159272e-03
#> 7504   7504      anova full           NIPA2   4.186137 1.159521e-03
#> 7505   7505      anova full           LARP4   4.185905 1.160034e-03
#> 7506   7506      anova full        Z95115.1   4.185277 1.161421e-03
#> 7507   7507      anova full           BOLA1   4.185082 1.161852e-03
#> 7508   7508      anova full          FBXO32   4.184176 1.163856e-03
#> 7509   7509      anova full           RBM20   4.182158 1.168334e-03
#> 7510   7510      anova full         FAM185A   4.181318 1.170202e-03
#> 7511   7511      anova full           TMEM9   4.181057 1.170784e-03
#> 7512   7512      anova full            TSKU   4.180661 1.171666e-03
#> 7513   7513      anova full      AP001972.3   4.179074 1.175209e-03
#> 7514   7514      anova full        SERPINE1   4.178855 1.175699e-03
#> 7515   7515      anova full      AP000223.1   4.178415 1.176682e-03
#> 7516   7516      anova full           LOXL3   4.178016 1.177578e-03
#> 7517   7517      anova full       CCDC144NL   4.174962 1.184439e-03
#> 7518   7518      anova full          LINGO3   4.173400 1.187965e-03
#> 7519   7519      anova full            TCN2   4.173065 1.188724e-03
#> 7520   7520      anova full      AL390115.1   4.172931 1.189027e-03
#> 7521   7521      anova full       LINC02567   4.172357 1.190327e-03
#> 7522   7522      anova full           MED27   4.171557 1.192140e-03
#> 7523   7523      anova full       LINC02562   4.169006 1.197943e-03
#> 7524   7524      anova full       LINC00623   4.168660 1.198730e-03
#> 7525   7525      anova full           CHST8   4.168531 1.199027e-03
#> 7526   7526      anova full            TTF2   4.168457 1.199194e-03
#> 7527   7527      anova full         C2orf68   4.167839 1.200605e-03
#> 7528   7528      anova full           MRVI1   4.167341 1.201745e-03
#> 7529   7529      anova full            PKP3   4.167131 1.202225e-03
#> 7530   7530      anova full           SGSM3   4.166831 1.202911e-03
#> 7531   7531      anova full             MPO   4.166800 1.202982e-03
#> 7532   7532      anova full            TMX1   4.166759 1.203076e-03
#> 7533   7533      anova full          S100A7   4.166702 1.203206e-03
#> 7534   7534      anova full            AOC3   4.166262 1.204215e-03
#> 7535   7535      anova full           KPNA4   4.165215 1.206617e-03
#> 7536   7536      anova full         ST6GAL1   4.164769 1.207643e-03
#> 7537   7537      anova full          CCDC97   4.163378 1.210844e-03
#> 7538   7538      anova full           MYEOV   4.162962 1.211803e-03
#> 7539   7539      anova full          SEC31A   4.162939 1.211856e-03
#> 7540   7540      anova full            GMNC   4.161334 1.215564e-03
#> 7541   7541      anova full           MUC19   4.160835 1.216719e-03
#> 7542   7542      anova full       LINC00570   4.160298 1.217963e-03
#> 7543   7543      anova full          TP53RK   4.157689 1.224028e-03
#> 7544   7544      anova full          MTSS1L   4.157639 1.224144e-03
#> 7545   7545      anova full            MXD3   4.157602 1.224231e-03
#> 7546   7546      anova full             TPO   4.155318 1.229566e-03
#> 7547   7547      anova full           VWC2L   4.154306 1.231938e-03
#> 7548   7548      anova full          ZNF169   4.151512 1.238509e-03
#> 7549   7549      anova full           SBNO1   4.151135 1.239397e-03
#> 7550   7550      anova full          TM9SF3   4.150871 1.240022e-03
#> 7551   7551      anova full        TMEM184B   4.149491 1.243284e-03
#> 7552   7552      anova full           SOX12   4.149211 1.243948e-03
#> 7553   7553      anova full           MXRA5   4.149142 1.244110e-03
#> 7554   7554      anova full        ATP6V1C2   4.148807 1.244903e-03
#> 7555   7555      anova full      AC008496.2   4.147954 1.246928e-03
#> 7556   7556      anova full            CILP   4.147909 1.247034e-03
#> 7557   7557      anova full           KDM3A   4.147672 1.247598e-03
#> 7558   7558      anova full      AC009831.1   4.147090 1.248980e-03
#> 7559   7559      anova full          ZNF786   4.146888 1.249463e-03
#> 7560   7560      anova full      AC093827.4   4.146639 1.250054e-03
#> 7561   7561      anova full      AC079148.1   4.145877 1.251870e-03
#> 7562   7562      anova full           ADAP1   4.145250 1.253365e-03
#> 7563   7563      anova full          RUNDC1   4.144571 1.254988e-03
#> 7564   7564      anova full            TC2N   4.143627 1.257245e-03
#> 7565   7565      anova full         CCDC120   4.142747 1.259354e-03
#> 7566   7566      anova full           GCNT2   4.141411 1.262564e-03
#> 7567   7567      anova full      AC012368.1   4.139024 1.268316e-03
#> 7568   7568      anova full          FBXO31   4.137934 1.270952e-03
#> 7569   7569      anova full          BTF3L4   4.136793 1.273718e-03
#> 7570   7570      anova full       LINC00877   4.136093 1.275416e-03
#> 7571   7571      anova full          NUDT15   4.135952 1.275759e-03
#> 7572   7572      anova full           RERGL   4.135837 1.276039e-03
#> 7573   7573      anova full        C6orf141   4.134912 1.278290e-03
#> 7574   7574      anova full           DNHD1   4.134075 1.280329e-03
#> 7575   7575      anova full          SLC7A4   4.133456 1.281839e-03
#> 7576   7576      anova full       LINC01511   4.132723 1.283630e-03
#> 7577   7577      anova full           CDK16   4.131025 1.287789e-03
#> 7578   7578      anova full           NOTUM   4.130499 1.289080e-03
#> 7579   7579      anova full          MRPL38   4.129076 1.292580e-03
#> 7580   7580      anova full          LMO7DN   4.128737 1.293416e-03
#> 7581   7581      anova full              TH   4.127818 1.295682e-03
#> 7582   7582      anova full        TRAPPC2B   4.127427 1.296646e-03
#> 7583   7583      anova full        ARHGAP35   4.126854 1.298062e-03
#> 7584   7584      anova full      AC110285.2   4.124037 1.305050e-03
#> 7585   7585      anova full          CDC123   4.123011 1.307602e-03
#> 7586   7586      anova full             VIT   4.121809 1.310601e-03
#> 7587   7587      anova full      AC140125.2   4.121205 1.312110e-03
#> 7588   7588      anova full           PSMA3   4.117301 1.321910e-03
#> 7589   7589      anova full           PHF14   4.116953 1.322785e-03
#> 7590   7590      anova full           HSPD1   4.116703 1.323416e-03
#> 7591   7591      anova full          EIF2B1   4.114411 1.329210e-03
#> 7592   7592      anova full          MAGEL2   4.111421 1.336806e-03
#> 7593   7593      anova full          RHBDF1   4.111231 1.337291e-03
#> 7594   7594      anova full            GJB3   4.110950 1.338007e-03
#> 7595   7595      anova full            RBM5   4.110404 1.339400e-03
#> 7596   7596      anova full          TM4SF1   4.110082 1.340221e-03
#> 7597   7597      anova full      AC008397.2   4.109229 1.342403e-03
#> 7598   7598      anova full      AC025175.1   4.106595 1.349159e-03
#> 7599   7599      anova full      AC063944.3   4.105927 1.350880e-03
#> 7600   7600      anova full           PARK7   4.105491 1.352003e-03
#> 7601   7601      anova full          MYBPC2   4.104971 1.353343e-03
#> 7602   7602      anova full           ROBO3   4.104005 1.355836e-03
#> 7603   7603      anova full             RS1   4.101738 1.361710e-03
#> 7604   7604      anova full         ATP5F1E   4.101120 1.363316e-03
#> 7605   7605      anova full       LINC00565   4.100366 1.365276e-03
#> 7606   7606      anova full            WWC1   4.099560 1.367375e-03
#> 7607   7607      anova full      AC044839.1   4.099199 1.368317e-03
#> 7608   7608      anova full          ADGRB3   4.099027 1.368765e-03
#> 7609   7609      anova full           DAPP1   4.098979 1.368892e-03
#> 7610   7610      anova full           CPSF4   4.098431 1.370322e-03
#> 7611   7611      anova full           JADE2   4.098089 1.371215e-03
#> 7612   7612      anova full          CDCA7L   4.097938 1.371611e-03
#> 7613   7613      anova full           PCGF6   4.097334 1.373190e-03
#> 7614   7614      anova full          PAFAH2   4.097091 1.373829e-03
#> 7615   7615      anova full          MTMR14   4.096715 1.374814e-03
#> 7616   7616      anova full            DPM3   4.096623 1.375054e-03
#> 7617   7617      anova full           FOXM1   4.096211 1.376135e-03
#> 7618   7618      anova full         FGFR1OP   4.095511 1.377974e-03
#> 7619   7619      anova full           PARP6   4.095443 1.378152e-03
#> 7620   7620      anova full           STX19   4.093215 1.384019e-03
#> 7621   7621      anova full           NUP43   4.092398 1.386177e-03
#> 7622   7622      anova full             GPT   4.091761 1.387861e-03
#> 7623   7623      anova full          DIAPH2   4.091243 1.389232e-03
#> 7624   7624      anova full           CDCA3   4.090163 1.392097e-03
#> 7625   7625      anova full         SNRNP27   4.089879 1.392850e-03
#> 7626   7626      anova full           YPEL1   4.089387 1.394158e-03
#> 7627   7627      anova full          TSEN34   4.088200 1.397318e-03
#> 7628   7628      anova full            GGT7   4.087266 1.399809e-03
#> 7629   7629      anova full       LINC02021   4.087093 1.400272e-03
#> 7630   7630      anova full           NUBPL   4.087043 1.400406e-03
#> 7631   7631      anova full      ATP2B1-AS1   4.086869 1.400871e-03
#> 7632   7632      anova full        TNFRSF1B   4.086718 1.401272e-03
#> 7633   7633      anova full          CARD16   4.085361 1.404903e-03
#> 7634   7634      anova full       LINC01608   4.084026 1.408487e-03
#> 7635   7635      anova full        MAD2L1BP   4.083460 1.410009e-03
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#> 7674   7674      anova full           GINS3   4.064589 1.461694e-03
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#> 7731   7731      anova full            HGH1   4.022285 1.584644e-03
#> 7732   7732      anova full          WDYHV1   4.022018 1.585451e-03
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#> 7757   7757      anova full         POM121C   4.004548 1.639259e-03
#> 7758   7758      anova full         CLEC16A   4.004000 1.640978e-03
#> 7759   7759      anova full           CARMN   4.003693 1.641941e-03
#> 7760   7760      anova full           RDH16   4.003092 1.643829e-03
#> 7761   7761      anova full          DAZAP1   4.002899 1.644434e-03
#> 7762   7762      anova full       LINC01273   4.002877 1.644504e-03
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#> 7770   7770      anova full          ASRGL1   4.002174 1.646712e-03
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#> 7776   7776      anova full          MTRF1L   3.996032 1.666156e-03
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#> 7778   7778      anova full            MPND   3.994385 1.671410e-03
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#> 7781   7781      anova full           PRRG4   3.992656 1.676942e-03
#> 7782   7782      anova full            GRK6   3.991601 1.680326e-03
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#> 7788   7788      anova full           RREB1   3.988939 1.688900e-03
#> 7789   7789      anova full            SGK3   3.988597 1.690003e-03
#> 7790   7790      anova full          ZNF831   3.987563 1.693346e-03
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#> 7795   7795      anova full            BCAM   3.985534 1.699929e-03
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#> 7801   7801      anova full           NPY1R   3.981321 1.713676e-03
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#> 7813   7813      anova full           HTR1F   3.972435 1.743039e-03
#> 7814   7814      anova full           GSTA1   3.972024 1.744409e-03
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#> 7816   7816      anova full      AL589765.7   3.971728 1.745397e-03
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#> 7819   7819      anova full       LINC00242   3.970241 1.750368e-03
#> 7820   7820      anova full           ZNF92   3.969668 1.752288e-03
#> 7821   7821      anova full        ADAMTSL2   3.969279 1.753590e-03
#> 7822   7822      anova full          SEPHS2   3.969016 1.754473e-03
#> 7823   7823      anova full           GINS2   3.966838 1.761796e-03
#> 7824   7824      anova full          LONRF3   3.966602 1.762591e-03
#> 7825   7825      anova full       MIR193BHG   3.965614 1.765927e-03
#> 7826   7826      anova full            SGSH   3.965281 1.767051e-03
#> 7827   7827      anova full          WDR45B   3.964705 1.769000e-03
#> 7828   7828      anova full          ZNF275   3.964522 1.769619e-03
#> 7829   7829      anova full           PRKG2   3.963997 1.771397e-03
#> 7830   7830      anova full     ATP13A5-AS1   3.963317 1.773701e-03
#> 7831   7831      anova full           ILDR2   3.963231 1.773994e-03
#> 7832   7832      anova full           BTNL9   3.963008 1.774750e-03
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#> 7837   7837      anova full           CCAR1   3.960583 1.783001e-03
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#> 7842   7842      anova full          ZNF516   3.958009 1.791802e-03
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#> 7845   7845      anova full          ASAH2B   3.955917 1.798987e-03
#> 7846   7846      anova full           MASP1   3.955083 1.801860e-03
#> 7847   7847      anova full          IFNAR1   3.954449 1.804046e-03
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#> 7849   7849      anova full      KCNK15-AS1   3.951911 1.812825e-03
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#> 7853   7853      anova full           OPLAH   3.950034 1.819348e-03
#> 7854   7854      anova full           KCNE5   3.950021 1.819394e-03
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#> 7857   7857      anova full           NFKB2   3.948091 1.826124e-03
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#> 7864   7864      anova full             NIN   3.944324 1.839332e-03
#> 7865   7865      anova full           CXCL5   3.941524 1.849215e-03
#> 7866   7866      anova full           ANXA7   3.941442 1.849504e-03
#> 7867   7867      anova full         THUMPD1   3.940420 1.853127e-03
#> 7868   7868      anova full         ELMSAN1   3.938211 1.860974e-03
#> 7869   7869      anova full            DAB2   3.938046 1.861564e-03
#> 7870   7870      anova full          TRARG1   3.935153 1.871900e-03
#> 7871   7871      anova full         DNAJC27   3.934518 1.874175e-03
#> 7872   7872      anova full           MYO7A   3.934428 1.874496e-03
#> 7873   7873      anova full            GBP2   3.934209 1.875284e-03
#> 7874   7874      anova full           CNTD1   3.933797 1.876762e-03
#> 7875   7875      anova full      AC239800.3   3.933493 1.877854e-03
#> 7876   7876      anova full            PIGO   3.933134 1.879146e-03
#> 7877   7877      anova full            EAPP   3.933000 1.879629e-03
#> 7878   7878      anova full      AC092652.1   3.932099 1.882870e-03
#> 7879   7879      anova full       INTS6-AS1   3.930560 1.888428e-03
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#> 7881   7881      anova full          LILRA2   3.929823 1.891092e-03
#> 7882   7882      anova full           RRP1B   3.929578 1.891978e-03
#> 7883   7883      anova full      AP001059.3   3.928179 1.897054e-03
#> 7884   7884      anova full        C14orf39   3.927546 1.899354e-03
#> 7885   7885      anova full         ANGPTL1   3.927427 1.899786e-03
#> 7886   7886      anova full            ASB6   3.927417 1.899820e-03
#> 7887   7887      anova full          STK32B   3.926647 1.902624e-03
#> 7888   7888      anova full      AC060780.1   3.926286 1.903938e-03
#> 7889   7889      anova full           PSMD6   3.925427 1.907073e-03
#> 7890   7890      anova full         CCDC186   3.925392 1.907198e-03
#> 7891   7891      anova full          ZDHHC3   3.923499 1.914125e-03
#> 7892   7892      anova full            CDK2   3.922408 1.918126e-03
#> 7893   7893      anova full    EPB41L4A-AS1   3.922194 1.918910e-03
#> 7894   7894      anova full        HIST1H4C   3.922074 1.919353e-03
#> 7895   7895      anova full           ADRB3   3.920771 1.924148e-03
#> 7896   7896      anova full           PRAF2   3.920483 1.925206e-03
#> 7897   7897      anova full            BRF2   3.920365 1.925642e-03
#> 7898   7898      anova full            XPOT   3.920355 1.925679e-03
#> 7899   7899      anova full             SP3   3.919159 1.930093e-03
#> 7900   7900      anova full      AL451064.1   3.919143 1.930151e-03
#> 7901   7901      anova full           RDH12   3.915497 1.943674e-03
#> 7902   7902      anova full         SLC35E1   3.914110 1.948843e-03
#> 7903   7903      anova full             EMB   3.910718 1.961542e-03
#> 7904   7904      anova full         COL10A1   3.909332 1.966755e-03
#> 7905   7905      anova full            DGKE   3.907753 1.972710e-03
#> 7906   7906      anova full          ASPHD1   3.907020 1.975479e-03
#> 7907   7907      anova full          BABAM2   3.906850 1.976122e-03
#> 7908   7908      anova full         FLYWCH1   3.906649 1.976884e-03
#> 7909   7909      anova full           TGFB2   3.904674 1.984374e-03
#> 7910   7910      anova full           SATL1   3.904318 1.985727e-03
#> 7911   7911      anova full             AFP   3.903345 1.989433e-03
#> 7912   7912      anova full          ELAVL3   3.903207 1.989958e-03
#> 7913   7913      anova full           ICAM1   3.902054 1.994356e-03
#> 7914   7914      anova full            EML6   3.901912 1.994901e-03
#> 7915   7915      anova full          ZNF638   3.901740 1.995557e-03
#> 7916   7916      anova full            CD1A   3.900847 1.998975e-03
#> 7917   7917      anova full          TNRC6A   3.900663 1.999679e-03
#> 7918   7918      anova full         AKIRIN1   3.899220 2.005213e-03
#> 7919   7919      anova full         KREMEN1   3.899194 2.005314e-03
#> 7920   7920      anova full          SPTLC1   3.898216 2.009073e-03
#> 7921   7921      anova full           JMJD6   3.897707 2.011031e-03
#> 7